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Rhinosinusitis

MedGen UID:
923118
•Concept ID:
C0948780
•
Disease or Syndrome
Synonyms: Rhino sinusitis; Rhino-sinusitis
SNOMED CT: Rhinosinusitis (897656009)

Definition

Inflammation of the mucous membranes lining the nose and paranasal sinuses. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRhinosinusitis

Professional guidelines

PubMed

International consensus statement on allergy and rhinology: Allergic rhinitis - 2023.
Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K, Sedaghat AR, Toskala E, Villwock J, Abdullah B, Akdis C, Alt JA, Ansotegui IJ, Azar A, Baroody F, Benninger MS, Bernstein J, Brook C, Campbell R, Casale T, Chaaban MR, Chew FT, Chambliss J, Cianferoni A, Custovic A, Davis EM, DelGaudio JM, Ellis AK, Flanagan C, Fokkens WJ, Franzese C, Greenhawt M, Gill A, Halderman A, Hohlfeld JM, Incorvaia C, Joe SA, Joshi S, Kuruvilla ME, Kim J, Klein AM, Krouse HJ, Kuan EC, Lang D, Larenas-Linnemann D, Laury AM, Lechner M, Lee SE, Lee VS, Loftus P, Marcus S, Marzouk H, Mattos J, McCoul E, Melen E, Mims JW, Mullol J, Nayak JV, Oppenheimer J, Orlandi RR, Phillips K, Platt M, Ramanathan M Jr, Raymond M, Rhee CS, Reitsma S, Ryan M, Sastre J, Schlosser RJ, Schuman TA, Shaker MS, Sheikh A, Smith KA, Soyka MB, Takashima M, Tang M, Tantilipikorn P, Taw MB, Tversky J, Tyler MA, Veling MC, Wallace D, Wang Y, White A, Zhang L
Int Forum Allergy Rhinol 2023 Apr;13(4):293-859. Epub 2023 Mar 6 doi: 10.1002/alr.23090. PMID: 36878860
International consensus statement on allergy and rhinology: rhinosinusitis 2021.
Orlandi RR, Kingdom TT, Smith TL, Bleier B, DeConde A, Luong AU, Poetker DM, Soler Z, Welch KC, Wise SK, Adappa N, Alt JA, Anselmo-Lima WT, Bachert C, Baroody FM, Batra PS, Bernal-Sprekelsen M, Beswick D, Bhattacharyya N, Chandra RK, Chang EH, Chiu A, Chowdhury N, Citardi MJ, Cohen NA, Conley DB, DelGaudio J, Desrosiers M, Douglas R, Eloy JA, Fokkens WJ, Gray ST, Gudis DA, Hamilos DL, Han JK, Harvey R, Hellings P, Holbrook EH, Hopkins C, Hwang P, Javer AR, Jiang RS, Kennedy D, Kern R, Laidlaw T, Lal D, Lane A, Lee HM, Lee JT, Levy JM, Lin SY, Lund V, McMains KC, Metson R, Mullol J, Naclerio R, Oakley G, Otori N, Palmer JN, Parikh SR, Passali D, Patel Z, Peters A, Philpott C, Psaltis AJ, Ramakrishnan VR, Ramanathan M Jr, Roh HJ, Rudmik L, Sacks R, Schlosser RJ, Sedaghat AR, Senior BA, Sindwani R, Smith K, Snidvongs K, Stewart M, Suh JD, Tan BK, Turner JH, van Drunen CM, Voegels R, Wang Y, Woodworth BA, Wormald PJ, Wright ED, Yan C, Zhang L, Zhou B
Int Forum Allergy Rhinol 2021 Mar;11(3):213-739. doi: 10.1002/alr.22741. PMID: 33236525
International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.
Wise SK, Lin SY, Toskala E, Orlandi RR, Akdis CA, Alt JA, Azar A, Baroody FM, Bachert C, Canonica GW, Chacko T, Cingi C, Ciprandi G, Corey J, Cox LS, Creticos PS, Custovic A, Damask C, DeConde A, DelGaudio JM, Ebert CS, Eloy JA, Flanagan CE, Fokkens WJ, Franzese C, Gosepath J, Halderman A, Hamilton RG, Hoffman HJ, Hohlfeld JM, Houser SM, Hwang PH, Incorvaia C, Jarvis D, Khalid AN, Kilpeläinen M, Kingdom TT, Krouse H, Larenas-Linnemann D, Laury AM, Lee SE, Levy JM, Luong AU, Marple BF, McCoul ED, McMains KC, Melén E, Mims JW, Moscato G, Mullol J, Nelson HS, Patadia M, Pawankar R, Pfaar O, Platt MP, Reisacher W, Rondón C, Rudmik L, Ryan M, Sastre J, Schlosser RJ, Settipane RA, Sharma HP, Sheikh A, Smith TL, Tantilipikorn P, Tversky JR, Veling MC, Wang Y, Westman M, Wickman M, Zacharek M
Int Forum Allergy Rhinol 2018 Feb;8(2):108-352. doi: 10.1002/alr.22073. PMID: 29438602Free PMC Article

