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Cutaneous Malignant Melanoma 2

MedGen UID:
924394
Concept ID:
C4283859
Neoplastic Process

Definition

An autosomal dominant genetic disorder caused by mutations in the CDKN2A gene, encoding cyclin-dependent kinase inhibitor 2A. The condition is characterized by cutaneous malignant melanoma associated with this genetic alteration. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Malignant Melanoma 2

Professional guidelines

PubMed

Newlands C, Gurney B
Br J Oral Maxillofac Surg 2014 Apr;52(4):301-7. Epub 2014 Feb 22 doi: 10.1016/j.bjoms.2014.01.016. PMID: 24565440

Recent clinical studies

Etiology

Zhao N, Guo P, Tang M, Yang F, Zhang T, Mao R
Front Immunol 2023;14:1201167. Epub 2023 Jul 12 doi: 10.3389/fimmu.2023.1201167. PMID: 37503344Free PMC Article
Usatine RP, Heath CR
J Fam Pract 2022 May;71(4):178-179. doi: 10.12788/jfp.0410. PMID: 35730705
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Wright FC, Souter LH, Kellett S, Easson A, Murray C, Toye J, McCready D, Nessim C, Ghazarian D, Hong NJL, Johnson S, Goldstein DP, Petrella T; Melanoma Disease Site Group
Curr Oncol 2019 Aug;26(4):e541-e550. Epub 2019 Aug 1 doi: 10.3747/co.26.4885. PMID: 31548823Free PMC Article
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194

Diagnosis

Yoshimura T, Li C, Wang Y, Matsukawa A
Cell Mol Immunol 2023 Jul;20(7):714-738. Epub 2023 May 19 doi: 10.1038/s41423-023-01013-0. PMID: 37208442Free PMC Article
Usatine RP, Heath CR
J Fam Pract 2022 May;71(4):178-179. doi: 10.12788/jfp.0410. PMID: 35730705
Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Hoeller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:256-284. Epub 2022 May 24 doi: 10.1016/j.ejca.2022.04.018. PMID: 35623961
Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194

Therapy

Ning S, Lyu M, Zhu D, Lam JWY, Huang Q, Zhang T, Tang BZ
ACS Nano 2023 Jun 13;17(11):10206-10217. Epub 2023 May 15 doi: 10.1021/acsnano.3c00326. PMID: 37183977
Larkin J, Del Vecchio M, Mandalá M, Gogas H, Arance Fernandez AM, Dalle S, Cowey CL, Schenker M, Grob JJ, Chiarion-Sileni V, Marquez-Rodas I, Butler MO, Di Giacomo AM, Middleton MR, Lutzky J, de la Cruz-Merino L, Arenberger P, Atkinson V, Hill AG, Fecher LA, Millward M, Nathan PD, Khushalani NI, Queirolo P, Ritchings C, Lobo M, Askelson M, Tang H, Dolfi S, Ascierto PA, Weber J
Clin Cancer Res 2023 Sep 1;29(17):3352-3361. doi: 10.1158/1078-0432.CCR-22-3145. PMID: 37058595Free PMC Article
Versluis JM, Menzies AM, Sikorska K, Rozeman EA, Saw RPM, van Houdt WJ, Eriksson H, Klop WMC, Ch'ng S, van Thienen JV, Mallo H, Gonzalez M, Torres Acosta A, Grijpink-Ongering LG, van der Wal A, Bruining A, van de Wiel BA, Scolyer RA, Haanen JBAG, Schumacher TN, van Akkooi ACJ, Long GV, Blank CU
Ann Oncol 2023 Apr;34(4):420-430. Epub 2023 Jan 18 doi: 10.1016/j.annonc.2023.01.004. PMID: 36681299
Gorry C, McCullagh L, O'Donnell H, Barrett S, Schmitz S, Barry M, Curtin K, Beausang E, Barry R, Coyne I
Cochrane Database Syst Rev 2023 Jan 17;1(1):CD012974. doi: 10.1002/14651858.CD012974.pub2. PMID: 36648215Free PMC Article
Weber J, Mandala M, Del Vecchio M, Gogas HJ, Arance AM, Cowey CL, Dalle S, Schenker M, Chiarion-Sileni V, Marquez-Rodas I, Grob JJ, Butler MO, Middleton MR, Maio M, Atkinson V, Queirolo P, Gonzalez R, Kudchadkar RR, Smylie M, Meyer N, Mortier L, Atkins MB, Long GV, Bhatia S, Lebbé C, Rutkowski P, Yokota K, Yamazaki N, Kim TM, de Pril V, Sabater J, Qureshi A, Larkin J, Ascierto PA; CheckMate 238 Collaborators
N Engl J Med 2017 Nov 9;377(19):1824-1835. Epub 2017 Sep 10 doi: 10.1056/NEJMoa1709030. PMID: 28891423

