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Leakage

MedGen UID:
924095
•Concept ID:
C4281748
•
Finding
Synonym: Spillage

Definition

The unintentional discharge of a substance from a container or enclosed space. [from NCI]

Professional guidelines

PubMed

Central serous chorioretinopathy: An evidence-based treatment guideline.
Feenstra HMA, van Dijk EHC, Cheung CMG, Ohno-Matsui K, Lai TYY, Koizumi H, Larsen M, Querques G, Downes SM, Yzer S, Breazzano MP, Subhi Y, Tadayoni R, Priglinger SG, Pauleikhoff LJB, Lange CAK, Loewenstein A, Diederen RMH, Schlingemann RO, Hoyng CB, Chhablani JK, Holz FG, Sivaprasad S, Lotery AJ, Yannuzzi LA, Freund KB, Boon CJF
Prog Retin Eye Res 2024 Jul;101:101236. Epub 2024 Feb 1 doi: 10.1016/j.preteyeres.2024.101236. PMID: 38301969
Management of Dengue: An Updated Review.
Tayal A, Kabra SK, Lodha R
Indian J Pediatr 2023 Feb;90(2):168-177. Epub 2022 Dec 27 doi: 10.1007/s12098-022-04394-8. PMID: 36574088Free PMC Article
Capillary leak syndrome: etiologies, pathophysiology, and management.
Siddall E, Khatri M, Radhakrishnan J
Kidney Int 2017 Jul;92(1):37-46. Epub 2017 Mar 17 doi: 10.1016/j.kint.2016.11.029. PMID: 28318633

Recent clinical studies

Etiology

Coronal and apical leakage among five endodontic sealers.
Vo K, Daniel J, Ahn C, Primus C, Komabayashi T
J Oral Sci 2022 Jan 19;64(1):95-98. Epub 2021 Dec 29 doi: 10.2334/josnusd.21-0433. PMID: 34980828
Anastomotic leakage after esophagectomy for esophageal cancer: definitions, diagnostics, and treatment.
Fabbi M, Hagens ERC, van Berge Henegouwen MI, Gisbertz SS
Dis Esophagus 2021 Jan 11;34(1) doi: 10.1093/dote/doaa039. PMID: 32476017Free PMC Article
Combat with esophagojejunal anastomotic leakage after total gastrectomy for gastric cancer: A critical review of the literature.
Gong W, Li J
Int J Surg 2017 Nov;47:18-24. Epub 2017 Sep 18 doi: 10.1016/j.ijsu.2017.09.019. PMID: 28935529
Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery.
Koch M, Garden OJ, Padbury R, Rahbari NN, Adam R, Capussotti L, Fan ST, Yokoyama Y, Crawford M, Makuuchi M, Christophi C, Banting S, Brooke-Smith M, Usatoff V, Nagino M, Maddern G, Hugh TJ, Vauthey JN, Greig P, Rees M, Nimura Y, Figueras J, DeMatteo RP, Büchler MW, Weitz J
Surgery 2011 May;149(5):680-8. Epub 2011 Feb 12 doi: 10.1016/j.surg.2010.12.002. PMID: 21316725
Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer.
Rahbari NN, Weitz J, Hohenberger W, Heald RJ, Moran B, Ulrich A, Holm T, Wong WD, Tiret E, Moriya Y, Laurberg S, den Dulk M, van de Velde C, Büchler MW
Surgery 2010 Mar;147(3):339-51. Epub 2009 Dec 11 doi: 10.1016/j.surg.2009.10.012. PMID: 20004450

