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Islet Cell Adenoma

MedGen UID:
9562
Concept ID:
C0022134
Neoplastic Process
Synonyms: Adenoma, Islet Cell; Adenomas, Islet Cell; Islet Cell Adenomas
SNOMED CT: Islet cell adenoma (76345009); Islet cell tumor, benign (76345009); Pancreatic endocrine tumor, benign (76345009)

Definition

A benign endocrine neoplasm arising from the pancreas. It is separated from the normal pancreatic tissues by a thin collagenous capsule. It may secrete a hormone (e.g. insulin, gastrin) or it may be non-functional. [from NCI]

Professional guidelines

PubMed

Carcassonne M, DeLarue A, LeTourneau JN
J Pediatr Surg 1983 Feb;18(1):75-9. doi: 10.1016/s0022-3468(83)80277-2. PMID: 6300364
Rich RH, Dehner LP, Okinaga K, Deeb LC, Ulstrom RA, Leonard AS
Surgery 1978 Oct;84(4):519-26. PMID: 211657
Scandellari C, Zaccaria M, Sicolo N, Casara D, Erle G, Federspil G
Horm Metab Res 1976;Suppl 6:46-54. PMID: 179929

Recent clinical studies

Etiology

Cui Y, Yuan Q, Chen J, Jiang J, Guan H, Zhu R, Li N, Liu W, Wang C
Front Endocrinol (Lausanne) 2023;14:1127441. Epub 2023 May 8 doi: 10.3389/fendo.2023.1127441. PMID: 37223030Free PMC Article
Waters AM, Maizlin II, Russell RT, Dellinger M, Gow KW, Goldin A, Goldfarb M, Nuchtern JG, Langer M, Vasudevan SA, Doski JJ, Raval M, Beierle EA
J Pediatr Surg 2019 Oct;54(10):2103-2106. Epub 2019 Mar 27 doi: 10.1016/j.jpedsurg.2019.01.060. PMID: 30954230
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523
Zollinger RM
Am J Surg 1975 Feb;129(2):102-10. doi: 10.1016/0002-9610(75)90284-6. PMID: 164136
ReMine WH, Priestley JT, Judd ES, King JN
Ann Surg 1970 Oct;172(4):595-604. doi: 10.1097/00000658-197010000-00006. PMID: 4318798Free PMC Article

Diagnosis

Ekeblad S
Adv Exp Med Biol 2010;654:771-89. doi: 10.1007/978-90-481-3271-3_34. PMID: 20217524
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523
Vinik AI, Strodel WE, Eckhauser FE, Moattari AR, Lloyd R
Semin Oncol 1987 Sep;14(3):263-81. PMID: 2820062
Best JD, Chisholm DJ, Alford FP
Med J Aust 1978 Jul 1;2(1):10-2. doi: 10.5694/j.1326-5377.1978.tb131303.x. PMID: 210364
FAJANS SS
N Engl J Med 1965 Jun 10;272:1224-7. doi: 10.1056/NEJM196506102722308. PMID: 14284995

Therapy

Amin S, Kim MK
Gastroenterol Clin North Am 2016 Mar;45(1):83-100. Epub 2016 Jan 13 doi: 10.1016/j.gtc.2015.10.007. PMID: 26895682
Bloom SR, Polak JM
Am J Med 1987 May 29;82(5B):25-36. doi: 10.1016/0002-9343(87)90424-4. PMID: 2884877
Gardner JD
West J Med 1975 Oct;123(4):309-10. PMID: 173092Free PMC Article
Br Med J 1972 Nov 18;4(5837):417-8. PMID: 4344353Free PMC Article
Br Med J 1971 Aug 26;3(5773):524-5. PMID: 4327680Free PMC Article

Prognosis

Waters AM, Maizlin II, Russell RT, Dellinger M, Gow KW, Goldin A, Goldfarb M, Nuchtern JG, Langer M, Vasudevan SA, Doski JJ, Raval M, Beierle EA
J Pediatr Surg 2019 Oct;54(10):2103-2106. Epub 2019 Mar 27 doi: 10.1016/j.jpedsurg.2019.01.060. PMID: 30954230
Lewis RB, Lattin GE Jr, Paal E
Radiographics 2010 Oct;30(6):1445-64. doi: 10.1148/rg.306105523. PMID: 21071369
Ekeblad S
Adv Exp Med Biol 2010;654:771-89. doi: 10.1007/978-90-481-3271-3_34. PMID: 20217524
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523
Zollinger RM
Am J Surg 1975 Feb;129(2):102-10. doi: 10.1016/0002-9610(75)90284-6. PMID: 164136

Clinical prediction guides

Sinclair TJ, Poultsides GA
Adv Surg 2020 Sep;54:69-88. Epub 2020 Jun 17 doi: 10.1016/j.yasu.2020.04.004. PMID: 32713440
Thakker RV
Best Pract Res Clin Endocrinol Metab 2010 Jun;24(3):355-70. doi: 10.1016/j.beem.2010.07.003. PMID: 20833329
Frankel WL
Arch Pathol Lab Med 2006 Jul;130(7):963-6. doi: 10.5858/2006-130-963-UOPET. PMID: 16831051
Pelengaris S, Khan M
Endocr Relat Cancer 2001 Dec;8(4):307-14. doi: 10.1677/erc.0.0080307. PMID: 11733227
Krejs GJ
Am J Med 1987 May 29;82(5B):37-48. doi: 10.1016/0002-9343(87)90425-6. PMID: 3035922

Recent systematic reviews

Jilesen AP, van Eijck CH, in't Hof KH, van Dieren S, Gouma DJ, van Dijkum EJ
World J Surg 2016 Mar;40(3):729-48. doi: 10.1007/s00268-015-3328-6. PMID: 26661846Free PMC Article

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