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Gastroesophageal Junction Small Cell Neuroendocrine Carcinoma

MedGen UID:
925425
•Concept ID:
C4287893
•
Neoplastic Process
Synonym: Gastroesophageal Junction Small Cell Carcinoma

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastroesophageal Junction Small Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Novel treatment approaches for HER2 positive solid tumors (excluding breast cancer).
Gaye E, Penel N, Lebellec L
Curr Opin Oncol 2022 Sep 1;34(5):570-574. Epub 2022 Aug 5 doi: 10.1097/CCO.0000000000000873. PMID: 35943440
Evolution of ramucirumab in the treatment of cancer - A review of literature.
Vennepureddy A, Singh P, Rastogi R, Atallah JP, Terjanian T
J Oncol Pharm Pract 2017 Oct;23(7):525-539. Epub 2016 Jun 15 doi: 10.1177/1078155216655474. PMID: 27306885
A novel multiple tyrosine-kinase targeted agent to explore the future perspectives of anti-angiogenic therapy for the treatment of multiple solid tumors: cabozantinib.
Roy S, Narang BK, Rastogi SK, Rawal RK
Anticancer Agents Med Chem 2015;15(1):37-47. doi: 10.2174/1871520614666140902153840. PMID: 25181996

Recent clinical studies

Etiology

Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study.
Lakhani NJ, Chow LQM, Gainor JF, LoRusso P, Lee KW, Chung HC, Lee J, Bang YJ, Hodi FS, Kim WS, Santana-Davila R, Fanning P, Squifflet P, Jin F, Kuo TC, Wan HI, Pons J, Randolph SS, Messersmith WA
Lancet Oncol 2021 Dec;22(12):1740-1751. Epub 2021 Nov 15 doi: 10.1016/S1470-2045(21)00584-2. PMID: 34793719
Lesion-level heterogeneity of radiologic progression in patients treated with pembrolizumab.
Topp BG, Thiagarajan K, De Alwis DP, Snyder A, Hellmann MD
Ann Oncol 2021 Dec;32(12):1618-1625. Epub 2021 Sep 17 doi: 10.1016/j.annonc.2021.09.006. PMID: 34543717
SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.
Horton RK, Ahadi M, Gill AJ, Said S, Chen ZE, Bakhshwin A, Nichols M, Goldblum JR, Graham RP
Am J Surg Pathol 2021 Mar 1;45(3):414-420. doi: 10.1097/PAS.0000000000001599. PMID: 33027072
Surgical Resection of Rare Esophageal Cancers.
Saddoughi SA, Taswell J, Harmsen WS, Inra ML, Blackmon SH, Nichols FC 3rd, Cassivi SD, Wigle DA, Shen KR, Allen MS
Ann Thorac Surg 2016 Jan;101(1):311-5. Epub 2015 Aug 13 doi: 10.1016/j.athoracsur.2015.06.015. PMID: 26277558
Small-cell carcinoma of the esophagus and gastroesophageal junction: review of the Memorial Sloan-Kettering experience.
Ku GY, Minsky BD, Rusch VW, Bains M, Kelsen DP, Ilson DH
Ann Oncol 2008 Mar;19(3):533-7. Epub 2007 Oct 17 doi: 10.1093/annonc/mdm476. PMID: 17947223

Diagnosis

Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study.
Lakhani NJ, Chow LQM, Gainor JF, LoRusso P, Lee KW, Chung HC, Lee J, Bang YJ, Hodi FS, Kim WS, Santana-Davila R, Fanning P, Squifflet P, Jin F, Kuo TC, Wan HI, Pons J, Randolph SS, Messersmith WA
Lancet Oncol 2021 Dec;22(12):1740-1751. Epub 2021 Nov 15 doi: 10.1016/S1470-2045(21)00584-2. PMID: 34793719
Intrapatient Tumor Heterogeneity in IHC Interpretation Using PD-L1 IHC 22C3 pharmDx.
Kalpakoff M, Hund S, Musser J, Roach C, Apostolaki A, Vilardo M, Peltz L, Watts B, LaPlaca C, Tabuena-Frolli S, DiMaio MA, Welcher R, Kulangara K
Appl Immunohistochem Mol Morphol 2021 Oct 1;29(9):667-673. doi: 10.1097/PAI.0000000000000941. PMID: 33973887Free PMC Article
SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.
Horton RK, Ahadi M, Gill AJ, Said S, Chen ZE, Bakhshwin A, Nichols M, Goldblum JR, Graham RP
Am J Surg Pathol 2021 Mar 1;45(3):414-420. doi: 10.1097/PAS.0000000000001599. PMID: 33027072
Platinum-based chemotherapy in combination with PD-1/PD-L1 inhibitors: preclinical and clinical studies and mechanism of action.
Xue Y, Gao S, Gou J, Yin T, He H, Wang Y, Zhang Y, Tang X, Wu R
Expert Opin Drug Deliv 2021 Feb;18(2):187-203. Epub 2020 Oct 5 doi: 10.1080/17425247.2021.1825376. PMID: 32954856
Targeting HER2 expression in cancer: New drugs and new indications.
Vranić S, Bešlija S, Gatalica Z
Bosn J Basic Med Sci 2021 Feb 1;21(1):1-4. doi: 10.17305/bjbms.2020.4908. PMID: 32530388Free PMC Article

