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Transient neonatal myasthenia gravis

MedGen UID:
96918
•Concept ID:
C0495465
•
Disease or Syndrome
Synonyms: Myasthenia Gravis, Neonatal, Transient; Myasthenia Gravis, Transient, Neonatal; Neonatal Myasthenia Gravis, Transient; Transient Neonatal Myasthenia Gravis
SNOMED CT: Transient neonatal myasthenia (230683002); Transient neonatal myasthenia gravis (230683002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018326
Orphanet: ORPHA391504

Definition

Transient neonatal myasthenia gravis (MG) is a rare form of MG (see this term) occurring in neonates born to mothers who have the disorder or specific circulating autoantibodies. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransient neonatal myasthenia gravis

Professional guidelines

PubMed

Abdeg technology for the treatment of myasthenia gravis: efgartigimod drug experience.
Dos Santos JBR, Gomes RM, da Silva MRR
Expert Rev Clin Immunol 2022 Sep;18(9):879-888. Epub 2022 Aug 5 doi: 10.1080/1744666X.2022.2106972. PMID: 35892247
A Review of Disease Mechanisms and Current and Emerging Treatment Options for Generalized Myasthenia Gravis.
Bril V, Silvestri NJ, Barnett-Tapia C
Prim Care Companion CNS Disord 2022 May 24;24(3) doi: 10.4088/PCC.AR21018WC2C. PMID: 35621832
Diagnosis and treatment of myasthenia gravis.
Mantegazza R, Cavalcante P
Curr Opin Rheumatol 2019 Nov;31(6):623-633. doi: 10.1097/BOR.0000000000000647. PMID: 31385879

Recent clinical studies

Etiology

Transient neonatal myasthenia gravis: refining risk estimate for infants born to women with myasthenia gravis.
Kochhar PK, Schumacher RE, Sarkar S
J Perinatol 2021 Sep;41(9):2279-2283. Epub 2021 Feb 17 doi: 10.1038/s41372-021-00970-6. PMID: 33597740
Intravenous immunoglobulin as monotherapy for myasthenia gravis during pregnancy.
Gamez J, Salvado M, Casellas M, Manrique S, Castillo F
J Neurol Sci 2017 Dec 15;383:118-122. Epub 2017 Nov 6 doi: 10.1016/j.jns.2017.10.037. PMID: 29246598
Clinical follow-up of pregnancy in myasthenia gravis patients.
Ducci RD, Lorenzoni PJ, Kay CS, Werneck LC, Scola RH
Neuromuscul Disord 2017 Apr;27(4):352-357. Epub 2017 Feb 1 doi: 10.1016/j.nmd.2017.01.021. PMID: 28256306
Myasthenia gravis and pregnancy: clinical implications and neonatal outcome.
Téllez-Zenteno JF, Hernández-Ronquillo L, Salinas V, Estanol B, da Silva O
BMC Musculoskelet Disord 2004 Nov 16;5:42. doi: 10.1186/1471-2474-5-42. PMID: 15546494Free PMC Article
Transient neonatal myasthenia gravis.
Papazian O
J Child Neurol 1992 Apr;7(2):135-41. doi: 10.1177/088307389200700202. PMID: 1573230

Diagnosis

Transient Neonatal Myasthenia Gravis: A Case Report.
Ristovska S, Stomnaroska O, Dimitrioska R
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2023 Jul 1;44(2):165-169. Epub 2023 Jul 15 doi: 10.2478/prilozi-2023-0036. PMID: 37453109
Challenges in Diagnosing and Treating Myasthenia Gravis in Infants and Children with Presentation of Cases.
Bricoune O, Hamner B, Gieron-Korthals M
Adv Pediatr 2023 Aug;70(1):81-90. Epub 2023 May 10 doi: 10.1016/j.yapd.2023.03.007. PMID: 37422299
Transient neonatal myasthenia gravis: refining risk estimate for infants born to women with myasthenia gravis.
Kochhar PK, Schumacher RE, Sarkar S
J Perinatol 2021 Sep;41(9):2279-2283. Epub 2021 Feb 17 doi: 10.1038/s41372-021-00970-6. PMID: 33597740
Myasthenia gravis and pregnancy: clinical implications and neonatal outcome.
Téllez-Zenteno JF, Hernández-Ronquillo L, Salinas V, Estanol B, da Silva O
BMC Musculoskelet Disord 2004 Nov 16;5:42. doi: 10.1186/1471-2474-5-42. PMID: 15546494Free PMC Article
Transient neonatal myasthenia gravis.
Papazian O
J Child Neurol 1992 Apr;7(2):135-41. doi: 10.1177/088307389200700202. PMID: 1573230

