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Intestinal benign neoplasm

MedGen UID:
91124
•Concept ID:
C0347269
•
Neoplastic Process
Synonyms: Benign Intestinal Neoplasm; benign intestinal neoplasm; Benign Intestinal Neoplasms; benign intestinal neoplasms; Benign Intestinal Tumor; benign intestinal tumor; Benign Intestinal Tumors; benign intestinal tumors; Benign Intestine Neoplasm; benign intestine neoplasm; Benign Intestine Tumor; benign intestine tumor; Benign neoplasm of intestinal tract; Benign neoplasm of intestine; Benign Neoplasm of Intestines; benign neoplasm of intestines; Benign Neoplasm of the Intestines; benign neoplasm of the intestines; Benign Neoplasms of Large and/or Small Intestine; benign neoplasms of large and/or small intestine; Benign Neoplasms of the Large and/or Small Intestine; benign neoplasms of the large and/or small intestine; Benign tumor of intestine; Benign Tumor of Intestines; benign tumor of intestines; Benign Tumor of the Intestines; benign tumor of the intestines; intestinal benign neoplasm; Intestinal Neoplasms, Benign; intestinal neoplasms, benign; Intestinal Tumors, Benign; intestinal tumors, benign; intestine benign neoplasm
SNOMED CT: Benign neoplasm of intestinal tract (92151003); Benign neoplasm of intestine (92151003); Benign tumor of intestine (92151003)
 
Monarch Initiative: MONDO:0003062

Definition

A non-metastasizing neoplasm arising from the small or large intestine. [from NCI]

Professional guidelines

PubMed

AGA Clinical Practice Update on Management of Refractory Celiac Disease: Expert Review.
Green PHR, Paski S, Ko CW, Rubio-Tapia A
Gastroenterology 2022 Nov;163(5):1461-1469. Epub 2022 Sep 19 doi: 10.1053/j.gastro.2022.07.086. PMID: 36137844
Appendiceal Mucinous Neoplasms: Diagnosis and Management.
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.
Syngal S, Brand RE, Church JM, Giardiello FM, Hampel HL, Burt RW; American College of Gastroenterology
Am J Gastroenterol 2015 Feb;110(2):223-62; quiz 263. Epub 2015 Feb 3 doi: 10.1038/ajg.2014.435. PMID: 25645574Free PMC Article

Recent clinical studies

Etiology

Gastric Cancer Risk of Intestinal Metaplasia Subtypes: A Systematic Review and Meta-Analysis of Cohort Studies.
Du S, Yang Y, Fang S, Guo S, Xu C, Zhang P, Wei W
Clin Transl Gastroenterol 2021 Oct 1;12(10):e00402. doi: 10.14309/ctg.0000000000000402. PMID: 34597278Free PMC Article
Metformin, Microbiome and Protection Against Colorectal Cancer.
Jones GR, Molloy MP
Dig Dis Sci 2021 May;66(5):1409-1414. Epub 2020 Jun 12 doi: 10.1007/s10620-020-06390-4. PMID: 32533543
Intestinal microbiota and colorectal cancer: changes in the intestinal microenvironment and their relation to the disease.
Reis SAD, da Conceição LL, Peluzio MDCG
J Med Microbiol 2019 Oct;68(10):1391-1407. Epub 2019 Aug 19 doi: 10.1099/jmm.0.001049. PMID: 31424382
The Intestinal Microbiota in Colorectal Cancer.
Tilg H, Adolph TE, Gerner RR, Moschen AR
Cancer Cell 2018 Jun 11;33(6):954-964. Epub 2018 Apr 12 doi: 10.1016/j.ccell.2018.03.004. PMID: 29657127
Neutropenic enterocolitis.
Cloutier RL
Emerg Med Clin North Am 2009 Aug;27(3):415-22. doi: 10.1016/j.emc.2009.04.002. PMID: 19646645

Diagnosis

Intestinal microbiota and colorectal cancer: changes in the intestinal microenvironment and their relation to the disease.
Reis SAD, da Conceição LL, Peluzio MDCG
J Med Microbiol 2019 Oct;68(10):1391-1407. Epub 2019 Aug 19 doi: 10.1099/jmm.0.001049. PMID: 31424382
The role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection.
Zhou CB, Fang JY
Biochim Biophys Acta Rev Cancer 2019 Aug;1872(1):1-10. Epub 2019 May 3 doi: 10.1016/j.bbcan.2019.05.001. PMID: 31059737
Management of Small Bowel Neuroendocrine Tumors.
Scott AT, Howe JR
J Oncol Pract 2018 Aug;14(8):471-482. doi: 10.1200/JOP.18.00135. PMID: 30096273Free PMC Article
Neutropenic enterocolitis.
Cloutier RL
Emerg Med Clin North Am 2009 Aug;27(3):415-22. doi: 10.1016/j.emc.2009.04.002. PMID: 19646645
Small bowel tumors.
Abu-Hamda EM, Hattab EM, Lynch PM
Curr Gastroenterol Rep 2003 Oct;5(5):386-93. doi: 10.1007/s11894-003-0051-5. PMID: 12959719

