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Transient neonatal myasthenia gravis

MedGen UID:
96918
•Concept ID:
C0495465
•
Disease or Syndrome
Synonyms: Myasthenia Gravis, Neonatal, Transient; Myasthenia Gravis, Transient, Neonatal; Neonatal Myasthenia Gravis, Transient; Transient Neonatal Myasthenia Gravis
SNOMED CT: Transient neonatal myasthenia (230683002); Transient neonatal myasthenia gravis (230683002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018326
Orphanet: ORPHA391504

Definition

Transient neonatal myasthenia gravis (MG) is a rare form of MG (see this term) occurring in neonates born to mothers who have the disorder or specific circulating autoantibodies. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransient neonatal myasthenia gravis

Professional guidelines

PubMed

Myasthenia gravis-Pathophysiology, diagnosis, and treatment.
Tannemaat MR, Huijbers MG, Verschuuren JJGM
Handb Clin Neurol 2024;200:283-305. doi: 10.1016/B978-0-12-823912-4.00026-8. PMID: 38494283
Current drug treatment of myasthenia gravis.
Vanoli F, Mantegazza R
Curr Opin Neurol 2023 Oct 1;36(5):410-415. Epub 2023 Aug 30 doi: 10.1097/WCO.0000000000001196. PMID: 37678337
Diagnosis and treatment of myasthenia gravis.
Mantegazza R, Cavalcante P
Curr Opin Rheumatol 2019 Nov;31(6):623-633. doi: 10.1097/BOR.0000000000000647. PMID: 31385879

Recent clinical studies

Etiology

Pregnancy in myasthenia gravis: a retrospective analysis of maternal and neonatal outcome from a large tertiary care centre in Germany.
Draxler J, Meisel A, Stascheit F, Stein M, Gerischer L, Mergenthaler P, Herdick M, Doksani P, Lehnerer S, Verlohren S, Hoffmann S
Arch Gynecol Obstet 2024 Jul;310(1):277-284. Epub 2024 Mar 16 doi: 10.1007/s00404-024-07436-y. PMID: 38492082Free PMC Article
Transient neonatal myasthenia gravis: refining risk estimate for infants born to women with myasthenia gravis.
Kochhar PK, Schumacher RE, Sarkar S
J Perinatol 2021 Sep;41(9):2279-2283. Epub 2021 Feb 17 doi: 10.1038/s41372-021-00970-6. PMID: 33597740
Clinical follow-up of pregnancy in myasthenia gravis patients.
Ducci RD, Lorenzoni PJ, Kay CS, Werneck LC, Scola RH
Neuromuscul Disord 2017 Apr;27(4):352-357. Epub 2017 Feb 1 doi: 10.1016/j.nmd.2017.01.021. PMID: 28256306
Myasthenia gravis and pregnancy: clinical implications and neonatal outcome.
Téllez-Zenteno JF, Hernández-Ronquillo L, Salinas V, Estanol B, da Silva O
BMC Musculoskelet Disord 2004 Nov 16;5:42. doi: 10.1186/1471-2474-5-42. PMID: 15546494Free PMC Article
Transient neonatal myasthenia gravis.
Papazian O
J Child Neurol 1992 Apr;7(2):135-41. doi: 10.1177/088307389200700202. PMID: 1573230

Diagnosis

Transient Neonatal Myasthenia Gravis: A Case Report.
Ristovska S, Stomnaroska O, Dimitrioska R
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2023 Jul 1;44(2):165-169. Epub 2023 Jul 15 doi: 10.2478/prilozi-2023-0036. PMID: 37453109
Challenges in Diagnosing and Treating Myasthenia Gravis in Infants and Children with Presentation of Cases.
Bricoune O, Hamner B, Gieron-Korthals M
Adv Pediatr 2023 Aug;70(1):81-90. Epub 2023 May 10 doi: 10.1016/j.yapd.2023.03.007. PMID: 37422299
The emerging spectrum of fetal acetylcholine receptor antibody-related disorders (FARAD).
Allen NM, O'Rahelly M, Eymard B, Chouchane M, Hahn A, Kearns G, Kim DS, Byun SY, Nguyen CE, Schara-Schmidt U, Kölbel H, Marina AD, Schneider-Gold C, Roefke K, Thieme A, Van den Bergh P, Avalos G, Álvarez-Velasco R, Natera-de Benito D, Cheng MHM, Chan WK, Wan HS, Thomas MA, Borch L, Lauzon J, Kornblum C, Reimann J, Mueller A, Kuntzer T, Norwood F, Ramdas S, Jacobson LW, Jie X, Fernandez-Garcia MA, Wraige E, Lim M, Lin JP, Claeys KG, Aktas S, Oskoui M, Hacohen Y, Masud A, Leite MI, Palace J, De Vivo D, Vincent A, Jungbluth H
Brain 2023 Oct 3;146(10):4233-4246. doi: 10.1093/brain/awad153. PMID: 37186601Free PMC Article
Transient neonatal myasthenia gravis: refining risk estimate for infants born to women with myasthenia gravis.
Kochhar PK, Schumacher RE, Sarkar S
J Perinatol 2021 Sep;41(9):2279-2283. Epub 2021 Feb 17 doi: 10.1038/s41372-021-00970-6. PMID: 33597740
Transient neonatal myasthenia gravis.
Papazian O
J Child Neurol 1992 Apr;7(2):135-41. doi: 10.1177/088307389200700202. PMID: 1573230

