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Impetigo

MedGen UID:
9440
•Concept ID:
C0021099
•
Disease or Syndrome
Synonym: Impetigos
SNOMED CT: Impetigo (48277006)
 
Monarch Initiative: MONDO:0004592

Definition

A contagious bacterial cutaneous infection that affects children and is usually caused by Staphylococcus aureus. It usually presents in the face with honey colored scabs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpetigo

Professional guidelines

PubMed

Common Community-acquired Bacterial Skin and Soft-tissue Infections in Children: an Intersociety Consensus on Impetigo, Abscess, and Cellulitis Treatment.
Galli L, Venturini E, Bassi A, Gattinara GC, Chiappini E, Defilippi C, Diociaiuti A, Esposito S, Garazzino S, Giannattasio A, Krzysztofiak A, Latorre S, Lo Vecchio A, Marchisio P, Montagnani C, Nicolini G, Novelli A, Rossolini GM, Tersigni C, Villani A, El Hachem M, Neri I; Italian Pediatric Infectious Diseases Society; Italian Pediatric Dermatology Society
Clin Ther 2019 Mar;41(3):532-551.e17. Epub 2019 Feb 15 doi: 10.1016/j.clinthera.2019.01.010. PMID: 30777258
Generalized pustular psoriasis: a review and update on treatment.
Hoegler KM, John AM, Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2018 Oct;32(10):1645-1651. Epub 2018 Apr 11 doi: 10.1111/jdv.14949. PMID: 29573491
Impetigo: diagnosis and treatment.
Hartman-Adams H, Banvard C, Juckett G
Am Fam Physician 2014 Aug 15;90(4):229-35. PMID: 25250996

Curated

UK NICE Guidelines NG153, Impetigo: antimicrobial prescribing, 2020

Recent clinical studies

Etiology

Staphylococcal Skin and Soft Tissue Infections.
Hatlen TJ, Miller LG
Infect Dis Clin North Am 2021 Mar;35(1):81-105. Epub 2020 Dec 7 doi: 10.1016/j.idc.2020.10.003. PMID: 33303329
Common Community-acquired Bacterial Skin and Soft-tissue Infections in Children: an Intersociety Consensus on Impetigo, Abscess, and Cellulitis Treatment.
Galli L, Venturini E, Bassi A, Gattinara GC, Chiappini E, Defilippi C, Diociaiuti A, Esposito S, Garazzino S, Giannattasio A, Krzysztofiak A, Latorre S, Lo Vecchio A, Marchisio P, Montagnani C, Nicolini G, Novelli A, Rossolini GM, Tersigni C, Villani A, El Hachem M, Neri I; Italian Pediatric Infectious Diseases Society; Italian Pediatric Dermatology Society
Clin Ther 2019 Mar;41(3):532-551.e17. Epub 2019 Feb 15 doi: 10.1016/j.clinthera.2019.01.010. PMID: 30777258
Impetigo - review.
Pereira LB
An Bras Dermatol 2014 Mar-Apr;89(2):293-9. doi: 10.1590/abd1806-4841.20142283. PMID: 24770507Free PMC Article
Disease manifestations and pathogenic mechanisms of Group A Streptococcus.
Walker MJ, Barnett TC, McArthur JD, Cole JN, Gillen CM, Henningham A, Sriprakash KS, Sanderson-Smith ML, Nizet V
Clin Microbiol Rev 2014 Apr;27(2):264-301. doi: 10.1128/CMR.00101-13. PMID: 24696436Free PMC Article
Pyodermitis.
Empinotti JC, Uyeda H, Ruaro RT, Galhardo AP, Bonatto DC
An Bras Dermatol 2012 Mar-Apr;87(2):277-84. doi: 10.1590/s0365-05962012000200013. PMID: 22570033

Diagnosis

Staphylococcal Scalded Skin Syndrome and Bullous Impetigo.
Brazel M, Desai A, Are A, Motaparthi K
Medicina (Kaunas) 2021 Oct 24;57(11) doi: 10.3390/medicina57111157. PMID: 34833375Free PMC Article
Impetigo.
Johnson MK
Adv Emerg Nurs J 2020 Oct/Dec;42(4):262-269. doi: 10.1097/TME.0000000000000320. PMID: 33105179
Ectoparasites: Scabies.
Thomas C, Coates SJ, Engelman D, Chosidow O, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):533-548. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.109. PMID: 31310840
Skin Infections.
Clebak KT, Malone MA
Prim Care 2018 Sep;45(3):433-454. doi: 10.1016/j.pop.2018.05.004. PMID: 30115333
Impetigo: diagnosis and treatment.
Hartman-Adams H, Banvard C, Juckett G
Am Fam Physician 2014 Aug 15;90(4):229-35. PMID: 25250996

Therapy

Staphylococcal Skin and Soft Tissue Infections.
Hatlen TJ, Miller LG
Infect Dis Clin North Am 2021 Mar;35(1):81-105. Epub 2020 Dec 7 doi: 10.1016/j.idc.2020.10.003. PMID: 33303329
Impetigo.
Johnson MK
Adv Emerg Nurs J 2020 Oct/Dec;42(4):262-269. doi: 10.1097/TME.0000000000000320. PMID: 33105179
Ectoparasites: Scabies.
Thomas C, Coates SJ, Engelman D, Chosidow O, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):533-548. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.109. PMID: 31310840
Generalized pustular psoriasis: a review and update on treatment.
Hoegler KM, John AM, Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2018 Oct;32(10):1645-1651. Epub 2018 Apr 11 doi: 10.1111/jdv.14949. PMID: 29573491
Impetigo: diagnosis and treatment.
Hartman-Adams H, Banvard C, Juckett G
Am Fam Physician 2014 Aug 15;90(4):229-35. PMID: 25250996

