U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Recurrent Squamous Cell Carcinoma

MedGen UID:
930664
•Concept ID:
C4304995
•
Neoplastic Process
Synonym: Squamous cell carcinoma, recurrent
SNOMED CT: Recurrent squamous cell carcinoma (719052006)

Definition

A squamous cell carcinoma that has recurred after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Squamous Cell Carcinoma

Professional guidelines

PubMed

Toxicities Following Stereotactic Ablative Radiotherapy Treatment of Locally-Recurrent and Previously Irradiated Head and Neck Squamous Cell Carcinoma.
Quan K, Xu KM, Zhang Y, Clump DA, Flickinger JC, Lalonde R, Burton SA, Heron DE
Semin Radiat Oncol 2016 Apr;26(2):112-9. Epub 2015 Nov 27 doi: 10.1016/j.semradonc.2015.11.007. PMID: 27000507
Supracricoid partial laryngectomy for primary and recurrent laryngeal cancer.
Sperry SM, Rassekh CH, Laccourreye O, Weinstein GS
JAMA Otolaryngol Head Neck Surg 2013 Nov;139(11):1226-35. doi: 10.1001/jamaoto.2013.4990. PMID: 24092390
Management and palliative chemotherapy for metastatic or recurrent squamous cell carcinoma of the head and neck.
Machiels JP, Schmitz S
Expert Rev Anticancer Ther 2011 Mar;11(3):359-71. doi: 10.1586/era.10.178. PMID: 21534878

Recent clinical studies

Etiology

Salvage surgery for recurrent squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.
Bulbul MG, Genovese TJ, Hagan K, Rege S, Qureshi A, Varvares MA
Head Neck 2022 Jan;44(1):275-285. Epub 2021 Nov 3 doi: 10.1002/hed.26898. PMID: 34729845
Neoadjuvant and Adjuvant Nivolumab and Lirilumab in Patients with Recurrent, Resectable Squamous Cell Carcinoma of the Head and Neck.
Hanna GJ, O'Neill A, Shin KY, Wong K, Jo VY, Quinn CT, Cutler JM, Flynn M, Lizotte PH, Annino DJ Jr, Goguen LA, Kass JI, Rettig EM, Sethi RKV, Lorch JH, Schoenfeld JD, Margalit DN, Tishler RB, Everett PC, Desai AM, Cavanaugh ME, Paweletz CP, Egloff AM, Uppaluri R, Haddad RI
Clin Cancer Res 2022 Feb 1;28(3):468-478. Epub 2021 Oct 19 doi: 10.1158/1078-0432.CCR-21-2635. PMID: 34667025Free PMC Article
Recurrent squamous cell carcinoma of the lower lip: salvage surgery outcome.
Copelli C, Manfuso A, Cassano L, Pederneschi N, Tewfik K, Pansini A, Cocchi R
Br J Oral Maxillofac Surg 2021 Oct;59(8):921-927. Epub 2020 Nov 4 doi: 10.1016/j.bjoms.2020.10.019. PMID: 34456078
Capecitabine after Surgical Salvage in Recurrent Squamous Cell Carcinoma of Head and Neck.
Manohar PM, Sapir E, Bellile E, Swiecicki PL, Pearson AT, Prince ME, Shuman AG, Bradford CR, Chepeha DB, Wolf GT, Eisbruch A, Worden FP, Spector ME
Otolaryngol Head Neck Surg 2017 Dec;157(6):995-997. Epub 2017 Aug 15 doi: 10.1177/0194599817722948. PMID: 28809131
Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck.
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article

Diagnosis

Capecitabine after Surgical Salvage in Recurrent Squamous Cell Carcinoma of Head and Neck.
Manohar PM, Sapir E, Bellile E, Swiecicki PL, Pearson AT, Prince ME, Shuman AG, Bradford CR, Chepeha DB, Wolf GT, Eisbruch A, Worden FP, Spector ME
Otolaryngol Head Neck Surg 2017 Dec;157(6):995-997. Epub 2017 Aug 15 doi: 10.1177/0194599817722948. PMID: 28809131
Re-irradiation for head and neck squamous cell carcinoma.
Benson R, Giridhar P, Venkatesulu BP, Mallick S, Raza MW, Rath GK
J Egypt Natl Canc Inst 2017 Mar;29(1):1-9. Epub 2016 Aug 29 doi: 10.1016/j.jnci.2016.07.002. PMID: 27595192
Past approaches and future directions for targeting tumor hypoxia in squamous cell carcinomas of the head and neck.
Curtis KK, Wong WW, Ross HJ
Crit Rev Oncol Hematol 2016 Jul;103:86-98. Epub 2016 May 16 doi: 10.1016/j.critrevonc.2016.05.005. PMID: 27247118
Management and palliative chemotherapy for metastatic or recurrent squamous cell carcinoma of the head and neck.
Machiels JP, Schmitz S
Expert Rev Anticancer Ther 2011 Mar;11(3):359-71. doi: 10.1586/era.10.178. PMID: 21534878
Recurrent squamous cell carcinoma of the vulva: a study of 73 cases.
Piura B, Masotina A, Murdoch J, Lopes A, Morgan P, Monaghan J
Gynecol Oncol 1993 Feb;48(2):189-95. doi: 10.1006/gyno.1993.1032. PMID: 8428690

