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Complex regional pain syndrome

MedGen UID:
96846
Concept ID:
C0458219
Disease or Syndrome
Synonyms: Complex Regional Pain Syndrome; Complex Regional Pain Syndromes; CRPS (Complex Regional Pain Syndromes); Pain Syndromes, Regional Complex
SNOMED CT: Complex regional pain syndrome (128200000); Algodystrophy (128200000); CRPS - complex regional pain syndrome (128200000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019369
Orphanet: ORPHA83452

Definition

Complex regional pain syndrome (CRPS) is a rare neurologic disease painful progressive condition that corresponds to a group of disorders characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComplex regional pain syndrome
Follow this link to review classifications for Complex regional pain syndrome in Orphanet.

Professional guidelines

PubMed

Harden RN, McCabe CS, Goebel A, Massey M, Suvar T, Grieve S, Bruehl S
Pain Med 2022 Jun 10;23(Suppl 1):S1-S53. doi: 10.1093/pm/pnac046. PMID: 35687369Free PMC Article
Urits I, Shen AH, Jones MR, Viswanath O, Kaye AD
Curr Pain Headache Rep 2018 Feb 5;22(2):10. doi: 10.1007/s11916-018-0667-7. PMID: 29404787
Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD
Pain 2013 Nov;154(11):2249-2261. Epub 2013 Jun 6 doi: 10.1016/j.pain.2013.06.004. PMID: 23748119Free PMC Article

Recent clinical studies

Etiology

Limerick G, Christo DK, Tram J, Moheimani R, Manor J, Chakravarthy K, Karri J, Christo PJ
Curr Pain Headache Rep 2023 Sep;27(9):269-298. Epub 2023 Jul 8 doi: 10.1007/s11916-023-01130-5. PMID: 37421541
Shafiee E, MacDermid J, Packham T, Walton D, Grewal R, Farzad M
Clin J Pain 2023 Feb 1;39(2):91-105. doi: 10.1097/AJP.0000000000001089. PMID: 36650605
Méndez-Rebolledo G, Gatica-Rojas V, Torres-Cueco R, Albornoz-Verdugo M, Guzmán-Muñoz E
J Back Musculoskelet Rehabil 2017;30(3):441-449. doi: 10.3233/BMR-150500. PMID: 27858687
O'Connell NE, Wand BM, McAuley J, Marston L, Moseley GL
Cochrane Database Syst Rev 2013 Apr 30;2013(4):CD009416. doi: 10.1002/14651858.CD009416.pub2. PMID: 23633371Free PMC Article
Pertoldi S, Di Benedetto P
Eura Medicophys 2005 Dec;41(4):283-92. PMID: 16474282

Diagnosis

Harden RN, McCabe CS, Goebel A, Massey M, Suvar T, Grieve S, Bruehl S
Pain Med 2022 Jun 10;23(Suppl 1):S1-S53. doi: 10.1093/pm/pnac046. PMID: 35687369Free PMC Article
Kessler A, Yoo M, Calisoff R
NeuroRehabilitation 2020;47(3):253-264. doi: 10.3233/NRE-208001. PMID: 32986618
Neumeister MW, Romanelli MR
Clin Plast Surg 2020 Apr;47(2):305-310. Epub 2020 Jan 31 doi: 10.1016/j.cps.2019.12.009. PMID: 32115056
Ersoy H, Pomeranz SJ
J Surg Orthop Adv 2016 summer;25(2):117-20. PMID: 27518298
Bruehl S
BMJ 2015 Jul 29;351:h2730. doi: 10.1136/bmj.h2730. PMID: 26224572

