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Recurrent Lung Non-Squamous Non-Small Cell Carcinoma

MedGen UID:
925836
•Concept ID:
C4288304
•
Neoplastic Process
Synonyms: Recurrent Non-Squamous Non-Small Cell Lung Cancer; Recurrent Non-Squamous Non-Small Cell Lung Carcinoma

Definition

The reemergence of non-squamous non-small cell lung carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Lung Non-Squamous Non-Small Cell Carcinoma

Professional guidelines

PubMed

The Effect of Gefitinib on Treatment Necessity and Prognosis of NSCLC Patients with Early EGFR Mutations.
Song R, Cheng Y, Zheng T
Contrast Media Mol Imaging 2022;2022:2228744. Epub 2022 Oct 11 doi: 10.1155/2022/2228744. PMID: 36304772Free PMC Article
Pemetrexed in the treatment of advanced non-squamous lung cancer.
Rossi A, Ricciardi S, Maione P, de Marinis F, Gridelli C
Lung Cancer 2009 Nov;66(2):141-9. Epub 2009 Jul 4 doi: 10.1016/j.lungcan.2009.06.006. PMID: 19577816
Targeting the VEGF pathway: antiangiogenic strategies in the treatment of non-small cell lung cancer.
Aita M, Fasola G, Defferrari C, Brianti A, Bello MG, Follador A, Sinaccio G, Pronzato P, Grossi F
Crit Rev Oncol Hematol 2008 Dec;68(3):183-96. Epub 2008 Jul 7 doi: 10.1016/j.critrevonc.2008.05.002. PMID: 18606548

Recent clinical studies

Etiology

Candidate Bevacizumab Biosimilar CT-P16 versus European Union Reference Bevacizumab in Patients with Metastatic or Recurrent Non-Small Cell Lung Cancer: A Randomized Controlled Trial.
Verschraegen C, Andric Z, Moiseenko F, Makharadze T, Shevnya S, Oleksiienko A, Yañez Ruiz E, Kim S, Ahn K, Park T, Park S, Ju H, Ohe Y
BioDrugs 2022 Nov;36(6):749-760. Epub 2022 Sep 28 doi: 10.1007/s40259-022-00552-8. PMID: 36169807Free PMC Article
Molecular testing in stage I-III non-small cell lung cancer: Approaches and challenges.
Aggarwal C, Bubendorf L, Cooper WA, Illei P, Borralho Nunes P, Ong BH, Tsao MS, Yatabe Y, Kerr KM
Lung Cancer 2021 Dec;162:42-53. Epub 2021 Sep 15 doi: 10.1016/j.lungcan.2021.09.003. PMID: 34739853
Real world outcomes in KRAS G12C mutation positive non-small cell lung cancer.
Cui W, Franchini F, Alexander M, Officer A, Wong HL, IJzerman M, Desai J, Solomon BJ
Lung Cancer 2020 Aug;146:310-317. Epub 2020 Jun 26 doi: 10.1016/j.lungcan.2020.06.030. PMID: 32619782
Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial.
Saito H, Fukuhara T, Furuya N, Watanabe K, Sugawara S, Iwasawa S, Tsunezuka Y, Yamaguchi O, Okada M, Yoshimori K, Nakachi I, Gemma A, Azuma K, Kurimoto F, Tsubata Y, Fujita Y, Nagashima H, Asai G, Watanabe S, Miyazaki M, Hagiwara K, Nukiwa T, Morita S, Kobayashi K, Maemondo M
Lancet Oncol 2019 May;20(5):625-635. Epub 2019 Apr 8 doi: 10.1016/S1470-2045(19)30035-X. PMID: 30975627
Nivolumab in advanced non-small-cell lung cancer patients who failed prior platinum-based chemotherapy.
Lee JS, Lee KH, Cho EK, Kim DW, Kim SW, Kim JH, Cho BC, Kang JH, Han JY, Min YJ, Park K
Lung Cancer 2018 Aug;122:234-242. Epub 2018 May 24 doi: 10.1016/j.lungcan.2018.05.023. PMID: 30032838

