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Gingival Spindle Cell Carcinoma

MedGen UID:
926567
•Concept ID:
C4289035
•
Neoplastic Process

Definition

A poorly differentiated squamous cell carcinoma that arises from the gingiva. It is characterized by the presence of malignant pleomorphic spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGingival Spindle Cell Carcinoma

Professional guidelines

PubMed

Dental Implant Treatment in Patients Suffering from Oral Lichen Planus: A Narrative Review.
Górski B
Int J Environ Res Public Health 2022 Jul 9;19(14) doi: 10.3390/ijerph19148397. PMID: 35886246Free PMC Article
Management of gingivobuccal complex cancer.
Misra S, Chaturvedi A, Misra NC
Ann R Coll Surg Engl 2008 Oct;90(7):546-53. Epub 2008 Aug 12 doi: 10.1308/003588408X301136. PMID: 18701010Free PMC Article
Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival.
Brandwein-Gensler M, Teixeira MS, Lewis CM, Lee B, Rolnitzky L, Hille JJ, Genden E, Urken ML, Wang BY
Am J Surg Pathol 2005 Feb;29(2):167-78. doi: 10.1097/01.pas.0000149687.90710.21. PMID: 15644773

Recent clinical studies

Etiology

Orofacial Anomalies in Kindler Epidermolysis Bullosa.
Krämer S, Hillebrecht AL, Wang Y, Badea MA, Barrios JI, Danescu S, Fuentes I, Kartal D, Klausegger A, Ponce de León E, Schilke R, Yordanova I, Bloch-Zupan A, Has C
JAMA Dermatol 2024 May 1;160(5):544-549. doi: 10.1001/jamadermatol.2024.0065. PMID: 38506824Free PMC Article
Progression to malignancy in oral potentially malignant disorders: a retrospective study of 5,036 patients in Ontario, Canada.
McCord C, Achita P, Kiss A, Magalhaes MA, Darling M, Bradley G
Oral Surg Oral Med Oral Pathol Oral Radiol 2023 Oct;136(4):466-477. Epub 2023 Jun 13 doi: 10.1016/j.oooo.2023.06.006. PMID: 37563059
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival.
Brandwein-Gensler M, Teixeira MS, Lewis CM, Lee B, Rolnitzky L, Hille JJ, Genden E, Urken ML, Wang BY
Am J Surg Pathol 2005 Feb;29(2):167-78. doi: 10.1097/01.pas.0000149687.90710.21. PMID: 15644773

Diagnosis

Giant cell epulis.
Tchernev G, Kandathil LJ, Oliveira N
Wien Med Wochenschr 2023 Sep;173(11-12):249-250. Epub 2021 Nov 4 doi: 10.1007/s10354-021-00894-y. PMID: 34735668
Comprehensive analyses of intraoral spindle cell carcinoma: A rare disease entity revisited.
Sang L, Dai Y, Hu J, Zhu Y, Xu L, Zhang W, Cheng J
Oral Dis 2023 Mar;29(2):686-695. Epub 2021 Oct 7 doi: 10.1111/odi.14037. PMID: 34592043
Role of Salivary Biomarkers in Oral Cancer Detection.
Khurshid Z, Zafar MS, Khan RS, Najeeb S, Slowey PD, Rehman IU
Adv Clin Chem 2018;86:23-70. Epub 2018 Jul 23 doi: 10.1016/bs.acc.2018.05.002. PMID: 30144841
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499

Therapy

Health risks for body pierced community: a systematic review.
Sindoni A, Valeriani F, Protano C, Liguori G, Romano Spica V, Vitali M, Gallè F
Public Health 2022 Apr;205:202-215. Epub 2022 Mar 24 doi: 10.1016/j.puhe.2022.01.035. PMID: 35339940
Clinicopathologic evaluation of malignancy adjacent to dental implants.
Kaplan I, Zeevi I, Tal H, Rosenfeld E, Chaushu G
Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jan;123(1):103-112. Epub 2016 Sep 9 doi: 10.1016/j.oooo.2016.08.023. PMID: 27720649
Evaluation of the Effects of Dental Implants on Oral Lesions.
Agha-Hosseini F, Rohani B
J Contemp Dent Pract 2015 May 1;16(5):400-6. doi: 10.5005/jp-journals-10024-1697. PMID: 26162261
Peno-gingival lichen planus.
Petruzzi M, De Benedittis M, Pastore L, Grassi FR, Serpico R
J Periodontol 2005 Dec;76(12):2293-8. doi: 10.1902/jop.2005.76.12.2293. PMID: 16332242
Collagenase.
Mandl I
Science 1970 Sep 18;169(3951):1234-8. doi: 10.1126/science.169.3951.1234. PMID: 4317926

