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Cervical Transitional Metaplasia

MedGen UID:
925433
•Concept ID:
C4287901
•
Finding

Definition

Cervical metaplasia in which the cervical squamous epithelium resembles benign urothelium as a result of a lack of cellular maturation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Transitional Metaplasia

Recent clinical studies

Etiology

Histologic Findings in Gynecologic Tissue From Transmasculine Individuals Undergoing Gender-Affirming Surgery.
Lin LH, Hernandez A, Marcus A, Deng FM, Adler E
Arch Pathol Lab Med 2022 Jun 1;146(6):742-748. doi: 10.5858/arpa.2021-0199-OA. PMID: 34591101
Cytomorphologic findings of cervical Pap smears from female-to-male transgender patients on testosterone therapy.
Williams MPA, Kukkar V, Stemmer MN, Khurana KK
Cancer Cytopathol 2020 Jul;128(7):491-498. Epub 2020 Mar 3 doi: 10.1002/cncy.22259. PMID: 32125771
Transforming human papillomavirus infection and the esophageal transformation zone: prime time for total excision/ablative therapy?
Rajendra S, Sharma P
Dis Esophagus 2019 Jul 1;32(7) doi: 10.1093/dote/doz008. PMID: 31304554
Histologic Features of Hysterectomy Specimens From Female-Male Transgender Individuals.
Khalifa MA, Toyama A, Klein ME, Santiago V
Int J Gynecol Pathol 2019 Nov;38(6):520-527. doi: 10.1097/PGP.0000000000000548. PMID: 30252728
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172

Diagnosis

Never stop wondering: When cells become PAP-art on the slides.
Lombardo V, Cartesio S, Fadda G, Rossi ED
Cancer Cytopathol 2023 Feb;131(2):78-82. Epub 2022 Oct 10 doi: 10.1002/cncy.22650. PMID: 36217282
Role of Tropomyosin-related kinase B receptor and brain-derived neurotrophic factor in cancer.
Serafim Junior V, Fernandes GMM, Oliveira-Cucolo JG, Pavarino EC, Goloni-Bertollo EM
Cytokine 2020 Dec;136:155270. Epub 2020 Sep 7 doi: 10.1016/j.cyto.2020.155270. PMID: 32911446
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
The expression and diagnostic utility of p63 in the female genital tract.
Houghton O, McCluggage WG
Adv Anat Pathol 2009 Sep;16(5):316-21. doi: 10.1097/PAP.0b013e3181b507c6. PMID: 19700941
Cytologic and histologic diagnosis and significance of controversial squamous lesions of the uterine cervix.
Duggan MA
Mod Pathol 2000 Mar;13(3):252-60. doi: 10.1038/modpathol.3880046. PMID: 10757336

Therapy

Role of Tropomyosin-related kinase B receptor and brain-derived neurotrophic factor in cancer.
Serafim Junior V, Fernandes GMM, Oliveira-Cucolo JG, Pavarino EC, Goloni-Bertollo EM
Cytokine 2020 Dec;136:155270. Epub 2020 Sep 7 doi: 10.1016/j.cyto.2020.155270. PMID: 32911446
Cytomorphologic findings of cervical Pap smears from female-to-male transgender patients on testosterone therapy.
Williams MPA, Kukkar V, Stemmer MN, Khurana KK
Cancer Cytopathol 2020 Jul;128(7):491-498. Epub 2020 Mar 3 doi: 10.1002/cncy.22259. PMID: 32125771
Transforming human papillomavirus infection and the esophageal transformation zone: prime time for total excision/ablative therapy?
Rajendra S, Sharma P
Dis Esophagus 2019 Jul 1;32(7) doi: 10.1093/dote/doz008. PMID: 31304554
Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells.
Hsiao YH, Hsieh MJ, Yang SF, Chen SP, Tsai WC, Chen PN
Phytomedicine 2019 Sep;62:152964. Epub 2019 May 18 doi: 10.1016/j.phymed.2019.152964. PMID: 31153059
Histologic Features of Hysterectomy Specimens From Female-Male Transgender Individuals.
Khalifa MA, Toyama A, Klein ME, Santiago V
Int J Gynecol Pathol 2019 Nov;38(6):520-527. doi: 10.1097/PGP.0000000000000548. PMID: 30252728

