U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rhinosinusitis

MedGen UID:
923118
•Concept ID:
C0948780
•
Disease or Syndrome
Synonyms: Rhino sinusitis; Rhino-sinusitis
SNOMED CT: Rhinosinusitis (897656009)

Definition

Inflammation of the mucous membranes lining the nose and paranasal sinuses. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRhinosinusitis

Professional guidelines

PubMed

International consensus statement on allergy and rhinology: Allergic rhinitis - 2023.
Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K, Sedaghat AR, Toskala E, Villwock J, Abdullah B, Akdis C, Alt JA, Ansotegui IJ, Azar A, Baroody F, Benninger MS, Bernstein J, Brook C, Campbell R, Casale T, Chaaban MR, Chew FT, Chambliss J, Cianferoni A, Custovic A, Davis EM, DelGaudio JM, Ellis AK, Flanagan C, Fokkens WJ, Franzese C, Greenhawt M, Gill A, Halderman A, Hohlfeld JM, Incorvaia C, Joe SA, Joshi S, Kuruvilla ME, Kim J, Klein AM, Krouse HJ, Kuan EC, Lang D, Larenas-Linnemann D, Laury AM, Lechner M, Lee SE, Lee VS, Loftus P, Marcus S, Marzouk H, Mattos J, McCoul E, Melen E, Mims JW, Mullol J, Nayak JV, Oppenheimer J, Orlandi RR, Phillips K, Platt M, Ramanathan M Jr, Raymond M, Rhee CS, Reitsma S, Ryan M, Sastre J, Schlosser RJ, Schuman TA, Shaker MS, Sheikh A, Smith KA, Soyka MB, Takashima M, Tang M, Tantilipikorn P, Taw MB, Tversky J, Tyler MA, Veling MC, Wallace D, Wang Y, White A, Zhang L
Int Forum Allergy Rhinol 2023 Apr;13(4):293-859. Epub 2023 Mar 6 doi: 10.1002/alr.23090. PMID: 36878860
International consensus statement on allergy and rhinology: rhinosinusitis 2021.
Orlandi RR, Kingdom TT, Smith TL, Bleier B, DeConde A, Luong AU, Poetker DM, Soler Z, Welch KC, Wise SK, Adappa N, Alt JA, Anselmo-Lima WT, Bachert C, Baroody FM, Batra PS, Bernal-Sprekelsen M, Beswick D, Bhattacharyya N, Chandra RK, Chang EH, Chiu A, Chowdhury N, Citardi MJ, Cohen NA, Conley DB, DelGaudio J, Desrosiers M, Douglas R, Eloy JA, Fokkens WJ, Gray ST, Gudis DA, Hamilos DL, Han JK, Harvey R, Hellings P, Holbrook EH, Hopkins C, Hwang P, Javer AR, Jiang RS, Kennedy D, Kern R, Laidlaw T, Lal D, Lane A, Lee HM, Lee JT, Levy JM, Lin SY, Lund V, McMains KC, Metson R, Mullol J, Naclerio R, Oakley G, Otori N, Palmer JN, Parikh SR, Passali D, Patel Z, Peters A, Philpott C, Psaltis AJ, Ramakrishnan VR, Ramanathan M Jr, Roh HJ, Rudmik L, Sacks R, Schlosser RJ, Sedaghat AR, Senior BA, Sindwani R, Smith K, Snidvongs K, Stewart M, Suh JD, Tan BK, Turner JH, van Drunen CM, Voegels R, Wang Y, Woodworth BA, Wormald PJ, Wright ED, Yan C, Zhang L, Zhou B
Int Forum Allergy Rhinol 2021 Mar;11(3):213-739. doi: 10.1002/alr.22741. PMID: 33236525
Clinical practice guideline: Allergic rhinitis.
Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, Dawson DE, Dykewicz MS, Hackell JM, Han JK, Ishman SL, Krouse HJ, Malekzadeh S, Mims JW, Omole FS, Reddy WD, Wallace DV, Walsh SA, Warren BE, Wilson MN, Nnacheta LC; Guideline Otolaryngology Development Group. AAO-HNSF
Otolaryngol Head Neck Surg 2015 Feb;152(1 Suppl):S1-43. doi: 10.1177/0194599814561600. PMID: 25644617

