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Penile Intraepithelial Neoplasia

MedGen UID:
91118
•Concept ID:
C0347180
•
Neoplastic Process
Synonyms: Penile intraepithelial neoplasia; PIN - Penile intraepithelial neoplasia
SNOMED CT: Penile intraepithelial neoplasia (255148008); PIN - Penile intraepithelial neoplasia (255148008)

Definition

A precancerous neoplastic lesion that arises from the penis. It is characterized by dysplastic changes of the squamous epithelium with an intact basement membrane. [from NCI]

Professional guidelines

PubMed

2022 European guideline for the management of balanoposthitis.
Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
The management of penile intraepithelial neoplasia (PeIN): clinical and histological features and treatment of 345 patients and a review of the literature.
Kravvas G, Ge L, Ng J, Shim TN, Doiron PR, Watchorn R, Kentley J, Panou E, Dinneen M, Freeman A, Jameson C, Haider A, Francis N, Minhas S, Alnajjar H, Muneer A, Bunker CB
J Dermatolog Treat 2022 Mar;33(2):1047-1062. Epub 2020 Aug 6 doi: 10.1080/09546634.2020.1800574. PMID: 32705920
Imiquimod in the treatment of penile intraepithelial neoplasia: An update.
Deen K, Burdon-Jones D
Australas J Dermatol 2017 May;58(2):86-92. Epub 2016 Mar 8 doi: 10.1111/ajd.12466. PMID: 26952903

Recent clinical studies

Etiology

2022 European guideline for the management of balanoposthitis.
Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Pathology of Invasive and Intraepithelial Penile Neoplasia.
Canete-Portillo S, Sanchez DF, Cubilla AL
Eur Urol Focus 2019 Sep;5(5):713-717. Epub 2019 Jul 6 doi: 10.1016/j.euf.2019.06.013. PMID: 31288989
Efficacy, effectiveness and safety of vaccination against human papillomavirus in males: a systematic review.
Harder T, Wichmann O, Klug SJ, van der Sande MAB, Wiese-Posselt M
BMC Med 2018 Jul 18;16(1):110. doi: 10.1186/s12916-018-1098-3. PMID: 30016957Free PMC Article
Imiquimod in the treatment of penile intraepithelial neoplasia: An update.
Deen K, Burdon-Jones D
Australas J Dermatol 2017 May;58(2):86-92. Epub 2016 Mar 8 doi: 10.1111/ajd.12466. PMID: 26952903

Diagnosis

2022 European guideline for the management of balanoposthitis.
Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
Penile intraepithelial neoplasia: Distribution of subtypes, HPV genotypes and p16(INK4a) in 84 international cases.
Fernández-Nestosa MJ, Clavero O, Sánchez DF, Giannico GA, Lobatti A, Cañete-Portillo S, Velázquez EF, Alemany L, Muñoz N, de San José S, Bosch FX, Cubilla AL
Hum Pathol 2023 Jan;131:1-8. Epub 2022 Nov 24 doi: 10.1016/j.humpath.2022.11.006. PMID: 36427594
Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review.
Issa A, Sebro K, Kwok A, Janisch F, Grossmann NC, Lee E, Lucky M, Oliveira P, Lau M, Parnham A, Sangar V, Fankhauser CD
Eur Urol Focus 2022 May;8(3):829-832. Epub 2021 May 11 doi: 10.1016/j.euf.2021.04.026. PMID: 33994168
Pathology of Invasive and Intraepithelial Penile Neoplasia.
Canete-Portillo S, Sanchez DF, Cubilla AL
Eur Urol Focus 2019 Sep;5(5):713-717. Epub 2019 Jul 6 doi: 10.1016/j.euf.2019.06.013. PMID: 31288989
Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands.
Hoekstra RJ, Trip EJ, Ten Kate FJ, Horenblas S, Lock MT
Int J Urol 2019 Mar;26(3):353-357. Epub 2018 Dec 3 doi: 10.1111/iju.13871. PMID: 30508877

Therapy

2022 European guideline for the management of balanoposthitis.
Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
Incidence of penile intraepithelial neoplasia and treatment strategies in Sweden 2000-2019.
Kristiansen S, Torbrand C, Svensson Å, Forslund O, Bjartling C
BJU Int 2022 Jun;129(6):752-759. Epub 2022 Jan 24 doi: 10.1111/bju.15688. PMID: 35044047Free PMC Article
Efficacy, effectiveness and safety of vaccination against human papillomavirus in males: a systematic review.
Harder T, Wichmann O, Klug SJ, van der Sande MAB, Wiese-Posselt M
BMC Med 2018 Jul 18;16(1):110. doi: 10.1186/s12916-018-1098-3. PMID: 30016957Free PMC Article
Carbon dioxide laser treatment of penile intraepithelial neoplasia.
Zreik A, Rewhorn M, Vint R, Khan R, Hendry D
Surgeon 2017 Dec;15(6):321-324. Epub 2016 Dec 7 doi: 10.1016/j.surge.2016.11.001. PMID: 27964825
Imiquimod in the treatment of penile intraepithelial neoplasia: An update.
Deen K, Burdon-Jones D
Australas J Dermatol 2017 May;58(2):86-92. Epub 2016 Mar 8 doi: 10.1111/ajd.12466. PMID: 26952903

