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Susceptibility to esophageal cancer (in alcohol drinkers with the ALDH2 A allele)

MedGen UID:
940033
•Concept ID:
C4316066
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSusceptibility to esophageal cancer (in alcohol drinkers with the ALDH2 A allele)

Professional guidelines

PubMed

Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population.
Ding JH, Li SP, Cao HX, Wu JZ, Gao CM, Liu YT, Zhou JN, Chang J, Yao GH
J Hum Genet 2010 Feb;55(2):97-102. Epub 2009 Dec 11 doi: 10.1038/jhg.2009.129. PMID: 20010786
Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers.
Yokoyama A, Watanabe H, Fukuda H, Haneda T, Kato H, Yokoyama T, Muramatsu T, Igaki H, Tachimori Y
Cancer Epidemiol Biomarkers Prev 2002 Sep;11(9):895-900. PMID: 12223435

Recent clinical studies

Etiology

Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2-mutation carriers.
Mori T, Okamoto Y, Mu A, Ide Y, Yoshimura A, Senda N, Inagaki-Kawata Y, Kawashima M, Kitao H, Tokunaga E, Miyoshi Y, Ohsumi S, Tsugawa K, Ohta T, Katagiri T, Ohtsuru S, Koike K, Ogawa S, Toi M, Iwata H, Nakamura S, Matsuo K, Takata M
Cancer Med 2023 Mar;12(6):6594-6602. Epub 2022 Nov 7 doi: 10.1002/cam4.5430. PMID: 36345163Free PMC Article
Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk.
Suo C, Yang Y, Yuan Z, Zhang T, Yang X, Qing T, Gao P, Shi L, Fan M, Cheng H, Lu M, Jin L, Chen X, Ye W
J Thorac Oncol 2019 Apr;14(4):712-725. Epub 2019 Jan 9 doi: 10.1016/j.jtho.2018.12.023. PMID: 30639619
Genetic variant repressing ADH1A expression confers susceptibility to esophageal squamous-cell carcinoma.
Cui Q, Peng L, Wei L, Chang J, Tan W, Luo Y, Huang X, Zhao Y, Li J, Chu J, Shao M, Zhang C, Li C, Tan W, Lin D, Wu C
Cancer Lett 2018 May 1;421:43-50. Epub 2017 Dec 15 doi: 10.1016/j.canlet.2017.12.020. PMID: 29248712
ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma.
Kagemoto K, Urabe Y, Miwata T, Oka S, Ochi H, Kitadai Y, Tanaka S, Chayama K
Cancer Med 2016 Jul;5(7):1397-404. Epub 2016 Mar 31 doi: 10.1002/cam4.705. PMID: 27038040Free PMC Article
Meta-analysis of ALDH2 variants and esophageal cancer in Asians.
Fang P, Jiao S, Zhang X, Liu Z, Wang H, Gao Y, Luo H, Chen T, Shi L
Asian Pac J Cancer Prev 2011;12(10):2623-7. PMID: 22320964

Diagnosis

Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2-mutation carriers.
Mori T, Okamoto Y, Mu A, Ide Y, Yoshimura A, Senda N, Inagaki-Kawata Y, Kawashima M, Kitao H, Tokunaga E, Miyoshi Y, Ohsumi S, Tsugawa K, Ohta T, Katagiri T, Ohtsuru S, Koike K, Ogawa S, Toi M, Iwata H, Nakamura S, Matsuo K, Takata M
Cancer Med 2023 Mar;12(6):6594-6602. Epub 2022 Nov 7 doi: 10.1002/cam4.5430. PMID: 36345163Free PMC Article
ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma.
Kagemoto K, Urabe Y, Miwata T, Oka S, Ochi H, Kitadai Y, Tanaka S, Chayama K
Cancer Med 2016 Jul;5(7):1397-404. Epub 2016 Mar 31 doi: 10.1002/cam4.705. PMID: 27038040Free PMC Article
Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis.
Lee CH, Wu DC, Wu IC, Goan YG, Lee JM, Chou SH, Chan TF, Huang HL, Hung YH, Huang MC, Lai TC, Wang TN, Lan CC, Tsai S, Lin WY, Wu MT
Int J Cancer 2009 Sep 1;125(5):1134-42. doi: 10.1002/ijc.24357. PMID: 19449376
Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers.
Yokoyama A, Watanabe H, Fukuda H, Haneda T, Kato H, Yokoyama T, Muramatsu T, Igaki H, Tachimori Y
Cancer Epidemiol Biomarkers Prev 2002 Sep;11(9):895-900. PMID: 12223435

