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Neutrophilic dermatosis

MedGen UID:
923154
Concept ID:
C1142272
Disease or Syndrome
Synonym: Neutrophilic Dermatosis
SNOMED CT: Neutrophilic dermatosis (724834006)

Definition

A type of dermatosis characterized by dense infiltration of neutrophils in the skin without evidence of infection or vasculitis. It may be secondary to an underlying systemic illness. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeutrophilic dermatosis

Professional guidelines

PubMed

Dissemond J, Marzano AV, Hampton PJ, Ortega-Loayza AG
Drugs 2023 Sep;83(14):1255-1267. Epub 2023 Aug 23 doi: 10.1007/s40265-023-01931-3. PMID: 37610614Free PMC Article
George C, Deroide F, Rustin M
Clin Med (Lond) 2019 May;19(3):224-228. doi: 10.7861/clinmedicine.19-3-224. PMID: 31092515Free PMC Article
Cugno M, Borghi A, Marzano AV
Am J Clin Dermatol 2017 Aug;18(4):555-562. doi: 10.1007/s40257-017-0265-1. PMID: 28236224

Recent clinical studies

Etiology

Moreno-Artero E, Torrelo A
Dermatol Clin 2024 Apr;42(2):267-283. Epub 2024 Jan 20 doi: 10.1016/j.det.2023.12.005. PMID: 38423686
Zakine E, Schell B, Battistella M, Vignon-Pennamen MD, Chasset F, Mahévas T, Cordoliani F, Adès L, Sébert M, Delaleu J, Jachiet M, Lepelletier C, Lemaire P, Chauvel C, Dhouaieb B, Kim R, Cassius C, Georgin-Lavialle S, Mekinian A, Bagot M, Braun T, Rousset L, Begon E, de Masson A, Fenaux P, Clappier E, Bouaziz JD
JAMA Dermatol 2021 Nov 1;157(11):1349-1354. doi: 10.1001/jamadermatol.2021.3344. PMID: 34495287Free PMC Article
Fragoulis GE, McInnes IB, Siebert S
Rheumatology (Oxford) 2019 Feb 1;58(Suppl 1):i43-i54. doi: 10.1093/rheumatology/key276. PMID: 30806709Free PMC Article
Nelson CA, Stephen S, Ashchyan HJ, James WD, Micheletti RG, Rosenbach M
J Am Acad Dermatol 2018 Dec;79(6):987-1006. Epub 2018 Apr 11 doi: 10.1016/j.jaad.2017.11.064. PMID: 29653210
Sanchez GAM, Reinhardt A, Ramsey S, Wittkowski H, Hashkes PJ, Berkun Y, Schalm S, Murias S, Dare JA, Brown D, Stone DL, Gao L, Klausmeier T, Foell D, de Jesus AA, Chapelle DC, Kim H, Dill S, Colbert RA, Failla L, Kost B, O'Brien M, Reynolds JC, Folio LR, Calvo KR, Paul SM, Weir N, Brofferio A, Soldatos A, Biancotto A, Cowen EW, Digiovanna JJ, Gadina M, Lipton AJ, Hadigan C, Holland SM, Fontana J, Alawad AS, Brown RJ, Rother KI, Heller T, Brooks KM, Kumar P, Brooks SR, Waldman M, Singh HK, Nickeleit V, Silk M, Prakash A, Janes JM, Ozen S, Wakim PG, Brogan PA, Macias WL, Goldbach-Mansky R
J Clin Invest 2018 Jul 2;128(7):3041-3052. Epub 2018 Jun 11 doi: 10.1172/JCI98814. PMID: 29649002Free PMC Article

