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Fallopian Tube High Grade Serous Adenocarcinoma

MedGen UID:
926492
Concept ID:
C4288960
Neoplastic Process
Synonyms: Fallopian Tube High-Grade Serous Adenocarcinoma; High Grade Fallopian Tube Serous Adenocarcinoma; High Grade Fallopian Tube Serous Carcinoma

Definition

A rapidly growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of high grade cytologic features and frequent mitotic figures. [from NCI]

Professional guidelines

PubMed

Bogaerts JMA, van Bommel MHD, Hermens RPMG, Steenbeek MP, de Hullu JA, van der Laak JAWM; STIC consortium, Simons M
Histopathology 2023 Jul;83(1):67-79. Epub 2023 Mar 20 doi: 10.1111/his.14902. PMID: 36939551
De Jaeghere E, Vandecasteele K, Claes K, Makar A, Tummers P, Cocquyt V, Denys H
Acta Clin Belg 2017 Feb;72(1):6-11. Epub 2016 May 31 doi: 10.1080/17843286.2016.1188455. PMID: 27267353
Singh N, Gilks CB, Hirschowitz L, Kehoe S, McNeish IA, Miller D, Naik R, Wilkinson N, McCluggage WG
Gynecol Oncol 2016 May;141(2):195-198. Epub 2016 Jan 28 doi: 10.1016/j.ygyno.2015.10.022. PMID: 26827965

Recent clinical studies

Etiology

Lahtinen A, Lavikka K, Virtanen A, Li Y, Jamalzadeh S, Skorda A, Lauridsen AR, Zhang K, Marchi G, Isoviita VM, Ariotta V, Lehtonen O, Muranen TA, Huhtinen K, Carpén O, Hietanen S, Senkowski W, Kallunki T, Häkkinen A, Hynninen J, Oikkonen J, Hautaniemi S
Cancer Cell 2023 Jun 12;41(6):1103-1117.e12. Epub 2023 May 18 doi: 10.1016/j.ccell.2023.04.017. PMID: 37207655
Vang R, Shih IM
Histopathology 2022 Nov;81(5):542-555. Epub 2022 Aug 4 doi: 10.1111/his.14722. PMID: 35859323
Steenbeek MP, Bulten J, Snijders MPLM, Lombaers M, Hendriks J, van den Brand M, Kraayenbrink AA, Massuger LFAG, Sweegers S, de Hullu JA, Pijnenborg JMA, Küsters-Vandevelde HVN, Reijnen C
Gynecol Oncol 2020 Aug;158(2):339-346. Epub 2020 May 12 doi: 10.1016/j.ygyno.2020.04.707. PMID: 32409160
Kohn EC, Ivy SP
Am Soc Clin Oncol Educ Book 2017;37:443-448. doi: 10.1200/EDBK_174718. PMID: 28561656
Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190Free PMC Article

Diagnosis

Lahtinen A, Lavikka K, Virtanen A, Li Y, Jamalzadeh S, Skorda A, Lauridsen AR, Zhang K, Marchi G, Isoviita VM, Ariotta V, Lehtonen O, Muranen TA, Huhtinen K, Carpén O, Hietanen S, Senkowski W, Kallunki T, Häkkinen A, Hynninen J, Oikkonen J, Hautaniemi S
Cancer Cell 2023 Jun 12;41(6):1103-1117.e12. Epub 2023 May 18 doi: 10.1016/j.ccell.2023.04.017. PMID: 37207655
Shih IM, Wang Y, Wang TL
Am J Pathol 2021 Jan;191(1):26-39. Epub 2020 Oct 1 doi: 10.1016/j.ajpath.2020.09.006. PMID: 33011111Free PMC Article
Micek HM, Visetsouk MR, Fleszar AJ, Kreeger PK
Adv Exp Med Biol 2020;1296:199-213. doi: 10.1007/978-3-030-59038-3_12. PMID: 34185294Free PMC Article
Kolin DL, Nucci MR
Surg Pathol Clin 2019 Jun;12(2):457-479. doi: 10.1016/j.path.2019.01.006. PMID: 31097111
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480

