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Axial spondyloarthritis

MedGen UID:
923672
•Concept ID:
C3203547
•
Disease or Syndrome
Synonyms: Axial Spondyloarthritides; Axial Spondyloarthritis; AxSpA; Spondyloarthritides, Axial; Spondyloarthritis, Axial
SNOMED CT: Axial spondyloarthritis (723116002)

Definition

A spectrum of chronic inflammatory conditions affecting the axial joints (e.g., SPINE), characterized by pain, stiffness of joints (ANKYLOSIS), reduced mobility and inflammation. When joint inflammation and damage are visible on regular X-rays it is called ANKYLOSING SPONDYLITIS; otherwise it is referred to as NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS. HLA-B27 ANTIGEN is a biomarker and IL-23/IL-17 pathway a potential therapeutic target for axial and other related spondyloarthritis. [from MeSH]

Professional guidelines

PubMed

ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update.
Ramiro S, Nikiphorou E, Sepriano A, Ortolan A, Webers C, Baraliakos X, Landewé RBM, Van den Bosch FE, Boteva B, Bremander A, Carron P, Ciurea A, van Gaalen FA, Géher P, Gensler L, Hermann J, de Hooge M, Husakova M, Kiltz U, López-Medina C, Machado PM, Marzo-Ortega H, Molto A, Navarro-Compán V, Nissen MJ, Pimentel-Santos FM, Poddubnyy D, Proft F, Rudwaleit M, Telkman M, Zhao SS, Ziade N, van der Heijde D
Ann Rheum Dis 2023 Jan;82(1):19-34. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223296. PMID: 36270658
Treatment of axial spondyloarthritis: an update.
Danve A, Deodhar A
Nat Rev Rheumatol 2022 Apr;18(4):205-216. Epub 2022 Mar 10 doi: 10.1038/s41584-022-00761-z. PMID: 35273385
2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L
Arthritis Care Res (Hoboken) 2019 Oct;71(10):1285-1299. Epub 2019 Aug 21 doi: 10.1002/acr.24025. PMID: 31436026Free PMC Article

Recent clinical studies

Etiology

Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Joint together: The etiology and pathogenesis of ankylosing spondylitis.
Xiong Y, Cai M, Xu Y, Dong P, Chen H, He W, Zhang J
Front Immunol 2022;13:996103. Epub 2022 Oct 17 doi: 10.3389/fimmu.2022.996103. PMID: 36325352Free PMC Article
Ankylosing spondylitis risk factors: a systematic literature review.
Hwang MC, Ridley L, Reveille JD
Clin Rheumatol 2021 Aug;40(8):3079-3093. Epub 2021 Mar 22 doi: 10.1007/s10067-021-05679-7. PMID: 33754220Free PMC Article
Epidemiology of axial spondyloarthritis: an update.
Wang R, Ward MM
Curr Opin Rheumatol 2018 Mar;30(2):137-143. doi: 10.1097/BOR.0000000000000475. PMID: 29227352Free PMC Article
Genetics and the Causes of Ankylosing Spondylitis.
Hanson A, Brown MA
Rheum Dis Clin North Am 2017 Aug;43(3):401-414. doi: 10.1016/j.rdc.2017.04.006. PMID: 28711142Free PMC Article

Diagnosis

Treatment of axial spondyloarthritis: an update.
Danve A, Deodhar A
Nat Rev Rheumatol 2022 Apr;18(4):205-216. Epub 2022 Mar 10 doi: 10.1038/s41584-022-00761-z. PMID: 35273385
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
Axial spondyloarthritis: new advances in diagnosis and management.
Ritchlin C, Adamopoulos IE
BMJ 2021 Jan 4;372:m4447. doi: 10.1136/bmj.m4447. PMID: 33397652
Imaging of axial spondyloarthritis. New aspects and differential diagnoses.
Braun J, Baraliakos X, Buehring B, Kiltz U, Fruth M
Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):35-42. Epub 2018 Oct 1 PMID: 30296971
Axial spondyloarthritis.
Sieper J, Poddubnyy D
Lancet 2017 Jul 1;390(10089):73-84. Epub 2017 Jan 20 doi: 10.1016/S0140-6736(16)31591-4. PMID: 28110981

Therapy

Treatment of axial spondyloarthritis: an update.
Danve A, Deodhar A
Nat Rev Rheumatol 2022 Apr;18(4):205-216. Epub 2022 Mar 10 doi: 10.1038/s41584-022-00761-z. PMID: 35273385
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
Axial spondyloarthritis: new advances in diagnosis and management.
Ritchlin C, Adamopoulos IE
BMJ 2021 Jan 4;372:m4447. doi: 10.1136/bmj.m4447. PMID: 33397652
Non-radiographic axial spondyloarthritis.
Kameda H, Kobayashi S, Tamura N, Kadono Y, Tada K, Yamamura M, Tomita T
Mod Rheumatol 2021 Mar;31(2):277-282. Epub 2020 Oct 12 doi: 10.1080/14397595.2020.1830512. PMID: 32996809
2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L
Arthritis Care Res (Hoboken) 2019 Oct;71(10):1285-1299. Epub 2019 Aug 21 doi: 10.1002/acr.24025. PMID: 31436026Free PMC Article

