U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Islet Cell Adenoma

MedGen UID:
9562
•Concept ID:
C0022134
•
Neoplastic Process
Synonyms: Adenoma, Islet Cell; Adenomas, Islet Cell; Islet Cell Adenomas
SNOMED CT: Islet cell adenoma (76345009); Islet cell tumor, benign (76345009); Pancreatic endocrine tumor, benign (76345009)

Definition

A benign endocrine neoplasm arising from the pancreas. It is separated from the normal pancreatic tissues by a thin collagenous capsule. It may secrete a hormone (e.g. insulin, gastrin) or it may be non-functional. [from NCI]

Professional guidelines

PubMed

Surgical treatment of organic pancreatic hypoglycemia in the pediatric age.
Carcassonne M, DeLarue A, LeTourneau JN
J Pediatr Surg 1983 Feb;18(1):75-9. doi: 10.1016/s0022-3468(83)80277-2. PMID: 6300364
Surgical management of islet-cell adenoma in infancy.
Rich RH, Dehner LP, Okinaga K, Deeb LC, Ulstrom RA, Leonard AS
Surgery 1978 Oct;84(4):519-26. PMID: 211657
Medical treatment of endogenous organic hyperinsulinism.
Scandellari C, Zaccaria M, Sicolo N, Casara D, Erle G, Federspil G
Horm Metab Res 1976;Suppl 6:46-54. PMID: 179929

Recent clinical studies

Etiology

Pancreatic islet cell tumors in adolescents and young adults.
Waters AM, Maizlin II, Russell RT, Dellinger M, Gow KW, Goldin A, Goldfarb M, Nuchtern JG, Langer M, Vasudevan SA, Doski JJ, Raval M, Beierle EA
J Pediatr Surg 2019 Oct;54(10):2103-2106. Epub 2019 Mar 27 doi: 10.1016/j.jpedsurg.2019.01.060. PMID: 30954230
Pancreatic neuroendocrine tumours.
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523
Islet cell tumors of the pancreas.
Bieligk S, Jaffe BM
Surg Clin North Am 1995 Oct;75(5):1025-40. doi: 10.1016/s0039-6109(16)46744-7. PMID: 7660247
Apudomas.
Nakano PH, Bloom RR, Brown BC, Gray SW, Skandalakis JE, Kibbe JM
Am Surg 1987 Sep;53(9):505-9. PMID: 2820286
Islet cell tumors of the pancreas and the alimentary tract.
Zollinger RM
Am J Surg 1975 Feb;129(2):102-10. doi: 10.1016/0002-9610(75)90284-6. PMID: 164136

Diagnosis

Islet cell tumours.
Ekeblad S
Adv Exp Med Biol 2010;654:771-89. doi: 10.1007/978-90-481-3271-3_34. PMID: 20217524
Insulinoma.
Goode AW
J R Soc Med 1989 Jul;82(7):383-4. doi: 10.1177/014107688908200703. PMID: 2555506Free PMC Article
Insulinomas.
Br Med J (Clin Res Ed) 1981 Mar 21;282(6268):927-8. PMID: 6258701Free PMC Article
Glucagon.
Foà PP
Ergeb Physiol 1968;60:141-219. doi: 10.1007/BFb0107253. PMID: 4298671
LEUCINE-INDUCED HYPOGLYCEMIA.
FAJANS SS
N Engl J Med 1965 Jun 10;272:1224-7. doi: 10.1056/NEJM196506102722308. PMID: 14284995

Therapy

Islet Cell Tumors of the Pancreas.
Amin S, Kim MK
Gastroenterol Clin North Am 2016 Mar;45(1):83-100. Epub 2016 Jan 13 doi: 10.1016/j.gtc.2015.10.007. PMID: 26895682
Glucagonoma syndrome.
Bloom SR, Polak JM
Am J Med 1987 May 29;82(5B):25-36. doi: 10.1016/0002-9343(87)90424-4. PMID: 2884877
Insulinomas.
Br Med J (Clin Res Ed) 1981 Mar 21;282(6268):927-8. PMID: 6258701Free PMC Article
Diazoxide.
Br Med J 1972 Nov 18;4(5837):417-8. PMID: 4344353Free PMC Article
Glucagon.
Foà PP
Ergeb Physiol 1968;60:141-219. doi: 10.1007/BFb0107253. PMID: 4298671

Prognosis

Pancreatic islet cell tumors in adolescents and young adults.
Waters AM, Maizlin II, Russell RT, Dellinger M, Gow KW, Goldin A, Goldfarb M, Nuchtern JG, Langer M, Vasudevan SA, Doski JJ, Raval M, Beierle EA
J Pediatr Surg 2019 Oct;54(10):2103-2106. Epub 2019 Mar 27 doi: 10.1016/j.jpedsurg.2019.01.060. PMID: 30954230
Islet cell tumours.
Ekeblad S
Adv Exp Med Biol 2010;654:771-89. doi: 10.1007/978-90-481-3271-3_34. PMID: 20217524
Pancreatic neuroendocrine tumours.
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523
Endocrine tumors of the pancreas.
House MG, Schulick RD
Curr Opin Oncol 2006 Jan;18(1):23-9. doi: 10.1097/01.cco.0000198974.59239.3c. PMID: 16357560
Islet cell tumors of the pancreas and the alimentary tract.
Zollinger RM
Am J Surg 1975 Feb;129(2):102-10. doi: 10.1016/0002-9610(75)90284-6. PMID: 164136

Clinical prediction guides

Islet Tumors: Resect or Follow?
Sinclair TJ, Poultsides GA
Adv Surg 2020 Sep;54:69-88. Epub 2020 Jun 17 doi: 10.1016/j.yasu.2020.04.004. PMID: 32713440
Multiple endocrine neoplasia type 1 (MEN1).
Thakker RV
Best Pract Res Clin Endocrinol Metab 2010 Jun;24(3):355-70. doi: 10.1016/j.beem.2010.07.003. PMID: 20833329
Oncogenic co-operation in beta-cell tumorigenesis.
Pelengaris S, Khan M
Endocr Relat Cancer 2001 Dec;8(4):307-14. doi: 10.1677/erc.0.0080307. PMID: 11733227
VIPoma syndrome.
Krejs GJ
Am J Med 1987 May 29;82(5B):37-48. doi: 10.1016/0002-9343(87)90425-6. PMID: 3035922
The glucagonoma syndrome.
Lewis AE
Int J Dermatol 1979 Jan-Feb;18(1):17-22. doi: 10.1111/j.1365-4362.1979.tb01904.x. PMID: 216645

Recent systematic reviews

Postoperative Complications, In-Hospital Mortality and 5-Year Survival After Surgical Resection for Patients with a Pancreatic Neuroendocrine Tumor: A Systematic Review.
Jilesen AP, van Eijck CH, in't Hof KH, van Dieren S, Gouma DJ, van Dijkum EJ
World J Surg 2016 Mar;40(3):729-48. doi: 10.1007/s00268-015-3328-6. PMID: 26661846Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...