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Leiomyosarcoma of the cervix uteri

MedGen UID:
927349
Concept ID:
C4289817
Neoplastic Process
Synonyms: CELI; Cervical Leiomyosarcoma; Cervical leiomyosarcoma; cervical leiomyosarcoma; Leiomyosarcoma of cervix uteri; leiomyosarcoma of the cervix uteri; leiomyosarcoma of uterine cervix; uterine cervix leiomyosarcoma
SNOMED CT: Leiomyosarcoma of cervix uteri (763771009); Cervical leiomyosarcoma (763771009)
 
Monarch Initiative: MONDO:0016283
Orphanet: ORPHA213807

Definition

A rare malignant mesenchymal tumour of smooth muscle origin, macroscopically appearing as a large, poorly circumscribed mass, often protruding from the cervical canal or expanding it circumferentially. The most common presenting symptoms are vaginal discharge or bleeding, pain in the lower abdomen and a bulky cervical mass. There is a reported tendency to metastasise haematogenously, especially to the lungs, peritoneum, bones and the liver. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeiomyosarcoma of the cervix uteri

Professional guidelines

PubMed

Khosla D, Gupta R, Srinivasan R, Patel FD, Rajwanshi A
Int J Gynecol Cancer 2012 Jul;22(6):1026-30. doi: 10.1097/IGC.0b013e31825a97f6. PMID: 22740005

Recent clinical studies

Etiology

Missaoui N, Mestiri S, Bdioui A, Zahmoul T, Hamchi H, Mokni M, Hmissa S
Pathol Res Pract 2018 Apr;214(4):498-506. Epub 2018 Mar 6 doi: 10.1016/j.prp.2018.03.004. PMID: 29572122
Khosla D, Gupta R, Srinivasan R, Patel FD, Rajwanshi A
Int J Gynecol Cancer 2012 Jul;22(6):1026-30. doi: 10.1097/IGC.0b013e31825a97f6. PMID: 22740005
Wang X, Khoo US, Xue WC, Cheung AN
Acta Cytol 2002 May-Jun;46(3):465-9. doi: 10.1159/000326862. PMID: 12040638
Kawamura N, Ichimura T, Ito F, Shibata S, Takahashi K, Tsujimura A, Ishiko O, Haba T, Wakasa K, Ogita S
Cancer 2002 Mar 15;94(6):1713-20. doi: 10.1002/cncr.10382. PMID: 11920533
Abell MR, Ramirez JA
Cancer 1973 May;31(5):1176-92. doi: 10.1002/1097-0142(197305)31:5<1176::aid-cncr2820310521>3.0.co;2-k. PMID: 4705156

Diagnosis

Duraes M, Mandoul C, Perrochia H, Rathat G
Fertil Steril 2022 Jan;117(1):230-231. Epub 2021 Nov 6 doi: 10.1016/j.fertnstert.2021.09.028. PMID: 34753598
Kiliç C, Yuksel D, Cakir C, Turkmen O, Kimyon Comert G, Başaran D, Turan T
Tumori 2020 Oct;106(5):413-423. Epub 2020 May 13 doi: 10.1177/0300891620919161. PMID: 32403994
Missaoui N, Mestiri S, Bdioui A, Zahmoul T, Hamchi H, Mokni M, Hmissa S
Pathol Res Pract 2018 Apr;214(4):498-506. Epub 2018 Mar 6 doi: 10.1016/j.prp.2018.03.004. PMID: 29572122
Khosla D, Gupta R, Srinivasan R, Patel FD, Rajwanshi A
Int J Gynecol Cancer 2012 Jul;22(6):1026-30. doi: 10.1097/IGC.0b013e31825a97f6. PMID: 22740005
Kawamura N, Ichimura T, Ito F, Shibata S, Takahashi K, Tsujimura A, Ishiko O, Haba T, Wakasa K, Ogita S
Cancer 2002 Mar 15;94(6):1713-20. doi: 10.1002/cncr.10382. PMID: 11920533

Therapy

Kiliç C, Yuksel D, Cakir C, Turkmen O, Kimyon Comert G, Başaran D, Turan T
Tumori 2020 Oct;106(5):413-423. Epub 2020 May 13 doi: 10.1177/0300891620919161. PMID: 32403994
Kerimoglu OS, Pekin A, Yilmaz SA, Bakbak BB, Celik C
Eur J Gynaecol Oncol 2015;36(1):59-61. PMID: 25872336
Kawamura N, Ichimura T, Ito F, Shibata S, Takahashi K, Tsujimura A, Ishiko O, Haba T, Wakasa K, Ogita S
Cancer 2002 Mar 15;94(6):1713-20. doi: 10.1002/cncr.10382. PMID: 11920533
Sokal DC, Dabancens A, Guzman-Serani R, Zipper J
Fertil Steril 2000 Jul;74(1):169-71. doi: 10.1016/s0015-0282(00)00581-1. PMID: 10899517
Pritzker KP, Huang SN, Marshall KG
Can Med Assoc J 1970 Dec 19;103(13):1362-5. PMID: 4923839Free PMC Article

Prognosis

Kiliç C, Yuksel D, Cakir C, Turkmen O, Kimyon Comert G, Başaran D, Turan T
Tumori 2020 Oct;106(5):413-423. Epub 2020 May 13 doi: 10.1177/0300891620919161. PMID: 32403994
Missaoui N, Mestiri S, Bdioui A, Zahmoul T, Hamchi H, Mokni M, Hmissa S
Pathol Res Pract 2018 Apr;214(4):498-506. Epub 2018 Mar 6 doi: 10.1016/j.prp.2018.03.004. PMID: 29572122
Kawamura N, Ichimura T, Ito F, Shibata S, Takahashi K, Tsujimura A, Ishiko O, Haba T, Wakasa K, Ogita S
Cancer 2002 Mar 15;94(6):1713-20. doi: 10.1002/cncr.10382. PMID: 11920533
Sokal DC, Dabancens A, Guzman-Serani R, Zipper J
Fertil Steril 2000 Jul;74(1):169-71. doi: 10.1016/s0015-0282(00)00581-1. PMID: 10899517
Abell MR, Ramirez JA
Cancer 1973 May;31(5):1176-92. doi: 10.1002/1097-0142(197305)31:5<1176::aid-cncr2820310521>3.0.co;2-k. PMID: 4705156

Clinical prediction guides

Kawamura N, Ichimura T, Ito F, Shibata S, Takahashi K, Tsujimura A, Ishiko O, Haba T, Wakasa K, Ogita S
Cancer 2002 Mar 15;94(6):1713-20. doi: 10.1002/cncr.10382. PMID: 11920533
Sokal DC, Dabancens A, Guzman-Serani R, Zipper J
Fertil Steril 2000 Jul;74(1):169-71. doi: 10.1016/s0015-0282(00)00581-1. PMID: 10899517

Recent systematic reviews

Kiliç C, Yuksel D, Cakir C, Turkmen O, Kimyon Comert G, Başaran D, Turan T
Tumori 2020 Oct;106(5):413-423. Epub 2020 May 13 doi: 10.1177/0300891620919161. PMID: 32403994

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