Therapy

Pregnancy in myasthenia gravis: a retrospective analysis of maternal and neonatal outcome from a large tertiary care centre in Germany.
Draxler J, Meisel A, Stascheit F, Stein M, Gerischer L, Mergenthaler P, Herdick M, Doksani P, Lehnerer S, Verlohren S, Hoffmann S
Arch Gynecol Obstet 2024 Jul;310(1):277-284. Epub 2024 Mar 16 doi: 10.1007/s00404-024-07436-y. PMID: 38492082Free PMC Article
Intravenous immunoglobulin as monotherapy for myasthenia gravis during pregnancy.
Gamez J, Salvado M, Casellas M, Manrique S, Castillo F
J Neurol Sci 2017 Dec 15;383:118-122. Epub 2017 Nov 6 doi: 10.1016/j.jns.2017.10.037. PMID: 29246598
The Role of Sugammadex in Symptomatic Transient Neonatal Myasthenia Gravis: A Case Report.
Rubin JE, Ramamurthi RJ
A A Case Rep 2017 Nov 1;9(9):271-273. doi: 10.1213/XAA.0000000000000590. PMID: 28691986
Transient neonatal myasthenia gravis in a baby born to a mother with new-onset anti-MuSK-mediated myasthenia gravis.
O'carroll P, Bertorini TE, Jacob G, Mitchell CW, Graff J
J Clin Neuromuscul Dis 2009 Dec;11(2):69-71. doi: 10.1097/CND.0b013e3181a78280. PMID: 19955986
High-dose intravenous immunoglobulin in transient neonatal myasthenia gravis.
Bassan H, Muhlbaur B, Tomer A, Spirer Z
Pediatr Neurol 1998 Feb;18(2):181-3. doi: 10.1016/s0887-8994(97)00174-4. PMID: 9535308

Prognosis

The expectant management of a rare neonatal disease: transient neonatal myasthenia gravis.
Masra F, Ishak S, Cheah FC
Turk J Pediatr 2023;65(2):321-325. doi: 10.24953/turkjped.2022.717. PMID: 37114697
Intravenous immunoglobulin as monotherapy for myasthenia gravis during pregnancy.
Gamez J, Salvado M, Casellas M, Manrique S, Castillo F
J Neurol Sci 2017 Dec 15;383:118-122. Epub 2017 Nov 6 doi: 10.1016/j.jns.2017.10.037. PMID: 29246598
Clinical follow-up of pregnancy in myasthenia gravis patients.
Ducci RD, Lorenzoni PJ, Kay CS, Werneck LC, Scola RH
Neuromuscul Disord 2017 Apr;27(4):352-357. Epub 2017 Feb 1 doi: 10.1016/j.nmd.2017.01.021. PMID: 28256306
Pregnancy complicated by Myasthenia gravis - twelve years experience.
Podciechowski L, Brocka-Nitecka U, Dabrowska K, Bielak A, Hadacz B, Wilczynski J
Neuro Endocrinol Lett 2005 Oct;26(5):603-8. PMID: 16264394
Myasthenia gravis and pregnancy: clinical implications and neonatal outcome.
Téllez-Zenteno JF, Hernández-Ronquillo L, Salinas V, Estanol B, da Silva O
BMC Musculoskelet Disord 2004 Nov 16;5:42. doi: 10.1186/1471-2474-5-42. PMID: 15546494Free PMC Article

Clinical prediction guides

Transient neonatal myasthenia gravis: refining risk estimate for infants born to women with myasthenia gravis.
Kochhar PK, Schumacher RE, Sarkar S
J Perinatol 2021 Sep;41(9):2279-2283. Epub 2021 Feb 17 doi: 10.1038/s41372-021-00970-6. PMID: 33597740
Intravenous immunoglobulin as monotherapy for myasthenia gravis during pregnancy.
Gamez J, Salvado M, Casellas M, Manrique S, Castillo F
J Neurol Sci 2017 Dec 15;383:118-122. Epub 2017 Nov 6 doi: 10.1016/j.jns.2017.10.037. PMID: 29246598
Clinical follow-up of pregnancy in myasthenia gravis patients.
Ducci RD, Lorenzoni PJ, Kay CS, Werneck LC, Scola RH
Neuromuscul Disord 2017 Apr;27(4):352-357. Epub 2017 Feb 1 doi: 10.1016/j.nmd.2017.01.021. PMID: 28256306
Transient neonatal myasthenia gravis revealing a myasthenia gravis and a systemic lupus erythematosus in the mother: case report and review of the literature.
Saint-Faust M, Perelman S, Dupont D, Velin P, Chatel M
Am J Perinatol 2010 Feb;27(2):107-10. Epub 2009 Jun 1 doi: 10.1055/s-0029-1224873. PMID: 19488958
Neonatal myasthenia gravis: antigenic specificities of antibodies in sera from mothers and their infants.
Tzartos SJ, Efthimiadis A, Morel E, Eymard B, Bach JF
Clin Exp Immunol 1990 Jun;80(3):376-80. doi: 10.1111/j.1365-2249.1990.tb03296.x. PMID: 1695559Free PMC Article

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