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Cutaneous Malignant Melanoma 2

MedGen UID:
924394
Concept ID:
C4283859
Neoplastic Process

Definition

An autosomal dominant genetic disorder caused by mutations in the CDKN2A gene, encoding cyclin-dependent kinase inhibitor 2A. The condition is characterized by cutaneous malignant melanoma associated with this genetic alteration. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Malignant Melanoma 2

Professional guidelines

PubMed

Newlands C, Gurney B
Br J Oral Maxillofac Surg 2014 Apr;52(4):301-7. Epub 2014 Feb 22 doi: 10.1016/j.bjoms.2014.01.016. PMID: 24565440

Recent clinical studies

Etiology

Wu VF, Malloy KM
Otolaryngol Clin North Am 2021 Apr;54(2):281-294. doi: 10.1016/j.otc.2020.11.004. PMID: 33743887
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Burns D, George J, Aucoin D, Bower J, Burrell S, Gilbert R, Bower N
J Med Imaging Radiat Sci 2019 Sep;50(3):460-469.e1. Epub 2019 Jun 14 doi: 10.1016/j.jmir.2019.05.001. PMID: 31204313
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194
Nørgaard C, Glud M, Gniadecki R
Acta Derm Venereol 2011 Sep;91(5):499-503. doi: 10.2340/00015555-1177. PMID: 21874217

Diagnosis

Laudicella R, Baratto L, Minutoli F, Baldari S, Iagaru A
Curr Radiopharm 2020;13(1):14-23. doi: 10.2174/1874471012666191015095550. PMID: 31749439
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Burns D, George J, Aucoin D, Bower J, Burrell S, Gilbert R, Bower N
J Med Imaging Radiat Sci 2019 Sep;50(3):460-469.e1. Epub 2019 Jun 14 doi: 10.1016/j.jmir.2019.05.001. PMID: 31204313
Desai A, Ugorji R, Khachemoune A
Clin Exp Dermatol 2018 Mar;43(2):117-123. Epub 2017 Dec 13 doi: 10.1111/ced.13323. PMID: 29235153
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194

Therapy

Gorry C, McCullagh L, O'Donnell H, Barrett S, Schmitz S, Barry M, Curtin K, Beausang E, Barry R, Coyne I
Cochrane Database Syst Rev 2023 Jan 17;1(1):CD012974. doi: 10.1002/14651858.CD012974.pub2. PMID: 36648215Free PMC Article
Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, Besser MJ, Haanen J, Svane IM, Ohashi PS, Kammula US, Orcurto A, Zimmermann S, Trueb L, Klebanoff CA, Lotze MT, Kandalaft LE, Coukos G
Ann Oncol 2019 Dec 1;30(12):1902-1913. doi: 10.1093/annonc/mdz398. PMID: 31566658
Wright FC, Souter LH, Kellett S, Easson A, Murray C, Toye J, McCready D, Nessim C, Ghazarian D, Hong NJL, Johnson S, Goldstein DP, Petrella T; Melanoma Disease Site Group
Curr Oncol 2019 Aug;26(4):e541-e550. Epub 2019 Aug 1 doi: 10.3747/co.26.4885. PMID: 31548823Free PMC Article
Lorentzen HF
Curr Opin Pharmacol 2019 Jun;46:116-121. Epub 2019 Jun 28 doi: 10.1016/j.coph.2019.05.010. PMID: 31261023
Oglesby A, Algazi AP, Daud AI
Am J Clin Dermatol 2019 Dec;20(6):781-796. doi: 10.1007/s40257-019-00452-8. PMID: 31228012

Prognosis

Shi X, Zhou Q, Huang B, Xia S, Jiang Y, Fang S, Lin J
PLoS One 2022;17(2):e0263311. Epub 2022 Feb 16 doi: 10.1371/journal.pone.0263311. PMID: 35171924Free PMC Article
Anaba EL
Dermatol Ther 2021 Mar;34(2):e14790. Epub 2021 Jan 25 doi: 10.1111/dth.14790. PMID: 33480165
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Desai A, Ugorji R, Khachemoune A
Clin Exp Dermatol 2018 Mar;43(2):117-123. Epub 2017 Dec 13 doi: 10.1111/ced.13323. PMID: 29235153
Nørgaard C, Glud M, Gniadecki R
Acta Derm Venereol 2011 Sep;91(5):499-503. doi: 10.2340/00015555-1177. PMID: 21874217

Clinical prediction guides

Kamińska P, Buszka K, Zabel M, Nowicki M, Alix-Panabières C, Budna-Tukan J
Int J Mol Sci 2021 Sep 8;22(18) doi: 10.3390/ijms22189714. PMID: 34575876Free PMC Article
Tsuyama S, Kohsaka S, Hayashi T, Suehara Y, Hashimoto T, Kajiyama Y, Tsurumaru M, Ueno T, Mano H, Yao T, Saito T
Histopathology 2021 Jan;78(2):240-251. Epub 2020 Sep 20 doi: 10.1111/his.14210. PMID: 32654197
Eisenstein A, Gonzalez EC, Raghunathan R, Xu X, Wu M, McLean EO, McGee J, Ryu B, Alani RM
Mol Diagn Ther 2018 Apr;22(2):203-218. doi: 10.1007/s40291-018-0318-z. PMID: 29411301
Dvořánková B, Szabo P, Kodet O, Strnad H, Kolář M, Lacina L, Krejčí E, Naňka O, Šedo A, Smetana K Jr
Protoplasma 2017 May;254(3):1143-1150. Epub 2016 Nov 3 doi: 10.1007/s00709-016-1038-z. PMID: 27807664
Nørgaard C, Glud M, Gniadecki R
Acta Derm Venereol 2011 Sep;91(5):499-503. doi: 10.2340/00015555-1177. PMID: 21874217

Recent systematic reviews

Mainville L, Smilga AS, Fortin PR
J Cutan Med Surg 2022 May-Jun;26(3):297-308. Epub 2022 Feb 8 doi: 10.1177/12034754221078201. PMID: 35134311Free PMC Article
Lopes FCPS, Sleiman MG, Sebastian K, Bogucka R, Jacobs EA, Adamson AS
JAMA Dermatol 2021 Feb 1;157(2):213-219. doi: 10.1001/jamadermatol.2020.4616. PMID: 33325988
Kvaskoff M, Mahamat-Saleh Y, Farland LV, Shigesi N, Terry KL, Harris HR, Roman H, Becker CM, As-Sanie S, Zondervan KT, Horne AW, Missmer SA
Hum Reprod Update 2021 Feb 19;27(2):393-420. doi: 10.1093/humupd/dmaa045. PMID: 33202017
Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, Besser MJ, Haanen J, Svane IM, Ohashi PS, Kammula US, Orcurto A, Zimmermann S, Trueb L, Klebanoff CA, Lotze MT, Kandalaft LE, Coukos G
Ann Oncol 2019 Dec 1;30(12):1902-1913. doi: 10.1093/annonc/mdz398. PMID: 31566658
Wang DY, Salem JE, Cohen JV, Chandra S, Menzer C, Ye F, Zhao S, Das S, Beckermann KE, Ha L, Rathmell WK, Ancell KK, Balko JM, Bowman C, Davis EJ, Chism DD, Horn L, Long GV, Carlino MS, Lebrun-Vignes B, Eroglu Z, Hassel JC, Menzies AM, Sosman JA, Sullivan RJ, Moslehi JJ, Johnson DB
JAMA Oncol 2018 Dec 1;4(12):1721-1728. doi: 10.1001/jamaoncol.2018.3923. PMID: 30242316Free PMC Article

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