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Iatrogenic botulism

MedGen UID:
926454
Concept ID:
C4288922
Disease or Syndrome
Synonyms: accidental botulism; Iatrogenic Botulism; iatrogenic botulism; Iatrogenic infection caused by Clostridium botulinum; Inadvertent botulism; inadvertent botulism
SNOMED CT: Iatrogenic botulism (1156829005); Iatrogenic infection caused by Clostridium botulinum (1156829005)
 
Monarch Initiative: MONDO:0016778
Orphanet: ORPHA254509

Definition

Iatrogenic botulism is the most recent man-made form of botulism (see this term), a rare acquired neuromuscular junction disease with descending flaccid paralysis caused by botulinum neurotoxins (BoNTs), and it may occur as an adverse event after therapeutic or cosmetic use. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIatrogenic botulism

Professional guidelines

PubMed

Rao AK, Sobel J, Chatham-Stephens K, Luquez C
MMWR Recomm Rep 2021 May 7;70(2):1-30. doi: 10.15585/mmwr.rr7002a1. PMID: 33956777Free PMC Article
Brook I
Rev Neurol Dis 2006 Fall;3(4):182-9. PMID: 17224901

Recent clinical studies

Etiology

Hennen C, Demir S, Dafsari HS, Wunderlich G, Böll B, Hüser C, Barbe MT, Fink GR, Rueger MA
Eur J Neurol 2023 Dec;30(12):3979-3981. Epub 2023 Aug 29 doi: 10.1111/ene.16040. PMID: 37584071
Dorner MB, Wilking H, Skiba M, Wilk L, Steinberg M, Worbs S, Çeken S, Kaygusuz S, Simon S, Becher F, Mikolajewska A, Kornschober C, Bütler T, Jourdan-Da-Silva N, An der Heiden M, Schaade L, Stark K, Dorner BG, Frank C
Euro Surveill 2023 Jun;28(23) doi: 10.2807/1560-7917.ES.2023.28.23.2300203. PMID: 37289431Free PMC Article
Rashid EAMA, El-Mahdy NM, Kharoub HS, Gouda AS, ElNabarawy NA, Mégarbane B
Basic Clin Pharmacol Toxicol 2018 Nov;123(5):622-627. Epub 2018 Jun 21 doi: 10.1111/bcpt.13048. PMID: 29786953
Partikian A, Mitchell WG
J Child Neurol 2007 Oct;22(10):1235-7. doi: 10.1177/0883073807306269. PMID: 17940253

Diagnosis

Hagberg G, Skytøen ER, Nakstad I, O' Sullivan K, Koht J, Johansen TKB, Feruglio SL, Frøyshov S
Tidsskr Nor Laegeforen 2024 Feb 13;144(2) Epub 2024 Feb 12 doi: 10.4045/tidsskr.23.0625. PMID: 38349108
Rao AK, Sobel J, Chatham-Stephens K, Luquez C
MMWR Recomm Rep 2021 May 7;70(2):1-30. doi: 10.15585/mmwr.rr7002a1. PMID: 33956777Free PMC Article
Berkowitz AL
Continuum (Minneap Minn) 2018 Oct;24(5, Neuroinfectious Disease):1459-1488. doi: 10.1212/CON.0000000000000651. PMID: 30273248
Brook I
Rev Neurol Dis 2006 Fall;3(4):182-9. PMID: 17224901
Sobel J
Clin Infect Dis 2005 Oct 15;41(8):1167-73. Epub 2005 Aug 29 doi: 10.1086/444507. PMID: 16163636

Therapy

Eser F, Hasanoğlu İ, Kayaaslan B, Kaya Kalem A, Bilen Ş, Orhan G, Güner R
J Infect Dev Ctries 2024 Mar 31;18(3):480-487. doi: 10.3855/jidc.18868. PMID: 38635607
Hafeez MU, Moore M, Hafeez K, Jankovic J
Expert Rev Neurother 2021 Aug;21(8):881-894. Epub 2021 Aug 9 doi: 10.1080/14737175.2021.1958678. PMID: 34281468
Guidon AC
Continuum (Minneap Minn) 2019 Dec;25(6):1785-1806. doi: 10.1212/CON.0000000000000807. PMID: 31794471
Leonardi L, Haggiag S, Petrucci A, Lispi L
J Clin Neurosci 2019 Feb;60:138-141. Epub 2018 Oct 19 doi: 10.1016/j.jocn.2018.10.059. PMID: 30348587
Sobel J
Clin Infect Dis 2005 Oct 15;41(8):1167-73. Epub 2005 Aug 29 doi: 10.1086/444507. PMID: 16163636

Prognosis

Eser F, Hasanoğlu İ, Kayaaslan B, Kaya Kalem A, Bilen Ş, Orhan G, Güner R
J Infect Dev Ctries 2024 Mar 31;18(3):480-487. doi: 10.3855/jidc.18868. PMID: 38635607
Guidon AC
Continuum (Minneap Minn) 2019 Dec;25(6):1785-1806. doi: 10.1212/CON.0000000000000807. PMID: 31794471

Clinical prediction guides

Gonul Oner O, Gudek HC, Erturk Cetin O, Demir S
Clin Neuropharmacol 2023 Mar-Apr 01;46(2):82-84. Epub 2022 Dec 27 doi: 10.1097/WNF.0000000000000535. PMID: 36728838
Hafeez MU, Moore M, Hafeez K, Jankovic J
Expert Rev Neurother 2021 Aug;21(8):881-894. Epub 2021 Aug 9 doi: 10.1080/14737175.2021.1958678. PMID: 34281468
Rashid EAMA, El-Mahdy NM, Kharoub HS, Gouda AS, ElNabarawy NA, Mégarbane B
Basic Clin Pharmacol Toxicol 2018 Nov;123(5):622-627. Epub 2018 Jun 21 doi: 10.1111/bcpt.13048. PMID: 29786953

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