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Infiltrating duct carcinoma of breast

MedGen UID:
922812
•Concept ID:
CN253814
•
Disease or Syndrome
Synonyms: Invasive ductal breast carcinoma; Invasive Ductal Carcinoma, Not Otherwise Specified
 
Monarch Initiative: MONDO:0004953

Definition

The most common type of invasive breast carcinoma, accounting for approximately 70% of breast carcinomas. The gross appearance is usually typical with an irregular stellate outline. Microscopically, randomly arranged epithelial elements are seen. When large sheets of malignant cells are present, necrosis may be seen. With adequate tissue sampling, in situ carcinoma can be demonstrated in association with the infiltrating carcinoma. The in situ component is nearly always ductal but occasionally may be lobular or both. [from MONDO]

Professional guidelines

PubMed

Current and future diagnostic and treatment strategies for patients with invasive lobular breast cancer.
Van Baelen K, Geukens T, Maetens M, Tjan-Heijnen V, Lord CJ, Linn S, Bidard FC, Richard F, Yang WW, Steele RE, Pettitt SJ, Van Ongeval C, De Schepper M, Isnaldi E, Nevelsteen I, Smeets A, Punie K, Voorwerk L, Wildiers H, Floris G, Vincent-Salomon A, Derksen PWB, Neven P, Senkus E, Sawyer E, Kok M, Desmedt C
Ann Oncol 2022 Aug;33(8):769-785. Epub 2022 May 21 doi: 10.1016/j.annonc.2022.05.006. PMID: 35605746
Advances and controversies in management of breast ductal carcinoma in situ (DCIS).
Farante G, Toesca A, Magnoni F, Lissidini G, Vila J, Mastropasqua M, Viale G, Penco S, Cassano E, Lazzeroni M, Bonanni B, Leonardi MC, Ripoll-Orts F, Curigliano G, Orecchia R, Galimberti V, Veronesi P
Eur J Surg Oncol 2022 Apr;48(4):736-741. Epub 2021 Nov 9 doi: 10.1016/j.ejso.2021.10.030. PMID: 34772587
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487

Recent clinical studies

Etiology

Cytological grading, apoptosis, and Bcl-2 protein expression in breast cancer.
Hemachandran M, Nijhawan R, Joshi K
Diagn Cytopathol 2002 Jun;26(6):356-9. doi: 10.1002/dc.10105. PMID: 12112824
Concurrent angiomyolipomas and renal cell carcinoma harboring metastatic foci of mammary carcinoma in the same kidney: an incidental autopsy finding in a patient with a follow-up of thirty years.
Val-Bernal JF, Villoria F, Pérez-Expósito MA
Ann Diagn Pathol 2001 Oct;5(5):293-9. doi: 10.1053/adpa.2001.27920. PMID: 11598857
Cell mediated immune status in malignancy--pretherapy and post-therapy assessment.
Sinha SK, Basu N, Basu K, Sanyal S, Sur PK, Bhattacharyya KK
J Indian Med Assoc 1997 Jun;95(6):181-2, 188. PMID: 9420397
Reduced thoracic vertebrae metastases following post mastectomy parasternal irradiation.
Hercbergs A, Werner A, Brenner HJ
Int J Radiat Oncol Biol Phys 1985 Apr;11(4):773-6. doi: 10.1016/0360-3016(85)90310-4. PMID: 3980273