Recent clinical studies

Etiology

Microbiota and antibiotic therapy in rhinosinusitis.
Zawadzka-Głos L
Otolaryngol Pol 2023 Sep 13;77(5):36-42. doi: 10.5604/01.3001.0053.8709. PMID: 38032332
Epidemiology of Chronic Rhinosinusitis: Prevalence and Risk Factors.
Sedaghat AR, Kuan EC, Scadding GK
J Allergy Clin Immunol Pract 2022 Jun;10(6):1395-1403. Epub 2022 Jan 29 doi: 10.1016/j.jaip.2022.01.016. PMID: 35092822
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968
Pediatric rhinosinusitis.
Magit A
Otolaryngol Clin North Am 2014 Oct;47(5):733-46. Epub 2014 Aug 3 doi: 10.1016/j.otc.2014.06.003. PMID: 25213280
Occupational rhinosinusitis.
Hellgren J
Curr Allergy Asthma Rep 2008 May;8(3):234-9. doi: 10.1007/s11882-008-0039-1. PMID: 18589842

Diagnosis

Pediatric Rhinosinusitis.
Ramadan HH, Chaiban R, Makary C
Pediatr Clin North Am 2022 Apr;69(2):275-286. doi: 10.1016/j.pcl.2022.01.002. PMID: 35337539
Epidemiology of Chronic Rhinosinusitis: Prevalence and Risk Factors.
Sedaghat AR, Kuan EC, Scadding GK
J Allergy Clin Immunol Pract 2022 Jun;10(6):1395-1403. Epub 2022 Jan 29 doi: 10.1016/j.jaip.2022.01.016. PMID: 35092822
Common Cold and Acute Rhinosinusitis: Up-to-Date Management in 2020.
Jaume F, Valls-Mateus M, Mullol J
Curr Allergy Asthma Rep 2020 Jun 3;20(7):28. doi: 10.1007/s11882-020-00917-5. PMID: 32495003Free PMC Article
Phenotypes of Chronic Rhinosinusitis.
Cho SH, Hamilos DL, Han DH, Laidlaw TM
J Allergy Clin Immunol Pract 2020 May;8(5):1505-1511. doi: 10.1016/j.jaip.2019.12.021. PMID: 32389275Free PMC Article
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Therapy

Biologics for chronic rhinosinusitis.
Chong LY, Piromchai P, Sharp S, Snidvongs K, Webster KE, Philpott C, Hopkins C, Burton MJ
Cochrane Database Syst Rev 2021 Mar 12;3(3):CD013513. doi: 10.1002/14651858.CD013513.pub3. PMID: 33710614Free PMC Article
Conjunctivitis in dupilumab clinical trials.
Akinlade B, Guttman-Yassky E, de Bruin-Weller M, Simpson EL, Blauvelt A, Cork MJ, Prens E, Asbell P, Akpek E, Corren J, Bachert C, Hirano I, Weyne J, Korotzer A, Chen Z, Hultsch T, Zhu X, Davis JD, Mannent L, Hamilton JD, Teper A, Staudinger H, Rizova E, Pirozzi G, Graham NMH, Shumel B, Ardeleanu M, Wollenberg A
Br J Dermatol 2019 Sep;181(3):459-473. Epub 2019 May 7 doi: 10.1111/bjd.17869. PMID: 30851191Free PMC Article
Antibiotics for acute rhinosinusitis in adults.
Lemiengre MB, van Driel ML, Merenstein D, Liira H, Mäkelä M, De Sutter AI
Cochrane Database Syst Rev 2018 Sep 10;9(9):CD006089. doi: 10.1002/14651858.CD006089.pub5. PMID: 30198548Free PMC Article
Hypertonic Saline Versus Isotonic Saline Nasal Irrigation: Systematic Review and Meta-analysis.
Kanjanawasee D, Seresirikachorn K, Chitsuthipakorn W, Snidvongs K
Am J Rhinol Allergy 2018 Jul;32(4):269-279. Epub 2018 May 18 doi: 10.1177/1945892418773566. PMID: 29774747
Saline nasal irrigation for acute upper respiratory tract infections.
King D, Mitchell B, Williams CP, Spurling GK
Cochrane Database Syst Rev 2015 Apr 20;2015(4):CD006821. doi: 10.1002/14651858.CD006821.pub3. PMID: 25892369Free PMC Article

Prognosis

Adult chronic rhinosinusitis.
Bachert C, Marple B, Schlosser RJ, Hopkins C, Schleimer RP, Lambrecht BN, Bröker BM, Laidlaw T, Song WJ
Nat Rev Dis Primers 2020 Oct 29;6(1):86. doi: 10.1038/s41572-020-00218-1. PMID: 33122665
Role of Obesity in Otorhinolaryngologic Diseases.
Jung SY, Park DC, Kim SH, Yeo SG
Curr Allergy Asthma Rep 2019 Jun 3;19(7):34. doi: 10.1007/s11882-019-0865-3. PMID: 31161431
Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study.
Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Teraguchi K, Okano M, Otori N, Yoshikawa M, Hirakawa K, Haruna S, Himi T, Ikeda K, Ishitoya J, Iino Y, Kawata R, Kawauchi H, Kobayashi M, Yamasoba T, Miwa T, Urashima M, Tamari M, Noguchi E, Ninomiya T, Imoto Y, Morikawa T, Tomita K, Takabayashi T, Fujieda S
Allergy 2015 Aug;70(8):995-1003. Epub 2015 May 26 doi: 10.1111/all.12644. PMID: 25945591Free PMC Article
Chronic rhinosinusitis.
Wang X, Cutting GR
Adv Otorhinolaryngol 2011;70:114-121. Epub 2011 Feb 24 doi: 10.1159/000322487. PMID: 21358193
Pediatric epistaxis.
Damrose JF, Maddalozzo J
Laryngoscope 2006 Mar;116(3):387-93. doi: 10.1097/01.MLG.0000195369.01289.9B. PMID: 16540895

