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Hyphema

MedGen UID:
9379
Concept ID:
C0020581
Pathologic Function
Synonym: Hyphemas
SNOMED CT: Blood in anterior chamber (75229002); Hyphema (75229002); Hyphemia (75229002)
 
HPO: HP:0011886

Definition

Bleeding in the anterior chamber of the eye. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyphema

Conditions with this feature

Persistent hyperplastic primary vitreous, autosomal recessive
MedGen UID:
370100
Concept ID:
C1969783
Disease or Syndrome
Persistent hyperplastic primary vitreous (PHPV), also termed 'persistent fetal vasculature,' is a developmental malformation of the eye in which the primary vitreous fails to regress in utero, resulting in the presence of a retrolental fibrovascular membrane with persistence of the posterior portion of the tunica vasculosa lentis and hyaloid artery. This abnormality is usually unilateral and associated with microphthalmia, cataract, glaucoma, and congenital retinal nonattachment (see Haddad et al., 1978; Khaliq et al., 2001; Prasov et al., 2012). PHPV shares phenotypic overlap with Norrie disease (310600). Genetic Heterogeneity of Persistent Hyperplastic Primary Vitreous A dominant form of PHPV has been described (PHPVAD; 611308).

Professional guidelines

PubMed

Accorinti M, Saturno MC, Paroli MP, De Geronimo D, Gilardi M
Ocul Immunol Inflamm 2022 Aug;30(6):1408-1413. Epub 2021 Apr 1 doi: 10.1080/09273948.2021.1881563. PMID: 33793379
Razeghinejad R, Lin MM, Lee D, Katz LJ, Myers JS
Surv Ophthalmol 2020 Sep-Oct;65(5):530-547. Epub 2020 Feb 11 doi: 10.1016/j.survophthal.2020.02.003. PMID: 32057763
Bansal S, Gunasekeran DV, Ang B, Lee J, Khandelwal R, Sullivan P, Agrawal R
Surv Ophthalmol 2016 May-Jun;61(3):297-308. Epub 2015 Nov 26 doi: 10.1016/j.survophthal.2015.11.005. PMID: 26632664

Recent clinical studies

Etiology

Zhang Y, Yu P, Zhang Y, Sugihara K, Zhu X, Zhang Y, Yang X, Li X, Liu Y, Zhang H, Yan X, Zhang H, Lin F, Song Y, Gao X, Yuan H, Tang G, Zhou W, Fan S, Dang G, Tang L, Chen W, Wang N, Park KH, Barton K, Aung T, Lam DSC, Weinreb RN, Xie L, Tanito M, Zeng L, Zhang X; PVP Study Group
Am J Ophthalmol 2023 Dec;256:118-125. Epub 2023 Aug 11 doi: 10.1016/j.ajo.2023.08.002. PMID: 37573988
Song Y, Zhu X, Zhang Y, Shu J, Dang G, Zhou W, Sun L, Li F, Lin F, Zhang Y, Liang X, Wang Z, Zhang Y, Zhang Y, Chen W, Zeng L, Tang L, Xie L, Lam DSC, Wang N, Barton K, Weinreb RN, Zhang X; PVP study group
J Glaucoma 2023 Jul 1;32(7):563-568. Epub 2023 Mar 30 doi: 10.1097/IJG.0000000000002210. PMID: 37054442
Woreta FA, Lindsley KB, Gharaibeh A, Ng SM, Scherer RW, Goldberg MF
Cochrane Database Syst Rev 2023 Mar 13;3(3):CD005431. doi: 10.1002/14651858.CD005431.pub5. PMID: 36912744Free PMC Article
Accorinti M, Saturno MC, Paroli MP, De Geronimo D, Gilardi M
Ocul Immunol Inflamm 2022 Aug;30(6):1408-1413. Epub 2021 Apr 1 doi: 10.1080/09273948.2021.1881563. PMID: 33793379
Crouch ER Jr
J Pediatr Ophthalmol Strabismus 1986 Mar-Apr;23(2):95-7. doi: 10.3928/0191-3913-19860301-12. PMID: 3958878

Diagnosis

Bae E, Messman A, Shah K
Emerg Med Pract 2023 Oct 1;25(Suppl 10):1-38. PMID: 37768702
Accorinti M, Saturno MC, Paroli MP, De Geronimo D, Gilardi M
Ocul Immunol Inflamm 2022 Aug;30(6):1408-1413. Epub 2021 Apr 1 doi: 10.1080/09273948.2021.1881563. PMID: 33793379
Genadry KC, Shrock C, O'Shea D, Vatsa R, Shah AS, Gise R, Lipsett SC
J Emerg Med 2021 Dec;61(6):740-741. Epub 2021 Sep 11 doi: 10.1016/j.jemermed.2021.07.041. PMID: 34518051
Bansal S, Gunasekeran DV, Ang B, Lee J, Khandelwal R, Sullivan P, Agrawal R
Surv Ophthalmol 2016 May-Jun;61(3):297-308. Epub 2015 Nov 26 doi: 10.1016/j.survophthal.2015.11.005. PMID: 26632664
Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, Desjardins L
Orphanet J Rare Dis 2006 Aug 25;1:31. doi: 10.1186/1750-1172-1-31. PMID: 16934146Free PMC Article

