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Colon Adenoma with Severe Dysplasia

MedGen UID:
927300
•Concept ID:
C4289768
•
Neoplastic Process

Definition

An adenoma that arises from the colon. It is characterized by the presence of severe epithelial dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon Adenoma with Severe Dysplasia

Professional guidelines

PubMed

Endoscopic evaluation of gastrointestinal tract in patients with hereditary hemorrhagic telangiectasia and correlation with their genotypes.
Canzonieri C, Centenara L, Ornati F, Pagella F, Matti E, Alvisi C, Danesino C, Perego M, Olivieri C
Genet Med 2014 Jan;16(1):3-10. Epub 2013 May 30 doi: 10.1038/gim.2013.62. PMID: 23722869
Duration and severity of primary sclerosing cholangitis is not associated with risk of neoplastic changes in the colon in patients with ulcerative colitis.
Navaneethan U, Kochhar G, Venkatesh PG, Lewis B, Lashner BA, Remzi FH, Shen B, Kiran RP
Gastrointest Endosc 2012 May;75(5):1045-1054.e1. Epub 2012 Mar 8 doi: 10.1016/j.gie.2012.01.015. PMID: 22405258
Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.
Itzkowitz SH, Harpaz N
Gastroenterology 2004 May;126(6):1634-48. doi: 10.1053/j.gastro.2004.03.025. PMID: 15168373

Recent clinical studies

Etiology

Clinicopathological characterization of colonic polyps.
Qari YA
Niger J Clin Pract 2020 Aug;23(8):1048-1053. doi: 10.4103/njcp.njcp_490_19. PMID: 32788480
Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature.
Bains L, Lal P, Vindal A, Singh M
World J Surg Oncol 2019 Jun 25;17(1):109. doi: 10.1186/s12957-019-1650-4. PMID: 31238922Free PMC Article
Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?
Sourrouille I, Lefèvre JH, Shields C, Colas C, Bellanger J, Desaint B, Paye F, Tiret E, Parc Y
Dis Colon Rectum 2017 Nov;60(11):1137-1146. doi: 10.1097/DCR.0000000000000903. PMID: 28991077
Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.
Itzkowitz SH, Harpaz N
Gastroenterology 2004 May;126(6):1634-48. doi: 10.1053/j.gastro.2004.03.025. PMID: 15168373
Is the distal hyperplastic polyp a marker for proximal neoplasia?
Dave S, Hui S, Kroenke K, Imperiale TF
J Gen Intern Med 2003 Feb;18(2):128-37. doi: 10.1046/j.1525-1497.2003.20524.x. PMID: 12542588Free PMC Article

Diagnosis

Incidence and natural history of gastric high-grade dysplasia in patients with familial adenomatous polyposis syndrome.
DelSignore M, Jeong T, Denmark G, Feldman D, Shih A, Zukerberg L, Chung DC
Gastrointest Endosc 2023 Jan;97(1):25-34.e6. Epub 2022 Sep 14 doi: 10.1016/j.gie.2022.09.002. PMID: 36113625
Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?
Sourrouille I, Lefèvre JH, Shields C, Colas C, Bellanger J, Desaint B, Paye F, Tiret E, Parc Y
Dis Colon Rectum 2017 Nov;60(11):1137-1146. doi: 10.1097/DCR.0000000000000903. PMID: 28991077
Inflammatory bowel disease in Ashkenazi Jews: implications for familial colorectal cancer.
Lynch HT, Brand RE, Locker GY
Fam Cancer 2004;3(3-4):229-32. doi: 10.1007/s10689-004-9548-9. PMID: 15516846
Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.
Itzkowitz SH, Harpaz N
Gastroenterology 2004 May;126(6):1634-48. doi: 10.1053/j.gastro.2004.03.025. PMID: 15168373
Colorectal polyps and their relationship to cancer.
Kim EC, Lance P
Gastroenterol Clin North Am 1997 Mar;26(1):1-17. doi: 10.1016/s0889-8553(05)70280-6. PMID: 9119435