Diagnosis

Predictive value of EGFR mutation in non-small-cell lung cancer patients treated with platinum doublet postoperative chemotherapy.
Takahashi T, Sakai K, Kenmotsu H, Yoh K, Daga H, Ohira T, Ueno T, Aoki T, Hayashi H, Yamazaki K, Hosomi Y, Chen-Yoshikawa TF, Okumura N, Takiguchi Y, Sekine A, Haruki T, Yamamoto H, Sato Y, Akamatsu H, Seto T, Saeki S, Sugio K, Nishio M, Inokawa H, Yamamoto N, Nishio K, Tsuboi M
Cancer Sci 2022 Jan;113(1):287-296. Epub 2021 Nov 7 doi: 10.1111/cas.15171. PMID: 34689382Free PMC Article
Molecular testing in stage I-III non-small cell lung cancer: Approaches and challenges.
Aggarwal C, Bubendorf L, Cooper WA, Illei P, Borralho Nunes P, Ong BH, Tsao MS, Yatabe Y, Kerr KM
Lung Cancer 2021 Dec;162:42-53. Epub 2021 Sep 15 doi: 10.1016/j.lungcan.2021.09.003. PMID: 34739853
Morphological, immune and genetic features in biopsy sample associated with the efficacy of pembrolizumab in patients with non-squamous non-small cell lung cancer.
Sakai T, Udagawa H, Matsumoto S, Yoh K, Nosaki K, Ikeda T, Zenke Y, Kirita K, Niho S, Akimoto T, Goto K, Ishii G
J Cancer Res Clin Oncol 2021 Apr;147(4):1227-1237. Epub 2020 Sep 30 doi: 10.1007/s00432-020-03413-5. PMID: 32997195
Real world outcomes in KRAS G12C mutation positive non-small cell lung cancer.
Cui W, Franchini F, Alexander M, Officer A, Wong HL, IJzerman M, Desai J, Solomon BJ
Lung Cancer 2020 Aug;146:310-317. Epub 2020 Jun 26 doi: 10.1016/j.lungcan.2020.06.030. PMID: 32619782
Final results of the SENECA (SEcond line NintEdanib in non-small cell lung CAncer) trial.
Capelletto E, Migliorino MR, Morabito A, Chiari R, Grossi F, Tiseo M, Costanzo FD, Delmonte A, Romano G, Galetta D, Scotti V, Gregorc V, Pisconti S, Ceresoli GL, Del Conte A, Ciuffreda L, Colantonio I, Bria E, Ricciardi S, Manzo A, Metro G, Morelli AM, Critelli R, Pacchiana MV, Stura I, Migliaretti G, Novello S
Lung Cancer 2019 Aug;134:210-217. Epub 2019 Jun 27 doi: 10.1016/j.lungcan.2019.06.028. PMID: 31319983

Therapy

MYL-1402O: A Bevacizumab Biosimilar.
Lee A
Target Oncol 2022 Jan;17(1):85-88. Epub 2021 Dec 15 doi: 10.1007/s11523-021-00858-7. PMID: 34910269Free PMC Article
Molecular testing in stage I-III non-small cell lung cancer: Approaches and challenges.
Aggarwal C, Bubendorf L, Cooper WA, Illei P, Borralho Nunes P, Ong BH, Tsao MS, Yatabe Y, Kerr KM
Lung Cancer 2021 Dec;162:42-53. Epub 2021 Sep 15 doi: 10.1016/j.lungcan.2021.09.003. PMID: 34739853
Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial.
Saito H, Fukuhara T, Furuya N, Watanabe K, Sugawara S, Iwasawa S, Tsunezuka Y, Yamaguchi O, Okada M, Yoshimori K, Nakachi I, Gemma A, Azuma K, Kurimoto F, Tsubata Y, Fujita Y, Nagashima H, Asai G, Watanabe S, Miyazaki M, Hagiwara K, Nukiwa T, Morita S, Kobayashi K, Maemondo M
Lancet Oncol 2019 May;20(5):625-635. Epub 2019 Apr 8 doi: 10.1016/S1470-2045(19)30035-X. PMID: 30975627
Pemetrexed in the treatment of advanced non-squamous lung cancer.
Rossi A, Ricciardi S, Maione P, de Marinis F, Gridelli C
Lung Cancer 2009 Nov;66(2):141-9. Epub 2009 Jul 4 doi: 10.1016/j.lungcan.2009.06.006. PMID: 19577816
Bevacizumab in non-small cell lung cancer.
Di Costanzo F, Mazzoni F, Micol Mela M, Antonuzzo L, Checcacci D, Saggese M, Di Costanzo F
Drugs 2008;68(6):737-46. doi: 10.2165/00003495-200868060-00002. PMID: 18416583