Prognosis

Zhao N, Guo P, Tang M, Yang F, Zhang T, Mao R
Front Immunol 2023;14:1201167. Epub 2023 Jul 12 doi: 10.3389/fimmu.2023.1201167. PMID: 37503344Free PMC Article
Ogata D, Nishio S, Hatta N, Kaji T, Fujii K, Mikami M, Kiyohara Y, Enomoto T
Melanoma Res 2023 Aug 1;33(4):300-308. Epub 2023 May 26 doi: 10.1097/CMR.0000000000000894. PMID: 37162526Free PMC Article
Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Kuźbicki Ł, Brożyna AA
J Cutan Pathol 2020 Apr;47(4):363-380. Epub 2019 Dec 1 doi: 10.1111/cup.13606. PMID: 31675116

Clinical prediction guides

Versluis JM, Menzies AM, Sikorska K, Rozeman EA, Saw RPM, van Houdt WJ, Eriksson H, Klop WMC, Ch'ng S, van Thienen JV, Mallo H, Gonzalez M, Torres Acosta A, Grijpink-Ongering LG, van der Wal A, Bruining A, van de Wiel BA, Scolyer RA, Haanen JBAG, Schumacher TN, van Akkooi ACJ, Long GV, Blank CU
Ann Oncol 2023 Apr;34(4):420-430. Epub 2023 Jan 18 doi: 10.1016/j.annonc.2023.01.004. PMID: 36681299
Gorry C, McCullagh L, O'Donnell H, Barrett S, Schmitz S, Barry M, Curtin K, Beausang E, Barry R, Coyne I
Cochrane Database Syst Rev 2023 Jan 17;1(1):CD012974. doi: 10.1002/14651858.CD012974.pub2. PMID: 36648215Free PMC Article
Lee T, Semenova E, Proia AD, Materin MA
Retin Cases Brief Rep 2023 Mar 1;17(2):126-129. doi: 10.1097/ICB.0000000000001178. PMID: 34183612
Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Molodtsov AK, Khatwani N, Vella JL, Lewis KA, Zhao Y, Han J, Sullivan DE, Searles TG, Preiss NK, Shabaneh TB, Zhang P, Hawkes AR, Malik BT, Kolling FW 4th, Usherwood EJ, Wong SL, Phillips JD, Shirai K, Angeles CV, Yan S, Curiel TJ, Huang YH, Cheng C, Turk MJ
Immunity 2021 Sep 14;54(9):2117-2132.e7. doi: 10.1016/j.immuni.2021.08.019. PMID: 34525340Free PMC Article

Recent systematic reviews

Gorry C, McCullagh L, O'Donnell H, Barrett S, Schmitz S, Barry M, Curtin K, Beausang E, Barry R, Coyne I
Cochrane Database Syst Rev 2023 Jan 17;1(1):CD012974. doi: 10.1002/14651858.CD012974.pub2. PMID: 36648215Free PMC Article
Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, Besser MJ, Haanen J, Svane IM, Ohashi PS, Kammula US, Orcurto A, Zimmermann S, Trueb L, Klebanoff CA, Lotze MT, Kandalaft LE, Coukos G
Ann Oncol 2019 Dec 1;30(12):1902-1913. doi: 10.1093/annonc/mdz398. PMID: 31566658
Burgard B, Schöpe J, Holzschuh I, Schiekofer C, Reichrath S, Stefan W, Pilz S, Ordonez-Mena J, März W, Vogt T, Reichrath J
Anticancer Res 2018 Feb;38(2):1187-1199. doi: 10.21873/anticanres.12339. PMID: 29374757
Pampena R, Kyrgidis A, Lallas A, Moscarella E, Argenziano G, Longo C
J Am Acad Dermatol 2017 Nov;77(5):938-945.e4. Epub 2017 Aug 29 doi: 10.1016/j.jaad.2017.06.149. PMID: 28864306
Toia F, Garbo G, Tripoli M, Rinaldi G, Moschella F, Cordova A
J Plast Reconstr Aesthet Surg 2015 Jul;68(7):883-94. Epub 2015 Apr 20 doi: 10.1016/j.bjps.2015.04.003. PMID: 25971418

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