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Diffuse Glioma

MedGen UID:
927222
Concept ID:
C4289690
Neoplastic Process

Definition

A glioma that has diffusely infiltrated the surrounding central nervous system tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse Glioma

Professional guidelines

PubMed

van den Bent MJ, Geurts M, French PJ, Smits M, Capper D, Bromberg JEC, Chang SM
Lancet 2023 Oct 28;402(10412):1564-1579. Epub 2023 Sep 19 doi: 10.1016/S0140-6736(23)01054-1. PMID: 37738997
Jiang T, Nam DH, Ram Z, Poon WS, Wang J, Boldbaatar D, Mao Y, Ma W, Mao Q, You Y, Jiang C, Yang X, Kang C, Qiu X, Li W, Li S, Chen L, Li X, Liu Z, Wang W, Bai H, Yao Y, Li S, Wu A, Sai K, Li G, Yao K, Wei X, Liu X, Zhang Z, Dai Y, Lv S, Wang L, Lin Z, Dong J, Xu G, Ma X, Zhang W, Zhang C, Chen B, You G, Wang Y, Wang Y, Bao Z, Yang P, Fan X, Liu X, Zhao Z, Wang Z, Li Y, Wang Z, Li G, Fang S, Li L, Liu Y, Liu S, Shan X, Liu Y, Chai R, Hu H, Chen J, Yan W, Cai J, Wang H, Chen L, Yang Y, Wang Y, Han L, Wang Q; Chinese Glioma Cooperative Group (CGCG); Society for Neuro‐Oncology of China (SNO-China); Chinese Brain Cancer Association (CBCA); Chinese Glioma Genome Atlas (CGGA); Asian Glioma Genome Atlas (AGGA) network
Cancer Lett 2021 Feb 28;499:60-72. Epub 2020 Nov 6 doi: 10.1016/j.canlet.2020.10.050. PMID: 33166616
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE
Drug Resist Updat 2015 Mar;19:1-12. Epub 2015 Mar 6 doi: 10.1016/j.drup.2015.02.002. PMID: 25791797

Recent clinical studies

Etiology

Mu Q, Chai R, Pang B, Yang Y, Liu H, Zhao Z, Bao Z, Song D, Zhu Z, Yan M, Jiang B, Mo Z, Tang J, Sa JK, Cho HJ, Chang Y, Chan KHY, Loi DSC, Tam SST, Chan AKY, Wu AR, Liu Z, Poon WS, Ng HK, Chan DTM, Iavarone A, Nam DH, Jiang T, Wang J
Sci Transl Med 2023 Oct 4;15(716):eadh4181. doi: 10.1126/scitranslmed.adh4181. PMID: 37792958
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Nicholson JG, Fine HA
Cancer Discov 2021 Mar;11(3):575-590. Epub 2021 Feb 8 doi: 10.1158/2159-8290.CD-20-1474. PMID: 33558264
Jiang T, Nam DH, Ram Z, Poon WS, Wang J, Boldbaatar D, Mao Y, Ma W, Mao Q, You Y, Jiang C, Yang X, Kang C, Qiu X, Li W, Li S, Chen L, Li X, Liu Z, Wang W, Bai H, Yao Y, Li S, Wu A, Sai K, Li G, Yao K, Wei X, Liu X, Zhang Z, Dai Y, Lv S, Wang L, Lin Z, Dong J, Xu G, Ma X, Zhang W, Zhang C, Chen B, You G, Wang Y, Wang Y, Bao Z, Yang P, Fan X, Liu X, Zhao Z, Wang Z, Li Y, Wang Z, Li G, Fang S, Li L, Liu Y, Liu S, Shan X, Liu Y, Chai R, Hu H, Chen J, Yan W, Cai J, Wang H, Chen L, Yang Y, Wang Y, Han L, Wang Q; Chinese Glioma Cooperative Group (CGCG); Society for Neuro‐Oncology of China (SNO-China); Chinese Brain Cancer Association (CBCA); Chinese Glioma Genome Atlas (CGGA); Asian Glioma Genome Atlas (AGGA) network
Cancer Lett 2021 Feb 28;499:60-72. Epub 2020 Nov 6 doi: 10.1016/j.canlet.2020.10.050. PMID: 33166616
Molinaro AM, Taylor JW, Wiencke JK, Wrensch MR
Nat Rev Neurol 2019 Jul;15(7):405-417. Epub 2019 Jun 21 doi: 10.1038/s41582-019-0220-2. PMID: 31227792Free PMC Article

