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Tooth agenesis, selective, 8(STHAG8)

MedGen UID:
934697
Concept ID:
C4310730
Disease or Syndrome
Synonym: STHAG8
 
Gene (location): WNT10B (12q13.12)
 
Monarch Initiative: MONDO:0014901
OMIM®: 617073

Definition

Any tooth agenesis in which the cause of the disease is a mutation in the WNT10B gene. [from MONDO]

Clinical features

From HPO
Microdontia
MedGen UID:
66008
Concept ID:
C0240340
Congenital Abnormality
Decreased size of the teeth, which can be defined as a mesiodistal tooth diameter (width) more than 2 SD below mean. Alternatively, an apparently decreased maximum width of tooth.
Sparse eyebrow
MedGen UID:
371332
Concept ID:
C1832446
Finding
Decreased density/number of eyebrow hairs.
Selective tooth agenesis
MedGen UID:
370882
Concept ID:
C1970308
Congenital Abnormality
Agenesis specifically affecting one of the classes incisor, premolar, or molar.
Dry skin
MedGen UID:
56250
Concept ID:
C0151908
Sign or Symptom
Skin characterized by the lack of natural or normal moisture.
Sparse hair
MedGen UID:
1790211
Concept ID:
C5551005
Finding
Reduced density of hairs.

Professional guidelines

PubMed

Costa FS, Silveira ER, Pinto GS, Nascimento GG, Thomson WM, Demarco FF
J Dent 2017 May;60:1-7. Epub 2017 Mar 24 doi: 10.1016/j.jdent.2017.03.006. PMID: 28347809
Kiliaridis S, Sidira M, Kirmanidou Y, Michalakis K
Eur J Oral Implantol 2016;9 Suppl 1:S5-24. PMID: 27314109
Al-Shammari KF, Kazor CE, Wang HL
J Clin Periodontol 2001 Aug;28(8):730-40. doi: 10.1034/j.1600-051x.2001.280803.x. PMID: 11442732

Recent clinical studies

Etiology

Zhu Y, Zhang Y, Dong J, Ruan W, Yang S, Huang P, Duan X
Oral Dis 2023 Nov;29(8):3168-3172. Epub 2022 Dec 20 doi: 10.1111/odi.14459. PMID: 36478500
Fonseca-Souza G, de Oliveira LB, Wambier LM, Scariot R, Feltrin-Souza J
Clin Oral Investig 2022 Aug;26(8):5089-5103. Epub 2022 Jun 21 doi: 10.1007/s00784-022-04540-8. PMID: 35729285
Baba R, Sato A, Arai K
Odontology 2022 Jan;110(1):183-192. Epub 2021 Jul 8 doi: 10.1007/s10266-021-00634-z. PMID: 34236541
Jonsson L, Magnusson TE, Thordarson A, Jonsson T, Geller F, Feenstra B, Melbye M, Nohr EA, Vucic S, Dhamo B, Rivadeneira F, Ongkosuwito EM, Wolvius EB, Leslie EJ, Marazita ML, Howe BJ, Moreno Uribe LM, Alonso I, Santos M, Pinho T, Jonsson R, Audolfsson G, Gudmundsson L, Nawaz MS, Olafsson S, Gustafsson O, Ingason A, Unnsteinsdottir U, Bjornsdottir G, Walters GB, Zervas M, Oddsson A, Gudbjartsson DF, Steinberg S, Stefansson H, Stefansson K
J Dent Res 2018 May;97(5):515-522. Epub 2018 Jan 24 doi: 10.1177/0022034517750109. PMID: 29364747Free PMC Article
Khalaf K, Miskelly J, Voge E, Macfarlane TV
J Orthod 2014 Dec;41(4):299-316. doi: 10.1179/1465313314Y.0000000116. PMID: 25404667

Diagnosis

Estrela CRA, Bueno MR, Estrela MRA, Estrela LRA, Guedes OA, Azevedo BC, Cintra LTA, Estrela C
J Endod 2022 Oct;48(10):1263-1272. Epub 2022 Aug 7 doi: 10.1016/j.joen.2022.07.011. PMID: 35948173
Aydın H, Mobaraki S
Arch Oral Biol 2021 Oct;130:105242. Epub 2021 Aug 13 doi: 10.1016/j.archoralbio.2021.105242. PMID: 34411883
Zeng Y, Baugh E, Akyalcin S, Letra A
J Dent Res 2021 Mar;100(3):302-309. Epub 2020 Oct 9 doi: 10.1177/0022034520962728. PMID: 33034246
Bekiroglu N, Mete S, Ozbay G, Yalcinkaya S, Kargul B
Niger J Clin Pract 2015 Jan-Feb;18(1):8-12. doi: 10.4103/1119-3077.146965. PMID: 25511336
Khalaf K, Miskelly J, Voge E, Macfarlane TV
J Orthod 2014 Dec;41(4):299-316. doi: 10.1179/1465313314Y.0000000116. PMID: 25404667

