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Myelofibrosis Transformation in Essential Thrombocythemia

MedGen UID:
923817
Concept ID:
C3805233
Neoplastic Process
Synonyms: Myelofibrosis due to and following essential thrombocythemia; Post Essential Thrombocythemia Myelofibrosis; Post-Essential Thrombocythemia Myelofibrosis; Post-essential thrombocythemia myelofibrosis; Post-Essential Thrombocytosis Myelofibrosis; Post-ET Myelofibrosis
SNOMED CT: Post-essential thrombocythemia myelofibrosis (871541008); Myelofibrosis due to and following essential thrombocythemia (871541008)

Definition

Myelofibrosis that develops in a patient with history of essential thrombocythemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyelofibrosis Transformation in Essential Thrombocythemia

Professional guidelines

PubMed

Loscocco GG, Coltro G, Guglielmelli P, Vannucchi AM
Cells 2021 Aug 2;10(8) doi: 10.3390/cells10081962. PMID: 34440731Free PMC Article
Tefferi A, Barbui T
Am J Hematol 2020 Dec;95(12):1599-1613. Epub 2020 Oct 23 doi: 10.1002/ajh.26008. PMID: 32974939
Tefferi A, Barbui T
Am J Hematol 2019 Jan;94(1):133-143. Epub 2018 Nov 9 doi: 10.1002/ajh.25303. PMID: 30281843

Recent clinical studies

Etiology

Baumeister J, Chatain N, Sofias AM, Lammers T, Koschmieder S
Cells 2021 Dec 16;10(12) doi: 10.3390/cells10123551. PMID: 34944059Free PMC Article
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
Tefferi A, Barbui T
Am J Hematol 2020 Dec;95(12):1599-1613. Epub 2020 Oct 23 doi: 10.1002/ajh.26008. PMID: 32974939
Grinfeld J, Nangalia J, Baxter EJ, Wedge DC, Angelopoulos N, Cantrill R, Godfrey AL, Papaemmanuil E, Gundem G, MacLean C, Cook J, O'Neil L, O'Meara S, Teague JW, Butler AP, Massie CE, Williams N, Nice FL, Andersen CL, Hasselbalch HC, Guglielmelli P, McMullin MF, Vannucchi AM, Harrison CN, Gerstung M, Green AR, Campbell PJ
N Engl J Med 2018 Oct 11;379(15):1416-1430. doi: 10.1056/NEJMoa1716614. PMID: 30304655Free PMC Article
Tefferi A, Pardanani A
JAMA Oncol 2015 Apr;1(1):97-105. doi: 10.1001/jamaoncol.2015.89. PMID: 26182311

Diagnosis

Baumeister J, Chatain N, Sofias AM, Lammers T, Koschmieder S
Cells 2021 Dec 16;10(12) doi: 10.3390/cells10123551. PMID: 34944059Free PMC Article
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
Tefferi A, Barbui T
Am J Hematol 2020 Dec;95(12):1599-1613. Epub 2020 Oct 23 doi: 10.1002/ajh.26008. PMID: 32974939
Grinfeld J, Nangalia J, Baxter EJ, Wedge DC, Angelopoulos N, Cantrill R, Godfrey AL, Papaemmanuil E, Gundem G, MacLean C, Cook J, O'Neil L, O'Meara S, Teague JW, Butler AP, Massie CE, Williams N, Nice FL, Andersen CL, Hasselbalch HC, Guglielmelli P, McMullin MF, Vannucchi AM, Harrison CN, Gerstung M, Green AR, Campbell PJ
N Engl J Med 2018 Oct 11;379(15):1416-1430. doi: 10.1056/NEJMoa1716614. PMID: 30304655Free PMC Article
Tefferi A, Pardanani A
JAMA Oncol 2015 Apr;1(1):97-105. doi: 10.1001/jamaoncol.2015.89. PMID: 26182311