Prognosis

Predictive value of EGFR mutation in non-small-cell lung cancer patients treated with platinum doublet postoperative chemotherapy.
Takahashi T, Sakai K, Kenmotsu H, Yoh K, Daga H, Ohira T, Ueno T, Aoki T, Hayashi H, Yamazaki K, Hosomi Y, Chen-Yoshikawa TF, Okumura N, Takiguchi Y, Sekine A, Haruki T, Yamamoto H, Sato Y, Akamatsu H, Seto T, Saeki S, Sugio K, Nishio M, Inokawa H, Yamamoto N, Nishio K, Tsuboi M
Cancer Sci 2022 Jan;113(1):287-296. Epub 2021 Nov 7 doi: 10.1111/cas.15171. PMID: 34689382Free PMC Article
Real world outcomes in KRAS G12C mutation positive non-small cell lung cancer.
Cui W, Franchini F, Alexander M, Officer A, Wong HL, IJzerman M, Desai J, Solomon BJ
Lung Cancer 2020 Aug;146:310-317. Epub 2020 Jun 26 doi: 10.1016/j.lungcan.2020.06.030. PMID: 32619782
Nivolumab in advanced non-small-cell lung cancer patients who failed prior platinum-based chemotherapy.
Lee JS, Lee KH, Cho EK, Kim DW, Kim SW, Kim JH, Cho BC, Kang JH, Han JY, Min YJ, Park K
Lung Cancer 2018 Aug;122:234-242. Epub 2018 May 24 doi: 10.1016/j.lungcan.2018.05.023. PMID: 30032838
Pemetrexed in the treatment of advanced non-squamous lung cancer.
Rossi A, Ricciardi S, Maione P, de Marinis F, Gridelli C
Lung Cancer 2009 Nov;66(2):141-9. Epub 2009 Jul 4 doi: 10.1016/j.lungcan.2009.06.006. PMID: 19577816
Emerging safety data for bevacizumab in advanced non-small-cell lung cancer.
Hirsh V
Clin Lung Cancer 2008 Mar;9 Suppl 2:S62-70. doi: 10.3816/CLC.2008.s.010. PMID: 21885001

Clinical prediction guides

Predictive value of EGFR mutation in non-small-cell lung cancer patients treated with platinum doublet postoperative chemotherapy.
Takahashi T, Sakai K, Kenmotsu H, Yoh K, Daga H, Ohira T, Ueno T, Aoki T, Hayashi H, Yamazaki K, Hosomi Y, Chen-Yoshikawa TF, Okumura N, Takiguchi Y, Sekine A, Haruki T, Yamamoto H, Sato Y, Akamatsu H, Seto T, Saeki S, Sugio K, Nishio M, Inokawa H, Yamamoto N, Nishio K, Tsuboi M
Cancer Sci 2022 Jan;113(1):287-296. Epub 2021 Nov 7 doi: 10.1111/cas.15171. PMID: 34689382Free PMC Article
Bevacizumab biosimilar LY01008 compared with bevacizumab (Avastin) as first-line treatment for Chinese patients with unresectable, metastatic, or recurrent non-squamous non-small-cell lung cancer: A multicenter, randomized, double-blinded, phase III trial.
Shi Y, Lei K, Jia Y, Ni B, He Z, Bi M, Wang X, Shi J, Zhou M, Sun Q, Wang G, Chen D, Shu Y, Liu L, Guo Z, Liu Y, Yang J, Wang K, Xiao K, Wu L, Yi T, Sun D, Kang M, Ma T, Mao Y, Shi J, Tang T, Wang Y, Xing P, Lv D, Liao W, Luo Z, Wang B, Wu X, Zhu X, Han S, Guo Q, Liu R, Lu Z, Zhang J, Fang J, Hu C, Ji Y, Liu G, Lu H, Wu D, Zhang J, Zhu S, Liu Z, Qiu W, Ye F, Yu Y, Zhao Y, Zheng Q, Chen J, Pan Z, Zhang Y, Lian W, Jiang B, Qiu B, Zhang G, Zhang H, Chen Y, Chen Y, Duan H, Li M, Liu S, Ma L, Pan H, Yuan X, Yuan X, Zheng Y, Gao E, Zhao L, Wang S, Wu C
Cancer Commun (Lond) 2021 Sep;41(9):889-903. Epub 2021 Jun 29 doi: 10.1002/cac2.12179. PMID: 34184418Free PMC Article
Real world outcomes in KRAS G12C mutation positive non-small cell lung cancer.
Cui W, Franchini F, Alexander M, Officer A, Wong HL, IJzerman M, Desai J, Solomon BJ
Lung Cancer 2020 Aug;146:310-317. Epub 2020 Jun 26 doi: 10.1016/j.lungcan.2020.06.030. PMID: 32619782
Predictive and prognostic clinical and pathological factors of nivolumab efficacy in non-small-cell lung cancer patients.
Garde-Noguera J, Martin-Martorell P, De Julián M, Perez-Altozano J, Salvador-Coloma C, García-Sanchez J, Insa-Molla A, Martín M, Mielgo-Rubio X, Marin-Liebana S, Blasco-Cordellat A, Blasco-Molla S, Gironés R, Marquez-Medina D, Aparisi F, Cerda MCB, Macia-Escalante S, Sánchez A, Juan-Vidal O
Clin Transl Oncol 2018 Aug;20(8):1072-1079. Epub 2018 Jan 24 doi: 10.1007/s12094-017-1829-5. PMID: 29368144
Pemetrexed in the treatment of advanced non-squamous lung cancer.
Rossi A, Ricciardi S, Maione P, de Marinis F, Gridelli C
Lung Cancer 2009 Nov;66(2):141-9. Epub 2009 Jul 4 doi: 10.1016/j.lungcan.2009.06.006. PMID: 19577816

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