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Lung Micropapillary Adenocarcinoma

MedGen UID:
926281
•Concept ID:
C4288749
•
Neoplastic Process

Definition

An aggressive variant of lung adenocarcinoma that exhibits a micropapillary architectural pattern. The prognosis is usually poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Micropapillary Adenocarcinoma

Professional guidelines

PubMed

Inclusion of multiple high-risk histopathological criteria improves the prediction of adjuvant chemotherapy efficacy in lung adenocarcinoma.
Sereno M, He Z, Smith CR, Baena J, Das M, Hastings RK, Rake G, Fennell DA, Nakas A, Moore DA, Le Quesne J
Histopathology 2021 May;78(6):838-848. Epub 2021 Feb 7 doi: 10.1111/his.14301. PMID: 33155719Free PMC Article
Lung adenocarcinoma with sarcomatoid transformation after tyrosine kinase inhibitor treatment and chemotherapy.
Hsieh MS, Lin MW, Lee YH
Lung Cancer 2019 Nov;137:76-84. Epub 2019 Aug 26 doi: 10.1016/j.lungcan.2019.08.029. PMID: 31561203
Micropapillary adenocarcinoma of lung: Morphological criteria and diagnostic reproducibility among pulmonary pathologists.
Monroig-Bosque PDC, Morales-Rosado JA, Roden AC, Churg A, Barrios R, Cagle P, Ge Y, Allen TC, Smith ML, Larsen BT, Sholl LM, Beasley MB, Borczuk A, Raparia K, Ayala A, Tazelaar HD, Miller R, Kalhor N, Moran CA, Ro JY
Ann Diagn Pathol 2019 Aug;41:43-50. Epub 2019 Apr 24 doi: 10.1016/j.anndiagpath.2019.04.008. PMID: 31132651

Recent clinical studies

Etiology

Evolutionary characterization of lung adenocarcinoma morphology in TRACERx.
Karasaki T, Moore DA, Veeriah S, Naceur-Lombardelli C, Toncheva A, Magno N, Ward S, Bakir MA, Watkins TBK, Grigoriadis K, Huebner A, Hill MS, Frankell AM, Abbosh C, Puttick C, Zhai H, Gimeno-Valiente F, Saghafinia S, Kanu N, Dietzen M, Pich O, Lim EL, Martínez-Ruiz C, Black JRM, Biswas D, Campbell BB, Lee C, Colliver E, Enfield KSS, Hessey S, Hiley CT, Zaccaria S, Litchfield K, Birkbak NJ, Cadieux EL, Demeulemeester J, Van Loo P, Adusumilli PS, Tan KS, Cheema W, Sanchez-Vega F, Jones DR, Rekhtman N, Travis WD, Hackshaw A, Marafioti T, Salgado R, Le Quesne J, Nicholson AG; TRACERx Consortium, McGranahan N, Swanton C, Jamal-Hanjani M
Nat Med 2023 Apr;29(4):833-845. Epub 2023 Apr 12 doi: 10.1038/s41591-023-02230-w. PMID: 37045996Free PMC Article
Feline pulmonary carcinoma: Gross, histological, metastatic, and immunohistochemical aspects.
Santos IR, Raiter J, Lamego ÉC, Bandinelli MB, Dal Pont TP, Siqueira KF, Almeida BA, Panzeira W, Sonne L, Driemeier D, Pavarini SP
Vet Pathol 2023 Jan;60(1):8-20. Epub 2022 Sep 13 doi: 10.1177/03009858221122517. PMID: 36112908
Histopathologic Basis for a Chest CT Deep Learning Survival Prediction Model in Patients with Lung Adenocarcinoma.
Nam JG, Park S, Park CM, Jeon YK, Chung DH, Goo JM, Kim YT, Kim H
Radiology 2022 Nov;305(2):441-451. Epub 2022 Jul 5 doi: 10.1148/radiol.213262. PMID: 35787198
CT-based Radiogenomic Analysis of Clinical Stage I Lung Adenocarcinoma with Histopathologic Features and Oncologic Outcomes.
Perez-Johnston R, Araujo-Filho JA, Connolly JG, Caso R, Whiting K, Tan KS, Zhou J, Gibbs P, Rekhtman N, Ginsberg MS, Jones DR
Radiology 2022 Jun;303(3):664-672. Epub 2022 Mar 1 doi: 10.1148/radiol.211582. PMID: 35230187Free PMC Article
A Grading System for Invasive Pulmonary Adenocarcinoma: A Proposal From the International Association for the Study of Lung Cancer Pathology Committee.
Moreira AL, Ocampo PSS, Xia Y, Zhong H, Russell PA, Minami Y, Cooper WA, Yoshida A, Bubendorf L, Papotti M, Pelosi G, Lopez-Rios F, Kunitoki K, Ferrari-Light D, Sholl LM, Beasley MB, Borczuk A, Botling J, Brambilla E, Chen G, Chou TY, Chung JH, Dacic S, Jain D, Hirsch FR, Hwang D, Lantuejoul S, Lin D, Longshore JW, Motoi N, Noguchi M, Poleri C, Rekhtman N, Tsao MS, Thunnissen E, Travis WD, Yatabe Y, Roden AC, Daigneault JB, Wistuba II, Kerr KM, Pass H, Nicholson AG, Mino-Kenudson M
J Thorac Oncol 2020 Oct;15(10):1599-1610. Epub 2020 Jun 17 doi: 10.1016/j.jtho.2020.06.001. PMID: 32562873Free PMC Article

