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Hypoalphalipoproteinemia

MedGen UID:: 96877
•Concept ID:: C0473527
•: Disease or Syndrome

Synonyms:	alpha Lipoproteinemia, Hypo; HDL Cholesterol, Low Serum; Hypo alpha Lipoproteinemia; Hypo alpha Lipoproteinemias; Hypoalphalipoproteinemias; Lipoproteinemia, Hypo alpha; Lipoproteinemias, Hypo alpha
SNOMED CT:	Hypoalphalipoproteinemia (190785000)

Definition

A metabolic disorder characterized by deficiency of high density (alpha) lipoprotein in the blood. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHypoalphalipoproteinemia

Abnormal circulating metabolite concentration
- Abnormal circulating organic compound concentration
  - Abnormal circulating lipid concentration
    - Abnormal circulating cholesterol concentration
      - Abnormality of lipoprotein cholesterol concentration
        Hypolipoproteinemia
        Hypoalphalipoproteinemia
        Norum disease
        Tangier disease

Professional guidelines

PubMed

Very low HDL levels: clinical assessment and management.

Bonilha I, Luchiari B, Nadruz W, Sposito AC
Arch Endocrinol Metab 2023 Jan 18;67(1):3-18. doi: 10.20945/2359-3997000000585. PMID: 36651718 Free PMC Article

Dyslipidemia prevalence, awareness, treatment and control in Mexico: results of the Ensanut 2012.

Hernández-Alcaraz C, Aguilar-Salinas CA, Mendoza-Herrera K, Pedroza-Tobías A, Villalpando S, Shamah-Levy T, Rivera-Dommarco J, Hernández-Ávila M, Barquera S
Salud Publica Mex 2020 Mar-Apr;62(2):137-146. doi: 10.21149/10520. PMID: 32237556

Diagnosis and management of familial dyslipoproteinemia in children and adolescents.

Kwiterovich PO Jr
Pediatr Clin North Am 1990 Dec;37(6):1489-523. doi: 10.1016/s0031-3955(16)37021-3. PMID: 2259550

See all (8)

Recent clinical studies

Etiology

Very low HDL levels: clinical assessment and management.

Bonilha I, Luchiari B, Nadruz W, Sposito AC
Arch Endocrinol Metab 2023 Jan 18;67(1):3-18. doi: 10.20945/2359-3997000000585. PMID: 36651718 Free PMC Article

Rare Diseases Related with Lipoprotein Metabolism.

Zhou H, Gong Y, Wu Q, Ye X, Yu B, Lu C, Jiang W, Ye J, Fu Z
Adv Exp Med Biol 2020;1276:171-188. doi: 10.1007/978-981-15-6082-8_11. PMID: 32705600

High density lipoprotein cholesterol and cancer: Marker or causative?

Pirro M, Ricciuti B, Rader DJ, Catapano AL, Sahebkar A, Banach M
Prog Lipid Res 2018 Jul;71:54-69. Epub 2018 Jun 4 doi: 10.1016/j.plipres.2018.06.001. PMID: 29879431

Gene-based therapies in lipidology: current status and future challenges.

Gaudet D, Brisson D
Curr Opin Lipidol 2015 Dec;26(6):553-65. doi: 10.1097/MOL.0000000000000240. PMID: 26780008

Diagnosis and management of familial dyslipoproteinemia in children and adolescents.

Kwiterovich PO Jr
Pediatr Clin North Am 1990 Dec;37(6):1489-523. doi: 10.1016/s0031-3955(16)37021-3. PMID: 2259550

See all (143)

Diagnosis

Progress in finding pathogenic DNA copy number variations in dyslipidemia.

Iacocca MA, Dron JS, Hegele RA
Curr Opin Lipidol 2019 Apr;30(2):63-70. doi: 10.1097/MOL.0000000000000581. PMID: 30664016

High density lipoprotein cholesterol and cancer: Marker or causative?

Pirro M, Ricciuti B, Rader DJ, Catapano AL, Sahebkar A, Banach M
Prog Lipid Res 2018 Jul;71:54-69. Epub 2018 Jun 4 doi: 10.1016/j.plipres.2018.06.001. PMID: 29879431

Analysis of familial hypoalphalipoproteinemia syndromes.

Frohlich J, Pritchard PH
Mol Cell Biochem 1992 Aug 18;113(2):141-9. doi: 10.1007/BF00231534. PMID: 1518505

Diagnosis and management of familial dyslipoproteinemia in children and adolescents.

Kwiterovich PO Jr
Pediatr Clin North Am 1990 Dec;37(6):1489-523. doi: 10.1016/s0031-3955(16)37021-3. PMID: 2259550

Familial hypoalphalipoproteinemias.