Prognosis

EBV promotes vascular mimicry of dormant cancer cells by potentiating stemness and EMT.
Cheng T, Zhang S, Xia T, Zhang Y, Ji Y, Pan S, Xie H, Ren Q, You Y, You B
Exp Cell Res 2022 Dec 15;421(2):113403. Epub 2022 Nov 4 doi: 10.1016/j.yexcr.2022.113403. PMID: 36336028
Role of Tropomyosin-related kinase B receptor and brain-derived neurotrophic factor in cancer.
Serafim Junior V, Fernandes GMM, Oliveira-Cucolo JG, Pavarino EC, Goloni-Bertollo EM
Cytokine 2020 Dec;136:155270. Epub 2020 Sep 7 doi: 10.1016/j.cyto.2020.155270. PMID: 32911446
The role of novel prognostic markers PROX1 and FOXC2 in carcinogenesis of oral squamous cell carcinoma.
Agnihotri NS, Astekar M
J Exp Ther Oncol 2018 May;12(3):171-184. PMID: 29790306
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Focus on the role of the CXCL12/CXCR4 chemokine axis in head and neck squamous cell carcinoma.
Albert S, Riveiro ME, Halimi C, Hourseau M, Couvelard A, Serova M, Barry B, Raymond E, Faivre S
Head Neck 2013 Dec;35(12):1819-28. Epub 2013 Mar 6 doi: 10.1002/hed.23217. PMID: 23468253

Clinical prediction guides

Role of Nasal Fibroblasts in Airway Remodeling of Chronic Rhinosinusitis: The Modulating Functions Reexamined.
Shin JM, Yang HW, Park JH, Kim TH
Int J Mol Sci 2023 Feb 16;24(4) doi: 10.3390/ijms24044017. PMID: 36835423Free PMC Article
Cervical Precancers Originate From Infected Proliferating Reserve Cells: A Comparative Histologic and Genetic Study of Thin and Thick High-grade Squamous Intraepithelial Lesions.
Regauer S, Reich O, Kashofer K
Am J Surg Pathol 2022 Apr 1;46(4):519-527. doi: 10.1097/PAS.0000000000001818. PMID: 34619706
Precursor Lesions of Cervical Clear Cell Carcinoma: Evidence For Origin From Tubo-Endometrial Metaplasia.
Talia KL, Arora R, McCluggage WG
Int J Gynecol Pathol 2022 Mar 1;41(2):105-112. doi: 10.1097/PGP.0000000000000785. PMID: 33770055
Histologic Features of Hysterectomy Specimens From Female-Male Transgender Individuals.
Khalifa MA, Toyama A, Klein ME, Santiago V
Int J Gynecol Pathol 2019 Nov;38(6):520-527. doi: 10.1097/PGP.0000000000000548. PMID: 30252728
NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus.
Demitrack ES, Gifford GB, Keeley TM, Horita N, Todisco A, Turgeon DK, Siebel CW, Samuelson LC
Am J Physiol Gastrointest Liver Physiol 2017 Feb 1;312(2):G133-G144. Epub 2016 Dec 8 doi: 10.1152/ajpgi.00325.2016. PMID: 27932500Free PMC Article

Recent systematic reviews

Histologic Findings in Surgical Pathology Specimens From Individuals Taking Masculinizing Hormone Therapy for the Purpose of Gender Transition.
Andrews AR, Kakadekar A, Greene DN, Khalifa MA, Santiago V, Schmidt RL
Arch Pathol Lab Med 2022 Jun 1;146(6):766-779. doi: 10.5858/arpa.2020-0774-RA. PMID: 34559874

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