Therapy

The Potential of Trastuzumab Deruxtecan as a Tissue Agnostic Drug.
Jørgensen JT
Oncology 2023;101(12):836-842. Epub 2023 Aug 31 doi: 10.1159/000533866. PMID: 37651992
Platinum-based chemotherapy in combination with PD-1/PD-L1 inhibitors: preclinical and clinical studies and mechanism of action.
Xue Y, Gao S, Gou J, Yin T, He H, Wang Y, Zhang Y, Tang X, Wu R
Expert Opin Drug Deliv 2021 Feb;18(2):187-203. Epub 2020 Oct 5 doi: 10.1080/17425247.2021.1825376. PMID: 32954856
Targeting HER2 expression in cancer: New drugs and new indications.
Vranić S, Bešlija S, Gatalica Z
Bosn J Basic Med Sci 2021 Feb 1;21(1):1-4. doi: 10.17305/bjbms.2020.4908. PMID: 32530388Free PMC Article
Camrelizumab: First Global Approval.
Markham A, Keam SJ
Drugs 2019 Aug;79(12):1355-1361. doi: 10.1007/s40265-019-01167-0. PMID: 31313098
Gastroesophageal junction adenocarcinoma.
Swisher SG, Pisters PW, Komaki R, Lahoti S, Ajani JA
Curr Treat Options Oncol 2000 Dec;1(5):387-98. doi: 10.1007/s11864-000-0066-1. PMID: 12057146

Prognosis

Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study.
Lakhani NJ, Chow LQM, Gainor JF, LoRusso P, Lee KW, Chung HC, Lee J, Bang YJ, Hodi FS, Kim WS, Santana-Davila R, Fanning P, Squifflet P, Jin F, Kuo TC, Wan HI, Pons J, Randolph SS, Messersmith WA
Lancet Oncol 2021 Dec;22(12):1740-1751. Epub 2021 Nov 15 doi: 10.1016/S1470-2045(21)00584-2. PMID: 34793719
SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.
Horton RK, Ahadi M, Gill AJ, Said S, Chen ZE, Bakhshwin A, Nichols M, Goldblum JR, Graham RP
Am J Surg Pathol 2021 Mar 1;45(3):414-420. doi: 10.1097/PAS.0000000000001599. PMID: 33027072
Targeting HER2 expression in cancer: New drugs and new indications.
Vranić S, Bešlija S, Gatalica Z
Bosn J Basic Med Sci 2021 Feb 1;21(1):1-4. doi: 10.17305/bjbms.2020.4908. PMID: 32530388Free PMC Article
Gastroesophageal junction Paneth cell carcinoma with extensive cystic and secretory features - case report and literature review.
Luo W, Hofstetter WL, Tan D
Diagn Pathol 2019 Jan 8;14(1):1. doi: 10.1186/s13000-018-0775-z. PMID: 30621725Free PMC Article
Surgical Resection of Rare Esophageal Cancers.
Saddoughi SA, Taswell J, Harmsen WS, Inra ML, Blackmon SH, Nichols FC 3rd, Cassivi SD, Wigle DA, Shen KR, Allen MS
Ann Thorac Surg 2016 Jan;101(1):311-5. Epub 2015 Aug 13 doi: 10.1016/j.athoracsur.2015.06.015. PMID: 26277558

Clinical prediction guides

Indirect Clinical Validation of a Programmed Death-Ligand 1 Laboratory-Developed Test for Gastric/Gastroesophageal Junction Adenocarcinoma with 22C3 Antibody Concentrate.
Kim JM, Kim B, Kim E, Jang M, Cho JH, Lee HS, Kwak Y, Huang L, Krishnan R, Bai SY, Mounawar M, Kim KM
Mol Diagn Ther 2022 Nov;26(6):679-688. Epub 2022 Sep 20 doi: 10.1007/s40291-022-00605-2. PMID: 36125657
Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study.
Lakhani NJ, Chow LQM, Gainor JF, LoRusso P, Lee KW, Chung HC, Lee J, Bang YJ, Hodi FS, Kim WS, Santana-Davila R, Fanning P, Squifflet P, Jin F, Kuo TC, Wan HI, Pons J, Randolph SS, Messersmith WA
Lancet Oncol 2021 Dec;22(12):1740-1751. Epub 2021 Nov 15 doi: 10.1016/S1470-2045(21)00584-2. PMID: 34793719
A Retrospective Study of 52 Patients With Primary Small Cell Carcinoma of the Esophagus Treated With Radical Surgery.
Fan N, Wang Z, Huang Y, Tan Z, Yang H, Lin P
Cancer Control 2021 Jan-Dec;28:10732748211027147. doi: 10.1177/10732748211027147. PMID: 34155924Free PMC Article
Platinum-based chemotherapy in combination with PD-1/PD-L1 inhibitors: preclinical and clinical studies and mechanism of action.
Xue Y, Gao S, Gou J, Yin T, He H, Wang Y, Zhang Y, Tang X, Wu R
Expert Opin Drug Deliv 2021 Feb;18(2):187-203. Epub 2020 Oct 5 doi: 10.1080/17425247.2021.1825376. PMID: 32954856
Targeting HER2 expression in cancer: New drugs and new indications.
Vranić S, Bešlija S, Gatalica Z
Bosn J Basic Med Sci 2021 Feb 1;21(1):1-4. doi: 10.17305/bjbms.2020.4908. PMID: 32530388Free PMC Article

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