Therapy

Salvage surgery for recurrent squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.
Bulbul MG, Genovese TJ, Hagan K, Rege S, Qureshi A, Varvares MA
Head Neck 2022 Jan;44(1):275-285. Epub 2021 Nov 3 doi: 10.1002/hed.26898. PMID: 34729845
Neoadjuvant and Adjuvant Nivolumab and Lirilumab in Patients with Recurrent, Resectable Squamous Cell Carcinoma of the Head and Neck.
Hanna GJ, O'Neill A, Shin KY, Wong K, Jo VY, Quinn CT, Cutler JM, Flynn M, Lizotte PH, Annino DJ Jr, Goguen LA, Kass JI, Rettig EM, Sethi RKV, Lorch JH, Schoenfeld JD, Margalit DN, Tishler RB, Everett PC, Desai AM, Cavanaugh ME, Paweletz CP, Egloff AM, Uppaluri R, Haddad RI
Clin Cancer Res 2022 Feb 1;28(3):468-478. Epub 2021 Oct 19 doi: 10.1158/1078-0432.CCR-21-2635. PMID: 34667025Free PMC Article
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Re-irradiation for head and neck squamous cell carcinoma.
Benson R, Giridhar P, Venkatesulu BP, Mallick S, Raza MW, Rath GK
J Egypt Natl Canc Inst 2017 Mar;29(1):1-9. Epub 2016 Aug 29 doi: 10.1016/j.jnci.2016.07.002. PMID: 27595192
Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck.
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article

Prognosis

Recurrent squamous cell carcinoma of the lower lip: salvage surgery outcome.
Copelli C, Manfuso A, Cassano L, Pederneschi N, Tewfik K, Pansini A, Cocchi R
Br J Oral Maxillofac Surg 2021 Oct;59(8):921-927. Epub 2020 Nov 4 doi: 10.1016/j.bjoms.2020.10.019. PMID: 34456078
Capecitabine after Surgical Salvage in Recurrent Squamous Cell Carcinoma of Head and Neck.
Manohar PM, Sapir E, Bellile E, Swiecicki PL, Pearson AT, Prince ME, Shuman AG, Bradford CR, Chepeha DB, Wolf GT, Eisbruch A, Worden FP, Spector ME
Otolaryngol Head Neck Surg 2017 Dec;157(6):995-997. Epub 2017 Aug 15 doi: 10.1177/0194599817722948. PMID: 28809131
Re-irradiation for head and neck squamous cell carcinoma.
Benson R, Giridhar P, Venkatesulu BP, Mallick S, Raza MW, Rath GK
J Egypt Natl Canc Inst 2017 Mar;29(1):1-9. Epub 2016 Aug 29 doi: 10.1016/j.jnci.2016.07.002. PMID: 27595192
Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck.
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article
Systemic Therapy for Metastatic or Recurrent Squamous Cell Carcinoma of the Head and Neck.
Colevas AD
J Natl Compr Canc Netw 2015 May;13(5):e37-48. doi: 10.6004/jnccn.2015.0080. PMID: 26158134

Clinical prediction guides

Neoadjuvant and Adjuvant Nivolumab and Lirilumab in Patients with Recurrent, Resectable Squamous Cell Carcinoma of the Head and Neck.
Hanna GJ, O'Neill A, Shin KY, Wong K, Jo VY, Quinn CT, Cutler JM, Flynn M, Lizotte PH, Annino DJ Jr, Goguen LA, Kass JI, Rettig EM, Sethi RKV, Lorch JH, Schoenfeld JD, Margalit DN, Tishler RB, Everett PC, Desai AM, Cavanaugh ME, Paweletz CP, Egloff AM, Uppaluri R, Haddad RI
Clin Cancer Res 2022 Feb 1;28(3):468-478. Epub 2021 Oct 19 doi: 10.1158/1078-0432.CCR-21-2635. PMID: 34667025Free PMC Article
Recurrent squamous cell carcinoma of the lower lip: salvage surgery outcome.
Copelli C, Manfuso A, Cassano L, Pederneschi N, Tewfik K, Pansini A, Cocchi R
Br J Oral Maxillofac Surg 2021 Oct;59(8):921-927. Epub 2020 Nov 4 doi: 10.1016/j.bjoms.2020.10.019. PMID: 34456078
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Immunohistochemical Expression of Cathepsin D in Primary and Recurrent Squamous Cell Carcinoma.
Satelur KP, Kumar GS
J Contemp Dent Pract 2017 Sep 1;18(9):795-801. doi: 10.5005/jp-journals-10024-2129. PMID: 28874644
Recurrent squamous cell carcinoma of the vulva: a study of 73 cases.
Piura B, Masotina A, Murdoch J, Lopes A, Morgan P, Monaghan J
Gynecol Oncol 1993 Feb;48(2):189-95. doi: 10.1006/gyno.1993.1032. PMID: 8428690

Recent systematic reviews

Functional and quality-of-life outcomes following salvage surgery for recurrent squamous cell carcinoma of the head and neck: a systematic review and meta-analysis.
Williamson A, Jashek-Ahmed F, Hardman J, Paleri V
Eur Arch Otorhinolaryngol 2023 Oct;280(10):4597-4618. Epub 2023 Jun 17 doi: 10.1007/s00405-023-08056-z. PMID: 37329358
Salvage surgery for recurrent squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.
Bulbul MG, Genovese TJ, Hagan K, Rege S, Qureshi A, Varvares MA
Head Neck 2022 Jan;44(1):275-285. Epub 2021 Nov 3 doi: 10.1002/hed.26898. PMID: 34729845
Elective neck dissection for salvage laryngectomy: A systematic review and meta-analysis.
Lin C, Puram SV, Bulbul MG, Sethi RK, Rocco JW, Old MO, Kang SY
Oral Oncol 2019 Sep;96:97-104. Epub 2019 Jul 17 doi: 10.1016/j.oraloncology.2019.07.008. PMID: 31422220

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...