Recent clinical studies

Etiology

Epidemiology of Chronic Rhinosinusitis: Prevalence and Risk Factors.
Sedaghat AR, Kuan EC, Scadding GK
J Allergy Clin Immunol Pract 2022 Jun;10(6):1395-1403. Epub 2022 Jan 29 doi: 10.1016/j.jaip.2022.01.016. PMID: 35092822
EPOS2020 and beyond.
Hellings PW
Rhinology 2019 Jun 1;57(3):161. doi: 10.4193/Rhin19.803. PMID: 31127931
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968
Pediatric rhinosinusitis.
Magit A
Otolaryngol Clin North Am 2014 Oct;47(5):733-46. Epub 2014 Aug 3 doi: 10.1016/j.otc.2014.06.003. PMID: 25213280
Chapter 8: Rhinosinusitis.
Georgy MS, Peters AT
Allergy Asthma Proc 2012 May-Jun;33 Suppl 1:24-27. doi: 10.2500/aap.2012.33.3538. PMID: 22794681

Diagnosis

Pediatric Rhinosinusitis.
Ramadan HH, Chaiban R, Makary C
Pediatr Clin North Am 2022 Apr;69(2):275-286. doi: 10.1016/j.pcl.2022.01.002. PMID: 35337539
Epidemiology of Chronic Rhinosinusitis: Prevalence and Risk Factors.
Sedaghat AR, Kuan EC, Scadding GK
J Allergy Clin Immunol Pract 2022 Jun;10(6):1395-1403. Epub 2022 Jan 29 doi: 10.1016/j.jaip.2022.01.016. PMID: 35092822
Common Cold and Acute Rhinosinusitis: Up-to-Date Management in 2020.
Jaume F, Valls-Mateus M, Mullol J
Curr Allergy Asthma Rep 2020 Jun 3;20(7):28. doi: 10.1007/s11882-020-00917-5. PMID: 32495003Free PMC Article
Phenotypes of Chronic Rhinosinusitis.
Cho SH, Hamilos DL, Han DH, Laidlaw TM
J Allergy Clin Immunol Pract 2020 May;8(5):1505-1511. doi: 10.1016/j.jaip.2019.12.021. PMID: 32389275Free PMC Article
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Therapy

Biologics for chronic rhinosinusitis.
Chong LY, Piromchai P, Sharp S, Snidvongs K, Webster KE, Philpott C, Hopkins C, Burton MJ
Cochrane Database Syst Rev 2021 Mar 12;3(3):CD013513. doi: 10.1002/14651858.CD013513.pub3. PMID: 33710614Free PMC Article
Conjunctivitis in dupilumab clinical trials.
Akinlade B, Guttman-Yassky E, de Bruin-Weller M, Simpson EL, Blauvelt A, Cork MJ, Prens E, Asbell P, Akpek E, Corren J, Bachert C, Hirano I, Weyne J, Korotzer A, Chen Z, Hultsch T, Zhu X, Davis JD, Mannent L, Hamilton JD, Teper A, Staudinger H, Rizova E, Pirozzi G, Graham NMH, Shumel B, Ardeleanu M, Wollenberg A
Br J Dermatol 2019 Sep;181(3):459-473. Epub 2019 May 7 doi: 10.1111/bjd.17869. PMID: 30851191Free PMC Article
Antibiotics for acute rhinosinusitis in adults.
Lemiengre MB, van Driel ML, Merenstein D, Liira H, Mäkelä M, De Sutter AI
Cochrane Database Syst Rev 2018 Sep 10;9(9):CD006089. doi: 10.1002/14651858.CD006089.pub5. PMID: 30198548Free PMC Article
Saline irrigation for allergic rhinitis.
Head K, Snidvongs K, Glew S, Scadding G, Schilder AG, Philpott C, Hopkins C
Cochrane Database Syst Rev 2018 Jun 22;6(6):CD012597. doi: 10.1002/14651858.CD012597.pub2. PMID: 29932206Free PMC Article
Saline nasal irrigation for acute upper respiratory tract infections.
King D, Mitchell B, Williams CP, Spurling GK
Cochrane Database Syst Rev 2015 Apr 20;2015(4):CD006821. doi: 10.1002/14651858.CD006821.pub3. PMID: 25892369Free PMC Article

