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JC Virus Infection

MedGen UID:
923064
•Concept ID:
C0857836
•
Disease or Syndrome
Synonyms: JC Polyomavirus Infection; JCV Infection; John Cunningham Virus Infection; Polyomavirus JC Infection

Definition

An infection that is caused by JC virus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJC Virus Infection

Professional guidelines

PubMed

The risk of progressive multifocal leukoencephalopathy under biological agents used in the treatment of chronic inflammatory diseases.
Toussirot É, Bereau M
Inflamm Allergy Drug Targets 2014;13(2):121-7. doi: 10.2174/1871528113666140224103712. PMID: 24559124
The London position statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organisation: safety.
Van Assche G, Lewis JD, Lichtenstein GR, Loftus EV, Ouyang Q, Panes J, Siegel CA, Sandborn WJ, Travis SP, Colombel JF
Am J Gastroenterol 2011 Sep;106(9):1594-602; quiz 1593, 1603. Epub 2011 Aug 16 doi: 10.1038/ajg.2011.211. PMID: 21844919
Management of infections by the human polyomavirus JC: past, present and future.
Hou J, Major E
Expert Rev Anti Infect Ther 2005 Aug;3(4):629-40. doi: 10.1586/14787210.3.4.629. PMID: 16107201

Recent clinical studies

Etiology

JC Virus and Lung Adenocarcinoma: Fact or Myth?
Sinagra E, Raimondo D, Gallo E, Stella M, Cottone M, Rossi F, Messina M, Spada M, Tomasello G, Ferrara G, Rizzo AG
Anticancer Res 2017 Jun;37(6):3311-3314. doi: 10.21873/anticanres.11699. PMID: 28551683
Update on disease-modifying therapies for multiple sclerosis.
Vargas DL, Tyor WR
J Investig Med 2017 Jun;65(5):883-891. Epub 2017 Jan 27 doi: 10.1136/jim-2016-000339. PMID: 28130412
JC virus infection is acquired very early in life: evidence from a longitudinal serological study.
Elia F, Villani S, Ambrogi F, Signorini L, Dallari S, Binda S, Primache V, Pellegrinelli L, Ferrante P, Delbue S
J Neurovirol 2017 Feb;23(1):99-105. Epub 2016 Aug 18 doi: 10.1007/s13365-016-0477-9. PMID: 27538993
The risk of progressive multifocal leukoencephalopathy under biological agents used in the treatment of chronic inflammatory diseases.
Toussirot É, Bereau M
Inflamm Allergy Drug Targets 2014;13(2):121-7. doi: 10.2174/1871528113666140224103712. PMID: 24559124
Immune reconstitution inflammatory syndrome and the central nervous system.
Johnson T, Nath A
Curr Opin Neurol 2011 Jun;24(3):284-90. doi: 10.1097/WCO.0b013e328346be57. PMID: 21499099

Diagnosis

Atypical presentations and course of JC virus infection.
Chatterton S, Dwyer L, Thomson C, Plit M, Longmuir H, Chaganti J, Barnett Y, Brew B
J Neurovirol 2022 Feb;28(1):183-186. Epub 2022 Jan 9 doi: 10.1007/s13365-021-01031-6. PMID: 35001250
JC Virus and Lung Adenocarcinoma: Fact or Myth?
Sinagra E, Raimondo D, Gallo E, Stella M, Cottone M, Rossi F, Messina M, Spada M, Tomasello G, Ferrara G, Rizzo AG
Anticancer Res 2017 Jun;37(6):3311-3314. doi: 10.21873/anticanres.11699. PMID: 28551683
Update on disease-modifying therapies for multiple sclerosis.
Vargas DL, Tyor WR
J Investig Med 2017 Jun;65(5):883-891. Epub 2017 Jan 27 doi: 10.1136/jim-2016-000339. PMID: 28130412
Progressive multifocal leukoencephalopathy: Dot-shaped inclusions and virus-host interactions.
Shishido-Hara Y
Neuropathology 2015 Oct;35(5):487-96. Epub 2015 May 6 doi: 10.1111/neup.12203. PMID: 25946231
Novel syndromes associated with JC virus infection of neurons and meningeal cells: no longer a gray area.
Miskin DP, Koralnik IJ
Curr Opin Neurol 2015 Jun;28(3):288-94. doi: 10.1097/WCO.0000000000000201. PMID: 25887767Free PMC Article