Therapy

Limerick G, Christo DK, Tram J, Moheimani R, Manor J, Chakravarthy K, Karri J, Christo PJ
Curr Pain Headache Rep 2023 Sep;27(9):269-298. Epub 2023 Jul 8 doi: 10.1007/s11916-023-01130-5. PMID: 37421541
Kessler A, Yoo M, Calisoff R
NeuroRehabilitation 2020;47(3):253-264. doi: 10.3233/NRE-208001. PMID: 32986618
Smart KM, Wand BM, O'Connell NE
Cochrane Database Syst Rev 2016 Feb 24;2(2):CD010853. doi: 10.1002/14651858.CD010853.pub2. PMID: 26905470Free PMC Article
Bruehl S
BMJ 2015 Jul 29;351:h2730. doi: 10.1136/bmj.h2730. PMID: 26224572
O'Connell NE, Wand BM, McAuley J, Marston L, Moseley GL
Cochrane Database Syst Rev 2013 Apr 30;2013(4):CD009416. doi: 10.1002/14651858.CD009416.pub2. PMID: 23633371Free PMC Article

Prognosis

Mills M, Howell CM
JAAPA 2023 Aug 1;36(8):1-5. doi: 10.1097/01.JAA.0000931440.10463.f2. PMID: 37493995
Ferraro MC, Cashin AG, Wand BM, Smart KM, Berryman C, Marston L, Moseley GL, McAuley JH, O'Connell NE
Cochrane Database Syst Rev 2023 Jun 12;6(6):CD009416. doi: 10.1002/14651858.CD009416.pub3. PMID: 37306570Free PMC Article
Urits I, Shen AH, Jones MR, Viswanath O, Kaye AD
Curr Pain Headache Rep 2018 Feb 5;22(2):10. doi: 10.1007/s11916-018-0667-7. PMID: 29404787
Rammelt S, Goronzy J
Foot Ankle Clin 2015 Jun;20(2):253-64. Epub 2015 Mar 29 doi: 10.1016/j.fcl.2015.02.008. PMID: 26043242
O'Connell NE, Wand BM, McAuley J, Marston L, Moseley GL
Cochrane Database Syst Rev 2013 Apr 30;2013(4):CD009416. doi: 10.1002/14651858.CD009416.pub2. PMID: 23633371Free PMC Article

Clinical prediction guides

Mills M, Howell CM
JAAPA 2023 Aug 1;36(8):1-5. doi: 10.1097/01.JAA.0000931440.10463.f2. PMID: 37493995
Vandecasteele L, Degreef I
Acta Orthop Belg 2020 Sep;86(3):555-562. PMID: 33581042
Orhurhu V, Orhurhu MS, Bhatia A, Cohen SP
Anesth Analg 2019 Jul;129(1):241-254. doi: 10.1213/ANE.0000000000004185. PMID: 31082965
Dawes JM, Vincent A
Curr Opin Support Palliat Care 2016 Jun;10(2):137-42. doi: 10.1097/SPC.0000000000000211. PMID: 27100817
Moseley GL
Pain 2004 Mar;108(1-2):192-8. doi: 10.1016/j.pain.2004.01.006. PMID: 15109523

Recent systematic reviews

Shafiee E, MacDermid J, Packham T, Walton D, Grewal R, Farzad M
Clin J Pain 2023 Feb 1;39(2):91-105. doi: 10.1097/AJP.0000000000001089. PMID: 36650605
Harden RN, McCabe CS, Goebel A, Massey M, Suvar T, Grieve S, Bruehl S
Pain Med 2022 Jun 10;23(Suppl 1):S1-S53. doi: 10.1093/pm/pnac046. PMID: 35687369Free PMC Article
Smart KM, Ferraro MC, Wand BM, O'Connell NE
Cochrane Database Syst Rev 2022 May 17;5(5):CD010853. doi: 10.1002/14651858.CD010853.pub3. PMID: 35579382Free PMC Article
Smart KM, Wand BM, O'Connell NE
Cochrane Database Syst Rev 2016 Feb 24;2(2):CD010853. doi: 10.1002/14651858.CD010853.pub2. PMID: 26905470Free PMC Article
O'Connell NE, Wand BM, McAuley J, Marston L, Moseley GL
Cochrane Database Syst Rev 2013 Apr 30;2013(4):CD009416. doi: 10.1002/14651858.CD009416.pub2. PMID: 23633371Free PMC Article

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