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Moderate myopia

MedGen UID:
939834
Concept ID:
C4315867
Disease or Syndrome
Synonym: Myopia, moderate
 
HPO: HP:0031624

Definition

A moderate form of myopia with refractive error of between -3.00 and -6.00 diopters. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerate myopia

Conditions with this feature

Facial dysmorphism-lens dislocation-anterior segment abnormalities-spontaneous filtering blebs syndrome
MedGen UID:
330396
Concept ID:
C1832167
Disease or Syndrome
Traboulsi syndrome is characterized by dislocated crystalline lenses and anterior segment abnormalities in association with a distinctive facies involving flat cheeks and a beaked nose. Some affected individuals develop highly unusual nontraumatic conjunctival cysts (filtering blebs), presumably caused by abnormal thinning of the sclera (Patel et al., 2014).
X-linked intellectual disability-retinitis pigmentosa syndrome
MedGen UID:
336862
Concept ID:
C1845136
Disease or Syndrome
X-linked intellectual disability-retinitis pigmentosa syndrome is characterized by moderate intellectual deficit and severe, early-onset retinitis pigmentosa. It has been described in five males spanning three generations of one family. Some patients also had microcephaly. It is transmitted as an X-linked recessive trait.
Congenital stationary night blindness autosomal dominant 2
MedGen UID:
361814
Concept ID:
C1876182
Disease or Syndrome
Any congenital stationary night blindness in which the cause of the disease is a mutation in the PDE6B gene.
Tessadori-van Haaften neurodevelopmental syndrome 1
MedGen UID:
1810348
Concept ID:
C5676922
Disease or Syndrome
Tessadori-Bicknell-van Haaften neurodevelopmental syndrome-1 (TEBIVANED1) is characterized by poor overall growth with short stature, microcephaly, hypotonia, profound global developmental delay often with poor or absent speech, and characteristic dysmorphic facial features, including hypertelorism and abnormal nose. Other variable neurologic and systemic features may also occur (Tessadori et al., 2017). Genetic Heterogeneity of Tessadori-van Haaften Neurodevelopmental Syndrome See also TEBIVANED2 (619759), caused by mutation in the H4C11 gene (602826); TEBIVANED3 (619950), caused by mutation in the H4C5 gene (602830); and TEBIVANED4 (619951), caused by mutation in the H4C9 gene (602833).
Stickler syndrome, IIa 6
MedGen UID:
1823980
Concept ID:
C5774207
Disease or Syndrome
Stickler syndrome type VI (STL6) is characterized by early-onset progressive hearing loss and progressive myopia, with variable manifestation of facial dysmorphism and skeletal anomalies (Nixon et al., 2019; Rad et al., 2022). For a general phenotypic description and discussion of genetic heterogeneity of Stickler syndrome, see STL1 (108300).
Tessadori-Van Haaften neurodevelopmental syndrome 3
MedGen UID:
1824083
Concept ID:
C5774310
Disease or Syndrome
Tessadori-Bicknell-van Haaften neurodevelopmental syndrome-3 (TEBIVANED3) is characterized by global developmental delay with poor overall growth, impaired intellectual development, and speech difficulties. More variable features include hypotonia, microcephaly, and dysmorphic facies. The severity and manifestations of the disorder are highly variable (Tessadori et al., 2022). For a discussion of genetic heterogeneity of Tessadori-Bicknell-van Haaften neurodevelopmental disorder, see TEBIVANED1 (619758).

Professional guidelines

PubMed

Hofmeister EM, Cason JB, Murdoch DM, Yau IW, Wang Y, Parizadeh DD, Janakiraman DP, Kasthurirangan S
J Cataract Refract Surg 2023 Mar 1;49(3):292-298. doi: 10.1097/j.jcrs.0000000000001083. PMID: 36730946
Xi L, Zhang C, He Y
BMC Ophthalmol 2018 Aug 28;18(1):209. doi: 10.1186/s12886-018-0888-x. PMID: 30153819Free PMC Article
Adatia FA, Damji KF
Can Fam Physician 2005 Sep;51(9):1229-37. PMID: 16190176Free PMC Article

Recent clinical studies

Etiology

Wu W, Song Y, Sun M, Li Y, Xu Y, Xu M, Yang Y, Li S, Zhang F
Exp Eye Res 2023 Dec;237:109689. Epub 2023 Oct 21 doi: 10.1016/j.exer.2023.109689. PMID: 37871883
Zhang RH, Yang Q, Dong L, Li YF, Zhou WD, Wu HT, Li HY, Shao L, Zhang C, Wang YX, Wei WB
Eur J Ophthalmol 2023 Sep;33(5):1883-1891. Epub 2023 Mar 3 doi: 10.1177/11206721231161498. PMID: 36866629
Lee S, Lee HJ, Lee KG, Kim J
PLoS One 2022;17(3):e0265317. Epub 2022 Mar 25 doi: 10.1371/journal.pone.0265317. PMID: 35333875Free PMC Article
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article
Chua WH, Balakrishnan V, Chan YH, Tong L, Ling Y, Quah BL, Tan D
Ophthalmology 2006 Dec;113(12):2285-91. Epub 2006 Sep 25 doi: 10.1016/j.ophtha.2006.05.062. PMID: 16996612

