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Brief resolved unexplained event

MedGen UID:
929412
Concept ID:
C4303743
Finding
Synonyms: ALTE Apparent Life Threatening Event; ALTE Apparent Life-Threatening Event; Apparent Life Threatening Event; Apparent Life-Threatening Event; Apparent Life-Threatening Events; Brief, Resolved, Unexplained Event; BRUE Brief, Resolved, Unexplained Event; Idiopathic Apparent Life Threatening Event; Idiopathic Apparent Life-Threatening Event; Life-Threatening Event, Apparent; Life-Threatening Events, Apparent
SNOMED CT: BRUE - Brief resolved unexplained event (720975008); Brief resolved unexplained event (720975008)

Definition

An event lasting less than a minute in an infant younger than 1 year of age reported by an observer that is now resolved. Including one or more of the following: cyanosis or pallor; absent, decreased, or irregular breathing; marked change in tone (hypertonia or hypotonia); and altered level of responsiveness. Diagnosed only when there is no explanation for a qualifying event after a history and physical examination and used to evaluate patients who are at lower risk for a subsequent event or serious underlying disorder. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBrief resolved unexplained event

Professional guidelines

PubMed

Austin-Page LR, Cho CS
Pediatr Emerg Med Pract 2024 Apr;21(4):1-24. Epub 2024 Apr 1 PMID: 38507230
Tanaka D, Amagasa S, Kikuchi N, Sasaki R, Uematsu S, Tsuji S, Kubota M, Nakagawa S
Pediatr Emerg Care 2023 Jul 1;39(7):507-510. doi: 10.1097/PEC.0000000000002986. PMID: 37318851
Tieder JS, Bonkowsky JL, Etzel RA, Franklin WH, Gremse DA, Herman B, Katz ES, Krilov LR, Merritt JL 2nd, Norlin C, Percelay J, Sapién RE, Shiffman RN, Smith MB; SUBCOMMITTEE ON APPARENT LIFE THREATENING EVENTS
Pediatrics 2016 May;137(5) Epub 2016 Apr 25 doi: 10.1542/peds.2016-0590. PMID: 27244835

Recent clinical studies

Etiology

Denis M, Brulé C, Lauzier B, Brossier D, Porcheret F
Arch Pediatr 2023 Aug;30(6):389-395. Epub 2023 Jun 17 doi: 10.1016/j.arcped.2023.05.005. PMID: 37330397
Nama N, Hall M, Neuman M, Sullivan E, Bochner R, De Laroche A, Hadvani T, Jain S, Katsogridakis Y, Kim E, Mittal M, Payson A, Prusakowski M, Shastri N, Stephans A, Westphal K, Wilkins V, Tieder J; Brief Resolved Unexplained Event Research and Quality Improvement Network
Hosp Pediatr 2022 Sep 1;12(9):772-785. doi: 10.1542/hpeds.2022-006637. PMID: 35965279
Ramgopal S, Colgan JY, Roland D, Pitetti RD, Katsogridakis Y
Eur J Pediatr 2022 Feb;181(2):463-470. Epub 2021 Aug 28 doi: 10.1007/s00431-021-04234-5. PMID: 34455524
Chaiyachati BH, Wood JN
Pediatr Radiol 2021 May;51(6):866-871. Epub 2021 May 17 doi: 10.1007/s00247-020-04793-z. PMID: 33999231
Tieder JS, Bonkowsky JL, Etzel RA, Franklin WH, Gremse DA, Herman B, Katz ES, Krilov LR, Merritt JL 2nd, Norlin C, Percelay J, Sapién RE, Shiffman RN, Smith MB; SUBCOMMITTEE ON APPARENT LIFE THREATENING EVENTS
Pediatrics 2016 May;137(5) Epub 2016 Apr 25 doi: 10.1542/peds.2016-0590. PMID: 27244835

Diagnosis

Nama N, Hall M, Neuman M, Sullivan E, Bochner R, De Laroche A, Hadvani T, Jain S, Katsogridakis Y, Kim E, Mittal M, Payson A, Prusakowski M, Shastri N, Stephans A, Westphal K, Wilkins V, Tieder J; Brief Resolved Unexplained Event Research and Quality Improvement Network
Hosp Pediatr 2022 Sep 1;12(9):772-785. doi: 10.1542/hpeds.2022-006637. PMID: 35965279
Ramgopal S, Colgan JY, Roland D, Pitetti RD, Katsogridakis Y
Eur J Pediatr 2022 Feb;181(2):463-470. Epub 2021 Aug 28 doi: 10.1007/s00431-021-04234-5. PMID: 34455524
Chaiyachati BH, Wood JN
Pediatr Radiol 2021 May;51(6):866-871. Epub 2021 May 17 doi: 10.1007/s00247-020-04793-z. PMID: 33999231
Patrinos ME, Martin RJ
Semin Fetal Neonatal Med 2017 Aug;22(4):240-244. Epub 2017 Apr 21 doi: 10.1016/j.siny.2017.04.003. PMID: 28438477
Tieder JS, Bonkowsky JL, Etzel RA, Franklin WH, Gremse DA, Herman B, Katz ES, Krilov LR, Merritt JL 2nd, Norlin C, Percelay J, Sapién RE, Shiffman RN, Smith MB; SUBCOMMITTEE ON APPARENT LIFE THREATENING EVENTS
Pediatrics 2016 May;137(5) Epub 2016 Apr 25 doi: 10.1542/peds.2016-0590. PMID: 27244835