Therapy

Fonseca-Souza G, de Oliveira LB, Wambier LM, Scariot R, Feltrin-Souza J
Clin Oral Investig 2022 Aug;26(8):5089-5103. Epub 2022 Jun 21 doi: 10.1007/s00784-022-04540-8. PMID: 35729285
Decaup PH, Couture C, Colin M, Garot E
Homo 2022 Nov 9;73(1):1-11. doi: 10.1127/homo/2021/1447. PMID: 34897365
Decaup PH, Garot E, Rouas P
Arch Oral Biol 2021 May;125:105112. Epub 2021 Mar 23 doi: 10.1016/j.archoralbio.2021.105112. PMID: 33780721
Kiliaridis S, Sidira M, Kirmanidou Y, Michalakis K
Eur J Oral Implantol 2016;9 Suppl 1:S5-24. PMID: 27314109
Bekiroglu N, Mete S, Ozbay G, Yalcinkaya S, Kargul B
Niger J Clin Pract 2015 Jan-Feb;18(1):8-12. doi: 10.4103/1119-3077.146965. PMID: 25511336

Prognosis

Chen J, Liu S, Liu M, Dong Y
Clin Oral Investig 2023 Sep;27(9):5287-5296. Epub 2023 Jul 25 doi: 10.1007/s00784-023-05148-2. PMID: 37490116
Zeng Y, Baugh E, Akyalcin S, Letra A
J Dent Res 2021 Mar;100(3):302-309. Epub 2020 Oct 9 doi: 10.1177/0022034520962728. PMID: 33034246
King P, Maiorana C, Luthardt RG, Sondell K, Øland J, Galindo-Moreno P, Nilsson P
Int J Prosthodont 2016 Mar-Apr;29(2):147-53. doi: 10.11607/ijp.4444. PMID: 26929953
Prokocimer T, Amir E, Blumer S, Peretz B
J Clin Pediatr Dent 2015 Summer;39(4):371-6. doi: 10.17796/1053-4628-39.4.371. PMID: 26161610
Sanadhya YK, Sanadhya S, Jalihal S, Nagarajappa R, Ramesh G, Tak M
J Indian Soc Pedod Prev Dent 2013 Jan-Mar;31(1):10-6. doi: 10.4103/0970-4388.112393. PMID: 23727736

Clinical prediction guides

Gibbison R, Crozier R
Evid Based Dent 2022 Sep;23(3):112-113. Epub 2022 Sep 23 doi: 10.1038/s41432-022-0808-z. PMID: 36151286
Fonseca-Souza G, de Oliveira LB, Wambier LM, Scariot R, Feltrin-Souza J
Clin Oral Investig 2022 Aug;26(8):5089-5103. Epub 2022 Jun 21 doi: 10.1007/s00784-022-04540-8. PMID: 35729285
Decaup PH, Garot E, Rouas P
Arch Oral Biol 2021 May;125:105112. Epub 2021 Mar 23 doi: 10.1016/j.archoralbio.2021.105112. PMID: 33780721
Zeng Y, Baugh E, Akyalcin S, Letra A
J Dent Res 2021 Mar;100(3):302-309. Epub 2020 Oct 9 doi: 10.1177/0022034520962728. PMID: 33034246
Souza-Silva BN, Vieira WA, Bernardino ÍM, Batista MJ, Bittencourt MAV, Paranhos LR
Arch Oral Biol 2018 Dec;96:26-32. Epub 2018 Aug 24 doi: 10.1016/j.archoralbio.2018.08.014. PMID: 30172942

Recent systematic reviews

Gibbison R, Crozier R
Evid Based Dent 2022 Sep;23(3):112-113. Epub 2022 Sep 23 doi: 10.1038/s41432-022-0808-z. PMID: 36151286
Fonseca-Souza G, de Oliveira LB, Wambier LM, Scariot R, Feltrin-Souza J
Clin Oral Investig 2022 Aug;26(8):5089-5103. Epub 2022 Jun 21 doi: 10.1007/s00784-022-04540-8. PMID: 35729285
Decaup PH, Garot E, Rouas P
Arch Oral Biol 2021 May;125:105112. Epub 2021 Mar 23 doi: 10.1016/j.archoralbio.2021.105112. PMID: 33780721
Kiliaridis S, Sidira M, Kirmanidou Y, Michalakis K
Eur J Oral Implantol 2016;9 Suppl 1:S5-24. PMID: 27314109
Khalaf K, Miskelly J, Voge E, Macfarlane TV
J Orthod 2014 Dec;41(4):299-316. doi: 10.1179/1465313314Y.0000000116. PMID: 25404667

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