Diagnosis

Dissemond J, Marzano AV, Hampton PJ, Ortega-Loayza AG
Drugs 2023 Sep;83(14):1255-1267. Epub 2023 Aug 23 doi: 10.1007/s40265-023-01931-3. PMID: 37610614Free PMC Article
Maverakis E, Marzano AV, Le ST, Callen JP, Brüggen MC, Guenova E, Dissemond J, Shinkai K, Langan SM
Nat Rev Dis Primers 2020 Oct 8;6(1):81. doi: 10.1038/s41572-020-0213-x. PMID: 33033263
Gusdorf L, Lipsker D
Ann Dermatol Venereol 2018 Dec;145(12):735-740. Epub 2018 Sep 14 doi: 10.1016/j.annder.2018.06.010. PMID: 30224079
Lora V, Cerroni L, Cota C
G Ital Dermatol Venereol 2018 Apr;153(2):243-255. Epub 2018 Jan 24 doi: 10.23736/S0392-0488.18.05872-8. PMID: 29368864
Lachmann HJ
Best Pract Res Clin Rheumatol 2017 Aug;31(4):596-609. Epub 2018 Jan 11 doi: 10.1016/j.berh.2017.12.001. PMID: 29773275

Therapy

Dissemond J, Marzano AV, Hampton PJ, Ortega-Loayza AG
Drugs 2023 Sep;83(14):1255-1267. Epub 2023 Aug 23 doi: 10.1007/s40265-023-01931-3. PMID: 37610614Free PMC Article
Joshi TP, Friske SK, Hsiou DA, Duvic M
Am J Clin Dermatol 2022 May;23(3):301-318. Epub 2022 Feb 14 doi: 10.1007/s40257-022-00673-4. PMID: 35157247Free PMC Article
Gusdorf L, Lipsker D
Ann Dermatol Venereol 2018 Dec;145(12):735-740. Epub 2018 Sep 14 doi: 10.1016/j.annder.2018.06.010. PMID: 30224079
Lora V, Cerroni L, Cota C
G Ital Dermatol Venereol 2018 Apr;153(2):243-255. Epub 2018 Jan 24 doi: 10.23736/S0392-0488.18.05872-8. PMID: 29368864
Lachmann HJ
Best Pract Res Clin Rheumatol 2017 Aug;31(4):596-609. Epub 2018 Jan 11 doi: 10.1016/j.berh.2017.12.001. PMID: 29773275

Prognosis

Vitale A, Caggiano V, Bimonte A, Caroni F, Tosi GM, Fabbiani A, Renieri A, Bocchia M, Frediani B, Fabiani C, Cantarini L
Intern Emerg Med 2023 Apr;18(3):711-722. Epub 2023 Jan 20 doi: 10.1007/s11739-023-03193-z. PMID: 36662445Free PMC Article
McClanahan D, Funk T, Small A
Dermatol Clin 2022 Apr;40(2):179-190. Epub 2022 Mar 4 doi: 10.1016/j.det.2021.12.005. PMID: 35366971
Sibaud V, Beylot-Barry M, Protin C, Vigarios E, Recher C, Ysebaert L
Am J Clin Dermatol 2020 Dec;21(6):799-812. doi: 10.1007/s40257-020-00535-x. PMID: 32613545
Borda LJ, Wong LL, Marzano AV, Ortega-Loayza AG
Arch Dermatol Res 2019 Aug;311(6):425-434. Epub 2019 Mar 29 doi: 10.1007/s00403-019-01912-1. PMID: 30923901
Limdiwala PG, Parikh SJ, Shah JS
Indian J Dent Res 2014 May-Jun;25(3):401-5. doi: 10.4103/0970-9290.138358. PMID: 25099003