Diagnosis

van den Bent MJ, Geurts M, French PJ, Smits M, Capper D, Bromberg JEC, Chang SM
Lancet 2023 Oct 28;402(10412):1564-1579. Epub 2023 Sep 19 doi: 10.1016/S0140-6736(23)01054-1. PMID: 37738997
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Nicholson JG, Fine HA
Cancer Discov 2021 Mar;11(3):575-590. Epub 2021 Feb 8 doi: 10.1158/2159-8290.CD-20-1474. PMID: 33558264
Slegers RJ, Blumcke I
Acta Neuropathol Commun 2020 Mar 9;8(1):27. doi: 10.1186/s40478-020-00904-x. PMID: 32151273Free PMC Article
Molinaro AM, Taylor JW, Wiencke JK, Wrensch MR
Nat Rev Neurol 2019 Jul;15(7):405-417. Epub 2019 Jun 21 doi: 10.1038/s41582-019-0220-2. PMID: 31227792Free PMC Article

Therapy

Mu Q, Chai R, Pang B, Yang Y, Liu H, Zhao Z, Bao Z, Song D, Zhu Z, Yan M, Jiang B, Mo Z, Tang J, Sa JK, Cho HJ, Chang Y, Chan KHY, Loi DSC, Tam SST, Chan AKY, Wu AR, Liu Z, Poon WS, Ng HK, Chan DTM, Iavarone A, Nam DH, Jiang T, Wang J
Sci Transl Med 2023 Oct 4;15(716):eadh4181. doi: 10.1126/scitranslmed.adh4181. PMID: 37792958
Hollon T, Jiang C, Chowdury A, Nasir-Moin M, Kondepudi A, Aabedi A, Adapa A, Al-Holou W, Heth J, Sagher O, Lowenstein P, Castro M, Wadiura LI, Widhalm G, Neuschmelting V, Reinecke D, von Spreckelsen N, Berger MS, Hervey-Jumper SL, Golfinos JG, Snuderl M, Camelo-Piragua S, Freudiger C, Lee H, Orringer DA
Nat Med 2023 Apr;29(4):828-832. Epub 2023 Mar 23 doi: 10.1038/s41591-023-02252-4. PMID: 36959422Free PMC Article
Platten M, Bunse L, Wick A, Bunse T, Le Cornet L, Harting I, Sahm F, Sanghvi K, Tan CL, Poschke I, Green E, Justesen S, Behrens GA, Breckwoldt MO, Freitag A, Rother LM, Schmitt A, Schnell O, Hense J, Misch M, Krex D, Stevanovic S, Tabatabai G, Steinbach JP, Bendszus M, von Deimling A, Schmitt M, Wick W
Nature 2021 Apr;592(7854):463-468. Epub 2021 Mar 24 doi: 10.1038/s41586-021-03363-z. PMID: 33762734Free PMC Article
Jiang T, Nam DH, Ram Z, Poon WS, Wang J, Boldbaatar D, Mao Y, Ma W, Mao Q, You Y, Jiang C, Yang X, Kang C, Qiu X, Li W, Li S, Chen L, Li X, Liu Z, Wang W, Bai H, Yao Y, Li S, Wu A, Sai K, Li G, Yao K, Wei X, Liu X, Zhang Z, Dai Y, Lv S, Wang L, Lin Z, Dong J, Xu G, Ma X, Zhang W, Zhang C, Chen B, You G, Wang Y, Wang Y, Bao Z, Yang P, Fan X, Liu X, Zhao Z, Wang Z, Li Y, Wang Z, Li G, Fang S, Li L, Liu Y, Liu S, Shan X, Liu Y, Chai R, Hu H, Chen J, Yan W, Cai J, Wang H, Chen L, Yang Y, Wang Y, Han L, Wang Q; Chinese Glioma Cooperative Group (CGCG); Society for Neuro‐Oncology of China (SNO-China); Chinese Brain Cancer Association (CBCA); Chinese Glioma Genome Atlas (CGGA); Asian Glioma Genome Atlas (AGGA) network
Cancer Lett 2021 Feb 28;499:60-72. Epub 2020 Nov 6 doi: 10.1016/j.canlet.2020.10.050. PMID: 33166616
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE
Drug Resist Updat 2015 Mar;19:1-12. Epub 2015 Mar 6 doi: 10.1016/j.drup.2015.02.002. PMID: 25791797