Diagnosis

Effectiveness of Leakage Prevention System in Communicating Important Diagnostic Information.
Tani Y, Hayashi T, Iwata T
Stud Health Technol Inform 2024 Jan 25;310:1400-1401. doi: 10.3233/SHTI231214. PMID: 38269666
Characterization of Fluorescein Angiography Features in Pediatric Patients with Uveitis.
Hossain HA, Ye S, Ward L, O'Keefe GD
Ocul Immunol Inflamm 2023 Oct;31(8):1635-1639. Epub 2022 Jul 25 doi: 10.1080/09273948.2022.2091616. PMID: 35877151
Anastomotic leakage in colorectal cancer surgery.
Chiarello MM, Fransvea P, Cariati M, Adams NJ, Bianchi V, Brisinda G
Surg Oncol 2022 Mar;40:101708. Epub 2022 Jan 24 doi: 10.1016/j.suronc.2022.101708. PMID: 35092916
Anastomotic leakage after esophagectomy for esophageal cancer: definitions, diagnostics, and treatment.
Fabbi M, Hagens ERC, van Berge Henegouwen MI, Gisbertz SS
Dis Esophagus 2021 Jan 11;34(1) doi: 10.1093/dote/doaa039. PMID: 32476017Free PMC Article
Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery.
Koch M, Garden OJ, Padbury R, Rahbari NN, Adam R, Capussotti L, Fan ST, Yokoyama Y, Crawford M, Makuuchi M, Christophi C, Banting S, Brooke-Smith M, Usatoff V, Nagino M, Maddern G, Hugh TJ, Vauthey JN, Greig P, Rees M, Nimura Y, Figueras J, DeMatteo RP, Büchler MW, Weitz J
Surgery 2011 May;149(5):680-8. Epub 2011 Feb 12 doi: 10.1016/j.surg.2010.12.002. PMID: 21316725

Therapy

Effect of Pelvic Floor Workout on Pelvic Floor Muscle Function Recovery of Postpartum Women: Protocol for a Randomized Controlled Trial.
Zhu H, Zhang D, Gao L, Liu H, Di Y, Xie B, Jiao W, Sun X
Int J Environ Res Public Health 2022 Sep 4;19(17) doi: 10.3390/ijerph191711073. PMID: 36078788Free PMC Article
Menstrual cup use, leakage, acceptability, safety, and availability: a systematic review and meta-analysis.
van Eijk AM, Zulaika G, Lenchner M, Mason L, Sivakami M, Nyothach E, Unger H, Laserson K, Phillips-Howard PA
Lancet Public Health 2019 Aug;4(8):e376-e393. Epub 2019 Jul 16 doi: 10.1016/S2468-2667(19)30111-2. PMID: 31324419Free PMC Article
Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women.
Dumoulin C, Cacciari LP, Hay-Smith EJC
Cochrane Database Syst Rev 2018 Oct 4;10(10):CD005654. doi: 10.1002/14651858.CD005654.pub4. PMID: 30288727Free PMC Article
Antibiotic prophylaxis for preventing meningitis in patients with basilar skull fractures.
Ratilal BO, Costa J, Pappamikail L, Sampaio C
Cochrane Database Syst Rev 2015 Apr 28;2015(4):CD004884. doi: 10.1002/14651858.CD004884.pub4. PMID: 25918919Free PMC Article
Laxatives after hemorrhoidectomy.
Johnson CD, Budd J, Ward AJ
Dis Colon Rectum 1987 Oct;30(10):780-1. doi: 10.1007/BF02554626. PMID: 2820672

Prognosis

Idiopathic systemic capillary leak syndrome (Clarkson disease).
Druey KM, Parikh SM
J Allergy Clin Immunol 2017 Sep;140(3):663-670. Epub 2016 Dec 22 doi: 10.1016/j.jaci.2016.10.042. PMID: 28012935Free PMC Article
Oncologic impact of anastomotic leakage after low anterior resection for rectal cancer.
Mantzoros I
Tech Coloproctol 2010 Nov;14 Suppl 1:S39-41. doi: 10.1007/s10151-010-0633-9. PMID: 20686806
Disposable diapers: a hygienic alternative.
Kamat M, Malkani R
Indian J Pediatr 2003 Nov;70(11):879-81. doi: 10.1007/BF02730591. PMID: 14703226
Traumatic oesophageal perforation.
Inci I, Ozcelik C, Nizam O, Balci AE, Eren N, Ozgen G
Scand Cardiovasc J 1997;31(2):97-100. doi: 10.3109/14017439709058076. PMID: 9211597
Bile duct injury and bile leakage in laparoscopic cholecystectomy.
McMahon AJ, Fullarton G, Baxter JN, O'Dwyer PJ
Br J Surg 1995 Mar;82(3):307-13. doi: 10.1002/bjs.1800820308. PMID: 7795992