Clinical prediction guides

Dissemond J, Marzano AV, Hampton PJ, Ortega-Loayza AG
Drugs 2023 Sep;83(14):1255-1267. Epub 2023 Aug 23 doi: 10.1007/s40265-023-01931-3. PMID: 37610614Free PMC Article
Papendorf JJ, Ebstein F, Alehashemi S, Piotto DGP, Kozlova A, Terreri MT, Shcherbina A, Rastegar A, Rodrigues M, Pereira R, Park S, Lin B, Uss K, Möller S, da Silva Pina AF, Sztajnbok F, Torreggiani S, Niemela J, Stoddard J, Rosenzweig SD, Oler AJ, McNinch C, de Guzman MM, Fonseca A, Micheloni N, Fraga MM, Perazzio SF, Goldbach-Mansky R, de Jesus AA, Krüger E
Front Immunol 2023;14:1190104. Epub 2023 Aug 4 doi: 10.3389/fimmu.2023.1190104. PMID: 37600812Free PMC Article
Joshi TP, Friske SK, Hsiou DA, Duvic M
Am J Clin Dermatol 2022 May;23(3):301-318. Epub 2022 Feb 14 doi: 10.1007/s40257-022-00673-4. PMID: 35157247Free PMC Article
Sanchez GAM, Reinhardt A, Ramsey S, Wittkowski H, Hashkes PJ, Berkun Y, Schalm S, Murias S, Dare JA, Brown D, Stone DL, Gao L, Klausmeier T, Foell D, de Jesus AA, Chapelle DC, Kim H, Dill S, Colbert RA, Failla L, Kost B, O'Brien M, Reynolds JC, Folio LR, Calvo KR, Paul SM, Weir N, Brofferio A, Soldatos A, Biancotto A, Cowen EW, Digiovanna JJ, Gadina M, Lipton AJ, Hadigan C, Holland SM, Fontana J, Alawad AS, Brown RJ, Rother KI, Heller T, Brooks KM, Kumar P, Brooks SR, Waldman M, Singh HK, Nickeleit V, Silk M, Prakash A, Janes JM, Ozen S, Wakim PG, Brogan PA, Macias WL, Goldbach-Mansky R
J Clin Invest 2018 Jul 2;128(7):3041-3052. Epub 2018 Jun 11 doi: 10.1172/JCI98814. PMID: 29649002Free PMC Article
Wang JY, French LE, Shear NH, Amiri A, Alavi A
Am J Clin Dermatol 2018 Feb;19(1):67-77. doi: 10.1007/s40257-017-0308-7. PMID: 28624960

Recent systematic reviews

Altom A, Khader SAE, Gad AG, Anadani R, Dang DP, Ansar F, Chaudhari J, Crespo-Quezada J, Huy NT
Am J Dermatopathol 2023 Jun 1;45(6):355-370. Epub 2023 Feb 17 doi: 10.1097/DAD.0000000000002345. PMID: 37191371
Cetin Gedik K, Lamot L, Romano M, Demirkaya E, Piskin D, Torreggiani S, Adang LA, Armangue T, Barchus K, Cordova DR, Crow YJ, Dale RC, Durrant KL, Eleftheriou D, Fazzi EM, Gattorno M, Gavazzi F, Hanson EP, Lee-Kirsch MA, Montealegre Sanchez GA, Neven B, Orcesi S, Ozen S, Poli MC, Schumacher E, Tonduti D, Uss K, Aletaha D, Feldman BM, Vanderver A, Brogan PA, Goldbach-Mansky R
Arthritis Rheumatol 2022 May;74(5):735-751. Epub 2022 Mar 21 doi: 10.1002/art.42087. PMID: 35315249
Flora A, Kozera E, Frew JW
Exp Dermatol 2022 Apr;31(4):498-515. Epub 2022 Feb 15 doi: 10.1111/exd.14534. PMID: 35114021
Cetin Gedik K, Lamot L, Romano M, Demirkaya E, Piskin D, Torreggiani S, Adang LA, Armangue T, Barchus K, Cordova DR, Crow YJ, Dale RC, Durrant KL, Eleftheriou D, Fazzi EM, Gattorno M, Gavazzi F, Hanson EP, Lee-Kirsch MA, Montealegre Sanchez GA, Neven B, Orcesi S, Ozen S, Poli MC, Schumacher E, Tonduti D, Uss K, Aletaha D, Feldman BM, Vanderver A, Brogan PA, Goldbach-Mansky R
Ann Rheum Dis 2022 May;81(5):601-613. Epub 2022 Jan 27 doi: 10.1136/annrheumdis-2021-221814. PMID: 35086813Free PMC Article
Delplanque M, Ducharme-Bénard S, Moguelet P, Chasset F, Grateau G, Georgin-Lavialle S, Bachmeyer C
Scand J Rheumatol 2022 Jan;51(1):42-49. Epub 2021 Jun 23 doi: 10.1080/03009742.2021.1904588. PMID: 34159892

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