Prognosis

Impetigo.
Johnson MK
Adv Emerg Nurs J 2020 Oct/Dec;42(4):262-269. doi: 10.1097/TME.0000000000000320. PMID: 33105179
Common Skin Rashes in Children.
Allmon A, Deane K, Martin KL
Am Fam Physician 2015 Aug 1;92(3):211-6. PMID: 26280141
Impetigo: diagnosis and treatment.
Hartman-Adams H, Banvard C, Juckett G
Am Fam Physician 2014 Aug 15;90(4):229-35. PMID: 25250996
The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions.
Hay RJ, Johns NE, Williams HC, Bolliger IW, Dellavalle RP, Margolis DJ, Marks R, Naldi L, Weinstock MA, Wulf SK, Michaud C, J L Murray C, Naghavi M
J Invest Dermatol 2014 Jun;134(6):1527-1534. Epub 2013 Oct 28 doi: 10.1038/jid.2013.446. PMID: 24166134
Interventions for impetigo.
Koning S, Verhagen AP, van Suijlekom-Smit LW, Morris A, Butler CC, van der Wouden JC
Cochrane Database Syst Rev 2004;(2):CD003261. doi: 10.1002/14651858.CD003261.pub2. PMID: 15106198

Clinical prediction guides

Phenotypic and Endotypic Determinants of Atopic Dermatitis Severity From the Atopic Dermatitis Research Network (ADRN) Registry.
Simpson EL, De Benedetto A, Boguniewicz M, Ong PY, Lussier S, Villarreal M, Schneider LC, Paller AS, Guttman-Yassky E, Hanifin JM, Spergel JM, Barnes KC, David G, Austin B, Leung DYM, Beck LA
J Allergy Clin Immunol Pract 2023 Aug;11(8):2504-2515. Epub 2023 May 12 doi: 10.1016/j.jaip.2023.04.052. PMID: 37182563Free PMC Article
Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F
Front Immunol 2021;12:720876. Epub 2021 Jul 27 doi: 10.3389/fimmu.2021.720876. PMID: 34386016Free PMC Article
Topical Ozenoxacin Cream 1% for Impetigo: A Review.
Schachner L, Andriessen A, Bhatia N, Grada A, Patele D
J Drugs Dermatol 2019 Jul 1;18(7):655-661. PMID: 31334625
Common Community-acquired Bacterial Skin and Soft-tissue Infections in Children: an Intersociety Consensus on Impetigo, Abscess, and Cellulitis Treatment.
Galli L, Venturini E, Bassi A, Gattinara GC, Chiappini E, Defilippi C, Diociaiuti A, Esposito S, Garazzino S, Giannattasio A, Krzysztofiak A, Latorre S, Lo Vecchio A, Marchisio P, Montagnani C, Nicolini G, Novelli A, Rossolini GM, Tersigni C, Villani A, El Hachem M, Neri I; Italian Pediatric Infectious Diseases Society; Italian Pediatric Dermatology Society
Clin Ther 2019 Mar;41(3):532-551.e17. Epub 2019 Feb 15 doi: 10.1016/j.clinthera.2019.01.010. PMID: 30777258
Staphylococcal epidermolysins.
Prévost G, Couppié P, Monteil H
Curr Opin Infect Dis 2003 Apr;16(2):71-6. doi: 10.1097/00001432-200304000-00002. PMID: 12734438

Recent systematic reviews

Emerging Treatment Strategies for Impetigo in Endemic and Nonendemic Settings: A Systematic Review.
Gahlawat G, Tesfaye W, Bushell M, Abrha S, Peterson GM, Mathew C, Sinnollareddy M, McMillan F, Samarawickrema I, Calma T, Chang AY, Engelman D, Steer A, Thomas J
Clin Ther 2021 Jun;43(6):986-1006. Epub 2021 May 27 doi: 10.1016/j.clinthera.2021.04.013. PMID: 34053699
Treatment, prevention and public health management of impetigo, scabies, crusted scabies and fungal skin infections in endemic populations: a systematic review.
May PJ, Tong SYC, Steer AC, Currie BJ, Andrews RM, Carapetis JR, Bowen AC
Trop Med Int Health 2019 Mar;24(3):280-293. Epub 2019 Jan 28 doi: 10.1111/tmi.13198. PMID: 30582783Free PMC Article
Prevalence of scabies and impetigo worldwide: a systematic review.
Romani L, Steer AC, Whitfeld MJ, Kaldor JM
Lancet Infect Dis 2015 Aug;15(8):960-7. Epub 2015 Jun 15 doi: 10.1016/S1473-3099(15)00132-2. PMID: 26088526
Interventions for impetigo.
Koning S, van der Sande R, Verhagen AP, van Suijlekom-Smit LW, Morris AD, Butler CC, Berger M, van der Wouden JC
Cochrane Database Syst Rev 2012 Jan 18;1(1):CD003261. doi: 10.1002/14651858.CD003261.pub3. PMID: 22258953Free PMC Article
Interventions for impetigo.
Koning S, Verhagen AP, van Suijlekom-Smit LW, Morris A, Butler CC, van der Wouden JC
Cochrane Database Syst Rev 2004;(2):CD003261. doi: 10.1002/14651858.CD003261.pub2. PMID: 15106198

Supplemental Content

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    Clinical resources

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Guidelines NG153, Impetigo: antimicrobial prescribing, 2020

    Consumer resources

    Reviews

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