Prognosis

Fungal infections in Algeria.
Aissat FZ, Denning DW
Mycoses 2023 Jul;66(7):594-603. Epub 2023 Apr 2 doi: 10.1111/myc.13585. PMID: 37005355
Adult chronic rhinosinusitis.
Bachert C, Marple B, Schlosser RJ, Hopkins C, Schleimer RP, Lambrecht BN, Bröker BM, Laidlaw T, Song WJ
Nat Rev Dis Primers 2020 Oct 29;6(1):86. doi: 10.1038/s41572-020-00218-1. PMID: 33122665
Role of Obesity in Otorhinolaryngologic Diseases.
Jung SY, Park DC, Kim SH, Yeo SG
Curr Allergy Asthma Rep 2019 Jun 3;19(7):34. doi: 10.1007/s11882-019-0865-3. PMID: 31161431
Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study.
Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Teraguchi K, Okano M, Otori N, Yoshikawa M, Hirakawa K, Haruna S, Himi T, Ikeda K, Ishitoya J, Iino Y, Kawata R, Kawauchi H, Kobayashi M, Yamasoba T, Miwa T, Urashima M, Tamari M, Noguchi E, Ninomiya T, Imoto Y, Morikawa T, Tomita K, Takabayashi T, Fujieda S
Allergy 2015 Aug;70(8):995-1003. Epub 2015 May 26 doi: 10.1111/all.12644. PMID: 25945591Free PMC Article
Pediatric epistaxis.
Damrose JF, Maddalozzo J
Laryngoscope 2006 Mar;116(3):387-93. doi: 10.1097/01.MLG.0000195369.01289.9B. PMID: 16540895

Clinical prediction guides

Dupilumab-induced eosinophilia in patients with diffuse type 2 chronic rhinosinusitis.
Ryser FS, Yalamanoglu A, Valaperti A, Brühlmann C, Mauthe T, Traidl S, Soyka MB, Steiner UC
Allergy 2023 Oct;78(10):2712-2723. Epub 2023 Aug 7 doi: 10.1111/all.15844. PMID: 37548395
IL-13-associated epithelial remodeling correlates with clinical severity in nasal polyposis.
Kotas ME, Patel NN, Cope EK, Gurrola JG 2nd, Goldberg AN, Pletcher SD, Seibold MA, Moore CM, Gordon ED
J Allergy Clin Immunol 2023 May;151(5):1277-1285. Epub 2023 Feb 2 doi: 10.1016/j.jaci.2022.12.826. PMID: 36736797Free PMC Article
Mepolizumab for chronic rhinosinusitis with nasal polyps: Treatment efficacy by comorbidity and blood eosinophil count.
Bachert C, Sousa AR, Han JK, Schlosser RJ, Sowerby LJ, Hopkins C, Maspero JF, Smith SG, Kante O, Karidi-Andrioti DE, Mayer B, Chan RH, Yancey SW, Chaker AM
J Allergy Clin Immunol 2022 May;149(5):1711-1721.e6. Epub 2022 Jan 7 doi: 10.1016/j.jaci.2021.10.040. PMID: 35007624
Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study.
Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Teraguchi K, Okano M, Otori N, Yoshikawa M, Hirakawa K, Haruna S, Himi T, Ikeda K, Ishitoya J, Iino Y, Kawata R, Kawauchi H, Kobayashi M, Yamasoba T, Miwa T, Urashima M, Tamari M, Noguchi E, Ninomiya T, Imoto Y, Morikawa T, Tomita K, Takabayashi T, Fujieda S
Allergy 2015 Aug;70(8):995-1003. Epub 2015 May 26 doi: 10.1111/all.12644. PMID: 25945591Free PMC Article
Psychometric validity of the 22-item Sinonasal Outcome Test.
Hopkins C, Gillett S, Slack R, Lund VJ, Browne JP
Clin Otolaryngol 2009 Oct;34(5):447-54. doi: 10.1111/j.1749-4486.2009.01995.x. PMID: 19793277

Recent systematic reviews

Which Is the Best Biologic for Nasal Polyps: Dupilumab, Omalizumab, or Mepolizumab? A Network Meta-Analysis.
Wu Q, Zhang Y, Kong W, Wang X, Yuan L, Zheng R, Qiu H, Huang X, Yang Q
Int Arch Allergy Immunol 2022;183(3):279-288. Epub 2021 Oct 4 doi: 10.1159/000519228. PMID: 34607329
Biologics for chronic rhinosinusitis.
Chong LY, Piromchai P, Sharp S, Snidvongs K, Webster KE, Philpott C, Hopkins C, Burton MJ
Cochrane Database Syst Rev 2021 Mar 12;3(3):CD013513. doi: 10.1002/14651858.CD013513.pub3. PMID: 33710614Free PMC Article
Antibiotics for acute rhinosinusitis in adults.
Lemiengre MB, van Driel ML, Merenstein D, Liira H, Mäkelä M, De Sutter AI
Cochrane Database Syst Rev 2018 Sep 10;9(9):CD006089. doi: 10.1002/14651858.CD006089.pub5. PMID: 30198548Free PMC Article
Eosinophils and eosinophil-associated diseases: An update.
O'Sullivan JA, Bochner BS
J Allergy Clin Immunol 2018 Feb;141(2):505-517. Epub 2017 Oct 16 doi: 10.1016/j.jaci.2017.09.022. PMID: 29045815Free PMC Article
Saline nasal irrigation for acute upper respiratory tract infections.
King D, Mitchell B, Williams CP, Spurling GK
Cochrane Database Syst Rev 2015 Apr 20;2015(4):CD006821. doi: 10.1002/14651858.CD006821.pub3. PMID: 25892369Free PMC Article

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