Diagnosis

Feline pulmonary carcinoma: Gross, histological, metastatic, and immunohistochemical aspects.
Santos IR, Raiter J, Lamego ÉC, Bandinelli MB, Dal Pont TP, Siqueira KF, Almeida BA, Panzeira W, Sonne L, Driemeier D, Pavarini SP
Vet Pathol 2023 Jan;60(1):8-20. Epub 2022 Sep 13 doi: 10.1177/03009858221122517. PMID: 36112908
Pathological and clinical features of multiple cancers and lung adenocarcinoma: a multicentre study.
Bertoglio P, Ventura L, Aprile V, Cattoni MA, Nachira D, Lococo F, Rodriguez Perez M, Guerrera F, Minervini F, Gnetti L, Lenzini A, Franzi F, Querzoli G, Rindi G, Bellafiore S, Femia F, Bogina GS, Bacchin D, Kestenholz P, Ruffini E, Paci M, Margaritora S, Imperatori AS, Lucchi M, Ampollini L, Terzi AC
Interact Cardiovasc Thorac Surg 2022 Jun 15;35(1) doi: 10.1093/icvts/ivac047. PMID: 35188192Free PMC Article
Cribriform growth pattern in lung adenocarcinoma: More aggressive and poorer prognosis than acinar growth pattern.
Yang F, Dong Z, Shen Y, Shi J, Wu Y, Zhao Z, Jiang G, Song X
Lung Cancer 2020 Sep;147:187-192. Epub 2020 Jul 21 doi: 10.1016/j.lungcan.2020.07.021. PMID: 32721653
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Therapy

Immunogenomic profiling of lung adenocarcinoma reveals poorly differentiated tumors are associated with an immunogenic tumor microenvironment.
Akhave N, Zhang J, Bayley E, Frank M, Chiou SH, Behrens C, Chen R, Hu X, Parra ER, Lee WC, Swisher S, Solis L, Weissferdt A, Moran C, Kalhor N, Zhang J, Scheet P, Vaporciyan AA, Sepesi B, Gibbons DL, Heymach JV, Lee JJ, Wistuba II, Andrew Futreal P, Zhang J, Fujimoto J, Reuben A
Lung Cancer 2022 Oct;172:19-28. Epub 2022 Aug 10 doi: 10.1016/j.lungcan.2022.08.007. PMID: 35973335Free PMC Article
Novel Histologic Classification of Small Tumor Cell Nests for Lung Adenocarcinoma With Prognostic and Etiological Significance: Small Solid Nests and Pure Micropapillary Nests.
Saito R, Ninomiya H, Okumura S, Mun M, Sasano H, Ishikawa Y
Am J Surg Pathol 2021 May 1;45(5):604-615. doi: 10.1097/PAS.0000000000001696. PMID: 33835080
Micropapillary pattern of stage IIIA-N(2) lung adenocarcinoma is a prognostic factor after adjuvant chemoradiotherapy.
Zeng J, Cui X, Cheng L, Chen Y, Du X, Sheng L
Future Oncol 2020 Dec;16(36):3075-3084. Epub 2020 Sep 1 doi: 10.2217/fon-2020-0597. PMID: 32869661
Micropapillary adenocarcinoma of lung: Morphological criteria and diagnostic reproducibility among pulmonary pathologists.
Monroig-Bosque PDC, Morales-Rosado JA, Roden AC, Churg A, Barrios R, Cagle P, Ge Y, Allen TC, Smith ML, Larsen BT, Sholl LM, Beasley MB, Borczuk A, Raparia K, Ayala A, Tazelaar HD, Miller R, Kalhor N, Moran CA, Ro JY
Ann Diagn Pathol 2019 Aug;41:43-50. Epub 2019 Apr 24 doi: 10.1016/j.anndiagpath.2019.04.008. PMID: 31132651
New pathologic classification of lung cancer: relevance for clinical practice and clinical trials.
Travis WD, Brambilla E, Riely GJ
J Clin Oncol 2013 Mar 10;31(8):992-1001. Epub 2013 Feb 11 doi: 10.1200/JCO.2012.46.9270. PMID: 23401443