Clinical prediction guides

Sustained efficacy of mepolizumab in patients with severe chronic rhinosinusitis with nasal polyps: SYNAPSE 24-week treatment-free follow-up.
Desrosiers M, Diamant Z, Castelnuovo P, Hellings PW, Han JK, Peters AT, Silver J, Smith SG, Fuller A, Sousa AR, Chan RH, Gevaert P; SYNAPSE study investigators
Int Forum Allergy Rhinol 2024 Jan;14(1):18-31. Epub 2023 Jul 18 doi: 10.1002/alr.23219. PMID: 37345861
Dupilumab-induced eosinophilia in patients with diffuse type 2 chronic rhinosinusitis.
Ryser FS, Yalamanoglu A, Valaperti A, Brühlmann C, Mauthe T, Traidl S, Soyka MB, Steiner UC
Allergy 2023 Oct;78(10):2712-2723. Epub 2023 Aug 7 doi: 10.1111/all.15844. PMID: 37548395
UNILATERAL VS. DIFFUSE CHRONIC RHINOSINUSITIS.
Vrljičak A, Penezić A, Gregurić T, Grgić MV, Baudoin T, Kalogjera L
Acta Clin Croat 2022 Oct;61(Suppl 4):63-69. doi: 10.20471/acc.2022.61.s4.8. PMID: 37250669Free PMC Article
Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study.
Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Teraguchi K, Okano M, Otori N, Yoshikawa M, Hirakawa K, Haruna S, Himi T, Ikeda K, Ishitoya J, Iino Y, Kawata R, Kawauchi H, Kobayashi M, Yamasoba T, Miwa T, Urashima M, Tamari M, Noguchi E, Ninomiya T, Imoto Y, Morikawa T, Tomita K, Takabayashi T, Fujieda S
Allergy 2015 Aug;70(8):995-1003. Epub 2015 May 26 doi: 10.1111/all.12644. PMID: 25945591Free PMC Article
Psychometric validity of the 22-item Sinonasal Outcome Test.
Hopkins C, Gillett S, Slack R, Lund VJ, Browne JP
Clin Otolaryngol 2009 Oct;34(5):447-54. doi: 10.1111/j.1749-4486.2009.01995.x. PMID: 19793277

Recent systematic reviews

Biologics for chronic rhinosinusitis.
Chong LY, Piromchai P, Sharp S, Snidvongs K, Webster KE, Philpott C, Hopkins C, Burton MJ
Cochrane Database Syst Rev 2021 Mar 12;3(3):CD013513. doi: 10.1002/14651858.CD013513.pub3. PMID: 33710614Free PMC Article
Antibiotics for acute rhinosinusitis in adults.
Lemiengre MB, van Driel ML, Merenstein D, Liira H, Mäkelä M, De Sutter AI
Cochrane Database Syst Rev 2018 Sep 10;9(9):CD006089. doi: 10.1002/14651858.CD006089.pub5. PMID: 30198548Free PMC Article
Hypertonic Saline Versus Isotonic Saline Nasal Irrigation: Systematic Review and Meta-analysis.
Kanjanawasee D, Seresirikachorn K, Chitsuthipakorn W, Snidvongs K
Am J Rhinol Allergy 2018 Jul;32(4):269-279. Epub 2018 May 18 doi: 10.1177/1945892418773566. PMID: 29774747
Eosinophils and eosinophil-associated diseases: An update.
O'Sullivan JA, Bochner BS
J Allergy Clin Immunol 2018 Feb;141(2):505-517. Epub 2017 Oct 16 doi: 10.1016/j.jaci.2017.09.022. PMID: 29045815Free PMC Article
Saline nasal irrigation for acute upper respiratory tract infections.
King D, Mitchell B, Williams CP, Spurling GK
Cochrane Database Syst Rev 2015 Apr 20;2015(4):CD006821. doi: 10.1002/14651858.CD006821.pub3. PMID: 25892369Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...