Prognosis

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Incidence of penile intraepithelial neoplasia and treatment strategies in Sweden 2000-2019.
Kristiansen S, Torbrand C, Svensson Å, Forslund O, Bjartling C
BJU Int 2022 Jun;129(6):752-759. Epub 2022 Jan 24 doi: 10.1111/bju.15688. PMID: 35044047Free PMC Article
Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review.
Issa A, Sebro K, Kwok A, Janisch F, Grossmann NC, Lee E, Lucky M, Oliveira P, Lau M, Parnham A, Sangar V, Fankhauser CD
Eur Urol Focus 2022 May;8(3):829-832. Epub 2021 May 11 doi: 10.1016/j.euf.2021.04.026. PMID: 33994168
Penile cancer: potential target for immunotherapy?
Vanthoor J, Vos G, Albersen M
World J Urol 2021 May;39(5):1405-1411. Epub 2020 Nov 3 doi: 10.1007/s00345-020-03510-7. PMID: 33145666
Pathology of Invasive and Intraepithelial Penile Neoplasia.
Canete-Portillo S, Sanchez DF, Cubilla AL
Eur Urol Focus 2019 Sep;5(5):713-717. Epub 2019 Jul 6 doi: 10.1016/j.euf.2019.06.013. PMID: 31288989

Clinical prediction guides

Incidence of penile intraepithelial neoplasia and incidence and survival of penile cancer in Denmark, 1997 to 2018.
Olesen TB, Sand FL, Aalborg GL, Munk C, Kjaer SK
Cancer Causes Control 2022 Jan;33(1):117-123. Epub 2021 Oct 26 doi: 10.1007/s10552-021-01510-5. PMID: 34698994
Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review.
Issa A, Sebro K, Kwok A, Janisch F, Grossmann NC, Lee E, Lucky M, Oliveira P, Lau M, Parnham A, Sangar V, Fankhauser CD
Eur Urol Focus 2022 May;8(3):829-832. Epub 2021 May 11 doi: 10.1016/j.euf.2021.04.026. PMID: 33994168
Pathology of Invasive and Intraepithelial Penile Neoplasia.
Canete-Portillo S, Sanchez DF, Cubilla AL
Eur Urol Focus 2019 Sep;5(5):713-717. Epub 2019 Jul 6 doi: 10.1016/j.euf.2019.06.013. PMID: 31288989
Risk Factors for Penile Intraepithelial Neoplasia: A Population-based Register Study in Sweden, 2000-2012.
Kristiansen S, Svensson Å, Drevin L, Forslund O, Torbrand C, Bjartling C
Acta Derm Venereol 2019 Mar 1;99(3):315-320. doi: 10.2340/00015555-3083. PMID: 30426132
Efficacy, effectiveness and safety of vaccination against human papillomavirus in males: a systematic review.
Harder T, Wichmann O, Klug SJ, van der Sande MAB, Wiese-Posselt M
BMC Med 2018 Jul 18;16(1):110. doi: 10.1186/s12916-018-1098-3. PMID: 30016957Free PMC Article

Recent systematic reviews

Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review.
Issa A, Sebro K, Kwok A, Janisch F, Grossmann NC, Lee E, Lucky M, Oliveira P, Lau M, Parnham A, Sangar V, Fankhauser CD
Eur Urol Focus 2022 May;8(3):829-832. Epub 2021 May 11 doi: 10.1016/j.euf.2021.04.026. PMID: 33994168
Prevalence of human papillomavirus DNA and p16(INK4a) in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis.
Olesen TB, Sand FL, Rasmussen CL, Albieri V, Toft BG, Norrild B, Munk C, Kjær SK
Lancet Oncol 2019 Jan;20(1):145-158. Epub 2018 Dec 17 doi: 10.1016/S1470-2045(18)30682-X. PMID: 30573285
Efficacy, effectiveness and safety of vaccination against human papillomavirus in males: a systematic review.
Harder T, Wichmann O, Klug SJ, van der Sande MAB, Wiese-Posselt M
BMC Med 2018 Jul 18;16(1):110. doi: 10.1186/s12916-018-1098-3. PMID: 30016957Free PMC Article
The management of penile intraepithelial neoplasia in genitourinary medicine.
Markos AR
Int J STD AIDS 2003 May;14(5):314-9. doi: 10.1258/095646203321605512. PMID: 12803938

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