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Vulvar Squamous Intraepithelial Lesion, HPV-Associated

MedGen UID:
925531
Concept ID:
C4287999
Disease or Syndrome
Synonyms: Vulvar Intraepithelial Neoplasia, HPV-Associated; Vulvar SIL; Vulvar Squamous Intraepithelial Lesion

Definition

An intraepithelial lesion of the vulvar squamous epithelium associated with HPV infection. It is characterized by maturation abnormalities and nuclear hyperchromasia that are confined to the basement membrane. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar Squamous Intraepithelial Lesion, HPV-Associated

Professional guidelines

PubMed

Cardinal LH, Carballo P, Lorenzo MC, García A, Suzuki V, Tatti S, Vighi S, Díaz LB
Diagn Cytopathol 2014 May;42(5):396-400. Epub 2013 Oct 25 doi: 10.1002/dc.23050. PMID: 24166879
Darragh TM, Colgan TJ, Cox JT, Heller DS, Henry MR, Luff RD, McCalmont T, Nayar R, Palefsky JM, Stoler MH, Wilkinson EJ, Zaino RJ, Wilbur DC; Members of LAST Project Work Groups
J Low Genit Tract Dis 2012 Jul;16(3):205-42. doi: 10.1097/LGT.0b013e31825c31dd. PMID: 22820980

Recent clinical studies

Etiology

Thuijs NB, van Beurden M, Duin S, Heideman DAM, Berkhof J, Steenbergen RDM, Bleeker MCG
Histopathology 2024 Jan;84(2):301-314. Epub 2023 Sep 19 doi: 10.1111/his.15050. PMID: 37726173
Yang H, Almadani N, Thompson EF, Tessier-Cloutier B, Chen J, Ho J, Senz J, McConechy MK, Chow C, Ta M, Cheng A, Karnezis A, Huvila J, McAlpine JN, Gilks B, Jamieson A, Hoang LN
Mod Pathol 2023 Jun;36(6):100145. Epub 2023 Feb 22 doi: 10.1016/j.modpat.2023.100145. PMID: 36828360
Janke MJ, DeBlanc J, Kobernik EK, Skala SL, Hiles GL, Kelly R, Welch KC
J Low Genit Tract Dis 2022 Oct 1;26(4):319-322. Epub 2022 Aug 15 doi: 10.1097/LGT.0000000000000690. PMID: 35972920
Jenkins TM, Mills AM
Semin Diagn Pathol 2021 Jan;38(1):27-36. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.006. PMID: 32948383
Yang EJ, Kong CS, Longacre TA
Adv Anat Pathol 2017 May;24(3):136-150. doi: 10.1097/PAP.0000000000000149. PMID: 28398952

Diagnosis

Yang H, Almadani N, Thompson EF, Tessier-Cloutier B, Chen J, Ho J, Senz J, McConechy MK, Chow C, Ta M, Cheng A, Karnezis A, Huvila J, McAlpine JN, Gilks B, Jamieson A, Hoang LN
Mod Pathol 2023 Jun;36(6):100145. Epub 2023 Feb 22 doi: 10.1016/j.modpat.2023.100145. PMID: 36828360
Janke MJ, DeBlanc J, Kobernik EK, Skala SL, Hiles GL, Kelly R, Welch KC
J Low Genit Tract Dis 2022 Oct 1;26(4):319-322. Epub 2022 Aug 15 doi: 10.1097/LGT.0000000000000690. PMID: 35972920
Jenkins TM, Mills AM
Semin Diagn Pathol 2021 Jan;38(1):27-36. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.006. PMID: 32948383
Singh N, Gilks CB
Histopathology 2020 Jan;76(1):128-138. doi: 10.1111/his.13989. PMID: 31846523
Yang EJ, Kong CS, Longacre TA
Adv Anat Pathol 2017 May;24(3):136-150. doi: 10.1097/PAP.0000000000000149. PMID: 28398952