Therapy

Song Y, Zhu X, Zhang Y, Shu J, Dang G, Zhou W, Sun L, Li F, Lin F, Zhang Y, Liang X, Wang Z, Zhang Y, Zhang Y, Chen W, Zeng L, Tang L, Xie L, Lam DSC, Wang N, Barton K, Weinreb RN, Zhang X; PVP study group
J Glaucoma 2023 Jul 1;32(7):563-568. Epub 2023 Mar 30 doi: 10.1097/IJG.0000000000002210. PMID: 37054442
Ramakrishnan MS, Wald KJ
Curr Eye Res 2023 Jun;48(6):529-535. Epub 2023 Jan 4 doi: 10.1080/02713683.2022.2156547. PMID: 36476057
Zemba M, Camburu G
Rom J Ophthalmol 2017 Jan-Mar;61(1):11-17. doi: 10.22336/rjo.2017.3. PMID: 29450365Free PMC Article
Bansal S, Gunasekeran DV, Ang B, Lee J, Khandelwal R, Sullivan P, Agrawal R
Surv Ophthalmol 2016 May-Jun;61(3):297-308. Epub 2015 Nov 26 doi: 10.1016/j.survophthal.2015.11.005. PMID: 26632664
Crouch ER Jr
J Pediatr Ophthalmol Strabismus 1986 Mar-Apr;23(2):95-7. doi: 10.3928/0191-3913-19860301-12. PMID: 3958878

Prognosis

Tan SI, Hoskin AK, Khatri A, Dave VP, Bhalerao S, Romero J, Agrawal R
Indian J Ophthalmol 2023 Dec 1;71(12):3587-3594. Epub 2023 Nov 20 doi: 10.4103/IJO.IJO_1496_23. PMID: 37991288Free PMC Article
Roy S, Mermoud A
Dev Ophthalmol 2017;59:36-42. Epub 2017 Apr 25 doi: 10.1159/000458484. PMID: 28442685
Roy S, Mermoud A
Dev Ophthalmol 2012;50:29-36. Epub 2012 Apr 17 doi: 10.1159/000334772. PMID: 22517171
Walton W, Von Hagen S, Grigorian R, Zarbin M
Surv Ophthalmol 2002 Jul-Aug;47(4):297-334. doi: 10.1016/s0039-6257(02)00317-x. PMID: 12161209
Sankar PS, Chen TC, Grosskreutz CL, Pasquale LR
Int Ophthalmol Clin 2002 Summer;42(3):57-68. doi: 10.1097/00004397-200207000-00008. PMID: 12131583

Clinical prediction guides

Tan SI, Hoskin AK, Khatri A, Dave VP, Bhalerao S, Romero J, Agrawal R
Indian J Ophthalmol 2023 Dec 1;71(12):3587-3594. Epub 2023 Nov 20 doi: 10.4103/IJO.IJO_1496_23. PMID: 37991288Free PMC Article
Vinod K, Gedde SJ
Curr Opin Ophthalmol 2021 Mar 1;32(2):160-168. doi: 10.1097/ICU.0000000000000731. PMID: 33315726
Roy S, Mermoud A
Dev Ophthalmol 2017;59:36-42. Epub 2017 Apr 25 doi: 10.1159/000458484. PMID: 28442685
Roy S, Mermoud A
Dev Ophthalmol 2012;50:29-36. Epub 2012 Apr 17 doi: 10.1159/000334772. PMID: 22517171
Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, Desjardins L
Orphanet J Rare Dis 2006 Aug 25;1:31. doi: 10.1186/1750-1172-1-31. PMID: 16934146Free PMC Article

Recent systematic reviews

Woreta FA, Lindsley KB, Gharaibeh A, Ng SM, Scherer RW, Goldberg MF
Cochrane Database Syst Rev 2023 Mar 13;3(3):CD005431. doi: 10.1002/14651858.CD005431.pub5. PMID: 36912744Free PMC Article
Gagrani M, Garg I, Ghate D
Cochrane Database Syst Rev 2020 Aug 25;8(8):CD008213. doi: 10.1002/14651858.CD008213.pub3. PMID: 32816311Free PMC Article
Michelessi M, Bicket AK, Lindsley K
Cochrane Database Syst Rev 2018 Apr 25;4(4):CD009313. doi: 10.1002/14651858.CD009313.pub2. PMID: 29694684Free PMC Article
Wang X, Khan R, Coleman A
Cochrane Database Syst Rev 2015 Dec 1;2015(12):CD010472. doi: 10.1002/14651858.CD010472.pub2. PMID: 26625212Free PMC Article
Ghate D, Wang X
Cochrane Database Syst Rev 2015 Jan 30;1:CD008213. doi: 10.1002/14651858.CD008213.pub2. PMID: 25636153Free PMC Article

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