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Elevated prostate-specific antigen level

MedGen UID:
927605
•Concept ID:
C4293696
•
Finding
HPO: HP:0025020

Definition

An increased concentration of prostate specific antigen (PSA) in the circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated prostate-specific antigen level

Professional guidelines

PubMed

Risk assessment for occult malignancy in the prostate before radical cystectomy.
Kefer JC, Voelzke BB, Flanigan RC, Wojcik EM, Waters WB, Campbell SC
Urology 2005 Dec;66(6):1251-5. doi: 10.1016/j.urology.2005.07.006. PMID: 16360452
Stage T1c prostate cancer: perspectives on clinical management.
Smith JA Jr
Semin Urol Oncol 1995 Aug;13(3):238-44. PMID: 8521137

Recent clinical studies

Etiology

The evaluation of prostate lesions with IVIM DWI and MR perfusion parameters at 3T MRI.
Beyhan M, Sade R, Koc E, Adanur S, Kantarci M
Radiol Med 2019 Feb;124(2):87-93. Epub 2018 Oct 1 doi: 10.1007/s11547-018-0930-3. PMID: 30276599
Location of Prostate Cancers Determined by Multiparametric and MRI-Guided Biopsy in Patients With Elevated Prostate-Specific Antigen Level and at Least One Negative Transrectal Ultrasound-Guided Biopsy.
Schouten MG, Hoeks CM, Bomers JG, Hulsbergen-van de Kaa CA, Witjes JA, Thompson LC, Rovers MM, Barentsz JO, Fütterer JJ
AJR Am J Roentgenol 2015 Jul;205(1):57-63. doi: 10.2214/AJR.14.12960. PMID: 26102380
Transperineal sector prostate biopsies: a local anesthetic outpatient technique.
Smith JB, Popert R, Nuttall MC, Vyas L, Kinsella J, Cahill D
Urology 2014 Jun;83(6):1344-9. Epub 2014 Apr 13 doi: 10.1016/j.urology.2014.02.008. PMID: 24726315
Diet, supplement use, and prostate cancer risk: results from the prostate cancer prevention trial.
Kristal AR, Arnold KB, Neuhouser ML, Goodman P, Platz EA, Albanes D, Thompson IM
Am J Epidemiol 2010 Sep 1;172(5):566-77. Epub 2010 Aug 6 doi: 10.1093/aje/kwq148. PMID: 20693267Free PMC Article
Long-term clinical outcome of diagnostic transurethral resection of the prostate in patients with elevated prostate-specific antigen level and minor lower urinary tract symptoms.
van Renterghem K, van Koeveringe G, Achten R, van Kerrebroeck P
Urol Int 2009;83(1):60-5. Epub 2009 Jul 27 doi: 10.1159/000224870. PMID: 19641361

Diagnosis

The evaluation of prostate lesions with IVIM DWI and MR perfusion parameters at 3T MRI.
Beyhan M, Sade R, Koc E, Adanur S, Kantarci M
Radiol Med 2019 Feb;124(2):87-93. Epub 2018 Oct 1 doi: 10.1007/s11547-018-0930-3. PMID: 30276599
Location of Prostate Cancers Determined by Multiparametric and MRI-Guided Biopsy in Patients With Elevated Prostate-Specific Antigen Level and at Least One Negative Transrectal Ultrasound-Guided Biopsy.
Schouten MG, Hoeks CM, Bomers JG, Hulsbergen-van de Kaa CA, Witjes JA, Thompson LC, Rovers MM, Barentsz JO, Fütterer JJ
AJR Am J Roentgenol 2015 Jul;205(1):57-63. doi: 10.2214/AJR.14.12960. PMID: 26102380
Transperineal sector prostate biopsies: a local anesthetic outpatient technique.
Smith JB, Popert R, Nuttall MC, Vyas L, Kinsella J, Cahill D
Urology 2014 Jun;83(6):1344-9. Epub 2014 Apr 13 doi: 10.1016/j.urology.2014.02.008. PMID: 24726315
Long-term clinical outcome of diagnostic transurethral resection of the prostate in patients with elevated prostate-specific antigen level and minor lower urinary tract symptoms.
van Renterghem K, van Koeveringe G, Achten R, van Kerrebroeck P
Urol Int 2009;83(1):60-5. Epub 2009 Jul 27 doi: 10.1159/000224870. PMID: 19641361
Diagnosis of prostate cancer in patients with an elevated prostate-specific antigen level: role of endorectal MRI and MR spectroscopic imaging.
Costouros NG, Coakley FV, Westphalen AC, Qayyum A, Yeh BM, Joe BN, Kurhanewicz J
AJR Am J Roentgenol 2007 Mar;188(3):812-6. doi: 10.2214/AJR.06.0165. PMID: 17312072

