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Endotheliitis

MedGen UID:
949193
Concept ID:
CN266165
Finding
Synonyms: Corneal endotheliitis; endotheliitis; endothelium inflammation; inflammation of endothelium
 
Monarch Initiative: MONDO:0015292
Orphanet: ORPHA137602

Definition

A rare corneal disorder characterized by inflammation of the corneal endothelium with corneal edema, keratic precipitates, mild to moderate anterior chamber reaction, and subsequent visual disturbances. It is often associated with increased intraocular pressure. Based on the distribution of the lesions, a linear, sectorial, disciform, and diffuse form can be distinguished. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndotheliitis

Professional guidelines

PubMed

La Distia Nora R, Putera I, Mayasari YD, Hikmahwati W, Pertiwi AM, Ridwan AS, Sitompul R, Westcott M, Chee SP, Pavesio C, Thng ZX, Gupta V, Agrawal R
Surv Ophthalmol 2022 Jul-Aug;67(4):1014-1030. Epub 2021 Dec 23 doi: 10.1016/j.survophthal.2021.12.006. PMID: 34954093
Ikezoe T
Int J Hematol 2021 Jan;113(1):34-44. Epub 2020 Sep 9 doi: 10.1007/s12185-020-02992-w. PMID: 32902759
Amigues I, Pearlman AH, Patel A, Reid P, Robinson PC, Sinha R, Kim AH, Youngstein T, Jayatilleke A, Konig M
Expert Rev Clin Immunol 2020 Dec;16(12):1185-1204. Epub 2020 Nov 25 doi: 10.1080/1744666X.2021.1847084. PMID: 33146561Free PMC Article

Recent clinical studies

Etiology

Liang TZ, Dong S, Fang M, Gong Y, Yaghmour G, Chopra S
Am J Clin Pathol 2022 Jun 7;157(6):948-955. doi: 10.1093/ajcp/aqab215. PMID: 35038720
Sarkar M, Madabhavi IV, Quy PN, Govindagoudar MB
Clin Respir J 2021 Dec;15(12):1259-1274. Epub 2021 Aug 30 doi: 10.1111/crj.13438. PMID: 34399021Free PMC Article
Uginet M, Breville G, Assal F, Lövblad KO, Vargas MI, Pugin J, Serratrice J, Herrmann FR, Lalive PH, Allali G
J Med Virol 2021 Jul;93(7):4374-4381. Epub 2021 Apr 23 doi: 10.1002/jmv.26973. PMID: 33782993Free PMC Article
Quinaglia T, Shabani M, Breder I, Silber HA, Lima JAC, Sposito AC
Atherosclerosis 2021 Apr;322:39-50. Epub 2021 Feb 15 doi: 10.1016/j.atherosclerosis.2021.02.009. PMID: 33706082Free PMC Article
Inoue Y
Cornea 2014 Nov;33 Suppl 11:S3-8. doi: 10.1097/ICO.0000000000000228. PMID: 25170583

Diagnosis

Haffke M, Freitag H, Rudolf G, Seifert M, Doehner W, Scherbakov N, Hanitsch L, Wittke K, Bauer S, Konietschke F, Paul F, Bellmann-Strobl J, Kedor C, Scheibenbogen C, Sotzny F
J Transl Med 2022 Mar 22;20(1):138. doi: 10.1186/s12967-022-03346-2. PMID: 35317812Free PMC Article
La Distia Nora R, Putera I, Mayasari YD, Hikmahwati W, Pertiwi AM, Ridwan AS, Sitompul R, Westcott M, Chee SP, Pavesio C, Thng ZX, Gupta V, Agrawal R
Surv Ophthalmol 2022 Jul-Aug;67(4):1014-1030. Epub 2021 Dec 23 doi: 10.1016/j.survophthal.2021.12.006. PMID: 34954093
Mele D, Flamigni F, Rapezzi C, Ferrari R
Intern Emerg Med 2021 Aug;16(5):1123-1129. Epub 2021 Jan 23 doi: 10.1007/s11739-021-02635-w. PMID: 33484452Free PMC Article
De Martin E, Michot JM, Papouin B, Champiat S, Mateus C, Lambotte O, Roche B, Antonini TM, Coilly A, Laghouati S, Robert C, Marabelle A, Guettier C, Samuel D
J Hepatol 2018 Jun;68(6):1181-1190. Epub 2018 Feb 8 doi: 10.1016/j.jhep.2018.01.033. PMID: 29427729
Chan NS, Chee SP, Caspers L, Bodaghi B
Ocul Immunol Inflamm 2018;26(1):107-115. Epub 2017 Nov 27 doi: 10.1080/09273948.2017.1394471. PMID: 29172842

