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Trisomy 11

MedGen UID:
96602
•Concept ID:
C0432409
•
Congenital Abnormality
SNOMED CT: Trisomy 11 (205652000)

Definition

The presence of a third copy of chromosome 11 in somatic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrisomy 11

Professional guidelines

PubMed

A laboratory-based scoring system predicts early treatment in Rai 0 chronic lymphocytic leukemia.
Cohen JA, Rossi FM, Zucchetto A, Bomben R, Terzi-di-Bergamo L, Rabe KG, Degan M, Steffan A, Polesel J, Santinelli E, Innocenti I, Cutrona G, D'Arena G, Pozzato G, Zaja F, Chiarenza A, Rossi D, Di Raimondo F, Laurenti L, Gentile M, Morabito F, Neri A, Ferrarini M, Fegan CD, Pepper CJ, Del Poeta G, Parikh SA, Kay NE, Gattei V
Haematologica 2020 Jun;105(6):1613-1620. Epub 2019 Oct 3 doi: 10.3324/haematol.2019.228171. PMID: 31582547Free PMC Article
Prenatal diagnosis of trisomy 21, 18 and 13 by quantitative pyrosequencing of segmental duplications.
Tong H, Jin Y, Xu Y, Zou B, Ye H, Wu H, Kumar S, Pitman JL, Zhou G, Song Q
Clin Genet 2016 Nov;90(5):451-455. Epub 2016 Apr 8 doi: 10.1111/cge.12772. PMID: 26948280

Recent clinical studies

Etiology

Single umbilical artery and reproduction losses in Slovak population: relation to karyotype and fetal anomalies.
Malova J, Bohmer D, Luha J, Pastorakova A, Cierna Z, Braxatorisova T
Bratisl Lek Listy 2018;119(6):330-334. doi: 10.4149/BLL_2018_062. PMID: 29947231
Chromosomal abnormalities associated with neural tube defects (I): full aneuploidy.
Chen CP
Taiwan J Obstet Gynecol 2007 Dec;46(4):325-35. doi: 10.1016/S1028-4559(08)60002-9. PMID: 18182338
Frequency and distribution of trisomy 11 in multiple myeloma patients: relation with overexpression of CCND1 and t(11;14).
Guglielmelli T, Giugliano E, Cappia S, Papotti M, Saglio G
Cancer Genet Cytogenet 2007 Feb;173(1):51-6. doi: 10.1016/j.cancergencyto.2006.09.017. PMID: 17284370
Clinical characteristics of patients with de novo acute myeloid leukaemia and isolated trisomy 11: a Cancer and Leukemia Group B study.
Heinonen K, Mrózek K, Lawrence D, Arthur DC, Pettenati MJ, Stamberg J, Qumsiyeh MB, Verma RS, MacCallum J, Schiffer CA, Bloomfield CD
Br J Haematol 1998 Jun;101(3):513-20. doi: 10.1046/j.1365-2141.1998.00714.x. PMID: 9633896
The role of cytogenetics in the classification of soft tissue tumours.
Dei Tos AP, Dal Cin P
Virchows Arch 1997 Aug;431(2):83-94. doi: 10.1007/s004280050073. PMID: 9293889

Diagnosis

Prenatal diagnosis of mosaicism for double trisomies of trisomy 11 and trisomy 12 in a single colony at amniocentesis in a pregnancy with a favorable outcome.
Chen CP, Wang LK, Chern SR, Wu PS, Chen SW, Wu FT, Chen YY, Wang W
Taiwan J Obstet Gynecol 2020 May;59(3):443-445. doi: 10.1016/j.tjog.2020.03.020. PMID: 32416896
Prenatal diagnosis of mosaicism for trisomy 11 in a single colony at amniocentesis in a pregnancy with a favorable outcome.
Chen CP, Weng SL, Chern SR, Wu PS, Chen SW, Wu FT, Lee MS, Wang W
Taiwan J Obstet Gynecol 2020 Mar;59(2):331-333. doi: 10.1016/j.tjog.2020.01.027. PMID: 32127160
Myeloid Sarcoma.
Magdy M, Abdel Karim N, Eldessouki I, Gaber O, Rahouma M, Ghareeb M
Oncol Res Treat 2019;42(4):224-229. Epub 2019 Mar 6 doi: 10.1159/000497210. PMID: 30840960
Chromosomal abnormalities associated with neural tube defects (I): full aneuploidy.
Chen CP
Taiwan J Obstet Gynecol 2007 Dec;46(4):325-35. doi: 10.1016/S1028-4559(08)60002-9. PMID: 18182338
The role of cytogenetics in the classification of soft tissue tumours.
Dei Tos AP, Dal Cin P
Virchows Arch 1997 Aug;431(2):83-94. doi: 10.1007/s004280050073. PMID: 9293889

