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Cerebellar pilocytic astrocytoma

MedGen UID:
91158
Concept ID:
C0349620
Neoplastic Process
Synonyms: Cerebellar Pilocytic Astrocytoma; cerebellar pilocytic astrocytoma; cerebellum pilocytic astrocytoma; Pilocytic astrocytoma of cerebellum; Pilocytic Astrocytoma of Cerebellum; pilocytic astrocytoma of cerebellum; Pilocytic Astrocytoma of the Cerebellum; pilocytic astrocytoma of the cerebellum
SNOMED CT: Pilocytic astrocytoma of cerebellum (277507004)
 
Monarch Initiative: MONDO:0003168

Definition

A WHO Grade 1 astrocytoma which arises in the cerebellum. The tumor is composed of spindle shaped cells with numerous collections of reddish astrocytic fibers called Rosenthal fibers. Over 80% or the cerebellar astrocytomas of childhood are pilocytic. Pilocytic astrocytomas may rarely occur in adults. They are usually treated by surgical resection and in most cases have a favorable prognosis. [from NCI]

Professional guidelines

PubMed

Dirven CM, Mooij JJ, Molenaar WM
Childs Nerv Syst 1997 Jan;13(1):17-23. doi: 10.1007/s003810050033. PMID: 9083697

Recent clinical studies

Etiology

Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Towner JE, Azriel A, Rogers T, Box G, Adamides AA, Drummond K
J Clin Neurosci 2019 Feb;60:155-157. Epub 2018 Oct 23 doi: 10.1016/j.jocn.2018.10.062. PMID: 30366781
Pletschko T, Felnhofer A, Lamplmair D, Dorfer C, Czech T, Chocholous M, Slavc I, Leiss U
Dev Neurorehabil 2018 Aug;21(6):415-422. Epub 2017 Oct 2 doi: 10.1080/17518423.2017.1370502. PMID: 28968151Free PMC Article
Alford R, Gargan L, Bowers DC, Klesse LJ, Weprin B, Koral K
J Neurooncol 2016 Oct;130(1):149-154. Epub 2016 Aug 9 doi: 10.1007/s11060-016-2222-x. PMID: 27502785
Dirven CM, Mooij JJ, Molenaar WM
Childs Nerv Syst 1997 Jan;13(1):17-23. doi: 10.1007/s003810050033. PMID: 9083697

Diagnosis

Donofrio CA, Gagliardi F, Callea M, da Passano CF, Terreni MR, Cavalli A, Spina A, Acerno S, Bailo M, Elbabaa SK, Mortini P
Neurosurg Rev 2020 Feb;43(1):9-16. Epub 2018 Mar 22 doi: 10.1007/s10143-018-0969-6. PMID: 29569086
Towner JE, Azriel A, Rogers T, Box G, Adamides AA, Drummond K
J Clin Neurosci 2019 Feb;60:155-157. Epub 2018 Oct 23 doi: 10.1016/j.jocn.2018.10.062. PMID: 30366781
Pletschko T, Felnhofer A, Lamplmair D, Dorfer C, Czech T, Chocholous M, Slavc I, Leiss U
Dev Neurorehabil 2018 Aug;21(6):415-422. Epub 2017 Oct 2 doi: 10.1080/17518423.2017.1370502. PMID: 28968151Free PMC Article
Brandão LA, Young Poussaint T
Neuroimaging Clin N Am 2017 Feb;27(1):1-37. doi: 10.1016/j.nic.2016.08.001. PMID: 27889018
Dirven CM, Mooij JJ, Molenaar WM
Childs Nerv Syst 1997 Jan;13(1):17-23. doi: 10.1007/s003810050033. PMID: 9083697

Therapy

Bonomo G, Rubiu E, Iess G, Bonomo R, Amato A, Restelli F, Falco J, Mazzapicchi E, Locatelli M, Rampini P, Carrabba GG
Pediatr Neurosurg 2022;57(5):358-364. Epub 2022 Aug 19 doi: 10.1159/000526645. PMID: 35988537
Panagopoulos D, Antoniades E, Karydakis P, Giakoumettis D, Themistocleous M
Am J Case Rep 2020 Mar 12;21:e920213. doi: 10.12659/AJCR.920213. PMID: 32161253Free PMC Article
Udayakumaran S, Ben Sira L, Constantini S
Childs Nerv Syst 2010 Feb;26(2):267-71. Epub 2009 Nov 14 doi: 10.1007/s00381-009-1027-z. PMID: 19915852
Strazzer S, Zucca C, Fiocchi I, Genitori L, Castelli E
J Child Neurol 2006 Sep;21(9):817-20. doi: 10.1177/08830738060210091701. PMID: 16970895
Aarsen FK, Van Dongen HR, Paquier PF, Van Mourik M, Catsman-Berrevoets CE
Neurology 2004 Apr 27;62(8):1311-6. doi: 10.1212/01.wnl.0000120549.77188.36. PMID: 15111667

Prognosis

Donofrio CA, Gagliardi F, Callea M, da Passano CF, Terreni MR, Cavalli A, Spina A, Acerno S, Bailo M, Elbabaa SK, Mortini P
Neurosurg Rev 2020 Feb;43(1):9-16. Epub 2018 Mar 22 doi: 10.1007/s10143-018-0969-6. PMID: 29569086
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Tateishi K, Nakamura T, Yamamoto T
Brain Tumor Pathol 2019 Apr;36(2):74-83. Epub 2019 Mar 30 doi: 10.1007/s10014-019-00340-3. PMID: 30929113
Alford R, Gargan L, Bowers DC, Klesse LJ, Weprin B, Koral K
J Neurooncol 2016 Oct;130(1):149-154. Epub 2016 Aug 9 doi: 10.1007/s11060-016-2222-x. PMID: 27502785
Dirven CM, Mooij JJ, Molenaar WM
Childs Nerv Syst 1997 Jan;13(1):17-23. doi: 10.1007/s003810050033. PMID: 9083697

Clinical prediction guides

Tanaka T, Teshigawara A, Takei J, Tochigi S, Hasegawa Y, Murayama Y, Yokoo H
World Neurosurg 2020 Oct;142:441-449. Epub 2020 Jul 4 doi: 10.1016/j.wneu.2020.06.173. PMID: 32634636
Panagopoulos D, Antoniades E, Karydakis P, Giakoumettis D, Themistocleous M
Am J Case Rep 2020 Mar 12;21:e920213. doi: 10.12659/AJCR.920213. PMID: 32161253Free PMC Article
Ait Khelifa-Gallois N, Laroussinie F, Puget S, Sainte-Rose C, Dellatolas G
Brain Inj 2015;29(3):366-73. Epub 2014 Nov 10 doi: 10.3109/02699052.2014.975281. PMID: 25383654
Shibao S, Kimura T, Sasaki H, Fujiwara H, Akiyama T, Ueno M, Shidoh S, Yoshida K
Brain Tumor Pathol 2012 Apr;29(2):96-102. Epub 2011 Oct 19 doi: 10.1007/s10014-011-0068-7. PMID: 22009025
O'Dorisio MS, Khanna G, Bushnell D
Cancer Metastasis Rev 2008 Dec;27(4):665-77. doi: 10.1007/s10555-008-9153-8. PMID: 18581060

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