Prognosis

Axial involvement in psoriatic arthritis: An update for rheumatologists.
Poddubnyy D, Jadon DR, Van den Bosch F, Mease PJ, Gladman DD
Semin Arthritis Rheum 2021 Aug;51(4):880-887. Epub 2021 Jun 19 doi: 10.1016/j.semarthrit.2021.06.006. PMID: 34198146
Golimumab (anti-TNF monoclonal antibody): where we stand today.
Melo AT, Campanilho-Marques R, Fonseca JE
Hum Vaccin Immunother 2021 Jun 3;17(6):1586-1598. Epub 2020 Dec 28 doi: 10.1080/21645515.2020.1836919. PMID: 33369527Free PMC Article
Clinical Manifestations and Diagnosis of Axial Spondyloarthritis.
Walsh JA, Magrey M
J Clin Rheumatol 2021 Dec 1;27(8):e547-e560. doi: 10.1097/RHU.0000000000001575. PMID: 33105312Free PMC Article
Imaging of axial spondyloarthritis. New aspects and differential diagnoses.
Braun J, Baraliakos X, Buehring B, Kiltz U, Fruth M
Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):35-42. Epub 2018 Oct 1 PMID: 30296971
The classification and diagnostic criteria of ankylosing spondylitis.
Raychaudhuri SP, Deodhar A
J Autoimmun 2014 Feb-Mar;48-49:128-33. Epub 2014 Feb 16 doi: 10.1016/j.jaut.2014.01.015. PMID: 24534717

Clinical prediction guides

Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Treatment Failure in Axial Spondyloarthritis: Insights for a Standardized Definition.
Juanola X, Ramos MJM, Belzunegui JM, Fernández-Carballido C, Gratacós J
Adv Ther 2022 Apr;39(4):1490-1501. Epub 2022 Feb 24 doi: 10.1007/s12325-022-02064-x. PMID: 35201604Free PMC Article
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
Serum calprotectin: a promising biomarker in rheumatoid arthritis and axial spondyloarthritis.
Jarlborg M, Courvoisier DS, Lamacchia C, Martinez Prat L, Mahler M, Bentow C, Finckh A, Gabay C, Nissen MJ; physicians of the Swiss Clinical Quality Management (SCQM) registry
Arthritis Res Ther 2020 May 6;22(1):105. doi: 10.1186/s13075-020-02190-3. PMID: 32375861Free PMC Article
Imaging of axial spondyloarthritis. New aspects and differential diagnoses.
Braun J, Baraliakos X, Buehring B, Kiltz U, Fruth M
Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):35-42. Epub 2018 Oct 1 PMID: 30296971

Recent systematic reviews

Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Efficacy and safety of non-pharmacological and non-biological interventions: a systematic literature review informing the 2022 update of the ASAS/EULAR recommendations for the management of axial spondyloarthritis.
Ortolan A, Webers C, Sepriano A, Falzon L, Baraliakos X, Landewé RB, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):142-152. Epub 2022 Oct 19 doi: 10.1136/ard-2022-223297. PMID: 36261247
Effects of diet on the outcomes of rheumatic and musculoskeletal diseases (RMDs): systematic review and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs.
Gwinnutt JM, Wieczorek M, Rodríguez-Carrio J, Balanescu A, Bischoff-Ferrari HA, Boonen A, Cavalli G, de Souza S, de Thurah A, Dorner TE, Moe RH, Putrik P, Silva-Fernández L, Stamm T, Walker-Bone K, Welling J, Zlatković-Švenda M, Guillemin F, Verstappen SMM
RMD Open 2022 Jun;8(2) doi: 10.1136/rmdopen-2021-002167. PMID: 35654458Free PMC Article
Ankylosing spondylitis risk factors: a systematic literature review.
Hwang MC, Ridley L, Reveille JD
Clin Rheumatol 2021 Aug;40(8):3079-3093. Epub 2021 Mar 22 doi: 10.1007/s10067-021-05679-7. PMID: 33754220Free PMC Article
Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review.
Strand V, Balsa A, Al-Saleh J, Barile-Fabris L, Horiuchi T, Takeuchi T, Lula S, Hawes C, Kola B, Marshall L
BioDrugs 2017 Aug;31(4):299-316. doi: 10.1007/s40259-017-0231-8. PMID: 28612180Free PMC Article

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