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Hypochondriasis

MedGen UID:
9382
•Concept ID:
C0020604
•
Mental or Behavioral Dysfunction
Synonyms: Hypochondriacal Neuroses; Hypochondriacal Neurosis; Neurosis, Hypochondriacal
SNOMED CT: Hypochondriasis (18193002); Hypochondriacal neurosis (18193002); Hypochondria (18193002)
 
Monarch Initiative: MONDO:0001596

Definition

A somatoform disorder in which an individual is preoccupied with having a serious illness despite not having been given a corroborating diagnosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypochondriasis

Professional guidelines

PubMed

Recent Advances in the Understanding and Treatment of Health Anxiety.
Tyrer P
Curr Psychiatry Rep 2018 Jun 22;20(7):49. doi: 10.1007/s11920-018-0912-0. PMID: 29931576
Hypochondriasis--recognition and management.
Riaz T, Kazi AN
J Pak Med Assoc 2011 Mar;61(3):302-3. PMID: 21465956
Epidemiology and treatment of hypochondriasis.
Magariños M, Zafar U, Nissenson K, Blanco C
CNS Drugs 2002;16(1):9-22. doi: 10.2165/00023210-200216010-00002. PMID: 11772116

Recent clinical studies

Etiology

Is cyberchondria specific to hypochondriasis?
Jungmann SM, Gropalis M, Schenkel SK, Witthöft M
J Anxiety Disord 2024 Mar;102:102798. Epub 2023 Dec 5 doi: 10.1016/j.janxdis.2023.102798. PMID: 38128287
Avoidance in hypochondriasis.
Doherty-Torstrick ER, Walton KE, Barsky AJ, Fallon BA
J Psychosom Res 2016 Oct;89:46-52. Epub 2016 Jul 19 doi: 10.1016/j.jpsychores.2016.07.010. PMID: 27663110
The classification of Obsessive-Compulsive and Related Disorders in the ICD-11.
Stein DJ, Kogan CS, Atmaca M, Fineberg NA, Fontenelle LF, Grant JE, Matsunaga H, Reddy YCJ, Simpson HB, Thomsen PH, van den Heuvel OA, Veale D, Woods DW, Reed GM
J Affect Disord 2016 Jan 15;190:663-674. Epub 2015 Nov 6 doi: 10.1016/j.jad.2015.10.061. PMID: 26590514
Medically unexplained symptoms, somatisation disorder and hypochondriasis: course and prognosis. A systematic review.
olde Hartman TC, Borghuis MS, Lucassen PL, van de Laar FA, Speckens AE, van Weel C
J Psychosom Res 2009 May;66(5):363-77. Epub 2008 Dec 16 doi: 10.1016/j.jpsychores.2008.09.018. PMID: 19379952
Somatoform disorders.
Oyama O, Paltoo C, Greengold J
Am Fam Physician 2007 Nov 1;76(9):1333-8. PMID: 18019877

Diagnosis

Is cyberchondria specific to hypochondriasis?
Jungmann SM, Gropalis M, Schenkel SK, Witthöft M
J Anxiety Disord 2024 Mar;102:102798. Epub 2023 Dec 5 doi: 10.1016/j.janxdis.2023.102798. PMID: 38128287
Illness behavior.
Sirri L, Grandi S
Adv Psychosom Med 2012;32:160-181. Epub 2011 Oct 19 doi: 10.1159/000330015. PMID: 22056904
The pharmacotherapy of hypochondriasis.
Fallon BA, Schneier FR, Marshall R, Campeas R, Vermes D, Goetz D, Liebowitz MR
Psychopharmacol Bull 1996;32(4):607-11. PMID: 8993081
Hypochondriasis and somatization.
Kellner R
JAMA 1987 Nov 20;258(19):2718-22. PMID: 3312664
Hypochondriacal states.
Kenyon FE
Br J Psychiatry 1976 Jul;129:1-14. doi: 10.1192/bjp.129.1.1. PMID: 779913

Therapy

Side Effect Profiles of Selective Serotonin Reuptake Inhibitors: A Cross-Sectional Study in a Naturalistic Setting.
Anagha K, Shihabudheen P, Uvais NA
Prim Care Companion CNS Disord 2021 Jul 29;23(4) doi: 10.4088/PCC.20m02747. PMID: 34324797
Recent Advances in the Understanding and Treatment of Health Anxiety.
Tyrer P
Curr Psychiatry Rep 2018 Jun 22;20(7):49. doi: 10.1007/s11920-018-0912-0. PMID: 29931576
Psychotherapies for hypochondriasis.
Thomson AB, Page LA
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD006520. doi: 10.1002/14651858.CD006520.pub2. PMID: 17943915Free PMC Article
Using antipsychotic agents in older patients.
Alexopoulos GS, Streim J, Carpenter D, Docherty JP; Expert Consensus Panel for Using Antipsychotic Drugs in Older Patients
J Clin Psychiatry 2004;65 Suppl 2:5-99; discussion 100-102; quiz 103-4. PMID: 14994733
Hypochondriasis and somatization.
Kellner R
JAMA 1987 Nov 20;258(19):2718-22. PMID: 3312664

