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Gemistocytic Astrocytoma, IDH-Mutant

MedGen UID:
926575
Concept ID:
C4289043
Neoplastic Process

Definition

Gemistocytic astrocytoma carrying IDH mutations. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGemistocytic Astrocytoma, IDH-Mutant

Professional guidelines

PubMed

van den Bent MJ
Rev Neurol (Paris) 2023 Jun;179(5):425-429. Epub 2023 Apr 5 doi: 10.1016/j.neurol.2023.03.001. PMID: 37029057
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Brat DJ, Aldape K, Colman H, Figrarella-Branger D, Fuller GN, Giannini C, Holland EC, Jenkins RB, Kleinschmidt-DeMasters B, Komori T, Kros JM, Louis DN, McLean C, Perry A, Reifenberger G, Sarkar C, Stupp R, van den Bent MJ, von Deimling A, Weller M
Acta Neuropathol 2020 Mar;139(3):603-608. Epub 2020 Jan 29 doi: 10.1007/s00401-020-02127-9. PMID: 31996992Free PMC Article

Recent clinical studies

Etiology

Demirdizen E, Al-Ali R, Narayanan A, Sun X, Varga JP, Steffl B, Brom M, Krunic D, Schmidt C, Schmidt G, Bestvater F, Taranda J, Turcan Ş
Neuro Oncol 2023 Jun 2;25(6):1031-1043. doi: 10.1093/neuonc/noac233. PMID: 36215168Free PMC Article
Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN
JAMA Oncol 2022 Oct 1;8(10):1493-1501. doi: 10.1001/jamaoncol.2022.2844. PMID: 36006639
Komori T
Lab Invest 2022 Feb;102(2):126-133. Epub 2021 Sep 9 doi: 10.1038/s41374-021-00667-6. PMID: 34504304
Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, Koelsche C, Wefers A, Reinhardt A, Huang K, Sievers P, Shimizu H, Nanjo H, Kobayashi Y, Miyake Y, Suzuki T, Adachi JI, Mishima K, Sasaki A, Nishikawa R, Bewerunge-Hudler M, Ryzhova M, Absalyamova O, Golanov A, Sinn P, Platten M, Jungk C, Winkler F, Wick A, Hänggi D, Unterberg A, Pfister SM, Jones DTW, van den Bent M, Hegi M, French P, Baumert BG, Stupp R, Gorlia T, Weller M, Capper D, Korshunov A, Herold-Mende C, Wick W, Louis DN, von Deimling A
Acta Neuropathol 2018 Jul;136(1):153-166. Epub 2018 Apr 23 doi: 10.1007/s00401-018-1849-4. PMID: 29687258
Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG Jr, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH; TCGA Research Network, Noushmehr H, Iavarone A, Verhaak RG
Cell 2016 Jan 28;164(3):550-63. doi: 10.1016/j.cell.2015.12.028. PMID: 26824661Free PMC Article

Diagnosis

Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, Reifenberger G
Nat Rev Dis Primers 2024 May 9;10(1):33. doi: 10.1038/s41572-024-00516-y. PMID: 38724526
de la Fuente MI
Continuum (Minneap Minn) 2023 Dec 1;29(6):1662-1679. doi: 10.1212/CON.0000000000001352. PMID: 38085893
van den Bent MJ
Rev Neurol (Paris) 2023 Jun;179(5):425-429. Epub 2023 Apr 5 doi: 10.1016/j.neurol.2023.03.001. PMID: 37029057
Horbinski C, Nabors LB, Portnow J, Baehring J, Bhatia A, Bloch O, Brem S, Butowski N, Cannon DM, Chao S, Chheda MG, Fabiano AJ, Forsyth P, Gigilio P, Hattangadi-Gluth J, Holdhoff M, Junck L, Kaley T, Merrell R, Mrugala MM, Nagpal S, Nedzi LA, Nevel K, Nghiemphu PL, Parney I, Patel TR, Peters K, Puduvalli VK, Rockhill J, Rusthoven C, Shonka N, Swinnen LJ, Weiss S, Wen PY, Willmarth NE, Bergman MA, Darlow S
J Natl Compr Canc Netw 2023 Jan;21(1):12-20. doi: 10.6004/jnccn.2023.0002. PMID: 36634606
Śledzińska P, Bebyn MG, Furtak J, Kowalewski J, Lewandowska MA
Int J Mol Sci 2021 Sep 26;22(19) doi: 10.3390/ijms221910373. PMID: 34638714Free PMC Article

Therapy

Lamb YN
Drugs 2024 Oct;84(10):1325-1331. Epub 2024 Oct 8 doi: 10.1007/s40265-024-02097-2. PMID: 39375303
Liu J, Hu S, Jiang H, Cui Y
Front Immunol 2024;15:1369972. Epub 2024 Apr 4 doi: 10.3389/fimmu.2024.1369972. PMID: 38690285Free PMC Article
Hervey-Jumper SL, Zhang Y, Phillips JJ, Morshed RA, Young JS, McCoy L, Lafontaine M, Luks T, Ammanuel S, Kakaizada S, Egladyous A, Gogos A, Villanueva-Meyer J, Shai A, Warrier G, Rice T, Crane J, Wrensch M, Wiencke JK, Daras M, Oberheim Bush NA, Taylor JW, Butowski N, Clarke J, Chang S, Chang E, Aghi M, Theodosopoulos P, McDermott M, Jakola AS, Kavouridis VK, Nawabi N, Solheim O, Smith T, Berger MS, Molinaro AM
J Clin Oncol 2023 Apr 10;41(11):2029-2042. Epub 2023 Jan 4 doi: 10.1200/JCO.21.02929. PMID: 36599113Free PMC Article
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Śledzińska P, Bebyn MG, Furtak J, Kowalewski J, Lewandowska MA
Int J Mol Sci 2021 Sep 26;22(19) doi: 10.3390/ijms221910373. PMID: 34638714Free PMC Article