Frohlich J, Westerlund J, Sparks D, Pritchard PH
Clin Invest Med 1990 Aug;13(4):202-10. PMID: 2119926

See all (43)

Therapy

Very low HDL levels: clinical assessment and management.

Bonilha I, Luchiari B, Nadruz W, Sposito AC
Arch Endocrinol Metab 2023 Jan 18;67(1):3-18. doi: 10.20945/2359-3997000000585. PMID: 36651718 Free PMC Article

Rare Diseases Related with Lipoprotein Metabolism.

Zhou H, Gong Y, Wu Q, Ye X, Yu B, Lu C, Jiang W, Ye J, Fu Z
Adv Exp Med Biol 2020;1276:171-188. doi: 10.1007/978-981-15-6082-8_11. PMID: 32705600

High density lipoprotein cholesterol and cancer: Marker or causative?

Pirro M, Ricciuti B, Rader DJ, Catapano AL, Sahebkar A, Banach M
Prog Lipid Res 2018 Jul;71:54-69. Epub 2018 Jun 4 doi: 10.1016/j.plipres.2018.06.001. PMID: 29879431

What combination therapy with a statin, if any, would you recommend?

Dujovne CA, Williams CD, Ito MK
Curr Atheroscler Rep 2011 Feb;13(1):12-22. doi: 10.1007/s11883-010-0150-3. PMID: 21107758

Familial hypoalphalipoproteinemia.

Glueck CJ, Melser MA, Borecki IB, Third JL, Rao DC, Laskarzewski PM
Adv Exp Med Biol 1986;201:83-92. doi: 10.1007/978-1-4684-1262-8_8. PMID: 3541525

See all (62)

Prognosis

Polygenic scores for dyslipidemia: the emerging genomic model of plasma lipoprotein trait inheritance.

Trinder M, Brunham LR
Curr Opin Lipidol 2021 Apr 1;32(2):103-111. doi: 10.1097/MOL.0000000000000737. PMID: 33395106

Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia.

Tobar HE, Cataldo LR, González T, Rodríguez R, Serrano V, Arteaga A, Álvarez-Mercado A, Lagos CF, Vicuña L, Miranda JP, Pereira A, Bravo C, Aguilera CM, Eyheramendy S, Uauy R, Martínez Á, Gil Á, Francone O, Rigotti A, Santos JL
Lipids Health Dis 2019 Jun 5;18(1):132. doi: 10.1186/s12944-019-1045-0. PMID: 31164121 Free PMC Article

Hypoalphalipoproteinemia and BRAF(V600E) Mutation Are Major Predictors of Aortic Infiltration in the Erdheim-Chester Disease.

Cohen-Aubart F, Guerin M, Poupel L, Cluzel P, Saint-Charles F, Charlotte F, Arsafi Y, Emile JF, Frisdal E, Le Goff C, Donadieu J, Amoura Z, Lesnik P, Haroche J, Le Goff W
Arterioscler Thromb Vasc Biol 2018 Aug;38(8):1913-1925. doi: 10.1161/ATVBAHA.118.310803. PMID: 29930009

Hypoalphalipoproteinemia (low high density lipoprotein) as a risk factor for coronary heart disease.

Vega GL, Grundy SM
Curr Opin Lipidol 1996 Aug;7(4):209-16. doi: 10.1097/00041433-199608000-00007. PMID: 8883496

Primary and familial hypoalphalipoproteinemia.

Third JL, Montag J, Flynn M, Freidel J, Laskarzewski P, Glueck CJ
Metabolism 1984 Feb;33(2):136-46. doi: 10.1016/0026-0495(84)90126-4. PMID: 6694557

See all (39)

Clinical prediction guides

Food Consumption and Metabolic Risks in Young University Students.

González-Torres S, González-Silva N, Pérez-Reyes Á, Anaya-Esparza LM, Sánchez-Enríquez S, Vargas-Becerra PN, Villagrán Z, García-García MR
Int J Environ Res Public Health 2021 Dec 31;19(1) doi: 10.3390/ijerph19010449. PMID: 35010709 Free PMC Article

Polygenic scores for dyslipidemia: the emerging genomic model of plasma lipoprotein trait inheritance.

Trinder M, Brunham LR
Curr Opin Lipidol 2021 Apr 1;32(2):103-111. doi: 10.1097/MOL.0000000000000737. PMID: 33395106

Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia.

Hypoalphalipoproteinemia and BRAF(V600E) Mutation Are Major Predictors of Aortic Infiltration in the Erdheim-Chester Disease.

Primary and familial hypoalphalipoproteinemia.

Third JL, Montag J, Flynn M, Freidel J, Laskarzewski P, Glueck CJ
Metabolism 1984 Feb;33(2):136-46. doi: 10.1016/0026-0495(84)90126-4. PMID: 6694557

See all (80)