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Epithelioid Glioblastoma

MedGen UID:
927112
Concept ID:
C4289580
Neoplastic Process
Synonym: Epithelioid glioblastoma
SNOMED CT: Epithelioid glioblastoma (733837004)

Definition

An IDH-wildtype glioblastoma characterized by the presence of large epithelioid cells with abundant eosinophilic cytoplasm, vesicular chromatin, and prominent nucleoli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpithelioid Glioblastoma

Professional guidelines

PubMed

Sun K, Zhou X, Li T, Zuo M, Li J, Liu Y
Neurosurg Rev 2021 Dec;44(6):3335-3348. Epub 2021 Feb 17 doi: 10.1007/s10143-021-01492-7. PMID: 33598819
Lu VM, George ND, Brown DA, Akinduro OO, Raghunathan A, Jentoft M, Quinones-Hinojosa A, Chaichana KL
World Neurosurg 2019 Nov;131:243-251.e2. Epub 2019 Aug 9 doi: 10.1016/j.wneu.2019.08.007. PMID: 31404694
Gokden M
Adv Anat Pathol 2017 Nov;24(6):379-391. doi: 10.1097/PAP.0000000000000170. PMID: 28885262

Recent clinical studies

Etiology

Chen J, Han P, Dahiya S
Indian J Pathol Microbiol 2022 May;65(Supplement):S24-S32. doi: 10.4103/ijpm.ijpm_1109_21. PMID: 35562131
Ebrahimi A, Korshunov A, Reifenberger G, Capper D, Felsberg J, Trisolini E, Pollo B, Calatozzolo C, Prinz M, Staszewski O, Schweizer L, Schittenhelm J, Harter PN, Paulus W, Thomas C, Kohlhof-Meinecke P, Seiz-Rosenhagen M, Milde T, Casalini BM, Suwala A, Wefers AK, Reinhardt A, Sievers P, Kramm CM, Etminam N, Unterberg A, Wick W, Herold-Mende C, Sturm D, Pfister SM, Sill M, Jones DTW, Schrimpf D, Reuss DE, Aldape K, Abdullaev Z, Sahm F, von Deimling A, Stichel D
Acta Neuropathol Commun 2022 Jan 10;10(1):5. doi: 10.1186/s40478-021-01308-1. PMID: 35012690Free PMC Article
Chatterjee D, Radotra BD, Aggarwal D, Madan R, Gupta SK
Ann Diagn Pathol 2021 Feb;50:151679. Epub 2020 Dec 13 doi: 10.1016/j.anndiagpath.2020.151679. PMID: 33341703
Wang J, Liu Z, Cui Y, Liu Y, Fang J, Xu L, He Y, Du J, Su Y, Zou W, Xu Z, Li G
J Neurooncol 2019 Aug;144(1):137-146. Epub 2019 Jun 18 doi: 10.1007/s11060-019-03212-0. PMID: 31214915
Gokden M
Adv Anat Pathol 2017 Nov;24(6):379-391. doi: 10.1097/PAP.0000000000000170. PMID: 28885262

Diagnosis

Chen J, Han P, Dahiya S
Indian J Pathol Microbiol 2022 May;65(Supplement):S24-S32. doi: 10.4103/ijpm.ijpm_1109_21. PMID: 35562131
Sun K, Zhou X, Li T, Zuo M, Li J, Liu Y
Neurosurg Rev 2021 Dec;44(6):3335-3348. Epub 2021 Feb 17 doi: 10.1007/s10143-021-01492-7. PMID: 33598819
Maraka S, Janku F
Discov Med 2018 Aug;26(141):51-60. PMID: 30265855
Khanna G, Pathak P, Suri V, Sharma MC, Chaturvedi S, Ahuja A, Bhardwaj M, Garg A, Sarkar C, Sharma R
Pathol Res Pract 2018 May;214(5):679-685. Epub 2018 Mar 22 doi: 10.1016/j.prp.2018.03.019. PMID: 29615337
Gokden M
Adv Anat Pathol 2017 Nov;24(6):379-391. doi: 10.1097/PAP.0000000000000170. PMID: 28885262