Therapy

Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk.
Suo C, Yang Y, Yuan Z, Zhang T, Yang X, Qing T, Gao P, Shi L, Fan M, Cheng H, Lu M, Jin L, Chen X, Ye W
J Thorac Oncol 2019 Apr;14(4):712-725. Epub 2019 Jan 9 doi: 10.1016/j.jtho.2018.12.023. PMID: 30639619
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.
Wu C, Kraft P, Zhai K, Chang J, Wang Z, Li Y, Hu Z, He Z, Jia W, Abnet CC, Liang L, Hu N, Miao X, Zhou Y, Liu Z, Zhan Q, Liu Y, Qiao Y, Zhou Y, Jin G, Guo C, Lu C, Yang H, Fu J, Yu D, Freedman ND, Ding T, Tan W, Goldstein AM, Wu T, Shen H, Ke Y, Zeng Y, Chanock SJ, Taylor PR, Lin D
Nat Genet 2012 Oct;44(10):1090-7. Epub 2012 Sep 9 doi: 10.1038/ng.2411. PMID: 22960999
Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population.
Ding JH, Li SP, Cao HX, Wu JZ, Gao CM, Liu YT, Zhou JN, Chang J, Yao GH
J Hum Genet 2010 Feb;55(2):97-102. Epub 2009 Dec 11 doi: 10.1038/jhg.2009.129. PMID: 20010786
Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers.
Yokoyama A, Watanabe H, Fukuda H, Haneda T, Kato H, Yokoyama T, Muramatsu T, Igaki H, Tachimori Y
Cancer Epidemiol Biomarkers Prev 2002 Sep;11(9):895-900. PMID: 12223435

Prognosis

ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma.
Kagemoto K, Urabe Y, Miwata T, Oka S, Ochi H, Kitadai Y, Tanaka S, Chayama K
Cancer Med 2016 Jul;5(7):1397-404. Epub 2016 Mar 31 doi: 10.1002/cam4.705. PMID: 27038040Free PMC Article
ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis.
Zhang G, Mai R, Huang B
PLoS One 2010 Oct 27;5(10):e13679. doi: 10.1371/journal.pone.0013679. PMID: 21048924Free PMC Article
Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis.
Lee CH, Wu DC, Wu IC, Goan YG, Lee JM, Chou SH, Chan TF, Huang HL, Hung YH, Huang MC, Lai TC, Wang TN, Lan CC, Tsai S, Lin WY, Wu MT
Int J Cancer 2009 Sep 1;125(5):1134-42. doi: 10.1002/ijc.24357. PMID: 19449376

Clinical prediction guides

Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk.
Suo C, Yang Y, Yuan Z, Zhang T, Yang X, Qing T, Gao P, Shi L, Fan M, Cheng H, Lu M, Jin L, Chen X, Ye W
J Thorac Oncol 2019 Apr;14(4):712-725. Epub 2019 Jan 9 doi: 10.1016/j.jtho.2018.12.023. PMID: 30639619
Single nucleotide polymorphisms of one-carbon metabolism and cancers of the esophagus, stomach, and liver in a Chinese population.
Chang SC, Chang PY, Butler B, Goldstein BY, Mu L, Cai L, You NC, Baecker A, Yu SZ, Heber D, Lu QY, Li L, Greenland S, Zhang ZF
PLoS One 2014;9(10):e109235. Epub 2014 Oct 22 doi: 10.1371/journal.pone.0109235. PMID: 25337902Free PMC Article
Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: a population-based case-control study in China.
Wu M, Chang SC, Kampman E, Yang J, Wang XS, Gu XP, Han RQ, Liu AM, Wallar G, Zhou JY, Kok FJ, Zhao JK, Zhang ZF
Int J Cancer 2013 Apr 15;132(8):1868-77. Epub 2012 Sep 28 doi: 10.1002/ijc.27803. PMID: 22930414Free PMC Article
Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract.
Hashibe M, Boffetta P, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Mates D, Janout V, Fabiánová E, Bencko V, Moullan N, Chabrier A, Hung R, Hall J, Canzian F, Brennan P
Cancer Epidemiol Biomarkers Prev 2006 Apr;15(4):696-703. doi: 10.1158/1055-9965.EPI-05-0710. PMID: 16614111

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