Therapy

Duncan DR, Liu E, Growdon AS, Larson K, Rosen RL
Hosp Pediatr 2022 Dec 1;12(12):1030-1043. doi: 10.1542/hpeds.2022-006550. PMID: 36336644Free PMC Article
Briggs KB, Svetanoff WJ, Fraser JA, Aguayo P, Fraser JD, HolcombIII GW, St Peter SD
J Pediatr Surg 2022 Aug;57(8):1499-1503. Epub 2021 Dec 11 doi: 10.1016/j.jpedsurg.2021.12.006. PMID: 34980467
Duncan H, Hudson AP
Arch Dis Child 2021 Mar;106(3):215-218. Epub 2020 Aug 11 doi: 10.1136/archdischild-2020-318795. PMID: 32788204
Brand DA, Fazzari MJ
J Pediatr 2018 Jun;197:63-67. Epub 2018 Feb 2 doi: 10.1016/j.jpeds.2017.12.028. PMID: 29398048
Triemstra J, Reno K, Chohlas-Wood R, Nash C
Pediatr Ann 2017 Feb 1;46(2):e61-e64. doi: 10.3928/19382359-20170118-02. PMID: 28192580

Prognosis

Nama N, Hall M, Neuman M, Sullivan E, Bochner R, De Laroche A, Hadvani T, Jain S, Katsogridakis Y, Kim E, Mittal M, Payson A, Prusakowski M, Shastri N, Stephans A, Westphal K, Wilkins V, Tieder J; Brief Resolved Unexplained Event Research and Quality Improvement Network
Hosp Pediatr 2022 Sep 1;12(9):772-785. doi: 10.1542/hpeds.2022-006637. PMID: 35965279
Ramgopal S, Colgan JY, Roland D, Pitetti RD, Katsogridakis Y
Eur J Pediatr 2022 Feb;181(2):463-470. Epub 2021 Aug 28 doi: 10.1007/s00431-021-04234-5. PMID: 34455524
Tieder JS, Sullivan E, Stephans A, Hall M, DeLaroche AM, Wilkins V, Neuman MI, Mittal MK, Kane E, Jain S, Shastri N, Katsogridakis Y, Vachani JG, Hochreiter D, Kim E, Nicholson J, Bochner R, Murphy K; Brief Resolved Unexplained Event Research and Quality Improvement Network
Pediatrics 2021 Jul;148(1) Epub 2021 Jun 24 doi: 10.1542/peds.2020-036095. PMID: 34168059
DeLaroche AM, Haddad R, Farooqi A, Sapién RE, Tieder JS
Hosp Pediatr 2020 Apr;10(4):303-310. Epub 2020 Mar 9 doi: 10.1542/hpeds.2019-0195. PMID: 32152008
Ramgopal S, Soung J, Pitetti RD
Acad Pediatr 2019 Nov-Dec;19(8):963-968. Epub 2019 Aug 8 doi: 10.1016/j.acap.2019.08.001. PMID: 31401230

Clinical prediction guides

Nama N, Hall M, Neuman M, Sullivan E, Bochner R, De Laroche A, Hadvani T, Jain S, Katsogridakis Y, Kim E, Mittal M, Payson A, Prusakowski M, Shastri N, Stephans A, Westphal K, Wilkins V, Tieder J; Brief Resolved Unexplained Event Research and Quality Improvement Network
Hosp Pediatr 2022 Sep 1;12(9):772-785. doi: 10.1542/hpeds.2022-006637. PMID: 35965279
Ramgopal S, Colgan JY, Roland D, Pitetti RD, Katsogridakis Y
Eur J Pediatr 2022 Feb;181(2):463-470. Epub 2021 Aug 28 doi: 10.1007/s00431-021-04234-5. PMID: 34455524
Minowa H
J Matern Fetal Neonatal Med 2022 Dec;35(25):7132-7138. Epub 2021 Jun 28 doi: 10.1080/14767058.2021.1944094. PMID: 34182876
DeLaroche AM, Haddad R, Farooqi A, Sapién RE, Tieder JS
Hosp Pediatr 2020 Apr;10(4):303-310. Epub 2020 Mar 9 doi: 10.1542/hpeds.2019-0195. PMID: 32152008
Tieder JS, Bonkowsky JL, Etzel RA, Franklin WH, Gremse DA, Herman B, Katz ES, Krilov LR, Merritt JL 2nd, Norlin C, Percelay J, Sapién RE, Shiffman RN, Smith MB; SUBCOMMITTEE ON APPARENT LIFE THREATENING EVENTS
Pediatrics 2016 May;137(5) Epub 2016 Apr 25 doi: 10.1542/peds.2016-0590. PMID: 27244835

Recent systematic reviews

Tieder JS, Altman RL, Bonkowsky JL, Brand DA, Claudius I, Cunningham DJ, DeWolfe C, Percelay JM, Pitetti RD, Smith MB
J Pediatr 2013 Jul;163(1):94-9.e1-6. Epub 2013 Feb 14 doi: 10.1016/j.jpeds.2012.12.086. PMID: 23415612

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