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Benign neoplasm of middle ear

MedGen UID:
91121
•Concept ID:
C0347213
•
Neoplastic Process
Synonyms: Benign Middle Ear Neoplasm; benign middle Ear neoplasm; Benign Middle Ear Tumor; benign middle Ear tumor; benign middle Ear tumour; Benign Neoplasm of Middle Ear; benign neoplasm of middle ear; Benign Neoplasm of the Middle Ear; benign neoplasm of the middle Ear; Benign tumor of middle ear; Benign Tumor of Middle Ear; benign tumor of middle Ear; Benign Tumor of the Middle Ear; benign tumor of the middle Ear; benign tumour of middle Ear; benign tumour of the middle Ear; middle ear benign neoplasm
SNOMED CT: Benign tumor of middle ear (92218002); Benign neoplasm of middle ear (92218002)
 
Monarch Initiative: MONDO:0021482

Definition

A neoplasm that arises from the middle ear and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of middle ear

Professional guidelines

PubMed

Management and outcome of middle ear adenomatous neuroendocrine tumours: A systematic review.
Engel MSD, van der Lans RJL, Jansen JC, Leemans CR, Bloemena E, Lissenberg-Witte BI, Rijken JA, Smit CF, Hensen EF
Oral Oncol 2021 Oct;121:105465. Epub 2021 Aug 2 doi: 10.1016/j.oraloncology.2021.105465. PMID: 34352556
Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article
Olanzapine for the prevention and treatment of cancer-related nausea and vomiting in adults.
Sutherland A, Naessens K, Plugge E, Ware L, Head K, Burton MJ, Wee B
Cochrane Database Syst Rev 2018 Sep 21;9(9):CD012555. doi: 10.1002/14651858.CD012555.pub2. PMID: 30246876Free PMC Article

Recent clinical studies

Etiology

Ear canal and middle-ear tumors: a single-institution series of 87 patients.
Nicoli TK, Atula T, Sinkkonen ST, Korpi J, Vnencak M, Tarkkanen J, Mäkitie AA, Jero J
Acta Otolaryngol 2022 Feb;142(2):132-139. Epub 2022 Feb 11 doi: 10.1080/00016489.2022.2032824. PMID: 35148225
A case series of dermoids in the middle ear.
Chen S, Huang Y, Li Y
Int J Pediatr Otorhinolaryngol 2021 Jan;140:110472. Epub 2020 Nov 4 doi: 10.1016/j.ijporl.2020.110472. PMID: 33221033
Neuroendocrine neoplasms of the head and neck and olfactory neuroblastoma. Diagnosis and classification.
Uccella S, Ottini G, Facco C, Maragliano R, Asioli S, Sessa F, La Rosa S
Pathologica 2017 Mar;109(1):14-30. PMID: 28635990
Temporal paragangliomas.
Suárez C, Sevilla MA, Llorente JL
Eur Arch Otorhinolaryngol 2007 Jul;264(7):719-31. Epub 2007 Mar 2 doi: 10.1007/s00405-007-0267-3. PMID: 17333230
Radiotherapy-induced ear toxicity.
Jereczek-Fossa BA, Zarowski A, Milani F, Orecchia R
Cancer Treat Rev 2003 Oct;29(5):417-30. doi: 10.1016/s0305-7372(03)00066-5. PMID: 12972360

Diagnosis

Middle ear adenoma: Cytohistologic features and differential diagnosis.
Almajnooni A, Vega M, Cheng L, Gattuso P, Allen-Proctor MK
Diagn Cytopathol 2023 Apr;51(4):E137-E141. Epub 2023 Jan 23 doi: 10.1002/dc.25103. PMID: 36688374
Ear canal and middle-ear tumors: a single-institution series of 87 patients.
Nicoli TK, Atula T, Sinkkonen ST, Korpi J, Vnencak M, Tarkkanen J, Mäkitie AA, Jero J
Acta Otolaryngol 2022 Feb;142(2):132-139. Epub 2022 Feb 11 doi: 10.1080/00016489.2022.2032824. PMID: 35148225
Management and outcome of middle ear adenomatous neuroendocrine tumours: A systematic review.
Engel MSD, van der Lans RJL, Jansen JC, Leemans CR, Bloemena E, Lissenberg-Witte BI, Rijken JA, Smit CF, Hensen EF
Oral Oncol 2021 Oct;121:105465. Epub 2021 Aug 2 doi: 10.1016/j.oraloncology.2021.105465. PMID: 34352556
Paragangliomas of the Head and Neck.
Woolen S, Gemmete JJ
Neuroimaging Clin N Am 2016 May;26(2):259-78. Epub 2016 Mar 5 doi: 10.1016/j.nic.2015.12.005. PMID: 27154608
Glomus tympanicum tumors.
Sweeney AD, Carlson ML, Wanna GB, Bennett ML
Otolaryngol Clin North Am 2015 Apr;48(2):293-304. Epub 2015 Feb 4 doi: 10.1016/j.otc.2014.12.004. PMID: 25659513

