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Infant Acute Biphenotypic Leukemia

MedGen UID:
926425
•Concept ID:
C4288893
•
Neoplastic Process

Definition

An acute biphenotypic leukemia that occurs in infancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfant Acute Biphenotypic Leukemia

Professional guidelines

PubMed

Acute lymphoblastic leukemia-like treatment regimen provides better response in mixed phenotype acute leukemia: a comparative study between adults and pediatric MPAL patients.
Rasekh EO, Osman R, Ibraheem D, Madney Y, Radwan E, Gameel A, Abdelhafiz A, Kamel A, Elfishawi S
Ann Hematol 2021 Mar;100(3):699-707. Epub 2020 Nov 23 doi: 10.1007/s00277-020-04354-2. PMID: 33230570
International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia.
Hrusak O, de Haas V, Stancikova J, Vakrmanova B, Janotova I, Mejstrikova E, Capek V, Trka J, Zaliova M, Luks A, Bleckmann K, Möricke A, Irving J, Konatkowska B, Alexander TB, Inaba H, Schmiegelow K, Stokley S, Zemanova Z, Moorman AV, Rossi JG, Felice MS, Dalla-Pozza L, Morales J, Dworzak M, Buldini B, Basso G, Campbell M, Cabrera ME, Marinov N, Elitzur S, Izraeli S, Luria D, Feuerstein T, Kolenova A, Svec P, Kreminska O, Rabin KR, Polychronopoulou S, da Costa E, Marquart HV, Kattamis A, Ratei R, Reinhardt D, Choi JK, Schrappe M, Stary J
Blood 2018 Jul 19;132(3):264-276. Epub 2018 May 2 doi: 10.1182/blood-2017-12-821363. PMID: 29720486
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298

Recent clinical studies

Etiology

Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.
Orgel E, Alexander TB, Wood BL, Kahwash SB, Devidas M, Dai Y, Alonzo TA, Mullighan CG, Inaba H, Hunger SP, Raetz EA, Gamis AS, Rabin KR, Carroll AJ 3rd, Heerema NA, Berman JN, Woods WG, Loh ML, Zweidler-McKay PA, Horan JT; Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force
Cancer 2020 Feb 1;126(3):593-601. Epub 2019 Oct 29 doi: 10.1002/cncr.32552. PMID: 31661160Free PMC Article
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Immunophenotypic profile of acute leukemia: critical analysis and insights gained at a tertiary care center in India.
Gujral S, Badrinath Y, Kumar A, Subramanian PG, Raje G, Jain H, Pais A, Amre Kadam PS, Banavali SD, Arora B, Kumar P, Hari Menon VG, Kurkure PA, Parikh PM, Mahadik S, Chogule AB, Shinde SC, Nair CN
Cytometry B Clin Cytom 2009 May;76(3):199-205. doi: 10.1002/cyto.b.20451. PMID: 18803279
Cytogenetics, molecular and ultrastructural characteristics of biphenotypic acute leukemia identified by the EGIL scoring system.
Owaidah TM, Al Beihany A, Iqbal MA, Elkum N, Roberts GT
Leukemia 2006 Apr;20(4):620-6. doi: 10.1038/sj.leu.2404128. PMID: 16437134
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085

Diagnosis

Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Infant acute bilineal leukemia.
Derwich K, Sedek L, Meyer C, Pieczonka A, Dawidowska M, Gaworczyk A, Wachowiak J, Konatkowska B, Witt M, Marschalek R, Szczepański T
Leuk Res 2009 Jul;33(7):1005-8. Epub 2009 Mar 16 doi: 10.1016/j.leukres.2009.02.007. PMID: 19286255
Cytogenetics, molecular and ultrastructural characteristics of biphenotypic acute leukemia identified by the EGIL scoring system.
Owaidah TM, Al Beihany A, Iqbal MA, Elkum N, Roberts GT
Leukemia 2006 Apr;20(4):620-6. doi: 10.1038/sj.leu.2404128. PMID: 16437134
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085

Therapy

A systematic description of MLL fusion gene formation.
Wright RL, Vaughan AT
Crit Rev Oncol Hematol 2014 Sep;91(3):283-91. Epub 2014 Apr 8 doi: 10.1016/j.critrevonc.2014.03.004. PMID: 24787275
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations.
Gerr H, Zimmermann M, Schrappe M, Dworzak M, Ludwig WD, Bradtke J, Moericke A, Schabath R, Creutzig U, Reinhardt D
Br J Haematol 2010 Apr;149(1):84-92. Epub 2010 Jan 18 doi: 10.1111/j.1365-2141.2009.08058.x. PMID: 20085575
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Chromosomal translocations involving the MLL gene: molecular mechanisms.
Aplan PD
DNA Repair (Amst) 2006 Sep 8;5(9-10):1265-72. Epub 2006 Jun 21 doi: 10.1016/j.dnarep.2006.05.034. PMID: 16797254Free PMC Article

Prognosis

Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.
Orgel E, Alexander TB, Wood BL, Kahwash SB, Devidas M, Dai Y, Alonzo TA, Mullighan CG, Inaba H, Hunger SP, Raetz EA, Gamis AS, Rabin KR, Carroll AJ 3rd, Heerema NA, Berman JN, Woods WG, Loh ML, Zweidler-McKay PA, Horan JT; Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force
Cancer 2020 Feb 1;126(3):593-601. Epub 2019 Oct 29 doi: 10.1002/cncr.32552. PMID: 31661160Free PMC Article
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085
Leukemia in Down syndrome: a review.
Zipursky A, Poon A, Doyle J
Pediatr Hematol Oncol 1992 Apr-Jun;9(2):139-49. doi: 10.3109/08880019209018329. PMID: 1388043

Clinical prediction guides

Mixed Phenotype Acute Leukemia, B/Myeloid (Bilineal and Biphenotypic), With t(2;22)(q35;q12);EWSR1-FEV.
Montgomery-Goecker C, Koduru P, Botten G, Xu J, Ghisoli M, Goldman SC, Krueger J, Bhushan V, Fuda F, Chen W
J Pediatr Hematol Oncol 2021 Apr 1;43(3):e388-e394. doi: 10.1097/MPH.0000000000001934. PMID: 32925408
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085
Leukemia in Down syndrome: a review.
Zipursky A, Poon A, Doyle J
Pediatr Hematol Oncol 1992 Apr-Jun;9(2):139-49. doi: 10.3109/08880019209018329. PMID: 1388043

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