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Diffuse Neurofibroma

MedGen UID:
96598
Concept ID:
C0432361
Neoplastic Process
Synonym: Diffuse neurofibroma
SNOMED CT: Diffuse neurofibroma (254242006)

Definition

A rare neurofibroma with an infiltrative growth pattern. It involves the skin and subcutaneous tissue and grows in a plaque-like fashion. Malignant transformation is rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse Neurofibroma

Professional guidelines

PubMed

Polster SP, Dougherty MC, Zeineddine HA, Lyne SB, Smith HL, MacKenzie C, Pytel P, Yang CW, Tonsgard JH, Warnke PC, Frim DM
Neurosurgery 2020 May 1;86(5):646-655. doi: 10.1093/neuros/nyz244. PMID: 31350851

Recent clinical studies

Etiology

Attia S, Guirguis M, Le LQ, Chhabra A
Skeletal Radiol 2024 Apr;53(4):769-777. Epub 2023 Oct 31 doi: 10.1007/s00256-023-04497-z. PMID: 37903998
García-Martínez FJ, Azorín D, Duat-Rodríguez A, Hernández-Martín Á
J Dtsch Dermatol Ges 2021 Jan;19(1):73-80. Epub 2021 Jan 14 doi: 10.1111/ddg.14322. PMID: 33448128
Polster SP, Dougherty MC, Zeineddine HA, Lyne SB, Smith HL, MacKenzie C, Pytel P, Yang CW, Tonsgard JH, Warnke PC, Frim DM
Neurosurgery 2020 May 1;86(5):646-655. doi: 10.1093/neuros/nyz244. PMID: 31350851
Wang W, Montgomery E, Epstein JI
Am J Surg Pathol 2008 Jun;32(6):907-12. doi: 10.1097/PAS.0b013e31815b0c9a. PMID: 18425043
Hassell DS, Bancroft LW, Kransdorf MJ, Peterson JJ, Berquist TH, Murphey MD, Fanburg-Smith JC
AJR Am J Roentgenol 2008 Mar;190(3):582-8. doi: 10.2214/AJR.07.2589. PMID: 18287425

Diagnosis

Attia S, Guirguis M, Le LQ, Chhabra A
Skeletal Radiol 2024 Apr;53(4):769-777. Epub 2023 Oct 31 doi: 10.1007/s00256-023-04497-z. PMID: 37903998
Friedrich RE, Nörnberg LKN, Hagel C
Anticancer Res 2022 Mar;42(3):1247-1261. doi: 10.21873/anticanres.15592. PMID: 35220215
Polster SP, Dougherty MC, Zeineddine HA, Lyne SB, Smith HL, MacKenzie C, Pytel P, Yang CW, Tonsgard JH, Warnke PC, Frim DM
Neurosurgery 2020 May 1;86(5):646-655. doi: 10.1093/neuros/nyz244. PMID: 31350851
Hassell DS, Bancroft LW, Kransdorf MJ, Peterson JJ, Berquist TH, Murphey MD, Fanburg-Smith JC
AJR Am J Roentgenol 2008 Mar;190(3):582-8. doi: 10.2214/AJR.07.2589. PMID: 18287425
Brownstein S, Little JM
Ophthalmology 1983 Dec;90(12):1595-9. doi: 10.1016/s0161-6420(83)34371-2. PMID: 6429597

Prognosis

Friedrich RE, Nörnberg LKN, Hagel C
Anticancer Res 2022 Mar;42(3):1247-1261. doi: 10.21873/anticanres.15592. PMID: 35220215
Polster SP, Dougherty MC, Zeineddine HA, Lyne SB, Smith HL, MacKenzie C, Pytel P, Yang CW, Tonsgard JH, Warnke PC, Frim DM
Neurosurgery 2020 May 1;86(5):646-655. doi: 10.1093/neuros/nyz244. PMID: 31350851
Evans HL
Am J Surg Pathol 2013 Jul;37(7):987-94. doi: 10.1097/PAS.0b013e31827c96f4. PMID: 23648456
Carbonnelle-Puscian A, Vidal V, Laurendeau I, Valeyrie-Allanore L, Vidaud D, Bièche I, Leroy K, Lantieri L, Wolkenstein P, Schedl A, Ortonne N
Hum Pathol 2011 Mar;42(3):434-43. Epub 2010 Dec 28 doi: 10.1016/j.humpath.2010.02.020. PMID: 21193222
McKee PH, Fletcher CD
J Cutan Pathol 1991 Aug;18(4):241-6. doi: 10.1111/j.1600-0560.1991.tb01230.x. PMID: 1939782

Clinical prediction guides

Ho JD, Ho JAS, Ruddock R, Spencer SA
Am J Dermatopathol 2022 Dec 1;44(12):904-912. doi: 10.1097/DAD.0000000000002322. PMID: 36395447
Friedrich RE, Nörnberg LKN, Hagel C
Anticancer Res 2022 May;42(5):2327-2340. doi: 10.21873/anticanres.15712. PMID: 35489721
Friedrich RE, Nörnberg LKN, Hagel C
Anticancer Res 2022 Mar;42(3):1247-1261. doi: 10.21873/anticanres.15592. PMID: 35220215
García-Martínez FJ, Azorín D, Duat-Rodríguez A, Hernández-Martín Á
J Dtsch Dermatol Ges 2021 Jan;19(1):73-80. Epub 2021 Jan 14 doi: 10.1111/ddg.14322. PMID: 33448128
Mariño-Enriquez A, Nascimento AF, Ligon AH, Liang C, Fletcher CD
Am J Surg Pathol 2017 Feb;41(2):234-244. doi: 10.1097/PAS.0000000000000770. PMID: 27879515

Recent systematic reviews

Ho JD, Ho JAS, Ruddock R, Spencer SA
Am J Dermatopathol 2022 Dec 1;44(12):904-912. doi: 10.1097/DAD.0000000000002322. PMID: 36395447

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