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Thyroid Gland Cribriform Morular Carcinoma

MedGen UID:
927266
•Concept ID:
C4289734
•
Neoplastic Process
Synonym: Cribriform Morular Thyroid Gland Carcinoma

Definition

A thyroid gland carcinoma characterized by the presence of cribriform, trabecular, follicular, papillary, and solid growth patterns and squamoid morulae formation. It may occur with familial adenomatous polyposis or sporadically. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Cribriform Morular Carcinoma

Recent clinical studies

Etiology

Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841

Diagnosis

Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Cribriform - morular thyroid carcinoma: a rare entity.
Michnová U, Traboulsi E, Peková B, Ryška A
Cesk Patol 2022 Summer;58(2):107-110. PMID: 35882545
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Sonographic and cytopathologic correlation of papillary thyroid carcinoma variants.
Lee JH, Shin JH, Lee HW, Oh YL, Hahn SY, Ko EY
J Ultrasound Med 2015 Jan;34(1):1-15. doi: 10.7863/ultra.34.1.1. PMID: 25542934
Unusual thyroid tumors: a review of pathologic and molecular diagnosis.
Hunt JL
Expert Rev Mol Diagn 2005 Sep;5(5):725-34. doi: 10.1586/14737159.5.5.725. PMID: 16149875

Therapy

Cribriform - morular thyroid carcinoma: a rare entity.
Michnová U, Traboulsi E, Peková B, Ryška A
Cesk Patol 2022 Summer;58(2):107-110. PMID: 35882545
Cribriform-morular variant of papillary thyroid carcinoma: characteristic histologic feature of adenomatous polyposis. A case report.
Gronnier C, Donatini G, Leteurtre E, Do Cao C, Carnaille B
Ann Endocrinol (Paris) 2012 Jun;73(3):213-5. Epub 2012 Mar 3 doi: 10.1016/j.ando.2012.01.003. PMID: 22387099

Prognosis

Cribriform - morular thyroid carcinoma: a rare entity.
Michnová U, Traboulsi E, Peková B, Ryška A
Cesk Patol 2022 Summer;58(2):107-110. PMID: 35882545
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Sonographic and cytopathologic correlation of papillary thyroid carcinoma variants.
Lee JH, Shin JH, Lee HW, Oh YL, Hahn SY, Ko EY
J Ultrasound Med 2015 Jan;34(1):1-15. doi: 10.7863/ultra.34.1.1. PMID: 25542934
Cribriform-morular variant of papillary thyroid carcinoma: characteristic histologic feature of adenomatous polyposis. A case report.
Gronnier C, Donatini G, Leteurtre E, Do Cao C, Carnaille B
Ann Endocrinol (Paris) 2012 Jun;73(3):213-5. Epub 2012 Mar 3 doi: 10.1016/j.ando.2012.01.003. PMID: 22387099

Clinical prediction guides

Cribriform-morular variant of papillary thyroid carcinoma: a pathological and molecular genetic study with evidence of frequent somatic mutations in exon 3 of the beta-catenin gene.
Xu B, Yoshimoto K, Miyauchi A, Kuma S, Mizusawa N, Hirokawa M, Sano T
J Pathol 2003 Jan;199(1):58-67. doi: 10.1002/path.1225. PMID: 12474227

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