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Spinal cord lipoma

MedGen UID:
91131
•Concept ID:
C0347446
•
Neoplastic Process
Synonyms: Lipoma of spinal cord; Lipoma of Spinal Cord; lipoma of spinal cord; Spinal Cord Lipoma; spinal cord lipoma
SNOMED CT: Lipoma of spinal cord (189017000)
 
Monarch Initiative: MONDO:0001790

Definition

A benign adipose tissue neoplasm of the spinal cord. It is usually associated with dysraphism in which the intraspinal component communicates with a subcutaneous lipoma through a defect in the posterior elements of the spine. Non-dysraphic intramedullary spinal cord lipomas are very rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpinal cord lipoma

Professional guidelines

PubMed

Conservative and surgical treatment of pediatric asymptomatic lumbosacral lipoma: a meta-analysis.
Xiong Y, Yang L, Zhen W, Fangyong D, Feng W, Ting L
Neurosurg Rev 2018 Jul;41(3):737-743. Epub 2016 Oct 28 doi: 10.1007/s10143-016-0796-6. PMID: 27796602
Recurrent tethered cord: radiological investigation and management.
Caldarelli M, Boscarelli A, Massimi L
Childs Nerv Syst 2013 Sep;29(9):1601-9. Epub 2013 Sep 7 doi: 10.1007/s00381-013-2150-4. PMID: 24013330
Closed spinal dysraphism: a review on diagnosis and treatment in infancy.
Cornette L, Verpoorten C, Lagae L, Plets C, Van Calenbergh F, Casaer P
Eur J Paediatr Neurol 1998;2(4):179-85. doi: 10.1016/s1090-3798(98)80017-2. PMID: 10726589

Recent clinical studies

Etiology

Non-dysraphic intramedullary spinal cord lipoma of the child: Report of 3 cases.
Sagenly M, Karnoub MA, Vinchon M
Neurochirurgie 2023 Sep;69(5):101473. Epub 2023 Jul 22 doi: 10.1016/j.neuchi.2023.101473. PMID: 37482183
Recurrent Tethering in Conus Lipomas: A Late Complication Not to Be Ignored.
Idriceanu T, Beuriat PA, Di Rocco F, Szathmari A, Mottolese C
World Neurosurg 2022 Dec;168:e12-e18. Epub 2022 Jul 19 doi: 10.1016/j.wneu.2022.07.048. PMID: 35863646
Giant bipolar intramedullary nondysraphic spinal cord lipoma: A case report.
Kouadria R, Si Ali A, Aidouni Y, Maaz W, Mhamdi C
Neurochirurgie 2018 Dec;64(6):442-444. Epub 2018 Nov 2 doi: 10.1016/j.neuchi.2018.08.005. PMID: 30396693
Non-dysraphic intradural spinal cord lipoma: case series, literature review and guidelines for management.
Kabir SM, Thompson D, Rezajooi K, Casey AT
Acta Neurochir (Wien) 2010 Jul;152(7):1139-44. Epub 2010 Mar 10 doi: 10.1007/s00701-010-0620-y. PMID: 20221647
Intramedullary spinal cord lipomas.
Lee M, Rezai AR, Abbott R, Coelho DH, Epstein FJ
J Neurosurg 1995 Mar;82(3):394-400. doi: 10.3171/jns.1995.82.3.0394. PMID: 7861216

Diagnosis

Non-dysraphic intramedullary spinal cord lipoma of the child: Report of 3 cases.
Sagenly M, Karnoub MA, Vinchon M
Neurochirurgie 2023 Sep;69(5):101473. Epub 2023 Jul 22 doi: 10.1016/j.neuchi.2023.101473. PMID: 37482183
Non-dysraphic extramedullary intradural spinal lipoma with neurocutaneous melanocytosis.
Raj S, Chouksey P, Shrivastava A, Mishra R, Tandon A, Prakash M, Agrawal A
Br J Neurosurg 2023 Dec;37(6):1824-1828. Epub 2021 Jun 21 doi: 10.1080/02688697.2021.1937518. PMID: 34148439
Non Dysraphic Intramedullary Spinal Cord Lipoma.
Balachandar D, Naidu PB, Sangeetha, Selvakumar K
Neurol India 2022 Sep-Oct;70(Supplement):S302-S305. doi: 10.4103/0028-3886.360941. PMID: 36412385
Recurrent Tethering in Conus Lipomas: A Late Complication Not to Be Ignored.
Idriceanu T, Beuriat PA, Di Rocco F, Szathmari A, Mottolese C
World Neurosurg 2022 Dec;168:e12-e18. Epub 2022 Jul 19 doi: 10.1016/j.wneu.2022.07.048. PMID: 35863646
Giant bipolar intramedullary nondysraphic spinal cord lipoma: A case report.
Kouadria R, Si Ali A, Aidouni Y, Maaz W, Mhamdi C
Neurochirurgie 2018 Dec;64(6):442-444. Epub 2018 Nov 2 doi: 10.1016/j.neuchi.2018.08.005. PMID: 30396693