Therapy

Myeloid Sarcoma.
Magdy M, Abdel Karim N, Eldessouki I, Gaber O, Rahouma M, Ghareeb M
Oncol Res Treat 2019;42(4):224-229. Epub 2019 Mar 6 doi: 10.1159/000497210. PMID: 30840960
Routine fluorescence in situ hybridization with the MLL probe does not reliably detect two separate signals on one chromosome 11 in patients with trisomy 11.
Smith A, Robson L, Heaps LS, Sharma P, Dunlop L, Bhave A, Bradstock K
Cancer Genet Cytogenet 2001 Sep;129(2):173-6. doi: 10.1016/s0165-4608(01)00449-6. PMID: 11566351
Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML.
Schnittger S, Kinkelin U, Schoch C, Heinecke A, Haase D, Haferlach T, Büchner T, Wörmann B, Hiddemann W, Griesinger F
Leukemia 2000 May;14(5):796-804. doi: 10.1038/sj.leu.2401773. PMID: 10803509
Clinical characteristics of patients with de novo acute myeloid leukaemia and isolated trisomy 11: a Cancer and Leukemia Group B study.
Heinonen K, Mrózek K, Lawrence D, Arthur DC, Pettenati MJ, Stamberg J, Qumsiyeh MB, Verma RS, MacCallum J, Schiffer CA, Bloomfield CD
Br J Haematol 1998 Jun;101(3):513-20. doi: 10.1046/j.1365-2141.1998.00714.x. PMID: 9633896
Regional cancer cytogenetics: a report on 1,143 diagnostic cases.
Perkins D, Brennan S, Carstairs K, Bailey D, Pantalony D, Poon A, Fernandes B, Dubé I
Cancer Genet Cytogenet 1997 Jul 1;96(1):64-80. doi: 10.1016/s0165-4608(96)00363-9. PMID: 9209473

Prognosis

Trisomy 11 as an isolated abnormality in acute myeloid leukemia is associated with unfavorable prognosis but not with an NPM1 or KIT mutation.
Alseraye FM, Zuo Z, Bueso-Ramos C, Wang S, Medeiros LJ, Lu G
Int J Clin Exp Pathol 2011 Apr;4(4):371-7. Epub 2011 Apr 25 PMID: 21577323Free PMC Article
The MLL partial tandem duplication in acute myeloid leukaemia.
Basecke J, Whelan JT, Griesinger F, Bertrand FE
Br J Haematol 2006 Nov;135(4):438-49. Epub 2006 Sep 11 doi: 10.1111/j.1365-2141.2006.06301.x. PMID: 16965385
Routine fluorescence in situ hybridization with the MLL probe does not reliably detect two separate signals on one chromosome 11 in patients with trisomy 11.
Smith A, Robson L, Heaps LS, Sharma P, Dunlop L, Bhave A, Bradstock K
Cancer Genet Cytogenet 2001 Sep;129(2):173-6. doi: 10.1016/s0165-4608(01)00449-6. PMID: 11566351
Clinical characteristics of patients with de novo acute myeloid leukaemia and isolated trisomy 11: a Cancer and Leukemia Group B study.
Heinonen K, Mrózek K, Lawrence D, Arthur DC, Pettenati MJ, Stamberg J, Qumsiyeh MB, Verma RS, MacCallum J, Schiffer CA, Bloomfield CD
Br J Haematol 1998 Jun;101(3):513-20. doi: 10.1046/j.1365-2141.1998.00714.x. PMID: 9633896
Trisomy 11: an association with stem/progenitor cell immunophenotype.
Slovak ML, Traweek ST, Willman CL, Head DR, Kopecky KJ, Magenis RE, Appelbaum FR, Forman SJ
Br J Haematol 1995 Jun;90(2):266-73. doi: 10.1111/j.1365-2141.1995.tb05146.x. PMID: 7794746

Clinical prediction guides

The Retinal Pigment Epithelial Cell Line (ARPE-19) Displays Mosaic Structural Chromosomal Aberrations.
Fasler-Kan E, Aliu N, Wunderlich K, Ketterer S, Ruggiero S, Berger S, Meyer P
Methods Mol Biol 2018;1745:305-314. doi: 10.1007/978-1-4939-7680-5_17. PMID: 29476476
Epigenetic Dysregulation Observed in Monosomy Blastocysts Further Compromises Developmental Potential.
Denomme MM, McCallie BR, Parks JC, Schoolcraft WB, Katz-Jaffe MG
PLoS One 2016;11(6):e0156980. Epub 2016 Jun 7 doi: 10.1371/journal.pone.0156980. PMID: 27271036Free PMC Article
The MLL partial tandem duplication in acute myeloid leukaemia.
Basecke J, Whelan JT, Griesinger F, Bertrand FE
Br J Haematol 2006 Nov;135(4):438-49. Epub 2006 Sep 11 doi: 10.1111/j.1365-2141.2006.06301.x. PMID: 16965385
Molecular approach to common causes of female infertility.
Simpson JL
Best Pract Res Clin Obstet Gynaecol 2002 Oct;16(5):685-702. doi: 10.1053/beog.2002.0317. PMID: 12475548
The role of cytogenetics in the classification of soft tissue tumours.
Dei Tos AP, Dal Cin P
Virchows Arch 1997 Aug;431(2):83-94. doi: 10.1007/s004280050073. PMID: 9293889

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