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Omsk hemorrhagic fever

MedGen UID:
9212
•Concept ID:
C0019103
•
Disease or Syndrome
Synonyms: Fever, Omsk Hemorrhagic; Hemorrhagic Fever, Omsk; Omsk Hemorrhagic Fever
SNOMED CT: OHF - Omsk hemorrhagic fever (48113006); Omsk hemorrhagic fever (48113006)
 
Monarch Initiative: MONDO:0017882
Orphanet: ORPHA319266

Definition

Omsk hemorrhagic fever (OHF), caused by Omsk hemorrhagic fever virus (OHFV), is a zoonotic disease characterized by fever, nausea, myalgia and moderately severe hemorrhagic manifestations as well as in some cases meningitis, pneumonia and nephrosis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOmsk hemorrhagic fever
Follow this link to review classifications for Omsk hemorrhagic fever in Orphanet.

Professional guidelines

PubMed

Molecular approaches for the treatment of hemorrhagic fever virus infections.
Andrei G, De Clercq E
Antiviral Res 1993 Sep;22(1):45-75. doi: 10.1016/0166-3542(93)90085-w. PMID: 8250543

Recent clinical studies

Etiology

Omsk hemorrhagic fever virus is a tick-borne encephalitis virus adapted to muskrat through host-jumping.
Kovalev SY, Mazurina EA
J Med Virol 2022 Jun;94(6):2510-2518. Epub 2022 Jan 23 doi: 10.1002/jmv.27581. PMID: 35001393
Tick-borne viruses: a review from the perspective of therapeutic approaches.
Lani R, Moghaddam E, Haghani A, Chang LY, AbuBakar S, Zandi K
Ticks Tick Borne Dis 2014 Sep;5(5):457-65. Epub 2014 May 21 doi: 10.1016/j.ttbdis.2014.04.001. PMID: 24907187
The deduced evolution history of Omsk hemorrhagic fever virus.
Karan LS, Ciccozzi M, Yakimenko VV, Lo Presti A, Cella E, Zehender G, Rezza G, Platonov AE
J Med Virol 2014 Jul;86(7):1181-7. Epub 2013 Nov 20 doi: 10.1002/jmv.23856. PMID: 24259273
Tick-borne flaviviruses.
Gritsun TS, Nuttall PA, Gould EA
Adv Virus Res 2003;61:317-71. doi: 10.1016/s0065-3527(03)61008-0. PMID: 14714436
Tick-borne encephalitis.
Gritsun TS, Lashkevich VA, Gould EA
Antiviral Res 2003 Jan;57(1-2):129-46. doi: 10.1016/s0166-3542(02)00206-1. PMID: 12615309

Diagnosis

Application of multiplex realtime PCR detection for hemorrhagic fever syndrome viruses.
Choi Y, Kim Y
J Infect Public Health 2023 Dec;16(12):1933-1941. Epub 2023 Oct 6 doi: 10.1016/j.jiph.2023.10.012. PMID: 37866271
Omsk haemorrhagic fever.
Růžek D, Yakimenko VV, Karan LS, Tkachev SE
Lancet 2010 Dec 18;376(9758):2104-13. Epub 2010 Sep 16 doi: 10.1016/S0140-6736(10)61120-8. PMID: 20850178
Tick-borne flaviviruses.
Lasala PR, Holbrook M
Clin Lab Med 2010 Mar;30(1):221-35. doi: 10.1016/j.cll.2010.01.002. PMID: 20513549
Zoonotic tick-borne flaviviruses.
Dobler G
Vet Microbiol 2010 Jan 27;140(3-4):221-8. Epub 2009 Aug 26 doi: 10.1016/j.vetmic.2009.08.024. PMID: 19765917
Tick-borne virus diseases of human interest in Europe.
Charrel RN, Attoui H, Butenko AM, Clegg JC, Deubel V, Frolova TV, Gould EA, Gritsun TS, Heinz FX, Labuda M, Lashkevich VA, Loktev V, Lundkvist A, Lvov DV, Mandl CW, Niedrig M, Papa A, Petrov VS, Plyusnin A, Randolph S, Süss J, Zlobin VI, de Lamballerie X
Clin Microbiol Infect 2004 Dec;10(12):1040-55. doi: 10.1111/j.1469-0691.2004.01022.x. PMID: 15606630

Therapy

Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease.
Agudelo M, Palus M, Keeffe JR, Bianchini F, Svoboda P, Salát J, Peace A, Gazumyan A, Cipolla M, Kapoor T, Guidetti F, Yao KH, Elsterová J, Teislerová D, Chrdle A, Hönig V, Oliveira T, West AP, Lee YE, Rice CM, MacDonald MR, Bjorkman PJ, Růžek D, Robbiani DF, Nussenzweig MC
J Exp Med 2021 May 3;218(5) doi: 10.1084/jem.20210236. PMID: 33831141Free PMC Article
Evaluation of the European tick-borne encephalitis vaccine against Omsk hemorrhagic fever virus.
Chidumayo NN, Yoshii K, Kariwa H
Microbiol Immunol 2014 Feb;58(2):112-8. doi: 10.1111/1348-0421.12122. PMID: 24329534
Omsk haemorrhagic fever.
Růžek D, Yakimenko VV, Karan LS, Tkachev SE
Lancet 2010 Dec 18;376(9758):2104-13. Epub 2010 Sep 16 doi: 10.1016/S0140-6736(10)61120-8. PMID: 20850178
Tick-borne encephalitis.
Gritsun TS, Lashkevich VA, Gould EA
Antiviral Res 2003 Jan;57(1-2):129-46. doi: 10.1016/s0166-3542(02)00206-1. PMID: 12615309
Molecular approaches for the treatment of hemorrhagic fever virus infections.
Andrei G, De Clercq E
Antiviral Res 1993 Sep;22(1):45-75. doi: 10.1016/0166-3542(93)90085-w. PMID: 8250543

Prognosis

Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.
Flint M, McMullan LK, Dodd KA, Bird BH, Khristova ML, Nichol ST, Spiropoulou CF
Antimicrob Agents Chemother 2014 Jun;58(6):3206-16. Epub 2014 Mar 24 doi: 10.1128/AAC.02393-14. PMID: 24663025Free PMC Article

Clinical prediction guides

Application of multiplex realtime PCR detection for hemorrhagic fever syndrome viruses.
Choi Y, Kim Y
J Infect Public Health 2023 Dec;16(12):1933-1941. Epub 2023 Oct 6 doi: 10.1016/j.jiph.2023.10.012. PMID: 37866271
Dermacentor reticulatus: a vector on the rise.
Földvári G, Široký P, Szekeres S, Majoros G, Sprong H
Parasit Vectors 2016 Jun 1;9(1):314. doi: 10.1186/s13071-016-1599-x. PMID: 27251148Free PMC Article
Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.
Flint M, McMullan LK, Dodd KA, Bird BH, Khristova ML, Nichol ST, Spiropoulou CF
Antimicrob Agents Chemother 2014 Jun;58(6):3206-16. Epub 2014 Mar 24 doi: 10.1128/AAC.02393-14. PMID: 24663025Free PMC Article
Tick-borne flaviviruses.
Lasala PR, Holbrook M
Clin Lab Med 2010 Mar;30(1):221-35. doi: 10.1016/j.cll.2010.01.002. PMID: 20513549
Tick-borne flaviviruses.
Gritsun TS, Nuttall PA, Gould EA
Adv Virus Res 2003;61:317-71. doi: 10.1016/s0065-3527(03)61008-0. PMID: 14714436

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