Therapy

Wang J, Li Q, Qiu Y, Lu H
Emerg Microbes Infect 2022 Dec;11(1):2393-2404. doi: 10.1080/22221751.2022.2122579. PMID: 36069182Free PMC Article
Hattori Y, Hattori K, Machida T, Matsuda N
Biochem Pharmacol 2022 Mar;197:114909. Epub 2022 Jan 10 doi: 10.1016/j.bcp.2022.114909. PMID: 35021044Free PMC Article
La Distia Nora R, Putera I, Mayasari YD, Hikmahwati W, Pertiwi AM, Ridwan AS, Sitompul R, Westcott M, Chee SP, Pavesio C, Thng ZX, Gupta V, Agrawal R
Surv Ophthalmol 2022 Jul-Aug;67(4):1014-1030. Epub 2021 Dec 23 doi: 10.1016/j.survophthal.2021.12.006. PMID: 34954093
De Martin E, Michot JM, Papouin B, Champiat S, Mateus C, Lambotte O, Roche B, Antonini TM, Coilly A, Laghouati S, Robert C, Marabelle A, Guettier C, Samuel D
J Hepatol 2018 Jun;68(6):1181-1190. Epub 2018 Feb 8 doi: 10.1016/j.jhep.2018.01.033. PMID: 29427729
Olsen TW, Hardten DR, Meiusi RS, Holland EJ
Am J Ophthalmol 1994 Apr 15;117(4):468-74. doi: 10.1016/s0002-9394(14)70006-6. PMID: 8154528

Prognosis

Liang TZ, Dong S, Fang M, Gong Y, Yaghmour G, Chopra S
Am J Clin Pathol 2022 Jun 7;157(6):948-955. doi: 10.1093/ajcp/aqab215. PMID: 35038720
Leslie-Mazwi TM, Srivatanakul K
Interv Neuroradiol 2021 Oct;27(1_suppl):13-18. Epub 2021 Oct 20 doi: 10.1177/15910199211035920. PMID: 34670419Free PMC Article
García de Guadiana-Romualdo L, Calvo Nieves MD, Rodríguez Mulero MD, Calcerrada Alises I, Hernández Olivo M, Trapiello Fernández W, González Morales M, Bolado Jiménez C, Albaladejo-Otón MD, Fernández Ovalle H, Conesa Hernández A, Azpeleta Manrique E, Consuegra-Sánchez L, Nogales Martín L, Conesa Zamora P, Andaluz-Ojeda D
Eur J Clin Invest 2021 May;51(5):e13511. Epub 2021 Feb 20 doi: 10.1111/eci.13511. PMID: 33569769Free PMC Article
Mele D, Flamigni F, Rapezzi C, Ferrari R
Intern Emerg Med 2021 Aug;16(5):1123-1129. Epub 2021 Jan 23 doi: 10.1007/s11739-021-02635-w. PMID: 33484452Free PMC Article
Cruz Rodriguez JB, Lange RA, Mukherjee D
J Investig Med 2020 Dec;68(8):1334-1340. Epub 2020 Oct 19 doi: 10.1136/jim-2020-001592. PMID: 33077488

Clinical prediction guides

Haberecker M, Schwarz EI, Steiger P, Frontzek K, Scholkmann F, Zeng X, Höller S, Moch H, Varga Z
Respiration 2022;101(2):155-165. Epub 2021 Sep 15 doi: 10.1159/000518914. PMID: 34525475Free PMC Article
Ahmed S, Zimba O, Gasparyan AY
Clin Rheumatol 2021 Jul;40(7):2611-2619. Epub 2021 Mar 17 doi: 10.1007/s10067-021-05691-x. PMID: 33733315Free PMC Article
Peng RM, Guo YX, Xiao GG, Lu Q, Sun BJ, Hong J
Ocul Immunol Inflamm 2019;27(8):1270-1279. Epub 2018 Sep 25 doi: 10.1080/09273948.2018.1521435. PMID: 30252558
Koizumi N, Inatomi T, Suzuki T, Shiraishi A, Ohashi Y, Kandori M, Miyazaki D, Inoue Y, Soma T, Nishida K, Takase H, Sugita S, Mochizuki M, Kinoshita S; Japan Corneal Endotheliitis Study Group
Br J Ophthalmol 2015 Jan;99(1):54-8. Epub 2014 Jul 29 doi: 10.1136/bjophthalmol-2013-304625. PMID: 25075122Free PMC Article
Souza PM, Holland EJ, Huang AJ
Ophthalmology 2003 Mar;110(3):493-6. doi: 10.1016/S0161-6420(02)01772-4. PMID: 12623810

Recent systematic reviews

Mahjani M, Parvin M, Ghobadi S, Jafari A, Ahangar H, Gohari S, Gohari S
Am J Clin Pathol 2023 May 2;159(5):429-436. doi: 10.1093/ajcp/aqad001. PMID: 36869828
Giryes S, Bragazzi NL, Bridgewood C, De Marco G, McGonagle D
Semin Immunopathol 2022 May;44(3):375-390. Epub 2022 Apr 12 doi: 10.1007/s00281-022-00928-6. PMID: 35412072Free PMC Article
La Distia Nora R, Putera I, Mayasari YD, Hikmahwati W, Pertiwi AM, Ridwan AS, Sitompul R, Westcott M, Chee SP, Pavesio C, Thng ZX, Gupta V, Agrawal R
Surv Ophthalmol 2022 Jul-Aug;67(4):1014-1030. Epub 2021 Dec 23 doi: 10.1016/j.survophthal.2021.12.006. PMID: 34954093
Satturwar S, Fowkes M, Farver C, Wilson AM, Eccher A, Girolami I, Pujadas E, Bryce C, Salem F, El Jamal SM, Paniz-Mondolfi A, Petersen B, Gordon RE, Reidy J, Fraggetta F, Marshall DA, Pantanowitz L
Am J Surg Pathol 2021 May 1;45(5):587-603. doi: 10.1097/PAS.0000000000001650. PMID: 33481385Free PMC Article

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