Prognosis

Comprehensive analyses of intraoral spindle cell carcinoma: A rare disease entity revisited.
Sang L, Dai Y, Hu J, Zhu Y, Xu L, Zhang W, Cheng J
Oral Dis 2023 Mar;29(2):686-695. Epub 2021 Oct 7 doi: 10.1111/odi.14037. PMID: 34592043
Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
Role of Salivary Biomarkers in Oral Cancer Detection.
Khurshid Z, Zafar MS, Khan RS, Najeeb S, Slowey PD, Rehman IU
Adv Clin Chem 2018;86:23-70. Epub 2018 Jul 23 doi: 10.1016/bs.acc.2018.05.002. PMID: 30144841
Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.
Zhang WB, Peng X
Head Neck 2016 Apr;38 Suppl 1:E2335-42. Epub 2016 Feb 18 doi: 10.1002/hed.24274. PMID: 26890607
Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival.
Brandwein-Gensler M, Teixeira MS, Lewis CM, Lee B, Rolnitzky L, Hille JJ, Genden E, Urken ML, Wang BY
Am J Surg Pathol 2005 Feb;29(2):167-78. doi: 10.1097/01.pas.0000149687.90710.21. PMID: 15644773

Clinical prediction guides

Understanding exosomes: Part 3-therapeutic + diagnostic potential in dentistry.
Miron RJ, Estrin NE, Sculean A, Zhang Y
Periodontol 2000 2024 Feb;94(1):415-482. Epub 2024 Mar 28 doi: 10.1111/prd.12557. PMID: 38546137
Orofacial Anomalies in Kindler Epidermolysis Bullosa.
Krämer S, Hillebrecht AL, Wang Y, Badea MA, Barrios JI, Danescu S, Fuentes I, Kartal D, Klausegger A, Ponce de León E, Schilke R, Yordanova I, Bloch-Zupan A, Has C
JAMA Dermatol 2024 May 1;160(5):544-549. doi: 10.1001/jamadermatol.2024.0065. PMID: 38506824Free PMC Article
A New Look at the History of Peripheral Ameloblastoma.
Ide F, Ito Y, Miyazaki Y, Nishimura M, Kusama K, Kikuchi K
Head Neck Pathol 2020 Dec;14(4):1052-1057. Epub 2020 May 25 doi: 10.1007/s12105-020-01168-6. PMID: 32451874Free PMC Article
Clinical analysis of second primary gingival squamous cell carcinoma after radiotherapy.
Fu X, Chen S, Chen W, Yang Z, Song M, Li H, Zhang H, Yao F, Su X, Liu T, Yang AK
Oral Oncol 2018 Sep;84:20-24. Epub 2018 Jun 30 doi: 10.1016/j.oraloncology.2018.06.018. PMID: 30115471
Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival.
Brandwein-Gensler M, Teixeira MS, Lewis CM, Lee B, Rolnitzky L, Hille JJ, Genden E, Urken ML, Wang BY
Am J Surg Pathol 2005 Feb;29(2):167-78. doi: 10.1097/01.pas.0000149687.90710.21. PMID: 15644773

Recent systematic reviews

Occult metastases of oral maxillary squamous cell carcinoma: Systematic review and meta-analysis.
de la Fuente C, Prat-Valero N, Alberola-Ferranti M, Mis-Castell D, Sáez-Barba M, Pujol-Pina R, Pamias-Romero J, Bescós-Atín C
Head Neck 2023 Mar;45(3):733-744. Epub 2022 Dec 14 doi: 10.1002/hed.27276. PMID: 36515647
Health risks for body pierced community: a systematic review.
Sindoni A, Valeriani F, Protano C, Liguori G, Romano Spica V, Vitali M, Gallè F
Public Health 2022 Apr;205:202-215. Epub 2022 Mar 24 doi: 10.1016/j.puhe.2022.01.035. PMID: 35339940
Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
Peripheral odontogenic keratocyst: Clinicopathological and immunohistochemical characterization.
Lafuente-Ibáñez de Mendoza I, Aguirre-Urizar JM, Villatoro-Ugalde V, Magaña-Quiñones JJ, Lana-Ojeda J, Mosqueda-Taylor A
Oral Dis 2022 May;28(4):1198-1206. Epub 2021 Mar 21 doi: 10.1111/odi.13834. PMID: 33682271
Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.
Zhang WB, Peng X
Head Neck 2016 Apr;38 Suppl 1:E2335-42. Epub 2016 Feb 18 doi: 10.1002/hed.24274. PMID: 26890607

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