Therapy

Skolnik JM, Morrow MP
Mol Aspects Med 2023 Dec;94:101224. Epub 2023 Nov 4 doi: 10.1016/j.mam.2023.101224. PMID: 37931422
Dibbern ME, Bullock TN, Jenkins TM, Duska LR, Stoler MH, Mills AM
Am J Surg Pathol 2020 Sep;44(9):1184-1191. doi: 10.1097/PAS.0000000000001506. PMID: 32496434
Heard I, Palefsky JM, Kazatchkine MD
Antivir Ther 2004 Feb;9(1):13-22. PMID: 15040532
Richter ON, Petrow W, Wardelmann E, Dorn C, Kupka M, Ulrich U
Arch Gynecol Obstet 2003 Oct;268(4):333-6. Epub 2003 Jan 23 doi: 10.1007/s00404-002-0385-5. PMID: 14504882
Wada H, Enomoto T, Yoshino K, Ozaki K, Kurachi H, Nomura T, Murata Y, Kim N, Weinrich S, Lea-Chou E, Lopez-Uribe D, Shroyer KR
Am J Clin Pathol 2000 Sep;114(3):371-9. doi: 10.1093/ajcp/114.3.371. PMID: 10989637

Prognosis

Yang H, Almadani N, Thompson EF, Tessier-Cloutier B, Chen J, Ho J, Senz J, McConechy MK, Chow C, Ta M, Cheng A, Karnezis A, Huvila J, McAlpine JN, Gilks B, Jamieson A, Hoang LN
Mod Pathol 2023 Jun;36(6):100145. Epub 2023 Feb 22 doi: 10.1016/j.modpat.2023.100145. PMID: 36828360
Jenkins TM, Mills AM
Semin Diagn Pathol 2021 Jan;38(1):27-36. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.006. PMID: 32948383
Singh N, Gilks CB
Histopathology 2020 Jan;76(1):128-138. doi: 10.1111/his.13989. PMID: 31846523
Rakislova N, Saco A, Sierra A, Del Pino M, Ordi J
Adv Anat Pathol 2017 Jul;24(4):201-214. doi: 10.1097/PAP.0000000000000155. PMID: 28590952
Del Pino M, Rodriguez-Carunchio L, Ordi J
Histopathology 2013 Jan;62(1):161-75. Epub 2012 Nov 27 doi: 10.1111/his.12034. PMID: 23190170

Clinical prediction guides

Thuijs NB, van Beurden M, Duin S, Heideman DAM, Berkhof J, Steenbergen RDM, Bleeker MCG
Histopathology 2024 Jan;84(2):301-314. Epub 2023 Sep 19 doi: 10.1111/his.15050. PMID: 37726173
Wu M, Zhang X, Kang Y, Zhu Y, Su Z, Liu J, Zhang W, Chen H, Li H
Viruses 2022 Sep 16;14(9) doi: 10.3390/v14092054. PMID: 36146860Free PMC Article
Neville G, Chapel DB, Crum CP, Song SJ, Yoon JY, Lee KR, Kolin DL, Hirsch MS, Nucci MR, Parra-Herran C
Histopathology 2021 Dec;79(6):957-965. Epub 2021 Sep 3 doi: 10.1111/his.14442. PMID: 34214216
Rakislova N, Alemany L, Clavero O, Del Pino M, Saco A, Quirós B, Lloveras B, Alejo M, Halec G, Quint W, de Sanjosé S, Ordi J; VVAP study group
Am J Surg Pathol 2018 Jun;42(6):828-835. doi: 10.1097/PAS.0000000000001047. PMID: 29505429
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148

Recent systematic reviews

Thomas LK, Bermejo JL, Vinokurova S, Jensen K, Bierkens M, Steenbergen R, Bergmann M, von Knebel Doeberitz M, Reuschenbach M
Eur J Cancer 2014 Jan;50(1):85-98. Epub 2013 Sep 17 doi: 10.1016/j.ejca.2013.08.022. PMID: 24054023

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