Therapy

Update on disease-modifying therapies for multiple sclerosis.
Vargas DL, Tyor WR
J Investig Med 2017 Jun;65(5):883-891. Epub 2017 Jan 27 doi: 10.1136/jim-2016-000339. PMID: 28130412
The risk of progressive multifocal leukoencephalopathy under biological agents used in the treatment of chronic inflammatory diseases.
Toussirot É, Bereau M
Inflamm Allergy Drug Targets 2014;13(2):121-7. doi: 10.2174/1871528113666140224103712. PMID: 24559124
Immune reconstitution inflammatory syndrome and the central nervous system.
Johnson T, Nath A
Curr Opin Neurol 2011 Jun;24(3):284-90. doi: 10.1097/WCO.0b013e328346be57. PMID: 21499099
Progressive multifocal leukoencephalopathy.
Weissert R
J Neuroimmunol 2011 Feb;231(1-2):73-7. doi: 10.1016/j.jneuroim.2010.09.021. PMID: 20937530
Novel treatment options for inflammatory bowel disease: targeting alpha 4 integrin.
Lanzarotto F, Carpani M, Chaudhary R, Ghosh S
Drugs 2006;66(9):1179-89. doi: 10.2165/00003495-200666090-00002. PMID: 16827596

Prognosis

Atypical presentations and course of JC virus infection.
Chatterton S, Dwyer L, Thomson C, Plit M, Longmuir H, Chaganti J, Barnett Y, Brew B
J Neurovirol 2022 Feb;28(1):183-186. Epub 2022 Jan 9 doi: 10.1007/s13365-021-01031-6. PMID: 35001250
JC Virus Infection: A Clinical Conundrum.
Farooq H, Niazi SK, Noor M, Ghani E
J Coll Physicians Surg Pak 2019 Jun;29(6):S18-S19. doi: 10.29271/jcpsp.2019.06.S18. PMID: 31142409
Progressive multifocal leukoencephalopathy: Dot-shaped inclusions and virus-host interactions.
Shishido-Hara Y
Neuropathology 2015 Oct;35(5):487-96. Epub 2015 May 6 doi: 10.1111/neup.12203. PMID: 25946231
Immune reconstitution inflammatory syndrome and the central nervous system.
Johnson T, Nath A
Curr Opin Neurol 2011 Jun;24(3):284-90. doi: 10.1097/WCO.0b013e328346be57. PMID: 21499099
Progressive multifocal leukoencephalopathy.
Weissert R
J Neuroimmunol 2011 Feb;231(1-2):73-7. doi: 10.1016/j.jneuroim.2010.09.021. PMID: 20937530

Clinical prediction guides

Central nervous system disease with JC virus infection in adults with congenital HIV.
McEntire CRS, Fong KT, Jia DT, Cooper ER, Cervantes-Arslanian AM, Mateen FJ, Anand P, Thakur KT
AIDS 2021 Feb 2;35(2):235-244. doi: 10.1097/QAD.0000000000002734. PMID: 33394671Free PMC Article
Incidence, risk factors and the effect of polyomavirus infection in hematopoietic stem cell transplant recipients.
Hu J, Li S, Yang M, Xu L, Zhang X, Zhao H, Dong H, Huang Y, Fan J, Li L
J Int Med Res 2017 Apr;45(2):762-770. Epub 2017 Mar 7 doi: 10.1177/0300060517691795. PMID: 28415933Free PMC Article
Progressive multifocal leukoencephalopathy.
Weissert R
J Neuroimmunol 2011 Feb;231(1-2):73-7. doi: 10.1016/j.jneuroim.2010.09.021. PMID: 20937530
hMLH1 promoter methylation and JC virus T antigen presence in the tumor tissue of colorectal cancer Israeli patients of different ethnic groups.
Niv Y, Vilkin A, Brenner B, Kendel Y, Morgenstern S, Levi Z
Eur J Gastroenterol Hepatol 2010 Aug;22(8):938-41. doi: 10.1097/MEG.0b013e32832e9d2c. PMID: 20531010
JC virus infection of the brain.
Bag AK, Curé JK, Chapman PR, Roberson GH, Shah R
AJNR Am J Neuroradiol 2010 Oct;31(9):1564-76. Epub 2010 Mar 18 doi: 10.3174/ajnr.A2035. PMID: 20299430Free PMC Article

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