Therapy

Modern Management of Complex Tympanojugular Paragangliomas: Systematic Review and Meta-Analysis.
Dharnipragada R, Butterfield JT, Dhawan S, Adams ME, Venteicher AS
World Neurosurg 2023 Feb;170:149-156.e3. Epub 2022 Nov 16 doi: 10.1016/j.wneu.2022.11.037. PMID: 36400356
Effectiveness of Electroacupuncture or Auricular Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among Cancer Survivors: The PEACE Randomized Clinical Trial.
Mao JJ, Liou KT, Baser RE, Bao T, Panageas KS, Romero SAD, Li QS, Gallagher RM, Kantoff PW
JAMA Oncol 2021 May 1;7(5):720-727. doi: 10.1001/jamaoncol.2021.0310. PMID: 33734288Free PMC Article
Acute otitis media and antibiotics - a systematic review.
Holm NH, Rusan M, Ovesen T
Dan Med J 2020 Oct 29;67(11) PMID: 33215607
Effectiveness of auricular acupuncture in the treatment of cancer pain: randomized clinical trial.
Ruela LO, Iunes DH, Nogueira DA, Stefanello J, Gradim CVC
Rev Esc Enferm USP 2018 Dec 13;52:e03402. doi: 10.1590/S1980-220X2017040503402. PMID: 30570087
Temporal bone resection.
Willging JP, Pensak ML
Ear Nose Throat J 1991 Sep;70(9):612-7. PMID: 1743111

Prognosis

Management and outcome of middle ear adenomatous neuroendocrine tumours: A systematic review.
Engel MSD, van der Lans RJL, Jansen JC, Leemans CR, Bloemena E, Lissenberg-Witte BI, Rijken JA, Smit CF, Hensen EF
Oral Oncol 2021 Oct;121:105465. Epub 2021 Aug 2 doi: 10.1016/j.oraloncology.2021.105465. PMID: 34352556
Uveal melanoma: Long-term survival.
Radivoyevitch T, Zabor EC, Singh AD
PLoS One 2021;16(5):e0250939. Epub 2021 May 18 doi: 10.1371/journal.pone.0250939. PMID: 34003826Free PMC Article
Adenomatous tumors of the middle ear.
Pelosi S, Koss S
Otolaryngol Clin North Am 2015 Apr;48(2):305-15. doi: 10.1016/j.otc.2014.12.005. PMID: 25769353
Glomus tympanicum tumors.
Sweeney AD, Carlson ML, Wanna GB, Bennett ML
Otolaryngol Clin North Am 2015 Apr;48(2):293-304. Epub 2015 Feb 4 doi: 10.1016/j.otc.2014.12.004. PMID: 25659513
Radiotherapy-induced ear toxicity.
Jereczek-Fossa BA, Zarowski A, Milani F, Orecchia R
Cancer Treat Rev 2003 Oct;29(5):417-30. doi: 10.1016/s0305-7372(03)00066-5. PMID: 12972360

Clinical prediction guides

Key Genes and Endoscopic Radical Surgery in Primary Middle Ear Oncocytic Papillomas.
Lyu J, Wang W, Chen B, Wang Y, Sun H, Yuan Y, Ren D
Otol Neurotol 2023 Oct 1;44(9):e676-e680. Epub 2023 Aug 19 doi: 10.1097/MAO.0000000000003993. PMID: 37604509
Morphological features of benign pigmented ear lesions: a cross-sectional study.
Rishpon A, Sprecher E, Dusza SW, Kleinman E, Haupt S, Rabinovitz H, Scope A
Int J Dermatol 2022 Feb;61(2):208-215. Epub 2021 Jul 4 doi: 10.1111/ijd.15754. PMID: 34219231
Management and outcome of middle ear adenomatous neuroendocrine tumours: A systematic review.
Engel MSD, van der Lans RJL, Jansen JC, Leemans CR, Bloemena E, Lissenberg-Witte BI, Rijken JA, Smit CF, Hensen EF
Oral Oncol 2021 Oct;121:105465. Epub 2021 Aug 2 doi: 10.1016/j.oraloncology.2021.105465. PMID: 34352556
A case series of dermoids in the middle ear.
Chen S, Huang Y, Li Y
Int J Pediatr Otorhinolaryngol 2021 Jan;140:110472. Epub 2020 Nov 4 doi: 10.1016/j.ijporl.2020.110472. PMID: 33221033
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Recent systematic reviews

Modern Management of Complex Tympanojugular Paragangliomas: Systematic Review and Meta-Analysis.
Dharnipragada R, Butterfield JT, Dhawan S, Adams ME, Venteicher AS
World Neurosurg 2023 Feb;170:149-156.e3. Epub 2022 Nov 16 doi: 10.1016/j.wneu.2022.11.037. PMID: 36400356
Mastoid Obliteration Decreases the Recurrent and Residual Disease: Systematic Review and Meta-analysis.
Illés K, Meznerics FA, Dembrovszky F, Fehérvári P, Bánvölgyi A, Csupor D, Hegyi P, Horváth T
Laryngoscope 2023 Jun;133(6):1297-1305. Epub 2022 Sep 28 doi: 10.1002/lary.30413. PMID: 36169349
Management and outcome of middle ear adenomatous neuroendocrine tumours: A systematic review.
Engel MSD, van der Lans RJL, Jansen JC, Leemans CR, Bloemena E, Lissenberg-Witte BI, Rijken JA, Smit CF, Hensen EF
Oral Oncol 2021 Oct;121:105465. Epub 2021 Aug 2 doi: 10.1016/j.oraloncology.2021.105465. PMID: 34352556
Acute otitis media and antibiotics - a systematic review.
Holm NH, Rusan M, Ovesen T
Dan Med J 2020 Oct 29;67(11) PMID: 33215607
Olanzapine for the prevention and treatment of cancer-related nausea and vomiting in adults.
Sutherland A, Naessens K, Plugge E, Ware L, Head K, Burton MJ, Wee B
Cochrane Database Syst Rev 2018 Sep 21;9(9):CD012555. doi: 10.1002/14651858.CD012555.pub2. PMID: 30246876Free PMC Article

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