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Intestinal benign neoplasm

MedGen UID:
91124
•Concept ID:
C0347269
•
Neoplastic Process
Synonyms: Benign Intestinal Neoplasm; benign intestinal neoplasm; Benign Intestinal Neoplasms; benign intestinal neoplasms; Benign Intestinal Tumor; benign intestinal tumor; Benign Intestinal Tumors; benign intestinal tumors; benign intestinal tumour; benign intestinal tumours; Benign Intestine Neoplasm; benign intestine neoplasm; Benign Intestine Tumor; benign intestine tumor; benign intestine tumour; Benign neoplasm of intestinal tract; Benign neoplasm of intestine; Benign Neoplasm of Intestines; benign neoplasm of intestines; Benign Neoplasm of the Intestines; benign neoplasm of the intestines; Benign Neoplasms of Large and/or Small Intestine; benign neoplasms of large and/or small intestine; Benign Neoplasms of the Large and/or Small Intestine; benign neoplasms of the large and/or small intestine; Benign tumor of intestine; Benign Tumor of Intestines; benign tumor of intestines; Benign Tumor of the Intestines; benign tumor of the intestines; benign tumour of intestines; benign tumour of the intestines; intestinal benign neoplasm; Intestinal Neoplasms, Benign; intestinal neoplasms, benign; Intestinal Tumors, Benign; intestinal tumors, benign; intestine benign neoplasm
SNOMED CT: Benign neoplasm of intestinal tract (92151003); Benign neoplasm of intestine (92151003); Benign tumor of intestine (92151003)
 
Monarch Initiative: MONDO:0003062

Definition

A neoplasm that arises from the small or large intestine and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

AGA Clinical Practice Update on Management of Refractory Celiac Disease: Expert Review.
Green PHR, Paski S, Ko CW, Rubio-Tapia A
Gastroenterology 2022 Nov;163(5):1461-1469. Epub 2022 Sep 19 doi: 10.1053/j.gastro.2022.07.086. PMID: 36137844
Appendiceal Mucinous Neoplasms: Diagnosis and Management.
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.
Syngal S, Brand RE, Church JM, Giardiello FM, Hampel HL, Burt RW; American College of Gastroenterology
Am J Gastroenterol 2015 Feb;110(2):223-62; quiz 263. Epub 2015 Feb 3 doi: 10.1038/ajg.2014.435. PMID: 25645574Free PMC Article

Recent clinical studies

Etiology

Updates in the diagnosis and management of small-bowel tumors.
Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
Inflammatory bowel disease and carcinogenesis.
Nagao-Kitamoto H, Kitamoto S, Kamada N
Cancer Metastasis Rev 2022 Jun;41(2):301-316. Epub 2022 Apr 13 doi: 10.1007/s10555-022-10028-4. PMID: 35416564
Small Bowel Neoplasms: A Pictorial Review.
Jasti R, Carucci LR
Radiographics 2020 Jul-Aug;40(4):1020-1038. Epub 2020 Jun 19 doi: 10.1148/rg.2020200011. PMID: 32559148
Intestinal microbiota and colorectal cancer: changes in the intestinal microenvironment and their relation to the disease.
Reis SAD, da Conceição LL, Peluzio MDCG
J Med Microbiol 2019 Oct;68(10):1391-1407. Epub 2019 Aug 19 doi: 10.1099/jmm.0.001049. PMID: 31424382
The Intestinal Microbiota in Colorectal Cancer.
Tilg H, Adolph TE, Gerner RR, Moschen AR
Cancer Cell 2018 Jun 11;33(6):954-964. Epub 2018 Apr 12 doi: 10.1016/j.ccell.2018.03.004. PMID: 29657127

Diagnosis

Updates in the diagnosis and management of small-bowel tumors.
Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
Intestinal microbiota and colorectal cancer: changes in the intestinal microenvironment and their relation to the disease.
Reis SAD, da Conceição LL, Peluzio MDCG
J Med Microbiol 2019 Oct;68(10):1391-1407. Epub 2019 Aug 19 doi: 10.1099/jmm.0.001049. PMID: 31424382
Management of Small Bowel Neuroendocrine Tumors.
Scott AT, Howe JR
J Oncol Pract 2018 Aug;14(8):471-482. doi: 10.1200/JOP.18.00135. PMID: 30096273Free PMC Article
Small bowel tumours: update in diagnosis and management.
Rondonotti E, Koulaouzidis A, Georgiou J, Pennazio M
Curr Opin Gastroenterol 2018 May;34(3):159-164. doi: 10.1097/MOG.0000000000000428. PMID: 29438117
Intestinal metaplasia of appendiceal endometriosis is not uncommon and may mimic appendiceal mucinous neoplasm.
Vyas M, Wong S, Zhang X
Pathol Res Pract 2017 Jan;213(1):39-44. Epub 2016 Oct 25 doi: 10.1016/j.prp.2016.10.011. PMID: 27913053

