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Somatotroph-Lactotroph Pituitary Neuroendocrine Tumor

MedGen UID:
926557
•Concept ID:
C4289025
•
Neoplastic Process
Synonyms: Growth Hormone and Prolactin-Producing Adenoma; Somatotroph-Lactotroph PitNET/Adenoma; Somatotroph-Lactotroph Pituitary Neuroendocrine Tumor/Adenoma; Somatotroph/Lactotroph Adenoma

Definition

A pituitary neuroendocrine tumor that produces both growth hormone and prolactin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSomatotroph-Lactotroph Pituitary Neuroendocrine Tumor

Professional guidelines

PubMed

High-risk pituitary adenomas and strategies for predicting response to treatment.
Kontogeorgos G, Thodou E, Osamura RY, Lloyd RV
Hormones (Athens) 2022 Mar;21(1):1-14. Epub 2022 Jan 21 doi: 10.1007/s42000-021-00333-y. PMID: 35061210

Recent clinical studies

Etiology

Refractory Pit1 plurihormonal tumours and thyrotroph adenomas.
Nf L, Ai M
Pituitary 2023 Apr;26(2):182-186. Epub 2023 Apr 29 doi: 10.1007/s11102-023-01312-9. PMID: 37117845Free PMC Article
Post-operative surveillance for somatotroph, lactotroph and non-functional pituitary adenomas after curative resection: a systematic review.
Caulley L, Whelan J, Khoury M, Mavedatnia D, Sahlollbey N, Amrani L, Eid A, Doyle MA, Malcolm J, Alkherayf F, Ramsay T, Moher D, Johnson-Obaseki S, Schramm D, Hunink MGM, Kilty SJ
Pituitary 2023 Feb;26(1):73-93. Epub 2022 Nov 23 doi: 10.1007/s11102-022-01289-x. PMID: 36422846
Outcome of giant pituitary tumors requiring surgery.
Gaillard S, Adeniran S, Villa C, Jouinot A, Raffin-Sanson ML, Feuvret L, Verrelle P, Bonnet F, Dohan A, Bertherat J, Assié G, Baussart B
Front Endocrinol (Lausanne) 2022;13:975560. Epub 2022 Aug 29 doi: 10.3389/fendo.2022.975560. PMID: 36105410Free PMC Article
High-risk pituitary adenomas and strategies for predicting response to treatment.
Kontogeorgos G, Thodou E, Osamura RY, Lloyd RV
Hormones (Athens) 2022 Mar;21(1):1-14. Epub 2022 Jan 21 doi: 10.1007/s42000-021-00333-y. PMID: 35061210
Mammosomatotroph and mixed somatotroph-lactotroph adenoma in acromegaly: a retrospective study with long-term follow-up.
Lv L, Jiang Y, Yin S, Hu Y, Chen C, Ma W, Jiang S, Zhou P
Endocrine 2019 Nov;66(2):310-318. Epub 2019 Jul 31 doi: 10.1007/s12020-019-02029-1. PMID: 31368083

Diagnosis

Outcome of giant pituitary tumors requiring surgery.
Gaillard S, Adeniran S, Villa C, Jouinot A, Raffin-Sanson ML, Feuvret L, Verrelle P, Bonnet F, Dohan A, Bertherat J, Assié G, Baussart B
Front Endocrinol (Lausanne) 2022;13:975560. Epub 2022 Aug 29 doi: 10.3389/fendo.2022.975560. PMID: 36105410Free PMC Article
High-risk pituitary adenomas and strategies for predicting response to treatment.
Kontogeorgos G, Thodou E, Osamura RY, Lloyd RV
Hormones (Athens) 2022 Mar;21(1):1-14. Epub 2022 Jan 21 doi: 10.1007/s42000-021-00333-y. PMID: 35061210
Liver metastases from pituitary carcinomas mimicking visceral well-differentiated neuroendocrine tumors: a series of four cases.
Venable ER, Kerr SE, Lopes MBS, Jones KA, Bellizzi AM, Mounajjed T, Raghunathan A, Hamidi O, Halfdanarson TR, Ryder M, Graham RP
Diagn Pathol 2020 Jul 4;15(1):81. doi: 10.1186/s13000-020-00997-x. PMID: 32622369Free PMC Article
GATA3 immunoreactivity expands the transcription factor profile of pituitary neuroendocrine tumors.
Mete O, Kefeli M, Çalışkan S, Asa SL
Mod Pathol 2019 Apr;32(4):484-489. Epub 2018 Nov 2 doi: 10.1038/s41379-018-0167-7. PMID: 30390035
Clinically non-functioning pituitary adenoma.
Jaffe CA
Pituitary 2006;9(4):317-21. doi: 10.1007/s11102-006-0412-9. PMID: 17082898