Clinical prediction guides

Intracerebral Hemorrhage.
Lee TH
Cerebrovasc Dis Extra 2025;15(1):1-8. Epub 2024 Nov 18 doi: 10.1159/000542566. PMID: 39557033Free PMC Article
Capillary leak syndrome: etiologies, pathophysiology, and management.
Siddall E, Khatri M, Radhakrishnan J
Kidney Int 2017 Jul;92(1):37-46. Epub 2017 Mar 17 doi: 10.1016/j.kint.2016.11.029. PMID: 28318633
Lymphoscintigraphy for Imaging of the Lymphatic Flow Disorders.
Yoshida RY, Kariya S, Ha-Kawa S, Tanigawa N
Tech Vasc Interv Radiol 2016 Dec;19(4):273-276. Epub 2016 Oct 8 doi: 10.1053/j.tvir.2016.10.009. PMID: 27993322
Interventional Management of Nonvascular Renal Transplant Complications.
Kolli KP, LaBerge JM
Tech Vasc Interv Radiol 2016 Sep;19(3):218-27. Epub 2016 Jun 3 doi: 10.1053/j.tvir.2016.06.007. PMID: 27641456
Cranial nerve VI palsy after dural-arachnoid puncture.
Hofer JE, Scavone BM
Anesth Analg 2015 Mar;120(3):644-646. doi: 10.1213/ANE.0000000000000587. PMID: 25695579

Recent systematic reviews

Machine Learning for Hypertension Prediction: a Systematic Review.
Silva GFS, Fagundes TP, Teixeira BC, Chiavegatto Filho ADP
Curr Hypertens Rep 2022 Nov;24(11):523-533. Epub 2022 Jun 22 doi: 10.1007/s11906-022-01212-6. PMID: 35731335
Long-Term Impact of Iatrogenic Bile Duct Injury.
Schreuder AM, Busch OR, Besselink MG, Ignatavicius P, Gulbinas A, Barauskas G, Gouma DJ, van Gulik TM
Dig Surg 2020;37(1):10-21. Epub 2019 Jan 17 doi: 10.1159/000496432. PMID: 30654363Free PMC Article
Menstrual cup use, leakage, acceptability, safety, and availability: a systematic review and meta-analysis.
van Eijk AM, Zulaika G, Lenchner M, Mason L, Sivakami M, Nyothach E, Unger H, Laserson K, Phillips-Howard PA
Lancet Public Health 2019 Aug;4(8):e376-e393. Epub 2019 Jul 16 doi: 10.1016/S2468-2667(19)30111-2. PMID: 31324419Free PMC Article
Open versus laparoscopic cholecystectomy in acute cholecystitis. Systematic review and meta-analysis.
Coccolini F, Catena F, Pisano M, Gheza F, Fagiuoli S, Di Saverio S, Leandro G, Montori G, Ceresoli M, Corbella D, Sartelli M, Sugrue M, Ansaloni L
Int J Surg 2015 Jun;18:196-204. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.083. PMID: 25958296
Antibiotic prophylaxis for preventing meningitis in patients with basilar skull fractures.
Ratilal BO, Costa J, Pappamikail L, Sampaio C
Cochrane Database Syst Rev 2015 Apr 28;2015(4):CD004884. doi: 10.1002/14651858.CD004884.pub4. PMID: 25918919Free PMC Article

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