Prognosis

Histopathologic Basis for a Chest CT Deep Learning Survival Prediction Model in Patients with Lung Adenocarcinoma.
Nam JG, Park S, Park CM, Jeon YK, Chung DH, Goo JM, Kim YT, Kim H
Radiology 2022 Nov;305(2):441-451. Epub 2022 Jul 5 doi: 10.1148/radiol.213262. PMID: 35787198
CT-based Radiogenomic Analysis of Clinical Stage I Lung Adenocarcinoma with Histopathologic Features and Oncologic Outcomes.
Perez-Johnston R, Araujo-Filho JA, Connolly JG, Caso R, Whiting K, Tan KS, Zhou J, Gibbs P, Rekhtman N, Ginsberg MS, Jones DR
Radiology 2022 Jun;303(3):664-672. Epub 2022 Mar 1 doi: 10.1148/radiol.211582. PMID: 35230187Free PMC Article
A Grading System for Invasive Pulmonary Adenocarcinoma: A Proposal From the International Association for the Study of Lung Cancer Pathology Committee.
Moreira AL, Ocampo PSS, Xia Y, Zhong H, Russell PA, Minami Y, Cooper WA, Yoshida A, Bubendorf L, Papotti M, Pelosi G, Lopez-Rios F, Kunitoki K, Ferrari-Light D, Sholl LM, Beasley MB, Borczuk A, Botling J, Brambilla E, Chen G, Chou TY, Chung JH, Dacic S, Jain D, Hirsch FR, Hwang D, Lantuejoul S, Lin D, Longshore JW, Motoi N, Noguchi M, Poleri C, Rekhtman N, Tsao MS, Thunnissen E, Travis WD, Yatabe Y, Roden AC, Daigneault JB, Wistuba II, Kerr KM, Pass H, Nicholson AG, Mino-Kenudson M
J Thorac Oncol 2020 Oct;15(10):1599-1610. Epub 2020 Jun 17 doi: 10.1016/j.jtho.2020.06.001. PMID: 32562873Free PMC Article
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Clinical prediction guides

Feline pulmonary carcinoma: Gross, histological, metastatic, and immunohistochemical aspects.
Santos IR, Raiter J, Lamego ÉC, Bandinelli MB, Dal Pont TP, Siqueira KF, Almeida BA, Panzeira W, Sonne L, Driemeier D, Pavarini SP
Vet Pathol 2023 Jan;60(1):8-20. Epub 2022 Sep 13 doi: 10.1177/03009858221122517. PMID: 36112908
Histopathologic Basis for a Chest CT Deep Learning Survival Prediction Model in Patients with Lung Adenocarcinoma.
Nam JG, Park S, Park CM, Jeon YK, Chung DH, Goo JM, Kim YT, Kim H
Radiology 2022 Nov;305(2):441-451. Epub 2022 Jul 5 doi: 10.1148/radiol.213262. PMID: 35787198
CT-based Radiogenomic Analysis of Clinical Stage I Lung Adenocarcinoma with Histopathologic Features and Oncologic Outcomes.
Perez-Johnston R, Araujo-Filho JA, Connolly JG, Caso R, Whiting K, Tan KS, Zhou J, Gibbs P, Rekhtman N, Ginsberg MS, Jones DR
Radiology 2022 Jun;303(3):664-672. Epub 2022 Mar 1 doi: 10.1148/radiol.211582. PMID: 35230187Free PMC Article
A Grading System for Invasive Pulmonary Adenocarcinoma: A Proposal From the International Association for the Study of Lung Cancer Pathology Committee.
Moreira AL, Ocampo PSS, Xia Y, Zhong H, Russell PA, Minami Y, Cooper WA, Yoshida A, Bubendorf L, Papotti M, Pelosi G, Lopez-Rios F, Kunitoki K, Ferrari-Light D, Sholl LM, Beasley MB, Borczuk A, Botling J, Brambilla E, Chen G, Chou TY, Chung JH, Dacic S, Jain D, Hirsch FR, Hwang D, Lantuejoul S, Lin D, Longshore JW, Motoi N, Noguchi M, Poleri C, Rekhtman N, Tsao MS, Thunnissen E, Travis WD, Yatabe Y, Roden AC, Daigneault JB, Wistuba II, Kerr KM, Pass H, Nicholson AG, Mino-Kenudson M
J Thorac Oncol 2020 Oct;15(10):1599-1610. Epub 2020 Jun 17 doi: 10.1016/j.jtho.2020.06.001. PMID: 32562873Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Recent systematic reviews

Association between the novel classification of lung adenocarcinoma subtypes and EGFR/KRAS mutation status: A systematic literature review and pooled-data analysis.
Jiang L, Mino-Kenudson M, Roden AC, Rosell R, Molina MÁ, Flores RM, Pilz LR, Brunelli A, Venuta F, He J; AME Lung Cancer Collaborative Group
Eur J Surg Oncol 2019 May;45(5):870-876. Epub 2019 Feb 16 doi: 10.1016/j.ejso.2019.02.006. PMID: 30833014
International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger K, Yatabe Y, Powell CA, Beer D, Riely G, Garg K, Austin JH, Rusch VW, Hirsch FR, Jett J, Yang PC, Gould M; American Thoracic Society
Proc Am Thorac Soc 2011 Sep;8(5):381-5. doi: 10.1513/pats.201107-042ST. PMID: 21926387
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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