Therapy

Transperineal sector prostate biopsies: a local anesthetic outpatient technique.
Smith JB, Popert R, Nuttall MC, Vyas L, Kinsella J, Cahill D
Urology 2014 Jun;83(6):1344-9. Epub 2014 Apr 13 doi: 10.1016/j.urology.2014.02.008. PMID: 24726315
Diet, supplement use, and prostate cancer risk: results from the prostate cancer prevention trial.
Kristal AR, Arnold KB, Neuhouser ML, Goodman P, Platz EA, Albanes D, Thompson IM
Am J Epidemiol 2010 Sep 1;172(5):566-77. Epub 2010 Aug 6 doi: 10.1093/aje/kwq148. PMID: 20693267Free PMC Article
Lesion localization in patients with a previous negative transrectal ultrasound biopsy and persistently elevated prostate specific antigen level using diffusion-weighted imaging at three Tesla before rebiopsy.
Park BK, Lee HM, Kim CK, Choi HY, Park JW
Invest Radiol 2008 Nov;43(11):789-93. doi: 10.1097/RLI.0b013e318183725e. PMID: 18923258
Clinical relevance of transurethral resection of the prostate in "asymptomatic" patients with an elevated prostate-specific antigen level.
van Renterghem K, Van Koeveringe G, Achten R, Van Kerrebroeck P
Eur Urol 2007 Sep;52(3):819-26. Epub 2007 Mar 28 doi: 10.1016/j.eururo.2007.03.055. PMID: 17418482
Age, body mass index, and serum prostate-specific antigen correlate with bone loss in men with prostate cancer not receiving androgen deprivation therapy.
Conde FA, Sarna L, Oka RK, Vredevoe DL, Rettig MB, Aronson WJ
Urology 2004 Aug;64(2):335-40. doi: 10.1016/j.urology.2004.03.036. PMID: 15302490

Prognosis

The Negative Predictive Value of a PI-RADS Version 2 Score of 1 on Prostate MRI and the Factors Associated With a False-Negative MRI Study.
Ma HY, Ahmed FS, Luk L, Martina LAP, Wenske S, Shaish H
AJR Am J Roentgenol 2020 Sep;215(3):667-672. Epub 2020 Jul 1 doi: 10.2214/AJR.20.22784. PMID: 32755155
Why and Where do We Miss Significant Prostate Cancer with Multi-parametric Magnetic Resonance Imaging followed by Magnetic Resonance-guided and Transrectal Ultrasound-guided Biopsy in Biopsy-naïve Men?
Schouten MG, van der Leest M, Pokorny M, Hoogenboom M, Barentsz JO, Thompson LC, Fütterer JJ
Eur Urol 2017 Jun;71(6):896-903. Epub 2017 Jan 4 doi: 10.1016/j.eururo.2016.12.006. PMID: 28063613
Clinical relevance of transurethral resection of the prostate in "asymptomatic" patients with an elevated prostate-specific antigen level.
van Renterghem K, Van Koeveringe G, Achten R, Van Kerrebroeck P
Eur Urol 2007 Sep;52(3):819-26. Epub 2007 Mar 28 doi: 10.1016/j.eururo.2007.03.055. PMID: 17418482
Age, body mass index, and serum prostate-specific antigen correlate with bone loss in men with prostate cancer not receiving androgen deprivation therapy.
Conde FA, Sarna L, Oka RK, Vredevoe DL, Rettig MB, Aronson WJ
Urology 2004 Aug;64(2):335-40. doi: 10.1016/j.urology.2004.03.036. PMID: 15302490
Clinical evaluation of prostate biopsy parameters: gland volume and elevated prostate-specific antigen level.
Rubens DJ, Gottlieb RH, Maldonado CE Jr, Frank IN
Radiology 1996 Apr;199(1):159-63. doi: 10.1148/radiology.199.1.8633140. PMID: 8633140

Clinical prediction guides

Why and Where do We Miss Significant Prostate Cancer with Multi-parametric Magnetic Resonance Imaging followed by Magnetic Resonance-guided and Transrectal Ultrasound-guided Biopsy in Biopsy-naïve Men?
Schouten MG, van der Leest M, Pokorny M, Hoogenboom M, Barentsz JO, Thompson LC, Fütterer JJ
Eur Urol 2017 Jun;71(6):896-903. Epub 2017 Jan 4 doi: 10.1016/j.eururo.2016.12.006. PMID: 28063613
Transperineal sector prostate biopsies: a local anesthetic outpatient technique.
Smith JB, Popert R, Nuttall MC, Vyas L, Kinsella J, Cahill D
Urology 2014 Jun;83(6):1344-9. Epub 2014 Apr 13 doi: 10.1016/j.urology.2014.02.008. PMID: 24726315
Diet, supplement use, and prostate cancer risk: results from the prostate cancer prevention trial.
Kristal AR, Arnold KB, Neuhouser ML, Goodman P, Platz EA, Albanes D, Thompson IM
Am J Epidemiol 2010 Sep 1;172(5):566-77. Epub 2010 Aug 6 doi: 10.1093/aje/kwq148. PMID: 20693267Free PMC Article
Long-term clinical outcome of diagnostic transurethral resection of the prostate in patients with elevated prostate-specific antigen level and minor lower urinary tract symptoms.
van Renterghem K, van Koeveringe G, Achten R, van Kerrebroeck P
Urol Int 2009;83(1):60-5. Epub 2009 Jul 27 doi: 10.1159/000224870. PMID: 19641361
Prospective study of the role of transurethral resection of the prostate in patients with an elevated prostate-specific antigen level, minor lower urinary tract symptoms, and proven bladder outlet obstruction.
van Renterghem K, Van Koeveringe G, Achten R, van Kerrebroeck P
Eur Urol 2008 Dec;54(6):1385-92. Epub 2008 Jun 26 doi: 10.1016/j.eururo.2008.06.069. PMID: 18599187

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