Therapy

Mallick S, Benson R, Venkatesulu B, Melgandi W, Rath GK
Neurol India 2022 Sep-Oct;70(5):2086-2092. doi: 10.4103/0028-3886.359222. PMID: 36352613
Andrews LJ, Thornton ZA, Saincher SS, Yao IY, Dawson S, McGuinness LA, Jones HE, Jefferies S, Short SC, Cheng HY, McAleenan A, Higgins JPT, Kurian KM
Neuro Oncol 2022 Apr 1;24(4):528-540. doi: 10.1093/neuonc/noab247. PMID: 34718782Free PMC Article
Venkatesh A, Joshi A, Allinson K, Das T, Santarius T, Jefferies SJ, Harris FP, Jena R, Doherty GJ
Curr Probl Cancer 2021 Oct;45(5):100701. Epub 2021 Jan 12 doi: 10.1016/j.currproblcancer.2020.100701. PMID: 33461766
Nakagomi N, Sakamoto D, Hirose T, Takagi T, Murase M, Nakagomi T, Yoshimura S, Hirota S
Brain Pathol 2020 Nov;30(6):1119-1133. Epub 2020 Aug 6 doi: 10.1111/bpa.12887. PMID: 32687679Free PMC Article
Ceccon G, Werner JM, Dunkl V, Tscherpel C, Stoffels G, Brunn A, Deckert M, Fink GR, Galldiks N
Int J Mol Sci 2018 Apr 5;19(4) doi: 10.3390/ijms19041090. PMID: 29621181Free PMC Article

Prognosis

Sun K, Zhou X, Li T, Zuo M, Li J, Liu Y
Neurosurg Rev 2021 Dec;44(6):3335-3348. Epub 2021 Feb 17 doi: 10.1007/s10143-021-01492-7. PMID: 33598819
Lu VM, George ND, Brown DA, Akinduro OO, Raghunathan A, Jentoft M, Quinones-Hinojosa A, Chaichana KL
World Neurosurg 2019 Nov;131:243-251.e2. Epub 2019 Aug 9 doi: 10.1016/j.wneu.2019.08.007. PMID: 31404694
Khanna G, Pathak P, Suri V, Sharma MC, Chaturvedi S, Ahuja A, Bhardwaj M, Garg A, Sarkar C, Sharma R
Pathol Res Pract 2018 May;214(5):679-685. Epub 2018 Mar 22 doi: 10.1016/j.prp.2018.03.019. PMID: 29615337
Gokden M
Adv Anat Pathol 2017 Nov;24(6):379-391. doi: 10.1097/PAP.0000000000000170. PMID: 28885262
Alexandrescu S, Korshunov A, Lai SH, Dabiri S, Patil S, Li R, Shih CS, Bonnin JM, Baker JA, Du E, Scharnhorst DW, Samuel D, Ellison DW, Perry A
Brain Pathol 2016 Mar;26(2):215-23. Epub 2015 Sep 22 doi: 10.1111/bpa.12295. PMID: 26238627Free PMC Article

Clinical prediction guides

Chatterjee D, Radotra BD, Aggarwal D, Madan R, Gupta SK
Ann Diagn Pathol 2021 Feb;50:151679. Epub 2020 Dec 13 doi: 10.1016/j.anndiagpath.2020.151679. PMID: 33341703
Lu VM, George ND, Brown DA, Akinduro OO, Raghunathan A, Jentoft M, Quinones-Hinojosa A, Chaichana KL
World Neurosurg 2019 Nov;131:243-251.e2. Epub 2019 Aug 9 doi: 10.1016/j.wneu.2019.08.007. PMID: 31404694
Furuta T, Miyoshi H, Komaki S, Arakawa F, Morioka M, Ohshima K, Nakada M, Sugita Y
Neuropathology 2018 Jun;38(3):218-227. Epub 2018 Mar 13 doi: 10.1111/neup.12459. PMID: 29532523
Nitta N, Moritani S, Fukami T, Yoshimura Y, Hirai H, Nozaki K
World Neurosurg 2018 Apr;112:257-263. Epub 2018 Feb 6 doi: 10.1016/j.wneu.2018.01.200. PMID: 29425978
Gokden M
Adv Anat Pathol 2017 Nov;24(6):379-391. doi: 10.1097/PAP.0000000000000170. PMID: 28885262

Recent systematic reviews

Mallick S, Benson R, Venkatesulu B, Melgandi W, Rath GK
Neurol India 2022 Sep-Oct;70(5):2086-2092. doi: 10.4103/0028-3886.359222. PMID: 36352613
Andrews LJ, Thornton ZA, Saincher SS, Yao IY, Dawson S, McGuinness LA, Jones HE, Jefferies S, Short SC, Cheng HY, McAleenan A, Higgins JPT, Kurian KM
Neuro Oncol 2022 Apr 1;24(4):528-540. doi: 10.1093/neuonc/noab247. PMID: 34718782Free PMC Article
Lu VM, George ND, Brown DA, Akinduro OO, Raghunathan A, Jentoft M, Quinones-Hinojosa A, Chaichana KL
World Neurosurg 2019 Nov;131:243-251.e2. Epub 2019 Aug 9 doi: 10.1016/j.wneu.2019.08.007. PMID: 31404694
Sugiura Y, Nagaishi M
J Clin Neurosci 2019 Aug;66:196-201. Epub 2019 May 27 doi: 10.1016/j.jocn.2019.05.014. PMID: 31147232

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