Therapy

Three-dimensional reconstructed computed tomography-magnetic resonance fusion image-based preoperative planning for surgical procedures for spinal lipoma or tethered spinal cord after myelomeningocele repair.
Bamba Y, Nonaka M, Nakajima S, Yamasaki M
Neurol Med Chir (Tokyo) 2011;51(5):397-402. doi: 10.2176/nmc.51.397. PMID: 21613771
Occult tethered cord syndrome: a survey of practice patterns.
Steinbok P, Garton HJ, Gupta N
J Neurosurg 2006 May;104(5 Suppl):309-13. doi: 10.3171/ped.2006.104.5.309. PMID: 16848087

Prognosis

Spinal cord lipoma without dysraphism in the infancy that extends intracranially. Case report and review of the literature.
Vila Mengual M, Miranda Lloret P, López González A, Simal JA, Alvarez Garijo JA
Surg Neurol 2009 May;71(5):613-5. Epub 2008 Mar 4 doi: 10.1016/j.surneu.2007.10.036. PMID: 18291460
Long-term urologic outcome in patients with caudal regression syndrome, compared with meningomyelocele and spinal cord lipoma.
Torre M, Buffa P, Jasonni V, Cama A
J Pediatr Surg 2008 Mar;43(3):530-3. doi: 10.1016/j.jpedsurg.2007.10.036. PMID: 18358295
Occult tethered cord syndrome: a survey of practice patterns.
Steinbok P, Garton HJ, Gupta N
J Neurosurg 2006 May;104(5 Suppl):309-13. doi: 10.3171/ped.2006.104.5.309. PMID: 16848087
Use of the prone position in the MRI evaluation of spinal cord retethering.
Vernet O, O'Gorman AM, Farmer JP, McPhillips M, Montes JL
Pediatr Neurosurg 1996 Dec;25(6):286-94. doi: 10.1159/000121142. PMID: 9348148
Intramedullary spinal cord lipomas.
Lee M, Rezai AR, Abbott R, Coelho DH, Epstein FJ
J Neurosurg 1995 Mar;82(3):394-400. doi: 10.3171/jns.1995.82.3.0394. PMID: 7861216

Clinical prediction guides

Spinal cord lipomas: lessons learned in the era of total resection.
Casado-Ruiz J, Ros B, Iglesias S, Ros A, Arráez MA
Childs Nerv Syst 2024 Apr;40(4):1121-1128. Epub 2023 Dec 16 doi: 10.1007/s00381-023-06251-1. PMID: 38103091
Non-dysraphic intramedullary spinal cord lipoma of the child: Report of 3 cases.
Sagenly M, Karnoub MA, Vinchon M
Neurochirurgie 2023 Sep;69(5):101473. Epub 2023 Jul 22 doi: 10.1016/j.neuchi.2023.101473. PMID: 37482183
Use of the prone position in the MRI evaluation of spinal cord retethering.
Vernet O, O'Gorman AM, Farmer JP, McPhillips M, Montes JL
Pediatr Neurosurg 1996 Dec;25(6):286-94. doi: 10.1159/000121142. PMID: 9348148
Symptomatic Chiari malformations. An analysis of presentation, management, and long-term outcome.
Dyste GN, Menezes AH, VanGilder JC
J Neurosurg 1989 Aug;71(2):159-68. doi: 10.3171/jns.1989.71.2.0159. PMID: 2746341

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