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Bile duct adenoma

MedGen UID:: 918
•Concept ID:: C0008309
•: Neoplastic Process

Synonyms:	Adenoma, Bile Duct; Adenomas, Bile Duct; Bile Duct Adenoma; Bile Duct Adenomas; Cholangioma; Cholangiomas
SNOMED CT:	Cholangioadenoma (424091006); Bile duct adenoma (39471001); Cholangioma (39471001)

Monarch Initiative:	MONDO:0006108

Definition

A benign, well-demarcated polypoid neoplasm arising from the bile duct epithelium. According to the growth pattern, it is classified as tubular, papillary, or tubulopapillary. Adenomas arising from the extrahepatic bile ducts usually produce symptoms related to biliary obstruction. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBile duct adenoma

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Epithelial neoplasm
        Adenoma
        Bile duct adenoma
        Extrahepatic bile duct adenoma
        Extrahepatic bile duct papillary adenoma
        Extrahepatic Bile Duct Tubular Adenoma
        Extrahepatic Bile Duct Tubulopapillary Adenoma
        Intrahepatic bile duct adenoma
        Intrahepatic Bile Duct Microcystic Adenoma

Professional guidelines

PubMed

Cholangiocarcinoma: A position paper by the Italian Society of Gastroenterology (SIGE), the Italian Association of Hospital Gastroenterology (AIGO), the Italian Association of Medical Oncology (AIOM) and the Italian Association of Oncological Radiotherapy (AIRO).

Alvaro D, Cannizzaro R, Labianca R, Valvo F, Farinati F; Italian Society of Gastroenterology (SIGE); Italian Association of Hospital Gastroenterology (AIGO); Italian Association of Medical Oncology (AIOM); Italian Association of Oncological Radiotherapy (AIRO)
Dig Liver Dis 2010 Dec;42(12):831-8. Epub 2010 Aug 11 doi: 10.1016/j.dld.2010.06.005. PMID: 20702152

See all (1)

Recent clinical studies

Etiology

Bile duct adenoma: imaging features and radiologic-pathologic correlation.

Tatsumi R, Ichihara S, Suii H, Yamaguchi M, Arakawa T, Nakajima T, Kuwata Y, Ozeki I, Hige S, Toyota J, Karino Y
Jpn J Radiol 2020 Jun;38(6):561-571. Epub 2020 Mar 3 doi: 10.1007/s11604-020-00938-0. PMID: 32128668

Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis.

Lendvai G, Szekerczés T, Illyés I, Dóra R, Kontsek E, Gógl A, Kiss A, Werling K, Kovalszky I, Schaff Z, Borka K
Pathol Oncol Res 2020 Jan;26(1):3-15. Epub 2018 Nov 17 doi: 10.1007/s12253-018-0491-8. PMID: 30448973

Imaging features of bile duct adenoma: case series and review of literature.

Chuy JA, Garg I, Graham RP, VanBuren WM, Venkatesh SK
Diagn Interv Radiol 2018 Sep;24(5):249-254. doi: 10.5152/dir.2018.18036. PMID: 30211677 Free PMC Article

Benign hepatic tumours.

Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132

Benign tumors and pseudotumors of the liver.

Ishak KG
Appl Pathol 1988;6(2):82-104. PMID: 3291906

See all (248)

Diagnosis

Bile duct adenoma and small-sized small duct type intrahepatic cholangiocarcinoma show distinct differences in genetic alterations, expression of IMP3 and EZH2 and stromal and inflammatory components.

Sasaki M, Sato Y, Nakanuma Y
Histopathology 2023 Aug;83(2):298-309. Epub 2023 May 4 doi: 10.1111/his.14932. PMID: 37140546

Bile duct adenoma may be a precursor lesion of small duct type intrahepatic cholangiocarcinoma.

Sasaki M, Sato Y, Nakanuma Y
Histopathology 2021 Jan;78(2):310-320. Epub 2020 Sep 15 doi: 10.1111/his.14222. PMID: 33405289

Bile duct adenoma: imaging features and radiologic-pathologic correlation.

Benign hepatic tumours.

Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132

Cholangiocarcinoma.

Yeo CJ, Pitt HA, Cameron JL
Surg Clin North Am 1990 Dec;70(6):1429-47. doi: 10.1016/s0039-6109(16)45293-x. PMID: 2174191

See all (469)

Therapy

Endogenously formed N-nitroso compounds and nitrosating agents in human cancer etiology.

Bartsch H, Ohshima H, Pignatelli B, Calmels S
Pharmacogenetics 1992 Dec;2(6):272-7. doi: 10.1097/00008571-199212000-00005. PMID: 1339085

Cholangiocarcinoma.

Yeo CJ, Pitt HA, Cameron JL
Surg Clin North Am 1990 Dec;70(6):1429-47. doi: 10.1016/s0039-6109(16)45293-x. PMID: 2174191

Pathomorphologic characteristics of 102 cases of thorotrast-related hepatocellular carcinoma, cholangiocarcinoma, and hepatic angiosarcoma.

Ito Y, Kojiro M, Nakashima T, Mori T
Cancer 1988 Sep 15;62(6):1153-62. doi: 10.1002/1097-0142(19880915)62:6<1153::aid-cncr2820620619>3.0.co;2-i. PMID: 2457426

Chemotherapy and radiotherapy of malignant hepatic tumours.

Forbes A, Williams R
Baillieres Clin Gastroenterol 1987 Jan;1(1):151-69. doi: 10.1016/0950-3528(87)90038-8. PMID: 3034357

Benign hepatocellular tumors.

Guzman IJ, Gold JH, Rosai J, Schneider PD, Varco RL, Buchwald H
Surgery 1977 Oct;82(4):495-503. PMID: 197654

See all (162)

Prognosis

Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis.

Bile duct adenoma: a case report and literature review.

Chen L, Xu MY, Chen F
World J Surg Oncol 2014 Apr 26;12:125. doi: 10.1186/1477-7819-12-125. PMID: 24767257 Free PMC Article

Cholangiocarcinoma complicating primary sclerosing cholangitis.

Rosen CB, Nagorney DM
Semin Liver Dis 1991 Feb;11(1):26-30. doi: 10.1055/s-2008-1040419. PMID: 1646485

Is liver transplantation justified for the treatment of hepatic malignancies?

Olthoff KM, Millis JM, Rosove MH, Goldstein LI, Ramming KP, Busuttil RW
Arch Surg 1990 Oct;125(10):1261-6; discussion 1266-8. doi: 10.1001/archsurg.1990.01410220045007. PMID: 2171452

Chemotherapy and radiotherapy of malignant hepatic tumours.

Forbes A, Williams R
Baillieres Clin Gastroenterol 1987 Jan;1(1):151-69. doi: 10.1016/0950-3528(87)90038-8. PMID: 3034357

See all (192)