Therapy

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy.
Zhang D, Zhong D, Ouyang J, He J, Qi Y, Chen W, Zhang X, Tao W, Zhou M
Nat Commun 2022 Mar 17;13(1):1413. doi: 10.1038/s41467-022-28744-4. PMID: 35301299Free PMC Article
Impact of a high‑fat diet on intestinal stem cells and epithelial barrier function in middle‑aged female mice.
Xie Y, Ding F, Di W, Lv Y, Xia F, Sheng Y, Yu J, Ding G
Mol Med Rep 2020 Mar;21(3):1133-1144. Epub 2020 Jan 13 doi: 10.3892/mmr.2020.10932. PMID: 32016468Free PMC Article
Understanding short bowel syndrome: Current status and future perspectives.
Massironi S, Cavalcoli F, Rausa E, Invernizzi P, Braga M, Vecchi M
Dig Liver Dis 2020 Mar;52(3):253-261. Epub 2019 Dec 28 doi: 10.1016/j.dld.2019.11.013. PMID: 31892505
Microbiota and aging.
Bischoff SC
Curr Opin Clin Nutr Metab Care 2016 Jan;19(1):26-30. doi: 10.1097/MCO.0000000000000242. PMID: 26560527

Prognosis

The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis.
Datorre JG, de Carvalho AC, Guimarães DP, Reis RM
Pathobiology 2021;88(2):127-140. Epub 2020 Dec 8 doi: 10.1159/000512175. PMID: 33291114
The Small Bowel Cancer Incidence Enigma.
Assumpção P, Khayat A, Araújo T, Barra W, Ishak G, Cruz A, Santos S, Santos Â, Demachki S, Assumpção P, Calcagno D, Santos N, Assumpção M, Moreira F, Santos A, Assumpção C, Riggins G, Burbano R
Pathol Oncol Res 2020 Apr;26(2):635-639. Epub 2019 Jun 5 doi: 10.1007/s12253-019-00682-5. PMID: 31165996
The impact of the intestinal microbiota in therapeutic responses against cancer.
Goubet AG, Daillère R, Routy B, Derosa L, M Roberti P, Zitvogel L
C R Biol 2018 May-Jun;341(5):284-289. Epub 2018 Apr 7 doi: 10.1016/j.crvi.2018.03.004. PMID: 29631891
Adenocarcinoma risk in gastric atrophy and intestinal metaplasia: a systematic review.
Spence AD, Cardwell CR, McMenamin ÚC, Hicks BM, Johnston BT, Murray LJ, Coleman HG
BMC Gastroenterol 2017 Dec 11;17(1):157. doi: 10.1186/s12876-017-0708-4. PMID: 29228909Free PMC Article
Small intestinal neoplasms.
Gill SS, Heuman DM, Mihas AA
J Clin Gastroenterol 2001 Oct;33(4):267-82. doi: 10.1097/00004836-200110000-00004. PMID: 11588539

Clinical prediction guides

The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis.
Datorre JG, de Carvalho AC, Guimarães DP, Reis RM
Pathobiology 2021;88(2):127-140. Epub 2020 Dec 8 doi: 10.1159/000512175. PMID: 33291114
Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis.
Liu L , Dong W , Wang S , Zhang Y , Liu T , Xie R , Wang B , Cao H
Food Funct 2018 Nov 14;9(11):5588-5597. doi: 10.1039/c8fo01143e. PMID: 30339173
Luminally expressed gastrointestinal biomarkers.
Cummins G, Yung DE, Cox BF, Koulaouzidis A, Desmulliez MPY, Cochran S
Expert Rev Gastroenterol Hepatol 2017 Dec;11(12):1119-1134. Epub 2017 Sep 14 doi: 10.1080/17474124.2017.1373017. PMID: 28849686
Update on imaging of Peutz-Jeghers syndrome.
Tomas C, Soyer P, Dohan A, Dray X, Boudiaf M, Hoeffel C
World J Gastroenterol 2014 Aug 21;20(31):10864-75. doi: 10.3748/wjg.v20.i31.10864. PMID: 25152588Free PMC Article
Intestinal iron homeostasis and colon tumorigenesis.
Xue X, Shah YM
Nutrients 2013 Jun 28;5(7):2333-51. doi: 10.3390/nu5072333. PMID: 23812305Free PMC Article

Recent systematic reviews

Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Systematic review and meta-analysis of the association between diverticulosis of the appendix and neoplasia.
Lim CSH, Cheah SY, Kwok AMF, Ravindran P, Chan DL
ANZ J Surg 2020 Oct;90(10):1871-1877. Epub 2020 Mar 24 doi: 10.1111/ans.15811. PMID: 32207873
Transperineal versus transrectal prostate biopsy in the diagnosis of prostate cancer: a systematic review and meta-analysis.
Xiang J, Yan H, Li J, Wang X, Chen H, Zheng X
World J Surg Oncol 2019 Feb 13;17(1):31. doi: 10.1186/s12957-019-1573-0. PMID: 30760274Free PMC Article
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845
Lifestyle Risk Factors for Serrated Colorectal Polyps: A Systematic Review and Meta-analysis.
Bailie L, Loughrey MB, Coleman HG
Gastroenterology 2017 Jan;152(1):92-104. Epub 2016 Sep 14 doi: 10.1053/j.gastro.2016.09.003. PMID: 27639804

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