Prognosis

Mu Q, Chai R, Pang B, Yang Y, Liu H, Zhao Z, Bao Z, Song D, Zhu Z, Yan M, Jiang B, Mo Z, Tang J, Sa JK, Cho HJ, Chang Y, Chan KHY, Loi DSC, Tam SST, Chan AKY, Wu AR, Liu Z, Poon WS, Ng HK, Chan DTM, Iavarone A, Nam DH, Jiang T, Wang J
Sci Transl Med 2023 Oct 4;15(716):eadh4181. doi: 10.1126/scitranslmed.adh4181. PMID: 37792958
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Nicholson JG, Fine HA
Cancer Discov 2021 Mar;11(3):575-590. Epub 2021 Feb 8 doi: 10.1158/2159-8290.CD-20-1474. PMID: 33558264
Molinaro AM, Taylor JW, Wiencke JK, Wrensch MR
Nat Rev Neurol 2019 Jul;15(7):405-417. Epub 2019 Jun 21 doi: 10.1038/s41582-019-0220-2. PMID: 31227792Free PMC Article
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE
Drug Resist Updat 2015 Mar;19:1-12. Epub 2015 Mar 6 doi: 10.1016/j.drup.2015.02.002. PMID: 25791797

Clinical prediction guides

Mu Q, Chai R, Pang B, Yang Y, Liu H, Zhao Z, Bao Z, Song D, Zhu Z, Yan M, Jiang B, Mo Z, Tang J, Sa JK, Cho HJ, Chang Y, Chan KHY, Loi DSC, Tam SST, Chan AKY, Wu AR, Liu Z, Poon WS, Ng HK, Chan DTM, Iavarone A, Nam DH, Jiang T, Wang J
Sci Transl Med 2023 Oct 4;15(716):eadh4181. doi: 10.1126/scitranslmed.adh4181. PMID: 37792958
Hollon T, Jiang C, Chowdury A, Nasir-Moin M, Kondepudi A, Aabedi A, Adapa A, Al-Holou W, Heth J, Sagher O, Lowenstein P, Castro M, Wadiura LI, Widhalm G, Neuschmelting V, Reinecke D, von Spreckelsen N, Berger MS, Hervey-Jumper SL, Golfinos JG, Snuderl M, Camelo-Piragua S, Freudiger C, Lee H, Orringer DA
Nat Med 2023 Apr;29(4):828-832. Epub 2023 Mar 23 doi: 10.1038/s41591-023-02252-4. PMID: 36959422Free PMC Article
Platten M, Bunse L, Wick A, Bunse T, Le Cornet L, Harting I, Sahm F, Sanghvi K, Tan CL, Poschke I, Green E, Justesen S, Behrens GA, Breckwoldt MO, Freitag A, Rother LM, Schmitt A, Schnell O, Hense J, Misch M, Krex D, Stevanovic S, Tabatabai G, Steinbach JP, Bendszus M, von Deimling A, Schmitt M, Wick W
Nature 2021 Apr;592(7854):463-468. Epub 2021 Mar 24 doi: 10.1038/s41586-021-03363-z. PMID: 33762734Free PMC Article
Siegal T
Adv Tech Stand Neurosurg 2016;(43):91-108. doi: 10.1007/978-3-319-21359-0_4. PMID: 26508407
Olar A, Sulman EP
Semin Radiat Oncol 2015 Jul;25(3):155-63. Epub 2015 Feb 23 doi: 10.1016/j.semradonc.2015.02.006. PMID: 26050585Free PMC Article

Recent systematic reviews

Muzyka L, Goff NK, Choudhary N, Koltz MT
Int J Mol Sci 2023 Jun 21;24(13) doi: 10.3390/ijms241310456. PMID: 37445633Free PMC Article
Young JS, Al-Adli N, Sibih YE, Scotford KL, Casey M, James S, Berger MS
J Neurosurg 2023 Jul 1;139(1):11-19. Epub 2022 Nov 4 doi: 10.3171/2022.9.JNS221139. PMID: 36334288Free PMC Article
Lasocki A, Anjari M, Ӧrs Kokurcan S, Thust SC
Neuroradiology 2021 Mar;63(3):353-362. Epub 2020 Aug 25 doi: 10.1007/s00234-020-02532-7. PMID: 32840682
Di Carlo DT, Duffau H, Cagnazzo F, Benedetto N, Morganti R, Perrini P
Neurosurg Rev 2020 Apr;43(2):383-395. Epub 2018 Jun 26 doi: 10.1007/s10143-018-0996-3. PMID: 29943141
van Kessel E, Baumfalk AE, van Zandvoort MJE, Robe PA, Snijders TJ
J Neurooncol 2017 Aug;134(1):9-18. Epub 2017 May 31 doi: 10.1007/s11060-017-2503-z. PMID: 28567586Free PMC Article

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