U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lobular Endocervical Glandular Hyperplasia

MedGen UID:
926345
•Concept ID:
C4288813
•
Pathologic Function
Synonym: Pyloric Gland Metaplasia

Definition

Lobular proliferations of benign-appearing small to moderate sized endocervical glands in the inner half of the cervical stroma. The glands are lined by columnar epithelial cells which contain pyloric gland-type mucin. There is minimal atypia and mitotic figures are rare. Some cases have been associated with adenocarcinoma in situ/high grade cervical glandular intraepithelial neoplasia and gastric-type adenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLobular Endocervical Glandular Hyperplasia

Professional guidelines

PubMed

Image quantification technology of the heterochromatin and euchromatin region for differential diagnosis in the lobular endocervical glandular hyperplasia.
Kimura F, Kobayashi T, Kanai R, Kobayashi Y, Yuhi O, Ota H, Yamaguchi M, Yokokawa Y, Uehara T, Ishii K
Diagn Cytopathol 2019 Jun;47(6):553-563. Epub 2019 Feb 13 doi: 10.1002/dc.24155. PMID: 30761780
Peutz-Jeghers Syndrome: Pathobiology, Pathologic Manifestations, and Suggestions for Recommending Genetic Testing in Pathology Reports.
Meserve EE, Nucci MR
Surg Pathol Clin 2016 Jun;9(2):243-68. doi: 10.1016/j.path.2016.01.006. PMID: 27241107
Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings.
Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, Kaku T, Mikami Y, Kiyokawa T, Tsuda H, Ishii K, Togashi K, Koyama T, Fujinaga Y, Kadoya M, Hashi A, Susumu N, Konishi I
Int J Gynecol Cancer 2011 Oct;21(7):1287-96. doi: 10.1097/IGC.0b013e31821f746c. PMID: 21685796

Recent clinical studies

Etiology

Limited frequency of malignant change in lobular endocervical glandular hyperplasia.
Kobara H, Miyamoto T, Ando H, Asaka R, Takatsu A, Ohya A, Asaka S, Shiozawa T
Int J Gynecol Cancer 2020 Oct;30(10):1480-1487. Epub 2020 Sep 3 doi: 10.1136/ijgc-2020-001612. PMID: 32883699Free PMC Article
Characteristic Cytological Findings of Lobular Endocervical Glandular Hyperplasia Associated with Adenocarcinoma of the Uterine Cervix.
Ishii S, Ito T, Yamada M, Yamazaki N, Ikebata K, Fujiyama J, Furuta N, Komatsu K, Takeuchi K, Sugiyama Y, Takazawa Y
Acta Cytol 2020;64(6):556-562. Epub 2020 Aug 19 doi: 10.1159/000509667. PMID: 32814324
Clinical and MRI Characteristics of Uterine Cervical Adenocarcinoma: Its Variants and Mimics.
Saida T, Sakata A, Tanaka YO, Ochi H, Ishiguro T, Sakai M, Takahashi H, Satoh T, Minami M
Korean J Radiol 2019 Mar;20(3):364-377. doi: 10.3348/kjr.2018.0458. PMID: 30799567Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447

Diagnosis

Biology and management of lobular endocervical glandular hyperplasia.
Miyamoto T, Kobara H, Shiozawa T
J Obstet Gynaecol Res 2022 Dec;48(12):3056-3067. Epub 2022 Sep 30 doi: 10.1111/jog.15441. PMID: 36177810Free PMC Article
Limited frequency of malignant change in lobular endocervical glandular hyperplasia.
Kobara H, Miyamoto T, Ando H, Asaka R, Takatsu A, Ohya A, Asaka S, Shiozawa T
Int J Gynecol Cancer 2020 Oct;30(10):1480-1487. Epub 2020 Sep 3 doi: 10.1136/ijgc-2020-001612. PMID: 32883699Free PMC Article
The Evolving Spectrum of Precursor Lesions of Cervical Adenocarcinomas.
Stolnicu S, Talia KL, McCluggage WG
Adv Anat Pathol 2020 Sep;27(5):278-293. doi: 10.1097/PAP.0000000000000266. PMID: 32482967
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Uterine cervical adenocarcinoma associated with lobular endocervical glandular hyperplasia: Radiologic-pathologic correlation.
Ohya A, Asaka S, Fujinaga Y, Kadoya M
J Obstet Gynaecol Res 2018 Feb;44(2):312-322. Epub 2017 Nov 16 doi: 10.1111/jog.13528. PMID: 29144012