Prognosis

Somatic symptom disorder: a diagnostic dilemma.
Dunphy L, Penna M, El-Kafsi J
BMJ Case Rep 2019 Nov 25;12(11) doi: 10.1136/bcr-2019-231550. PMID: 31772129Free PMC Article
Psychogenic movement disorders.
Hinson VK, Haren WB
Lancet Neurol 2006 Aug;5(8):695-700. doi: 10.1016/S1474-4422(06)70523-3. PMID: 16857575
Hypochondriasis and somatization.
Kellner R
JAMA 1987 Nov 20;258(19):2718-22. PMID: 3312664
Hypochondriacal states.
Kenyon FE
Br J Psychiatry 1976 Jul;129:1-14. doi: 10.1192/bjp.129.1.1. PMID: 779913
Hysteria.
Reed JL
Br J Psychiatry 1975;Spec No 9:141-9. PMID: 1102011

Clinical prediction guides

Is cyberchondria specific to hypochondriasis?
Jungmann SM, Gropalis M, Schenkel SK, Witthöft M
J Anxiety Disord 2024 Mar;102:102798. Epub 2023 Dec 5 doi: 10.1016/j.janxdis.2023.102798. PMID: 38128287
All-Cause and Cause-Specific Mortality Among Individuals With Hypochondriasis.
Mataix-Cols D, Isomura K, Sidorchuk A, Rautio D, Ivanov VZ, Rück C, Österman S, Lichtenstein P, Larsson H, Kuja-Halkola R, Chang Z, Brickell I, Hedman-Lagerlöf E, Fernández de la Cruz L
JAMA Psychiatry 2024 Mar 1;81(3):284-291. doi: 10.1001/jamapsychiatry.2023.4744. PMID: 38091000Free PMC Article
Hypochondriasis and Personality Traits of Patients with Chronic Plaque Psoriasis.
Gisondi P, Geat D, Ferrazzi A, Bellinato F, Girolomoni G
Dermatology 2022;238(2):276-282. Epub 2021 Jul 29 doi: 10.1159/000517018. PMID: 34325430
Emotion dysregulation in hypochondriasis and depression.
Bailer J, Witthöft M, Erkic M, Mier D
Clin Psychol Psychother 2017 Nov;24(6):1254-1262. Epub 2017 Apr 26 doi: 10.1002/cpp.2089. PMID: 28444850
Medically unexplained symptoms, somatisation disorder and hypochondriasis: course and prognosis. A systematic review.
olde Hartman TC, Borghuis MS, Lucassen PL, van de Laar FA, Speckens AE, van Weel C
J Psychosom Res 2009 May;66(5):363-77. Epub 2008 Dec 16 doi: 10.1016/j.jpsychores.2008.09.018. PMID: 19379952

Recent systematic reviews

Personality and insomnia: A systematic review and narrative synthesis.
Akram U, Stevenson JC, Gardani M, Allen S, Johann AF
J Sleep Res 2023 Dec;32(6):e14031. Epub 2023 Sep 1 doi: 10.1111/jsr.14031. PMID: 37654128
Conceptualizations of Cyberchondria and Relations to the Anxiety Spectrum: Systematic Review and Meta-analysis.
Schenkel SK, Jungmann SM, Gropalis M, Witthöft M
J Med Internet Res 2021 Nov 18;23(11):e27835. doi: 10.2196/27835. PMID: 34792473Free PMC Article
Cognitive Behaviour Therapy for Health Anxiety: A Systematic Review and Meta-Analysis.
Cooper K, Gregory JD, Walker I, Lambe S, Salkovskis PM
Behav Cogn Psychother 2017 Mar;45(2):110-123. doi: 10.1017/S1352465816000527. PMID: 28229805
Medically unexplained symptoms, somatisation disorder and hypochondriasis: course and prognosis. A systematic review.
olde Hartman TC, Borghuis MS, Lucassen PL, van de Laar FA, Speckens AE, van Weel C
J Psychosom Res 2009 May;66(5):363-77. Epub 2008 Dec 16 doi: 10.1016/j.jpsychores.2008.09.018. PMID: 19379952
Psychotherapies for hypochondriasis.
Thomson AB, Page LA
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD006520. doi: 10.1002/14651858.CD006520.pub2. PMID: 17943915Free PMC Article

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