Prognosis

Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, Reifenberger G
Nat Rev Dis Primers 2024 May 9;10(1):33. doi: 10.1038/s41572-024-00516-y. PMID: 38724526
de la Fuente MI
Continuum (Minneap Minn) 2023 Dec 1;29(6):1662-1679. doi: 10.1212/CON.0000000000001352. PMID: 38085893
Park JW
Int J Mol Sci 2023 Apr 16;24(8) doi: 10.3390/ijms24087348. PMID: 37108511Free PMC Article
van den Bent MJ
Rev Neurol (Paris) 2023 Jun;179(5):425-429. Epub 2023 Apr 5 doi: 10.1016/j.neurol.2023.03.001. PMID: 37029057
Śledzińska P, Bebyn MG, Furtak J, Kowalewski J, Lewandowska MA
Int J Mol Sci 2021 Sep 26;22(19) doi: 10.3390/ijms221910373. PMID: 34638714Free PMC Article

Clinical prediction guides

Wang W, Li T, Cheng Y, Li F, Qi S, Mao M, Wu J, Liu Q, Zhang X, Li X, Zhang L, Qi H, Yang L, Yang K, He Z, Ding S, Qin Z, Yang Y, Yang X, Luo C, Guo Y, Wang C, Liu X, Zhou L, Liu Y, Kong W, Miao J, Ye S, Luo M, An L, Wang L, Che L, Niu Q, Ma Q, Zhang X, Zhang Z, Hu R, Feng H, Ping YF, Bian XW, Shi Y
Cancer Cell 2024 May 13;42(5):815-832.e12. Epub 2024 Apr 18 doi: 10.1016/j.ccell.2024.03.013. PMID: 38640932
Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN
JAMA Oncol 2022 Oct 1;8(10):1493-1501. doi: 10.1001/jamaoncol.2022.2844. PMID: 36006639
Śledzińska P, Bebyn MG, Furtak J, Kowalewski J, Lewandowska MA
Int J Mol Sci 2021 Sep 26;22(19) doi: 10.3390/ijms221910373. PMID: 34638714Free PMC Article
Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, Koelsche C, Wefers A, Reinhardt A, Huang K, Sievers P, Shimizu H, Nanjo H, Kobayashi Y, Miyake Y, Suzuki T, Adachi JI, Mishima K, Sasaki A, Nishikawa R, Bewerunge-Hudler M, Ryzhova M, Absalyamova O, Golanov A, Sinn P, Platten M, Jungk C, Winkler F, Wick A, Hänggi D, Unterberg A, Pfister SM, Jones DTW, van den Bent M, Hegi M, French P, Baumert BG, Stupp R, Gorlia T, Weller M, Capper D, Korshunov A, Herold-Mende C, Wick W, Louis DN, von Deimling A
Acta Neuropathol 2018 Jul;136(1):153-166. Epub 2018 Apr 23 doi: 10.1007/s00401-018-1849-4. PMID: 29687258
Aldape K, Zadeh G, Mansouri S, Reifenberger G, von Deimling A
Acta Neuropathol 2015 Jun;129(6):829-48. Epub 2015 May 6 doi: 10.1007/s00401-015-1432-1. PMID: 25943888

Recent systematic reviews

Mier-García JF, Ospina-Santa S, Orozco-Mera J, Ma R, Plaha P
J Neurooncol 2023 Aug;164(1):31-41. Epub 2023 Aug 10 doi: 10.1007/s11060-023-04409-0. PMID: 37561356
Ji H, Wang F, Liu Z, Li Y, Sun H, Xiao A, Zhang H, You C, Hu S, Liu Y
J Transl Med 2023 Aug 8;21(1):533. doi: 10.1186/s12967-023-04382-2. PMID: 37553713Free PMC Article
Tesileanu CMS, Vallentgoed WR, French PJ, van den Bent MJ
Eur J Cancer 2022 Nov;175:214-223. Epub 2022 Sep 21 doi: 10.1016/j.ejca.2022.08.016. PMID: 36152406
Halasz LM, Attia A, Bradfield L, Brat DJ, Kirkpatrick JP, Laack NN, Lalani N, Lebow ES, Liu AK, Niemeier HM, Palmer JD, Peters KB, Sheehan J, Thomas RP, Vora SA, Wahl DR, Weiss SE, Yeboa DN, Zhong J, Shih HA
Pract Radiat Oncol 2022 Sep-Oct;12(5):370-386. Epub 2022 May 31 doi: 10.1016/j.prro.2022.05.004. PMID: 35902341
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238

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