Therapy

Zwimpfer TA, Tal O, Geissler F, Coelho R, Rimmer N, Jacob F, Heinzelmann-Schwarz V
Cancer Treat Rev 2023 Jan;112:102497. Epub 2022 Dec 10 doi: 10.1016/j.ctrv.2022.102497. PMID: 36525716
Casey L, Singh N
Surg Pathol Clin 2019 Jun;12(2):515-528. doi: 10.1016/j.path.2019.01.007. PMID: 31097113
Kroeger PT Jr, Drapkin R
Curr Opin Obstet Gynecol 2017 Feb;29(1):26-34. doi: 10.1097/GCO.0000000000000340. PMID: 27898521Free PMC Article
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480
Salvador S, Gilks B, Köbel M, Huntsman D, Rosen B, Miller D
Int J Gynecol Cancer 2009 Jan;19(1):58-64. doi: 10.1111/IGC.0b013e318199009c. PMID: 19258943

Prognosis

Chien YW, Wang Y, Huang P, Lawson BC, Kolin DL, Chui MH, Vang R, Numan TA, Soong TR, Wang BG, Smith SA, Chen CL, Stone R, Douville C, Wang TL, Shih IM
Am J Surg Pathol 2024 Apr 1;48(4):475-486. Epub 2024 Feb 1 doi: 10.1097/PAS.0000000000002187. PMID: 38298022Free PMC Article
Lecker LSM, Berlato C, Maniati E, Delaine-Smith R, Pearce OMT, Heath O, Nichols SJ, Trevisan C, Novak M, McDermott J, Brenton JD, Cutillas PR, Rajeeve V, Hennino A, Drapkin R, Loessner D, Balkwill FR
Cancer Res 2021 Nov 15;81(22):5706-5719. Epub 2021 Sep 24 doi: 10.1158/0008-5472.CAN-21-0536. PMID: 34561272Free PMC Article
Micek HM, Visetsouk MR, Fleszar AJ, Kreeger PK
Adv Exp Med Biol 2020;1296:199-213. doi: 10.1007/978-3-030-59038-3_12. PMID: 34185294Free PMC Article
Kohn EC, Ivy SP
Am Soc Clin Oncol Educ Book 2017;37:443-448. doi: 10.1200/EDBK_174718. PMID: 28561656
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480

Clinical prediction guides

Chien YW, Wang Y, Huang P, Lawson BC, Kolin DL, Chui MH, Vang R, Numan TA, Soong TR, Wang BG, Smith SA, Chen CL, Stone R, Douville C, Wang TL, Shih IM
Am J Surg Pathol 2024 Apr 1;48(4):475-486. Epub 2024 Feb 1 doi: 10.1097/PAS.0000000000002187. PMID: 38298022Free PMC Article
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
Otsuka I
Int J Mol Sci 2021 Apr 23;22(9) doi: 10.3390/ijms22094409. PMID: 33922503Free PMC Article
Kohn EC, Ivy SP
Am Soc Clin Oncol Educ Book 2017;37:443-448. doi: 10.1200/EDBK_174718. PMID: 28561656
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480

Recent systematic reviews

Ruel-Laliberté J, Kasasni SM, Oprea D, Viau M
J Obstet Gynaecol Can 2022 Nov;44(11):1174-1180. Epub 2022 Sep 12 doi: 10.1016/j.jogc.2022.08.018. PMID: 36099965
Steenbeek MP, van Bommel MHD, Bulten J, Hulsmann JA, Bogaerts J, Garcia C, Cun HT, Lu KH, van Beekhuizen HJ, Minig L, Gaarenstroom KN, Nobbenhuis M, Krajc M, Rudaitis V, Norquist BM, Swisher EM, Mourits MJE, Massuger LFAG, Hoogerbrugge N, Hermens RPMG, IntHout J, de Hullu JA
J Clin Oncol 2022 Jun 10;40(17):1879-1891. Epub 2022 Mar 18 doi: 10.1200/JCO.21.02016. PMID: 35302882Free PMC Article
Bogaerts JMA, Steenbeek MP, van Bommel MHD, Bulten J, van der Laak JAWM, de Hullu JA, Simons M
Virchows Arch 2022 Apr;480(4):725-737. Epub 2021 Dec 1 doi: 10.1007/s00428-021-03244-w. PMID: 34850262Free PMC Article

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