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Crescentic glomerulonephritis

MedGen UID:
96040
Concept ID:
C0403416
Disease or Syndrome
Synonym: Crescentic glomerulonephritis (disease)
SNOMED CT: Proliferative crescentic glomerulonephritis (236398000); Idiopathic crescentic glomerulonephritis (236398000); Crescentic glomerulonephritis (236398000); CGN - Crescentic glomerulonephritis (236398000)
 
HPO: HP:0008653
Monarch Initiative: MONDO:0001645

Definition

A type of extracapillary glomerulonephritis characterized by the formation of crescent-like cellular proliferation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Crescentic glomerulonephritis
  • Crescentic glomerulonephritis
    • Crescentic glomerulonephritis
      • Crescentic glomerulonephritis
        • Crescentic glomerulonephritis
          • Crescentic glomerulonephritis
            • Crescentic glomerulonephritis
              • Crescentic glomerulonephritis

Conditions with this feature

Autoimmune interstitial lung disease-arthritis syndrome
MedGen UID:
1800821
Concept ID:
C5243948
Disease or Syndrome
Autoimmune interstitial lung, joint, and kidney disease is an autosomal dominant systemic autoimmune disorder characterized by interstitial lung disease, inflammatory arthritis, and immune complex-mediated renal disease. Laboratory studies show high-titer autoantibodies. Symptoms appear in the first 2 decades of life, but there is incomplete penetrance (summary by Watkin et al., 2015).

Professional guidelines

PubMed

Henderson SR, Salama AD
Nephrol Dial Transplant 2018 Feb 1;33(2):196-202. doi: 10.1093/ndt/gfx057. PMID: 28459999
Moroni G, Ponticelli C
Autoimmun Rev 2014 Jul;13(7):723-9. Epub 2014 Mar 19 doi: 10.1016/j.autrev.2014.02.007. PMID: 24657897
Li X, Chen N
Contrib Nephrol 2013;181:229-39. Epub 2013 May 8 doi: 10.1159/000348479. PMID: 23689584

Recent clinical studies

Etiology

Su X, Song R, Li S, Guo W, Guo X, Qiao X, Wang L
J Nephrol 2023 May;36(4):1027-1035. Epub 2023 Feb 14 doi: 10.1007/s40620-022-01550-3. PMID: 36786975
Wong MN, Tharaux PL, Grahammer F, Puelles VG
Cell Tissue Res 2021 Aug;385(2):345-354. Epub 2021 Aug 28 doi: 10.1007/s00441-021-03513-9. PMID: 34453566Free PMC Article
Mayer U, Schmitz J, Bräsen JH, Pape L
Pediatr Nephrol 2020 May;35(5):829-842. Epub 2020 Feb 12 doi: 10.1007/s00467-019-04436-y. PMID: 32052153Free PMC Article
Prakash J, Patel PS, Prakash S, Iqbal M, Sharma SS, Singh S, Singh U
J Assoc Physicians India 2019 Nov;67(11):18-21. PMID: 31793263
Balow JE
Curr Opin Nephrol Hypertens 1993 Mar;2(2):231-7. doi: 10.1097/00041552-199303000-00009. PMID: 7922182

Diagnosis

Reggiani F, L'Imperio V, Calatroni M, Pagni F, Sinico RA
Clin Exp Rheumatol 2023 Apr;41(4):964-974. Epub 2023 Mar 30 doi: 10.55563/clinexprheumatol/tep3k5. PMID: 36995324
Mayer U, Schmitz J, Bräsen JH, Pape L
Pediatr Nephrol 2020 May;35(5):829-842. Epub 2020 Feb 12 doi: 10.1007/s00467-019-04436-y. PMID: 32052153Free PMC Article
Sharma H, Keshavan A, Little MA, Cross J, Lipman MC, Talukdar S, Hopkins S
Ren Fail 2012;34(3):378-82. Epub 2012 Jan 17 doi: 10.3109/0886022X.2011.647337. PMID: 22250755
Bosch X, Guilabert A, Font J
Lancet 2006 Jul 29;368(9533):404-18. doi: 10.1016/S0140-6736(06)69114-9. PMID: 16876669
Gupta RK
Indian J Pathol Microbiol 2003 Jul;46(3):357-66. PMID: 15025274