Therapy

Tefferi A, Barbui T
Am J Hematol 2020 Dec;95(12):1599-1613. Epub 2020 Oct 23 doi: 10.1002/ajh.26008. PMID: 32974939
Tefferi A, Barbui T
Am J Hematol 2019 Jan;94(1):133-143. Epub 2018 Nov 9 doi: 10.1002/ajh.25303. PMID: 30281843
Harrison CN, Mead AJ, Panchal A, Fox S, Yap C, Gbandi E, Houlton A, Alimam S, Ewing J, Wood M, Chen F, Coppell J, Panoskaltsis N, Knapper S, Ali S, Hamblin A, Scherber R, Dueck AC, Cross NCP, Mesa R, McMullin MF
Blood 2017 Oct 26;130(17):1889-1897. Epub 2017 Aug 9 doi: 10.1182/blood-2017-05-785790. PMID: 29074595Free PMC Article
Tefferi A, Pardanani A
JAMA Oncol 2015 Apr;1(1):97-105. doi: 10.1001/jamaoncol.2015.89. PMID: 26182311
Finazzi G, Harrison C
Semin Hematol 2005 Oct;42(4):230-8. doi: 10.1053/j.seminhematol.2005.05.022. PMID: 16210036

Prognosis

Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
Tefferi A, Barbui T
Am J Hematol 2020 Dec;95(12):1599-1613. Epub 2020 Oct 23 doi: 10.1002/ajh.26008. PMID: 32974939
Tefferi A, Guglielmelli P, Lasho TL, Coltro G, Finke CM, Loscocco GG, Sordi B, Szuber N, Rotunno G, Pacilli A, Hanson CA, Ketterling RP, Pardanani A, Gangat N, Vannucchi AM
Br J Haematol 2020 Apr;189(2):291-302. Epub 2020 Jan 16 doi: 10.1111/bjh.16380. PMID: 31945802
Grinfeld J, Nangalia J, Baxter EJ, Wedge DC, Angelopoulos N, Cantrill R, Godfrey AL, Papaemmanuil E, Gundem G, MacLean C, Cook J, O'Neil L, O'Meara S, Teague JW, Butler AP, Massie CE, Williams N, Nice FL, Andersen CL, Hasselbalch HC, Guglielmelli P, McMullin MF, Vannucchi AM, Harrison CN, Gerstung M, Green AR, Campbell PJ
N Engl J Med 2018 Oct 11;379(15):1416-1430. doi: 10.1056/NEJMoa1716614. PMID: 30304655Free PMC Article
Tefferi A, Pardanani A
JAMA Oncol 2015 Apr;1(1):97-105. doi: 10.1001/jamaoncol.2015.89. PMID: 26182311

Clinical prediction guides

Grinfeld J
Blood Rev 2020 Jul;42:100713. Epub 2020 May 30 doi: 10.1016/j.blre.2020.100713. PMID: 32532453
Tefferi A, Guglielmelli P, Lasho TL, Coltro G, Finke CM, Loscocco GG, Sordi B, Szuber N, Rotunno G, Pacilli A, Hanson CA, Ketterling RP, Pardanani A, Gangat N, Vannucchi AM
Br J Haematol 2020 Apr;189(2):291-302. Epub 2020 Jan 16 doi: 10.1111/bjh.16380. PMID: 31945802
Grinfeld J, Nangalia J, Baxter EJ, Wedge DC, Angelopoulos N, Cantrill R, Godfrey AL, Papaemmanuil E, Gundem G, MacLean C, Cook J, O'Neil L, O'Meara S, Teague JW, Butler AP, Massie CE, Williams N, Nice FL, Andersen CL, Hasselbalch HC, Guglielmelli P, McMullin MF, Vannucchi AM, Harrison CN, Gerstung M, Green AR, Campbell PJ
N Engl J Med 2018 Oct 11;379(15):1416-1430. doi: 10.1056/NEJMoa1716614. PMID: 30304655Free PMC Article
Bose P, Verstovsek S
Cancer 2016 Mar 1;122(5):681-92. Epub 2015 Dec 30 doi: 10.1002/cncr.29842. PMID: 26717494
Tefferi A, Pardanani A
JAMA Oncol 2015 Apr;1(1):97-105. doi: 10.1001/jamaoncol.2015.89. PMID: 26182311

Recent systematic reviews

Rungjirajittranon T, Owattanapanich W, Ungprasert P, Siritanaratkul N, Ruchutrakool T
BMC Cancer 2019 Feb 28;19(1):184. doi: 10.1186/s12885-019-5387-9. PMID: 30819138Free PMC Article

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