Therapy

Intravenous immunoglobulin as monotherapy for myasthenia gravis during pregnancy.
Gamez J, Salvado M, Casellas M, Manrique S, Castillo F
J Neurol Sci 2017 Dec 15;383:118-122. Epub 2017 Nov 6 doi: 10.1016/j.jns.2017.10.037. PMID: 29246598
The Role of Sugammadex in Symptomatic Transient Neonatal Myasthenia Gravis: A Case Report.
Rubin JE, Ramamurthi RJ
A A Case Rep 2017 Nov 1;9(9):271-273. doi: 10.1213/XAA.0000000000000590. PMID: 28691986
Transient neonatal myasthenia gravis in a baby born to a mother with new-onset anti-MuSK-mediated myasthenia gravis.
O'carroll P, Bertorini TE, Jacob G, Mitchell CW, Graff J
J Clin Neuromuscul Dis 2009 Dec;11(2):69-71. doi: 10.1097/CND.0b013e3181a78280. PMID: 19955986
Myasthenia gravis in childhood.
Gamio S, Garcia-Erro M, Vaccarezza MM, Minella JA
Binocul Vis Strabismus Q 2004;19(4):223-31. PMID: 15530139
High-dose intravenous immunoglobulin in transient neonatal myasthenia gravis.
Bassan H, Muhlbaur B, Tomer A, Spirer Z
Pediatr Neurol 1998 Feb;18(2):181-3. doi: 10.1016/s0887-8994(97)00174-4. PMID: 9535308

Prognosis

The expectant management of a rare neonatal disease: transient neonatal myasthenia gravis.
Masra F, Ishak S, Cheah FC
Turk J Pediatr 2023;65(2):321-325. doi: 10.24953/turkjped.2022.717. PMID: 37114697
Intravenous immunoglobulin as monotherapy for myasthenia gravis during pregnancy.
Gamez J, Salvado M, Casellas M, Manrique S, Castillo F
J Neurol Sci 2017 Dec 15;383:118-122. Epub 2017 Nov 6 doi: 10.1016/j.jns.2017.10.037. PMID: 29246598
Clinical follow-up of pregnancy in myasthenia gravis patients.
Ducci RD, Lorenzoni PJ, Kay CS, Werneck LC, Scola RH
Neuromuscul Disord 2017 Apr;27(4):352-357. Epub 2017 Feb 1 doi: 10.1016/j.nmd.2017.01.021. PMID: 28256306
Pregnancy complicated by Myasthenia gravis - twelve years experience.
Podciechowski L, Brocka-Nitecka U, Dabrowska K, Bielak A, Hadacz B, Wilczynski J
Neuro Endocrinol Lett 2005 Oct;26(5):603-8. PMID: 16264394
Myasthenia gravis and pregnancy: clinical implications and neonatal outcome.
Téllez-Zenteno JF, Hernández-Ronquillo L, Salinas V, Estanol B, da Silva O
BMC Musculoskelet Disord 2004 Nov 16;5:42. doi: 10.1186/1471-2474-5-42. PMID: 15546494Free PMC Article

Clinical prediction guides

Transient neonatal myasthenia gravis: refining risk estimate for infants born to women with myasthenia gravis.
Kochhar PK, Schumacher RE, Sarkar S
J Perinatol 2021 Sep;41(9):2279-2283. Epub 2021 Feb 17 doi: 10.1038/s41372-021-00970-6. PMID: 33597740
Intravenous immunoglobulin as monotherapy for myasthenia gravis during pregnancy.
Gamez J, Salvado M, Casellas M, Manrique S, Castillo F
J Neurol Sci 2017 Dec 15;383:118-122. Epub 2017 Nov 6 doi: 10.1016/j.jns.2017.10.037. PMID: 29246598
Clinical follow-up of pregnancy in myasthenia gravis patients.
Ducci RD, Lorenzoni PJ, Kay CS, Werneck LC, Scola RH
Neuromuscul Disord 2017 Apr;27(4):352-357. Epub 2017 Feb 1 doi: 10.1016/j.nmd.2017.01.021. PMID: 28256306
Transient neonatal myasthenia gravis revealing a myasthenia gravis and a systemic lupus erythematosus in the mother: case report and review of the literature.
Saint-Faust M, Perelman S, Dupont D, Velin P, Chatel M
Am J Perinatol 2010 Feb;27(2):107-10. Epub 2009 Jun 1 doi: 10.1055/s-0029-1224873. PMID: 19488958
Neonatal myasthenia gravis: antigenic specificities of antibodies in sera from mothers and their infants.
Tzartos SJ, Efthimiadis A, Morel E, Eymard B, Bach JF
Clin Exp Immunol 1990 Jun;80(3):376-80. doi: 10.1111/j.1365-2249.1990.tb03296.x. PMID: 1695559Free PMC Article

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