Diagnosis

Carcinoma en cuirasse : a rare presentation of breast cancer.
Mahore SD, Bothale KA, Patrikar AD, Joshi AM
Indian J Pathol Microbiol 2010 Apr-Jun;53(2):351-8. doi: 10.4103/0377-4929.64346. PMID: 20551556
Cytological grading, apoptosis, and Bcl-2 protein expression in breast cancer.
Hemachandran M, Nijhawan R, Joshi K
Diagn Cytopathol 2002 Jun;26(6):356-9. doi: 10.1002/dc.10105. PMID: 12112824
Cell mediated immune status in malignancy--pretherapy and post-therapy assessment.
Sinha SK, Basu N, Basu K, Sanyal S, Sur PK, Bhattacharyya KK
J Indian Med Assoc 1997 Jun;95(6):181-2, 188. PMID: 9420397
Reduced thoracic vertebrae metastases following post mastectomy parasternal irradiation.
Hercbergs A, Werner A, Brenner HJ
Int J Radiat Oncol Biol Phys 1985 Apr;11(4):773-6. doi: 10.1016/0360-3016(85)90310-4. PMID: 3980273

Therapy

Cell mediated immune status in malignancy--pretherapy and post-therapy assessment.
Sinha SK, Basu N, Basu K, Sanyal S, Sur PK, Bhattacharyya KK
J Indian Med Assoc 1997 Jun;95(6):181-2, 188. PMID: 9420397

Prognosis

Sodium iodide symporter, estrogen receptor, and progesterone receptor expression in carcinoma breast--an immunohistochemical analysis.
Tandon A, Shrivastava A, Kumar A, Prayaga AK, Sundaram C, Godbole MM
Indian J Pathol Microbiol 2011 Oct-Dec;54(4):745-51. doi: 10.4103/0377-4929.91514. PMID: 22234102
Concurrent angiomyolipomas and renal cell carcinoma harboring metastatic foci of mammary carcinoma in the same kidney: an incidental autopsy finding in a patient with a follow-up of thirty years.
Val-Bernal JF, Villoria F, Pérez-Expósito MA
Ann Diagn Pathol 2001 Oct;5(5):293-9. doi: 10.1053/adpa.2001.27920. PMID: 11598857
Cell mediated immune status in malignancy--pretherapy and post-therapy assessment.
Sinha SK, Basu N, Basu K, Sanyal S, Sur PK, Bhattacharyya KK
J Indian Med Assoc 1997 Jun;95(6):181-2, 188. PMID: 9420397
The relationship of nuclear staining density and mode of stromal invasion with axillary metastases and hormone receptor status in human breast cancer.
Bell CD, Shokry PE, Stadler J
Am J Clin Pathol 1989 Apr;91(4):377-85. doi: 10.1093/ajcp/91.4.377. PMID: 2467548
Medullary carcinoma of breast: an immunohistochemical study of its lymphoid stroma.
Hsu SM, Raine L, Nayak RN
Cancer 1981 Sep 15;48(6):1368-76. doi: 10.1002/1097-0142(19810915)48:6<1368::aid-cncr2820480619>3.0.co;2-1. PMID: 6268284

Clinical prediction guides

A new Ki-67 / E-cadherin cocktail reduces inter-observer variation of the calculated proliferative index.
Bubis G, Hilly O, Bubis R, Halpern M, Schwartz A, Koren R, Rath-Wolfson L
Pathol Oncol Res 2013 Oct;19(4):875-9. Epub 2013 Jul 7 doi: 10.1007/s12253-013-9655-8. PMID: 23832820
Cytological grading, apoptosis, and Bcl-2 protein expression in breast cancer.
Hemachandran M, Nijhawan R, Joshi K
Diagn Cytopathol 2002 Jun;26(6):356-9. doi: 10.1002/dc.10105. PMID: 12112824
Cell mediated immune status in malignancy--pretherapy and post-therapy assessment.
Sinha SK, Basu N, Basu K, Sanyal S, Sur PK, Bhattacharyya KK
J Indian Med Assoc 1997 Jun;95(6):181-2, 188. PMID: 9420397
Reduced thoracic vertebrae metastases following post mastectomy parasternal irradiation.
Hercbergs A, Werner A, Brenner HJ
Int J Radiat Oncol Biol Phys 1985 Apr;11(4):773-6. doi: 10.1016/0360-3016(85)90310-4. PMID: 3980273

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