Therapy

Huang Y, Zhao X, Zhang Q, Yang X, Hou G, Peng C, Jia M, Zhou L, Yamamoto T, Zheng J
Expert Opin Ther Targets 2023 Jan;27(1):55-69. Epub 2023 Feb 16 doi: 10.1080/14728222.2023.2177534. PMID: 36738160
Melica ME, Antonelli G, Semeraro R, Angelotti ML, Lugli G, Landini S, Ravaglia F, Regina G, Conte C, De Chiara L, Peired AJ, Mazzinghi B, Donati M, Molli A, Steiger S, Magi A, Bartalucci N, Raglianti V, Guzzi F, Maggi L, Annunziato F, Burger A, Lazzeri E, Anders HJ, Lasagni L, Romagnani P
Sci Transl Med 2022 Aug 10;14(657):eabg3277. doi: 10.1126/scitranslmed.abg3277. PMID: 35947676Free PMC Article
Maritati F, Canzian A, Fenaroli P, Vaglio A
Presse Med 2020 Oct;49(3):104035. Epub 2020 Jul 6 doi: 10.1016/j.lpm.2020.104035. PMID: 32645417
Mayer U, Schmitz J, Bräsen JH, Pape L
Pediatr Nephrol 2020 May;35(5):829-842. Epub 2020 Feb 12 doi: 10.1007/s00467-019-04436-y. PMID: 32052153Free PMC Article
Sharma H, Keshavan A, Little MA, Cross J, Lipman MC, Talukdar S, Hopkins S
Ren Fail 2012;34(3):378-82. Epub 2012 Jan 17 doi: 10.3109/0886022X.2011.647337. PMID: 22250755

Prognosis

Maritati F, Canzian A, Fenaroli P, Vaglio A
Presse Med 2020 Oct;49(3):104035. Epub 2020 Jul 6 doi: 10.1016/j.lpm.2020.104035. PMID: 32645417
Mayer U, Schmitz J, Bräsen JH, Pape L
Pediatr Nephrol 2020 May;35(5):829-842. Epub 2020 Feb 12 doi: 10.1007/s00467-019-04436-y. PMID: 32052153Free PMC Article
Zonozi R, Niles JL, Cortazar FB
Rheum Dis Clin North Am 2018 Nov;44(4):525-543. Epub 2018 Sep 7 doi: 10.1016/j.rdc.2018.06.001. PMID: 30274621
Sharma H, Keshavan A, Little MA, Cross J, Lipman MC, Talukdar S, Hopkins S
Ren Fail 2012;34(3):378-82. Epub 2012 Jan 17 doi: 10.3109/0886022X.2011.647337. PMID: 22250755
Gupta RK
Indian J Pathol Microbiol 2003 Jul;46(3):357-66. PMID: 15025274

Clinical prediction guides

Liu Y, Xu K, Xiang Y, Ma B, Li H, Li Y, Shi Y, Li S, Bai Y
Front Immunol 2023;14:1303076. Epub 2024 Jan 4 doi: 10.3389/fimmu.2023.1303076. PMID: 38239353Free PMC Article
García-Giménez J, Córdoba-David G, Rayego-Mateos S, Cannata-Ortiz P, Carrasco S, Ruiz-Ortega M, Fernandez-Fernandez B, Ortiz A, Ramos AM
J Pathol 2023 Nov;261(3):309-322. Epub 2023 Aug 31 doi: 10.1002/path.6177. PMID: 37650295
Kuang H, Shen CR, Jia XY, Tan M, Yang XF, Cui Z, Borza DB, Zhao MH
Kidney Int 2023 Dec;104(6):1124-1134. Epub 2023 Aug 19 doi: 10.1016/j.kint.2023.07.023. PMID: 37598856Free PMC Article
Diefenhardt P, Braumann M, Schömig T, Trinsch B, Sierra Gonzalez C, Becker-Gotot J, Völker LA, Ester L, Mandel AM, Hawiger D, Abdallah AT, Schermer B, Göbel H, Brinkkötter P, Kurts C, Benzing T, Brähler S
J Am Soc Nephrol 2023 Aug 1;34(8):1366-1380. Epub 2023 Jun 26 doi: 10.1681/ASN.0000000000000159. PMID: 37367205Free PMC Article
Charles Jennette J, Xiao H, Hu P
Semin Nephrol 2013 Nov;33(6):557-64. doi: 10.1016/j.semnephrol.2013.08.006. PMID: 24161040Free PMC Article

Recent systematic reviews

Rajagopala S, Parameswaran S, Ajmera JS, Ganesh RN, Katrevula A
Int J Rheum Dis 2017 Jan;20(1):109-121. Epub 2016 Feb 4 doi: 10.1111/1756-185X.12818. PMID: 26845236
Syeda UA, Singer NG, Magrey M
Semin Arthritis Rheum 2013 Jun;42(6):567-72. Epub 2013 Jan 24 doi: 10.1016/j.semarthrit.2012.10.007. PMID: 23352254
Chan PT, Mok CC
Clin Rheumatol 2012 Aug;31(8):1273-7. Epub 2012 May 30 doi: 10.1007/s10067-012-2010-8. PMID: 22644090

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