Therapy

Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy.
Ryu HS, Yu CS, Kim YI, Lee JL, Kim CW, Yoon YS, Park IJ, Lim SB, Kim JC
World J Gastroenterol 2022 Aug 14;28(30):4152-4162. doi: 10.3748/wjg.v28.i30.4152. PMID: 36157110Free PMC Article
Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms.
Lv C, Zhao X, Gu H, Huang L, Zhou S, Zhi F
Med Sci Monit 2016 Dec 7;22:4794-4802. doi: 10.12659/msm.902274. PMID: 27926694Free PMC Article
Chemoprevention for colon cancer: new opportunities, fact or fiction?
Terhaar Sive Droste JS, Tuynman JB, Van Dullemen HM, Mulder CJ
Scand J Gastroenterol Suppl 2006;(243):158-64. doi: 10.1080/00365520600664284. PMID: 16782636
Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.
Itzkowitz SH, Harpaz N
Gastroenterology 2004 May;126(6):1634-48. doi: 10.1053/j.gastro.2004.03.025. PMID: 15168373
Copper, zinc and superoxide dismutase in precancerous, benign diseases and gastric, colorectal and breast cancer.
Magálová T, Bella V, Brtková A, Beno I, Kudlácková M, Volkovová K
Neoplasma 1999;46(2):100-4. PMID: 10466433

Prognosis

Incidence and natural history of gastric high-grade dysplasia in patients with familial adenomatous polyposis syndrome.
DelSignore M, Jeong T, Denmark G, Feldman D, Shih A, Zukerberg L, Chung DC
Gastrointest Endosc 2023 Jan;97(1):25-34.e6. Epub 2022 Sep 14 doi: 10.1016/j.gie.2022.09.002. PMID: 36113625
Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature.
Bains L, Lal P, Vindal A, Singh M
World J Surg Oncol 2019 Jun 25;17(1):109. doi: 10.1186/s12957-019-1650-4. PMID: 31238922Free PMC Article
Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?
Sourrouille I, Lefèvre JH, Shields C, Colas C, Bellanger J, Desaint B, Paye F, Tiret E, Parc Y
Dis Colon Rectum 2017 Nov;60(11):1137-1146. doi: 10.1097/DCR.0000000000000903. PMID: 28991077
Colorectal cancer in patients with inflammatory bowel disease: the true impact of the risk.
Herszényi L, Barabás L, Miheller P, Tulassay Z
Dig Dis 2015;33(1):52-7. Epub 2014 Dec 17 doi: 10.1159/000368447. PMID: 25531497
Inflammatory bowel disease in Ashkenazi Jews: implications for familial colorectal cancer.
Lynch HT, Brand RE, Locker GY
Fam Cancer 2004;3(3-4):229-32. doi: 10.1007/s10689-004-9548-9. PMID: 15516846

Clinical prediction guides

Routine colonoscopy may be needed for uncomplicated acute right colonic diverticulitis.
Lee KY, Lee J, Park YY, Oh ST
BMC Gastroenterol 2021 Feb 27;21(1):91. doi: 10.1186/s12876-021-01672-1. PMID: 33639847Free PMC Article
Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?
Sourrouille I, Lefèvre JH, Shields C, Colas C, Bellanger J, Desaint B, Paye F, Tiret E, Parc Y
Dis Colon Rectum 2017 Nov;60(11):1137-1146. doi: 10.1097/DCR.0000000000000903. PMID: 28991077
Chemoprevention for colon cancer: new opportunities, fact or fiction?
Terhaar Sive Droste JS, Tuynman JB, Van Dullemen HM, Mulder CJ
Scand J Gastroenterol Suppl 2006;(243):158-64. doi: 10.1080/00365520600664284. PMID: 16782636
Severe dysplasia in children with familial adenomatous polyposis: rare or simply overlooked?
Vasudevan SA, Patel JC, Wesson DE, Plon SE, Finegold MJ, Nuchtern JG
J Pediatr Surg 2006 Apr;41(4):658-61. doi: 10.1016/j.jpedsurg.2005.12.005. PMID: 16567172
Adenomas with severe dysplasia and early carcinoma of the colon-rectum: our experience of 27 patients.
Brini C, Bogliolo G, Pontone S, Ierfone N, Chessa A, Pontone P
G Chir 2001 Jan-Feb;22(1-2):26-8. PMID: 11272432

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