Diagnosis

Wakabayashi T, Yonekawa Y, Ohno-Matsui K, Cohen SY, Rowland C, Pulido JS
Retin Cases Brief Rep 2024 Jan 1;18(1):11-14. doi: 10.1097/ICB.0000000000001308. PMID: 36007179
Wu W, Song Y, Sun M, Li Y, Xu Y, Xu M, Yang Y, Li S, Zhang F
Exp Eye Res 2023 Dec;237:109689. Epub 2023 Oct 21 doi: 10.1016/j.exer.2023.109689. PMID: 37871883
Ren Q, Yang B, Liu L, Cho P
Cont Lens Anterior Eye 2023 Jun;46(3):101824. Epub 2023 Mar 9 doi: 10.1016/j.clae.2023.101824. PMID: 36898875
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article
Oshika T, Klyce SD
Semin Ophthalmol 1998 Jun;13(2):64-70. doi: 10.3109/08820539809059820. PMID: 9758650

Therapy

Chin JY, Lin MT, Lee IXY, Mehta JS, Liu YC
J Refract Surg 2021 Aug;37(8):516-523. Epub 2021 Aug 1 doi: 10.3928/1081597X-20210423-01. PMID: 34388069
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article
Chua WH, Balakrishnan V, Chan YH, Tong L, Ling Y, Quah BL, Tan D
Ophthalmology 2006 Dec;113(12):2285-91. Epub 2006 Sep 25 doi: 10.1016/j.ophtha.2006.05.062. PMID: 16996612
Bower KS, Weichel ED, Kim TJ
Am Fam Physician 2001 Oct 1;64(7):1183-90. PMID: 11601800
Oshika T, Klyce SD
Semin Ophthalmol 1998 Jun;13(2):64-70. doi: 10.3109/08820539809059820. PMID: 9758650

Prognosis

Wang Q, Fan L, Zhou Q
Int Ophthalmol 2023 Feb;43(2):575-581. Epub 2022 Aug 19 doi: 10.1007/s10792-022-02459-3. PMID: 35984557Free PMC Article
López-Artero E, Poyales F, Garzón N, Matamoros A, Sáez A, Zhou Y, García-Montero M
Int J Environ Res Public Health 2022 May 31;19(11) doi: 10.3390/ijerph19116716. PMID: 35682300Free PMC Article
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article
Kim A, Chuck RS
Curr Opin Ophthalmol 2008 Jul;19(4):314-20. doi: 10.1097/ICU.0b013e328302ccae. PMID: 18545014
Bower KS, Weichel ED, Kim TJ
Am Fam Physician 2001 Oct 1;64(7):1183-90. PMID: 11601800

Clinical prediction guides

Ren Q, Yang B, Liu L, Cho P
Cont Lens Anterior Eye 2023 Jun;46(3):101824. Epub 2023 Mar 9 doi: 10.1016/j.clae.2023.101824. PMID: 36898875
Zhang RH, Yang Q, Dong L, Li YF, Zhou WD, Wu HT, Li HY, Shao L, Zhang C, Wang YX, Wei WB
Eur J Ophthalmol 2023 Sep;33(5):1883-1891. Epub 2023 Mar 3 doi: 10.1177/11206721231161498. PMID: 36866629
Yao H, Xin D, Li Z
Ophthalmic Res 2022;65(4):455-465. Epub 2022 Mar 16 doi: 10.1159/000523938. PMID: 35294948
Yin Y, Zhao Y, Fu Y, Xiang A, Wu X, Wen D
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Aug 28;45(8):966-972. doi: 10.11817/j.issn.1672-7347.2020.190196. PMID: 33053540
Bower KS, Weichel ED, Kim TJ
Am Fam Physician 2001 Oct 1;64(7):1183-90. PMID: 11601800

Recent systematic reviews

Ullrich M, Zwickl H, Findl O
J Cataract Refract Surg 2021 Apr 1;47(4):533-541. doi: 10.1097/j.jcrs.0000000000000420. PMID: 32925646
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article
Pakbin M, Khabazkhoob M, Pakravan M, Fotouhi A, Jafarzadehpour E, Aghamirsalim M, Seyedian MA, Hashemi H
J Cataract Refract Surg 2020 Apr;46(4):622-632. doi: 10.1097/j.jcrs.0000000000000060. PMID: 32271298
Kuryan J, Cheema A, Chuck RS
Cochrane Database Syst Rev 2017 Feb 15;2(2):CD011080. doi: 10.1002/14651858.CD011080.pub2. PMID: 28197998Free PMC Article
Li SM, Zhan S, Li SY, Peng XX, Hu J, Law HA, Wang NL
Cochrane Database Syst Rev 2016 Feb 22;2(2):CD009799. doi: 10.1002/14651858.CD009799.pub2. PMID: 26899152Free PMC Article

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