Prognosis

Limited frequency of malignant change in lobular endocervical glandular hyperplasia.
Kobara H, Miyamoto T, Ando H, Asaka R, Takatsu A, Ohya A, Asaka S, Shiozawa T
Int J Gynecol Cancer 2020 Oct;30(10):1480-1487. Epub 2020 Sep 3 doi: 10.1136/ijgc-2020-001612. PMID: 32883699Free PMC Article
Clinical and MRI Characteristics of Uterine Cervical Adenocarcinoma: Its Variants and Mimics.
Saida T, Sakata A, Tanaka YO, Ochi H, Ishiguro T, Sakai M, Takahashi H, Satoh T, Minami M
Korean J Radiol 2019 Mar;20(3):364-377. doi: 10.3348/kjr.2018.0458. PMID: 30799567Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions.
Mikami Y, McCluggage WG
Adv Anat Pathol 2013 Jul;20(4):227-37. doi: 10.1097/PAP.0b013e31829c2d66. PMID: 23752085
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447

Clinical prediction guides

Ovarian Mucinous Tumor Presenting Atypical Lobular Endocervical Glandular Hyperplasia-Like Appearance in a Patient With Germline STK11 p.F354L Variant: A Case Report.
Yoshida H, Hiranuma K, Nakahara M, Kobayashi-Kato M, Tanase Y, Uno M, Shiraishi K, Ishikawa M, Kato T
Int J Surg Pathol 2024 Apr;32(2):394-400. Epub 2023 May 24 doi: 10.1177/10668969231177256. PMID: 37226494
Characteristic Cytological Findings of Lobular Endocervical Glandular Hyperplasia Associated with Adenocarcinoma of the Uterine Cervix.
Ishii S, Ito T, Yamada M, Yamazaki N, Ikebata K, Fujiyama J, Furuta N, Komatsu K, Takeuchi K, Sugiyama Y, Takazawa Y
Acta Cytol 2020;64(6):556-562. Epub 2020 Aug 19 doi: 10.1159/000509667. PMID: 32814324
Utility of imaging modalities for predicting carcinogenesis in lobular endocervical glandular hyperplasia.
Omori M, Kondo T, Tagaya H, Watanabe Y, Fukasawa H, Kawai M, Nakazawa K, Hashi A, Hirata S
PLoS One 2019;14(8):e0221088. Epub 2019 Aug 15 doi: 10.1371/journal.pone.0221088. PMID: 31415639Free PMC Article
Trefoil factor family 2 protein: a potential immunohistochemical marker for aiding diagnosis of lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix.
Asaka S, Nakajima T, Momose M, Miyamoto T, Uehara T, Ota H
Virchows Arch 2019 Jan;474(1):79-86. Epub 2018 Oct 15 doi: 10.1007/s00428-018-2469-z. PMID: 30324235
Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions.
Mikami Y, McCluggage WG
Adv Anat Pathol 2013 Jul;20(4):227-37. doi: 10.1097/PAP.0b013e31829c2d66. PMID: 23752085

Recent systematic reviews

Gastric-type adenocarcinoma of the cervix in patients with Peutz-Jeghers syndrome: a systematic review of the literature with proposed screening guidelines.
Gordhandas SB, Kahn R, Sassine D, Aviki EM, Baltich Nelson B, Catchings A, Liu YL, Lakhman Y, Abu-Rustum NR, Park KJ, Mueller JJ
Int J Gynecol Cancer 2022 Jan;32(1):79-88. Epub 2021 Dec 13 doi: 10.1136/ijgc-2021-002997. PMID: 34903560
Tissue-based Immunohistochemical Biomarker Expression in Malignant Glandular Lesions of the Uterine Cervix: A Systematic Review.
Lee S, Sahasrabuddhe VV, Mendoza-Cervantes D, Zhao R, Duggan MA
Int J Gynecol Pathol 2018 Mar;37(2):128-140. doi: 10.1097/PGP.0000000000000406. PMID: 28582347

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...