Therapy

Improvement of metabolic syndrome and its components in patients who underwent transsphenoidal resection for pituitary adenoma.
Cortés-Contreras AP, Salazar-Pigeon A, González-Almazán JA, Flores-Rabasa R, Navarro-Olvera JL, Méndez-García LA, Carrillo-Ruiz JD
Acta Neurochir (Wien) 2024 Feb 16;166(1):86. doi: 10.1007/s00701-024-05938-x. PMID: 38363400
Pituitary Adenomas in Transgender Individuals?
Kleinschmidt-DeMasters BK
J Neuropathol Exp Neurol 2020 Jan 1;79(1):62-66. doi: 10.1093/jnen/nlz118. PMID: 31769844
Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation.
Zimmerman D, Young WF Jr, Ebersold MJ, Scheithauer BW, Kovacs K, Horvath E, Whitaker MD, Eberhardt NL, Downs TR, Frohman LA
J Clin Endocrinol Metab 1993 Jan;76(1):216-22. doi: 10.1210/jcem.76.1.8421089. PMID: 8421089

Prognosis

High-risk pituitary adenomas and strategies for predicting response to treatment.
Kontogeorgos G, Thodou E, Osamura RY, Lloyd RV
Hormones (Athens) 2022 Mar;21(1):1-14. Epub 2022 Jan 21 doi: 10.1007/s42000-021-00333-y. PMID: 35061210
Mammosomatotroph and mixed somatotroph-lactotroph adenoma in acromegaly: a retrospective study with long-term follow-up.
Lv L, Jiang Y, Yin S, Hu Y, Chen C, Ma W, Jiang S, Zhou P
Endocrine 2019 Nov;66(2):310-318. Epub 2019 Jul 31 doi: 10.1007/s12020-019-02029-1. PMID: 31368083
p53 expression in pituitary adenomas and carcinomas: correlation with invasiveness and tumor growth fractions.
Thapar K, Scheithauer BW, Kovacs K, Pernicone PJ, Laws ER Jr
Neurosurgery 1996 Apr;38(4):765-70; discussion 770-1. PMID: 8692397

Clinical prediction guides

Post-operative surveillance for somatotroph, lactotroph and non-functional pituitary adenomas after curative resection: a systematic review.
Caulley L, Whelan J, Khoury M, Mavedatnia D, Sahlollbey N, Amrani L, Eid A, Doyle MA, Malcolm J, Alkherayf F, Ramsay T, Moher D, Johnson-Obaseki S, Schramm D, Hunink MGM, Kilty SJ
Pituitary 2023 Feb;26(1):73-93. Epub 2022 Nov 23 doi: 10.1007/s11102-022-01289-x. PMID: 36422846
High-risk pituitary adenomas and strategies for predicting response to treatment.
Kontogeorgos G, Thodou E, Osamura RY, Lloyd RV
Hormones (Athens) 2022 Mar;21(1):1-14. Epub 2022 Jan 21 doi: 10.1007/s42000-021-00333-y. PMID: 35061210
Immune Landscape of Pituitary Tumors Reveals Association Between Macrophages and Gonadotroph Tumor Invasion.
Principe M, Chanal M, Ilie MD, Ziverec A, Vasiljevic A, Jouanneau E, Hennino A, Raverot G, Bertolino P
J Clin Endocrinol Metab 2020 Nov 1;105(11) doi: 10.1210/clinem/dgaa520. PMID: 32785693
Mammosomatotroph and mixed somatotroph-lactotroph adenoma in acromegaly: a retrospective study with long-term follow-up.
Lv L, Jiang Y, Yin S, Hu Y, Chen C, Ma W, Jiang S, Zhou P
Endocrine 2019 Nov;66(2):310-318. Epub 2019 Jul 31 doi: 10.1007/s12020-019-02029-1. PMID: 31368083
cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors.
Bolger GB, Bizzi MF, Pinheiro SV, Trivellin G, Smoot L, Accavitti MA, Korbonits M, Ribeiro-Oliveira A Jr
Endocr Relat Cancer 2016 May;23(5):419-31. doi: 10.1530/ERC-15-0205. PMID: 27267386Free PMC Article

Recent systematic reviews

Post-operative surveillance for somatotroph, lactotroph and non-functional pituitary adenomas after curative resection: a systematic review.
Caulley L, Whelan J, Khoury M, Mavedatnia D, Sahlollbey N, Amrani L, Eid A, Doyle MA, Malcolm J, Alkherayf F, Ramsay T, Moher D, Johnson-Obaseki S, Schramm D, Hunink MGM, Kilty SJ
Pituitary 2023 Feb;26(1):73-93. Epub 2022 Nov 23 doi: 10.1007/s11102-022-01289-x. PMID: 36422846

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