Therapy

Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy.
Zhang D, Zhong D, Ouyang J, He J, Qi Y, Chen W, Zhang X, Tao W, Zhou M
Nat Commun 2022 Mar 17;13(1):1413. doi: 10.1038/s41467-022-28744-4. PMID: 35301299Free PMC Article
Impact of a high‑fat diet on intestinal stem cells and epithelial barrier function in middle‑aged female mice.
Xie Y, Ding F, Di W, Lv Y, Xia F, Sheng Y, Yu J, Ding G
Mol Med Rep 2020 Mar;21(3):1133-1144. Epub 2020 Jan 13 doi: 10.3892/mmr.2020.10932. PMID: 32016468Free PMC Article
Understanding short bowel syndrome: Current status and future perspectives.
Massironi S, Cavalcoli F, Rausa E, Invernizzi P, Braga M, Vecchi M
Dig Liver Dis 2020 Mar;52(3):253-261. Epub 2019 Dec 28 doi: 10.1016/j.dld.2019.11.013. PMID: 31892505
Saponins regulate intestinal inflammation in colon cancer and IBD.
Dong J, Liang W, Wang T, Sui J, Wang J, Deng Z, Chen D
Pharmacol Res 2019 Jun;144:66-72. Epub 2019 Apr 5 doi: 10.1016/j.phrs.2019.04.010. PMID: 30959159
Microbiota and aging.
Bischoff SC
Curr Opin Clin Nutr Metab Care 2016 Jan;19(1):26-30. doi: 10.1097/MCO.0000000000000242. PMID: 26560527

Prognosis

Risk of gastric cancer among patients with gastric intestinal metaplasia.
Shao L, Li P, Ye J, Chen J, Han Y, Cai J, Lu X
Int J Cancer 2018 Oct 1;143(7):1671-1677. Epub 2018 Jul 26 doi: 10.1002/ijc.31571. PMID: 29707766
Large intestine.
Kelly CP
Curr Opin Gastroenterol 2010 Jan;26(1):45-6. doi: 10.1097/MOG.0b013e328333b040. PMID: 19881344
Small intestinal neoplasms.
Gill SS, Heuman DM, Mihas AA
J Clin Gastroenterol 2001 Oct;33(4):267-82. doi: 10.1097/00004836-200110000-00004. PMID: 11588539
Small-bowel tumors.
Minardi AJ Jr, Zibari GB, Aultman DF, McMillan RW, McDonald JC
J Am Coll Surg 1998 Jun;186(6):664-8. doi: 10.1016/s1072-7515(98)00092-1. PMID: 9632155
PANCREATODUODENECTOMY.
BUCKWALTER JA, LAWTON RI, TIDRICK RT
Arch Surg 1964 Aug;89:331-9. doi: 10.1001/archsurg.1964.01320020095015. PMID: 14160161

Clinical prediction guides

The Frontiers of Appendiceal Controversies: Mucinous Neoplasms and Pseudomyxoma Peritonei.
Hissong E, Yantiss RK
Am J Surg Pathol 2022 Jan 1;46(1):e27-e42. doi: 10.1097/PAS.0000000000001662. PMID: 33417324
The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis.
Datorre JG, de Carvalho AC, Guimarães DP, Reis RM
Pathobiology 2021;88(2):127-140. Epub 2020 Dec 8 doi: 10.1159/000512175. PMID: 33291114
Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis.
Liu L , Dong W , Wang S , Zhang Y , Liu T , Xie R , Wang B , Cao H
Food Funct 2018 Nov 14;9(11):5588-5597. doi: 10.1039/c8fo01143e. PMID: 30339173
Luminally expressed gastrointestinal biomarkers.
Cummins G, Yung DE, Cox BF, Koulaouzidis A, Desmulliez MPY, Cochran S
Expert Rev Gastroenterol Hepatol 2017 Dec;11(12):1119-1134. Epub 2017 Sep 14 doi: 10.1080/17474124.2017.1373017. PMID: 28849686
Enteroscopy.
Mönkemüller K, Bellutti M, Fry LC, Malfertheiner P
Best Pract Res Clin Gastroenterol 2008;22(5):789-811. doi: 10.1016/j.bpg.2008.05.005. PMID: 18790433

Recent systematic reviews

MASCC multidisciplinary evidence-based recommendations for the management of malignant bowel obstruction in advanced cancer.
Madariaga A, Lau J, Ghoshal A, Dzierżanowski T, Larkin P, Sobocki J, Dickman A, Furness K, Fazelzad R, Crawford GB, Lheureux S
Support Care Cancer 2022 Jun;30(6):4711-4728. Epub 2022 Mar 10 doi: 10.1007/s00520-022-06889-8. PMID: 35274188Free PMC Article
Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Metaanalysis of Oncological and Operative Outcomes.
Kong JC, Soucisse M, Michael M, Tie J, Ngan SY, Leong T, McCormick J, Warrier SK, Heriot AG
Ann Surg Oncol 2021 Nov;28(12):7476-7486. Epub 2021 Apr 23 doi: 10.1245/s10434-021-09837-8. PMID: 33891203
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845
Lifestyle Risk Factors for Serrated Colorectal Polyps: A Systematic Review and Meta-analysis.
Bailie L, Loughrey MB, Coleman HG
Gastroenterology 2017 Jan;152(1):92-104. Epub 2016 Sep 14 doi: 10.1053/j.gastro.2016.09.003. PMID: 27639804

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