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Cervical Mesonephric Remnants and Hyperplasia

MedGen UID:
927345
•Concept ID:
C4289813
•
Pathologic Function

Definition

The presence of embryonic remnants of mesonephric ducts in the cervix and their benign hyperplastic proliferations. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Mesonephric Remnants and Hyperplasia

Professional guidelines

PubMed

Immunohistochemical staining for Ki-67 antigen, carcinoembryonic antigen, and p53 in the differential diagnosis of glandular lesions of the cervix.
Cina SJ, Richardson MS, Austin RM, Kurman RJ
Mod Pathol 1997 Mar;10(3):176-80. PMID: 9071723

Recent clinical studies

Etiology

Differential Expression Patterns of GATA3 in Uterine Mesonephric and Nonmesonephric Lesions.
Roma AA, Goyal A, Yang B
Int J Gynecol Pathol 2015 Sep;34(5):480-6. doi: 10.1097/PGP.0000000000000167. PMID: 25851711
Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy.
Chen YB, Fine SW, Epstein JI
Am J Surg Pathol 2011 Jul;35(7):1054-61. doi: 10.1097/PAS.0b013e318218df97. PMID: 21606823

Diagnosis

Differential patterns of PAX8, p16, and ER immunostains in mesonephric lesions and adenocarcinomas of the cervix.
Goyal A, Yang B
Int J Gynecol Pathol 2014 Nov;33(6):613-9. doi: 10.1097/PGP.0000000000000102. PMID: 25272301
Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy.
Chen YB, Fine SW, Epstein JI
Am J Surg Pathol 2011 Jul;35(7):1054-61. doi: 10.1097/PAS.0b013e318218df97. PMID: 21606823
A pre-tailored panel of antibodies in the study of cervical mesonephric remnants.
Pavlakis K, Messini I, Yiannou P, Chrissanthakis D, Papaspyrou I, Panoskaltsis T, Stathopoulos EN
Gynecol Oncol 2010 Mar;116(3):468-72. Epub 2009 Nov 14 doi: 10.1016/j.ygyno.2009.10.055. PMID: 19913894
Mesonephric adenocarcinoma of the uterine corpus: a case report and review of the literature.
Wani Y, Notohara K, Tsukayama C
Int J Gynecol Pathol 2008 Jul;27(3):346-52. doi: 10.1097/PGP.0b013e318166067f. PMID: 18580312
Mesonephric remnants, hyperplasia, and neoplasia in the uterine cervix. A study of 49 cases.
Ferry JA, Scully RE
Am J Surg Pathol 1990 Dec;14(12):1100-11. doi: 10.1097/00000478-199012000-00002. PMID: 2252101

Prognosis

Atypical Mesonephric Hyperplasia of the Uterus Harbors Pathogenic Mutation of Kirsten Rat Sarcoma 2 Viral Oncogene Homolog (KRAS) and Gain of Chromosome 1q.
Kim H, Yoon N, Woo HY, Lee EJ, DO SI, Na K, Kim HS
Cancer Genomics Proteomics 2020 Nov-Dec;17(6):813-826. doi: 10.21873/cgp.20235. PMID: 33099482Free PMC Article
GATA3 Is a Sensitive and Specific Marker of Benign and Malignant Mesonephric Lesions in the Lower Female Genital Tract.
Howitt BE, Emori MM, Drapkin R, Gaspar C, Barletta JA, Nucci MR, McCluggage WG, Oliva E, Hirsch MS
Am J Surg Pathol 2015 Oct;39(10):1411-9. doi: 10.1097/PAS.0000000000000471. PMID: 26135559
PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
Rabban JT, McAlhany S, Lerwill MF, Grenert JP, Zaloudek CJ
Am J Surg Pathol 2010 Feb;34(2):137-46. doi: 10.1097/PAS.0b013e3181c89c98. PMID: 20061933
Florid mesonephric hyperplasia of the cervix: a report of a case with review of the literature.
Ayroud Y, Gelfand MM, Ferenczy A
Int J Gynecol Pathol 1985;4(3):245-54. doi: 10.1097/00004347-198509000-00009. PMID: 2414240

Clinical prediction guides

Corded and hyalinized mesonephric-like adenocarcinoma of the uterine corpus: report of a case mimicking endometrioid carcinoma.
Patel V, Kipp B, Schoolmeester JK
Hum Pathol 2019 Apr;86:243-248. Epub 2018 Aug 30 doi: 10.1016/j.humpath.2018.08.018. PMID: 30172914
GATA3 Is a Sensitive and Specific Marker of Benign and Malignant Mesonephric Lesions in the Lower Female Genital Tract.
Howitt BE, Emori MM, Drapkin R, Gaspar C, Barletta JA, Nucci MR, McCluggage WG, Oliva E, Hirsch MS
Am J Surg Pathol 2015 Oct;39(10):1411-9. doi: 10.1097/PAS.0000000000000471. PMID: 26135559
Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy.
Chen YB, Fine SW, Epstein JI
Am J Surg Pathol 2011 Jul;35(7):1054-61. doi: 10.1097/PAS.0b013e318218df97. PMID: 21606823
PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
Rabban JT, McAlhany S, Lerwill MF, Grenert JP, Zaloudek CJ
Am J Surg Pathol 2010 Feb;34(2):137-46. doi: 10.1097/PAS.0b013e3181c89c98. PMID: 20061933
CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma.
McCluggage WG, Oliva E, Herrington CS, McBride H, Young RH
Histopathology 2003 Aug;43(2):144-50. doi: 10.1046/j.1365-2559.2003.01684.x. PMID: 12877729

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